Inhibition of Notch Signaling Promotes the Differentiation of Epicardial Progenitor Cells into Adipocytes by Bin Liu, Dinghui Wang, Tianhua Xiong, Yajie Liu, Xiaodong Jing, Jianlin Du, Qiang She

“…Activating the Notch signaling with jagged-1 attenuated the adipogenic differentiation of EPCs and downregulated the key adipogenesis transcription factor peroxisome proliferator activated receptor-γ (PPAR-γ), while inhibiting the signaling promoted adipogenic differentiation and upregulated PPAR-γ. When blocking PPAR-γ, the role of Notch signaling in promoting adipogenic differentiation was inhibited. …”
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Simulation of the Vibration Characteristics for Agricultural Wheeled Tractor with Implement and Front Axle Hydropneumatic Suspension by Enlai Zheng, Song Cui, Yuanzhao Yang, Jinlin Xue, Yue Zhu, Xiangze Lin

“…The dynamic coupling relationship among cabin, three-point hitch structure, and implement are figured out, and the dynamic model of the half agricultural wheeled tractor/implement system is presented considering the effects of three-point hitch structure, passive silent blocks of cabin, and front axle hydropneumatic suspension together. …”
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Downregulation of mPGES-1 Expression via EGR1 Plays an Important Role in Inhibition of Caffeine on PGE2 Synthesis of HBx(+) Hepatocytes by Yan Ma, Xiaoqian Wang, Nanhong Tang

“…The results indicate that caffeine could effectively reduce PGE2 synthesis in HBx(+) hepatocytes by specifically blocking the PPARγ-EGR1-mPGES-1 pathway, thereby providing a new evidence of molecular biology for the hypothesis that drinking coffee is beneficial to HBV-infected patients.…”
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A novel ambiguity resolution model of BeiDou navigation satellite system/inertial navigation system tightly coupled for kinematic-to-kinematic precise relative positioning by Ling Wu, Yongrong Sun, Xiyu Fu, Qinghua Zeng

“…Especially, in the complex dynamic environment, ambiguity resolution effect is influenced by the satellite signal blocked, multipath outlier, and abnormal state prediction. …”
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Expression of Cyclin D1 in Oral Squamous Cell Carcinoma by Malak Abdulrahman Seid Ahmed, Nazik Omer, Ahmed M. Suliman, Mona Ellaithi

“…Methods: This cross-sectional study included 40 formalin-fixed paraffin-embedded tissue blocks specimens of OSCC with variable grades. The expression of cyclin D1 was evaluated through immunohistochemical (IHC) staining. …”
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Neurokinin-1 Receptor Antagonist Treatment in Polymicrobial Sepsis: Molecular Insights by Akhil Hegde, Yung-Hua Koh, Shabbir M. Moochhala, Madhav Bhatia

“…Neurokinin-1 receptor blocking has been shown to be beneficial against lung injury in polymicrobial sepsis. …”
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Living Together with LGBT: A Discussion from the Sharia Perspective by Mohd Azhar Abdullah, Nur Azwani Mansor, Abdul Azib Hussain, Muhammad Lukman Ibrahim, Khairulnazrin Nasir

“…Specifically, it looks at the possible dangers of slander (fitnah) and how the principle of sadd zara’i (blocking the means) can be used to stop immoral acts. …”
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Salvia-Nelumbinis Naturalis Formula Improved Inflammation in LPS Stressed Macrophages via Upregulating MicroRNA-152 by Zansong Ma, Xiangbing Shu, Jie Huang, Haiyan Zhang, Zhen Xiao, Li Zhang

“…We further verified the pharmacological effects in Raw264.7 cells; while transfection with miRNA-152 mimics could reduce TNF-α and IL-6, transfection with miRNA-152 inhibitor blocked the anti-inflammatory effect of SNN-containing serum. …”
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CAR T cells for treating autoimmune diseases by Dimitrios Mougiakakos, Ulrike Koehl, Stephan Fricke, Ulrich Blache, Sandy Tretbar

“…Currently, autoimmune disorders are largely treated by broad immunosuppressive agents and blocking antibodies, which can manage the diseases but often are not curative. …”
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Brewed for Performance: Caffeine’s Impact on Nutrition, Endurance and Strength in Sports by Michał Janiszewski, Marcin Komorowski, Rafał Kaczorowski, Jaromir Hunia, Jonasz Jurek, Alicja Kapciak, Julia Górny, Aleksandra Pelczarska, Tomasz Forenc

“…Our comprehensive review of literature indicates that caffeine typically ingested one hour before exercise in doses around 3-6 mg/kg raises metabolic rate, increases free fatty acids mobilization, extends time to exhaustion in running and cycling, improves maximal voluntary contraction and enhances high-speed muscular activity with low-load movements. It also blocks pain perception. These findings highlight caffeine’s role in endurance and strength sports. …”
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Oxide-Based Nanocomposites for Food Packaging Application: A Review by Aisha Idris Ali, Munir Abba Dandago, Fatima Idris Ali, Genitha Immanuel, Jishnu Naskar

“…Incorporation of metal oxide nanoparticles into polymers allows for the production of nanocomposites with increased mechanical strength, water and oxygen barrier properties, and can also confer other additional functional properties, such as antioxidant, antimicrobial activity and light-blocking properties. According to migration studies, only a small quantity of nanomaterial migrates from packaging into food simulants or foods, implying that consumer exposure to these nanomaterials and the health concerns associated with them are low. …”
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Prognositc Significance of Microcystic Elongated and Fragmanted (MELF) Myometrial Invasion Pattern: A Retrospective Study by Oguzhan OKCU, Gokce ASKAN, Bayram SEN, Cigdem OZTURK, Seda DUMAN OZTURK, Gulname FINDIK GUVENDI

“…Pan-cytokeratin staining was performed on paraffin-embedded blocks of lymph nodes for cases without lymph node metastasis. …”
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Designing inclusive tech playful educative solutions for visually impaired learners in STEM education by Jennifer A. Cardenas Castaneda, Pei-Chun Lin, Patrick C. K. Hung, Hua-Xu Zhong, Hao-An Tseng, Yung-Fa Huang, Rafiq Ahmad

“…Qualitative research was conducted through interviews and observations of the interactions between VI Learners playing an audio game and tactile 3D printed blocks, which covered an age range of young participants aged 8–18 years and adults aged 30–40 years in Taiwan. …”
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The EGF Receptor and HER2 Participate in TNF-α-Dependent MAPK Activation and IL-8 Secretion in Intestinal Epithelial Cells by Humberto B. Jijon, Andre Buret, Christina L. Hirota, Morley D. Hollenberg, Paul L. Beck

“…This requires EGFR autophosphorylation as it was blocked by the EGFR kinase inhibitor AG1478. Autophosphorylation was also inhibited by both a Src-kinase inhibitor and the metalloproteinase inhibitor batimastat. …”
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Influence of shortest path algorithms on energy consumption of multi-core processors by A. A. Prihozhy, O. N. Karasik

“…The classical Floyd-Warshall algorithm (FW) consumed up to twice as much energy, and the blocked homogeneous (BFW) and heterogeneous (HBFW) algorithms consumed up to 52.2 % and 21.2 % more energy than GEA. …”
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Government support for the agro-industrial complex: the experience of a programme-oriented approach in Australia by Yu. P. Maidanevych, N. S. Sergienko, Yu. V. Gnezdova

“…The Australian experience in implementing the Smart Farms programme is presented in the context of programme blocks with an analysis of the technologies used; key approaches in organising the selection of the programme participants and the risks of its realisation are highlighted. …”
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Leiomodin creates a leaky cap at the pointed end of actin-thin filaments. by Dmitri Tolkatchev, Garry E Smith, Lauren E Schultz, Mert Colpan, Gregory L Helms, John R Cort, Carol C Gregorio, Alla S Kostyukova

“…Our structural data indicate that the leiomodin/tropomyosin complex only forms at the pointed end of thin filaments, where the tropomyosin N-terminus is not blocked by an adjacent tropomyosin protomer. This discovery provides evidence supporting the debated mechanism where leiomodin and tropomodulin regulate thin filament lengths by competing for thin filament binding. …”
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Studies of biofilms and phenotypic characteristics of Candida fungi by E. M. Lenchenko, N. P. Sachivkina

“…The search and testing of multilevel algorithms for biofilm identification when exposed to chemotherapeutic and disinfectant drugs for blocking the synthesis or destruction of the intercellular matrix in the development of superficial, deep and systemic candidiasis of animals are relevant for developing and improving diagnostic and antiepidemic measures. …”
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Research on the Deformation Law and Stress Distribution Characteristics of Overburden under the Influence of Multiple Faults by Yaobin Qi, Weijian Yu, Desun Yu, Hanxiao Guo, Bao Pan

“…But as the working face continues to advance, the blocking effect of the roof plastic zone above the goaf on the transmission of the behind abutment pressure of the working face begins to appear and continues to increase, leading to a decrease in the peak stress at the lower strata of F1. …”
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Comparison of canal transportation and centering ability of three different endodontic rotary systems (an invitro study) by Shakhawan Kadir Kadir

“…Methods: Thirty simulated curved canals of 35° curvature manufactured in clear resin blocks were randomly assigned to 3 groups (n = 10) according to the system used for canal instrumentation: ProTaper next, two Shape and Pro Taper gold systems groups, Centering ability was evaluated; Pre‐and postoperative images of the canals were taken at a standardized position by a digital camera with a resolution of 25 mega pixel. …”
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