Identification of a distinctive immunogenomic gene signature in stage-matched colorectal cancer by Pankaj Ahluwalia, Ashis K. Mondal, Ashutosh Vashisht, Harmanpreet Singh, Ahmet Alptekin, Kalyani Ballur, Nivin Omar, Meenakshi Ahluwalia, Kimya Jones, Amanda Barrett, Vamsi Kota, Ravindra Kolhe

“…Method In this retrospective study, we used FFPE blocks of tissue samples from CRC patients at Augusta University (AU) to quantify a custom 15-gene panel. …”
Get full text

HINT1 suppression protects against age-related cardiac dysfunction by enhancing mitochondrial biogenesis by Michio Sato, Tsuyoshi Kadomatsu, Jun Morinaga, Yuya Kinoshita, Daisuke Torigoe, Haruki Horiguchi, Sumio Ohtsuki, Shuji Yamamura, Ryoko Kusaba, Takanori Yamaguchi, Goro Yoshioka, Kimi Araki, Tomohiko Wakayama, Keishi Miyata, Koichi Node, Yuichi Oike

“…Interestingly, CR not only suppressed age-related declines in cardiac function and mitochondrial biogenesis but blocked concomitant increases in cardiac HINT1 protein levels and maintained Tfam transcription. …”
Get full text

CD36 inhibition enhances the anti-proliferative effects of PI3K inhibitors in PTEN-loss anti-HER2 resistant breast cancer cells by You-Yu Liu, Wei-Lun Huang, Sin-Tian Wang, Hui-Ping Hsu, Tzu-Ching Kao, Wei-Pang Chung, Kung-Chia Young

“…CD36 was upregulated by blocking the PI3K signal pathway or limited serum supplementation, indicating that suppressing CD36 may decrease the excess transport of exogenous FA. …”
Get full text

Environmental microbial communications in gram-positive and gram-negative bacteria by P. Srikanth, D. Sivakumar, J. Nouri

“…The larger part of quorum sensing recognizing inhibitor takes bacterial quorum sensing share identifying as the even-handed and simply blocks the larger part recognizing plan of pathogenic organisms, which can demolish the pathogenicity of microorganisms without applying explicit squeezing factor, and doesn't execute the regular organisms or then again intrude with their standard physiological activities. …”
Get full text

Role of Vigilin and RACK1 in dengue virus-Aedes aegypti-Wolbachia interactions by Guijie Wang, Mazhar Hussain, Zhi Qi, Sassan Asgari

“…Furthermore, we found that both genes are induced in mosquito cells transinfected with Wolbachia, a bacterium that blocks DENV replication. The results help better understand the role of the common factors supporting DENV replication in mosquitoes and human cells.…”
Get full text

No easy way out: towards a framework concept of long-term governance by Dirk Scheer, Sandra Venghaus, Stefania Sardo, Sascha Stark, Sophie Kuppler, Michael W. Schmidt, Carsten Hoyer-Klick

“…Main text We elaborate an analytical framework for long-term governance (LTG), based on five building blocks: the ‘environment’, which details the policy-making arena; the ‘policy issues’, which elaborates on the problems to be dealt with by LTG; the ‘key challenges and driving force’, revealing LTG mechanisms; the ‘key strategies’, in which promising approaches for LTG are identified; and the ‘policy cycle’, where governance impacts on different policy phases are discussed. …”
Get full text

Effects of ruminal short-chain fatty acid concentration and pH on histology, hematology, and inflammation in cannulated Holstein dairy calves by A.R. Wolfe, M.H.P.M. Narciso, R.R.E. Uwiera, A.H. Laarman

“…Holstein calves (n = 32) had the rumen cannulated within the first week of life and at wk 2 were blocked by BW and randomly assigned in a 2 × 2 factorial arrangement of treatments. …”
Get full text

Multicenter Randomized Controlled Trial Comparing the Contribution of Proxabrushes with Regular Toothbrushes and Only Regular Toothbrushes to the Oral Health of Thai Elderly by Orachad Gururatana, Warangkana Vejvithee, Narisa Ekpatcha

“…Multicenter randomized controlled trial, parallel grouped, open label, blocked randomization was used at each province to allocate treatment. …”
Get full text

Wnt/ β-catenin and CTNNB1 gene mutation in hepatocellular carcinoma, a case study in Egyptian patients by Ramy A. Abdelsalam, Ibrahim M. El-Shawaf, Azza Abdel-Aziz, Tarek A. Bismar, Shaimaa M. Yussif

“…Tissue Microarray (TMAs) were prepared. β-Catenin and Wnt immunohistochemical (IHC) staining was performed on these blocks. Detection and scoring of CTNNB1 gene mutation were done by Chromogenic In Situ Hybridization (CISH). …”
Get full text

Inclusive educational process at the university: Theoretical and experimental model of teachers' psychological readiness by V. Z. Kantor, Yu. L. Proekt

“…In the diagnostic and methodological terms, the current study relied on the authors' questionnaire containing the blocks of questions built using a 5-point Likert scale and characterising the severity of the various components of such readiness among university teachers in relation to working with disabled students of diverse nosological groups. …”
Get full text

Linking the life stages of fish into a habitat-ecological flow assessment scheme under climate change and human activities by Yiming Zhang, Wensheng Wang, Siyi Yu

“…Then, a habitat assessment framework encompassing the swimming ability of fish during migration stage and their ecological preferences during spawning and feeding stages was developed to assess fish habitats under different scenarios. In this framework, blocked index (BI) and percentages of the longest continuous river reach (PLR) were proposed to quantify the habitat connectivity conditions during migration stage. …”
Get full text

In silico evaluation of missense SNPs in cancer-associated Cystatin A protein and their potential to disrupt Cathepsin B interaction by Shafaat Hossain, Omar Hamza Bin Manjur, Mst Sharmin Sultana Shimu, Tamanna Sultana, Mustafizur Rahman Naim, Shahariar Siddique, Abdullah Al Mamun, Md Miftaur Rahman, Md Abu Saleh, Md Rakibul Hasan, Tania Rahman

Get full text

Cross-Sectional Survey to Assess Tobacco and Nicotine Product Use since the Introduction of Heated Tobacco Products in Japan: Wave 2 by Prasad Krishna, Shetty Mandara, Edward Lauren, Kanitscheider Claudia, Marczykowski Felix

“…A 3-stage probability sampling method was applied that was geographically stratified by street blocks proportionate to population density. Respondents self-reported patterns of product use and reasons for HTP use. …”
Get full text

STRATEGY OF SOCIALLY-ANTHROPOLOGICAL DEVELOPMENT IN IDEAS AND SYSTEM OF MODERN SOCIAL PHILOSOPHY OF EDUCATION: INTEGRATION OF MODEL OF THE INSTRUMENTALISM AND THE NEOPRAGMATISM WIT... by Viktor Zinchenko

“…Considering growing requirement of a practical embodiment of ideas of freedom, justice, aspiration to realization of the human rights proclaimed a society, supporters of the concept of «new humanism» see the main objective in blocking a way to conformism, to a manipulation behaviour of the person and to create conditions for its free self-expression, for realization by the person of a fundamental choice of acts in a concrete situation and by that to warn danger of formation of the unified form of behaviour. …”
Get full text

ICAM1 blockade improves ischemic muscle reperfusion in diabetic mice by Ninon Foussard, Célia Bourguignon, Virginie Grouthier, Caroline Caradu, Candice Chapouly, Alain-Pierre Gadeau, Thierry Couffinhal, Marie-Ange Renault

“…Importantly, we used ICAM1-blocking antibodies to demonstrate that increased ICAM1 expression in HFD + STZ mice decreases white blood cell circulation velocity within the microcirculation, which impairs its perfusion. …”
Get full text

Comparing two corrective exercise approaches for body image and upper-quadrant posture in schoolgirls with hyperkyphosis by Samineh Mokhtaran, Hashem Piri, Rahman Sheikhhoseini, Mohammad Salsali

“…For the purpose of conducting the experiment, 14 subjects were assigned to two groups (eccentric-based and control), and 12 subjects were assigned to the NASM group by using a simple blocked randomization method. The body esteem scale questionnaire was used to assess participants’ body image in the groups. …”
Get full text

hCTLA4-Gene-Modified Human Bone Marrow-Derived Mesenchymal Stem Cells (hBMMSCs) Maintain POSTN Secretion to Enhance the Migration Capability of Allogeneic hBMMSCs through the Integ... by Lei Song, Fei Zhang, Rui Zhou, Jun Xiao, Lei He, Fei Dai

“…Additionally, these induced effects can be weakened by POSTN knockdown, and the migration capability of allo-hBMMSCs was blocked by anti-integrin αvβ3 IgG. In conclusion, hCTLA4-gene-modified hBMMSCs maintain POSTN secretion to enhance the migration capability of allogeneic hBMMSCs through the integrin αvβ3/FAK/ERK signaling pathway in the T cell immune activation environment.…”
Get full text

Medico-ethnobotanical survey of medicinal plants used in the treatment of skin diseases in Tiruppur District, Tamil Nadu, India by Prakasam Radha, Chinniaya Udhayavani, Raju Nagaraj, Kumarasamy Sivaranjani

“…Study methods: Medico-ethnobotanical survey was carried out from November 2017 to November 2020 in five blocks of Tiruppur District, Tamil Nadu, India. The data were documented from 194 key informants by using semi-structured questionnaire. …”
Get full text

Blockade of Erythropoietin-Producing Human Hepatocellular Carcinoma Receptor B1 in Spinal Dorsal Horn Alleviates Visceral Pain in Rats by Chen-Li Sun, Cheng-Wen Li, Nong He, Yuan-Zhang Tang, Xiu-Liang Li, Fu-Shan Xue, Jia-Xiang Ni

“…Adult male Sprague-Dawley rats were randomly divided into three groups receiving different treatments (n = 16 per group): intracolonic vehicle (control group), intracolonic 2, 4, 6-trinitrobenzene sulfonic acid (TNBS) (TNBS group), and intracolonic TNBS and intrathecal EphB1 receptor blocking reagent (TNBS + EphB2-Fc group). Visceral hyperalgesia was evaluated with quantification of visceral pain threshold induced by colorectal distention. …”
Get full text

The effect of depth data and upper limb impairment on lightweight monocular RGB human pose estimation models by Gloria-Edith Boudreault-Morales, Cesar Marquez-Chin, Xilin Liu, José Zariffa

“…The models were modified to include depth data as an input using three different fusion techniques: an early fusion method, a simple intermediate fusion method (using concatenation), and a complex intermediate fusion method (using specific fusion blocks, additional convolutional layers, and concatenation). …”
Get full text