Availability and accessibility of cytotoxic medicines in the WHO model list of essential medicines for childhood cancer in low and lower-middle- income countries: a systematic revi... by Maheeka Seneviwickrama, Sashini Shehana Denagamagei, Surangi Jayakody, Sanjeeva Gunasekera, Guwani Liyanage

“…Enablers and barriers were discussed based on the World Health Organization (WHO) health system building blocks. Results Out of the 29 articles retrieved for full-text screening, the final synthesis included nine articles. …”
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Genome-wide association analysis and KASP markers development for protein quality traits in winter wheat by Yousheng Tian, Pengpeng Liu, Dezhen Kong, Yingbin Nie, Hongjun Xu, Xinnian Han, Wei Sang, Weihua Li

“…Haplotype analysis of loci associated with the gluten index in the 412–416 Mb interval on chromosome 1D identified three blocks. Accessions with superior haplotypes showed a significantly higher gluten index than those with inferior haplotypes. …”
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Dissolution of Different Reservoir Rocks by Organic Acids in Laboratory Simulations: Implications for the Effect of Alteration on Deep Reservoirs by Jian Chen, Jie Xu, Susu Wang, Zhenyu Sun, Zhong Li, Wanglu Jia, Ping’an Peng

“…Both carbonate samples showed the development of large voids, including holes and cavities of micrometer scale, but nanopores of various sizes were blocked. In contrast, lithic arkose was heterogeneously altered, losing a weight proportion of about 13% by dissolution of calcite cement. …”
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Contradictory Effect of Lymphocyte Therapy and Prednisolone Therapy on CD3+CD8+CD56+ Natural Killer T Population in Women with Recurrent Spontaneous Abortion by Fatemeh Rezayat, Nafiseh Esmaeil, Abbas Rezaei, Roya Sherkat

“…Conclusion: The lower capability of LIT in changing the population of NKT cells compared to prednisolone therapy may be due to its mechanism of action, which is related to the production of blocking antibodies. These treatment approaches had different effects on NKT cells, indicating that NKT cell population and function can be affected using LIT and prednisolone therapy distinctly. …”
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Inhibition and evasion of neutrophil microbicidal responses by Legionella longbeachae by Hannah E. Hanford, Christopher T. D. Price, Silvia Uriarte, Yousef Abu Kwaik

“…By inhibiting of assembly of the phagocyte NADPH oxidase complex, the pathogen blocks neutrophils from generating microbicide reactive oxygen species. …”
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Efficacy of Simple Eye Ointment, Polyethylene Cover, and Eyelid Taping in Prevention of Ocular Surface Disorders in Critically Ill Patients: A Randomized Clinical Trial by Mehdi Ahmadinejad, Esmat Karbasi, Yunes Jahani, Maryam Ahmadipour, Maryam Soltaninejad, Zahra Karzari

“…However, patients admitted to the intensive care unit (ICU) for several reasons including loss of consciousness, receiving sedative and neuromuscular blocking agents, and mechanical ventilation may lose eye-protective mechanisms causing exposure keratopathy. …”
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Pretreatment with AM1241 Enhances the Analgesic Effect of Intrathecally Administrated Mesenchymal Stem Cells by Junran Xie, Jinxuan Ren, Na Liu, Chengwei Wu, Dongju Xiao, Huanyu Luo, Jingxian Du

“…In addition, i.t. injection of exogenous TGF-β1 slightly alleviated neuropathic pain whilst neutralization of TGF-β1 potently blocked the effect of AM1241-treated mesenchymal stem cells on thermal hyperalgesia and mechanical allodynia of CCI mice. …”
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Impact of cooling diabetic patients’ fingertips compared to vibrating stimulation on pain from the glucometer needle: A cross-over trial study by Vahid Vejdanihemmat, Hiva Azami, Leili Tapak, Shiva Borzouei, khodayar Oshvandi

“…The study design consisted of six blocks, each containing three interventions: vibration stimulation (A), cold therapy (B), and a combination of both C. …”
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Bank Credit and Loan Repayment During Covid-19 In Kabale District: A Case of Lyamujungu SACCO. by Byamukama, Dicky

“…Finally, results on the third objective indicated that quarantine and social distancing which blocked financial opportunities (M=4.78, SD=.418), consequences that drove SACCO members into loan repayment failure (M=4.70, SD=.459) and loss of savings leading to absolute poverty (M=4.56, SD=.600) were the major factors that determined the borrower’s credit on loan repayment during Covid-19 pandemic. …”
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Role of Cannabis in the Management of Chronic Non-Cancer Pain: A Narrative Review by Lou’i Al-Husinat, Shrouq Obeidat, Saif Azzam, Yara Al-Gwairy, Fatima Obeidat, Sarah Al Sharie, Deema Haddad, Fadi Haddad, Martina Rekatsina, Matteo Luigi Giuseppe Leoni, Giustino Varrassi

“…THC provides pain relief by blocking nociceptive stimuli but has psychoactive effects and may potentially induce dependency. …”
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Accelerated symptom improvement in Parkinson’s disease via remote internet-based optimization of deep brain stimulation therapy: a randomized controlled multicenter trial by Alireza Gharabaghi, Sergiu Groppa, Marta Navas-Garcia, Alfons Schnitzler, Laura Muñoz-Delgado, Vicky L. Marshall, Jessica Karl, Lin Zhang, Ramiro Alvarez, Mary S. Feldman, Michael J. Soileau, Lan Luo, S. Elizabeth Zauber, Benjamin L. Walter, Chengyuan Wu, Hong Lei, Damian M. Herz, Ming-Hua Chung, Yagna Pathak, Bram Blomme, Binith Cheeran, Corneliu Luca, Daniel Weiss

“…Ninety-six patients were randomly assigned in a 1:1 ratio using automated allocation, blocked into groups of 4, allocation concealed, and no stratification. …”
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Enhanced Interleukin 6 Trans-Signaling Modulates Disease Process in Amyotrophic Lateral Sclerosis Mouse Models by Carol Milligan, Dale O. Cowley, William Stewart, Alyson M. Curry, Elizabeth Forbes, Brian Rector, Annette Hastie, Liang Liu, Gregory A. Hawkins

“…Administration of an IL6R functional blocking antibody failed to alter accelerated symptom onset and disease progression. …”
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Can nebulised heparin reduce acute lung injury in patients with SARS‑CoV‑2 requiring advanced respiratory support in Ireland: the CHARTER‑Ireland phase Ib/IIa, randomised, parallel... by David Cosgrave, Bairbre McNicholas, Ciara Hanley, John Robert Sheehan, Padraig Calpin, Maeve Kernan, Darragh Murphy, Alberto Alvarez‑Iglesias, John Ferguson, Camilla Giacomini, Christine Greene, Catriona Cody, Shane McGeary, Marion Murphy, Marianne Fitzgerald, Gerard Curley, Barry Dixon, Roger J. Smith, Claire Masterson, Daniel O’Toole, Frank van Haren, John G. Laffey

“…Abstract Background Nebulised unfractionated heparin may attenuate COVID-19 ARDS by reducing pulmonary microvascular thrombosis, blocking SARS-CoV-2 entry into cells, and decreasing lung inflammation. …”
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Construction of a rodent neural network-skeletal muscle assembloid that simulate the postnatal development of spinal cord motor neuronal network by Haiyang Yu, Shangbin Yang, Yuanfeng Chen, Chuangran Wu, Jing Xu, Yue Yang, Rongjie Wu, Yinan Guo, Zhen Chen, Ying Ding, Xiang Zeng, Ge Li, Yuanhuan Ma, Qiujian Zheng, Yuanshan Zeng, Biqin Lai

“…The amplitude and frequency of SkM cell contraction in NN-SkM assembloids were increased by optogenetic and glutamate stimulation and blocked by tetrodotoxin and dizocilpine, respectively, confirming the existence of multisynaptic motor NNs. …”
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CC-96673 (BMS-986358), an affinity-tuned anti-CD47 and CD20 bispecific antibody with fully functional fc, selectively targets and depletes non-Hodgkin’s lymphoma by Dan Zhu, Haralambos Hadjivassiliou, Catherine Jennings, David Mikolon, Massimo Ammirante, Sharmistha Acharya, Jon Lloyd, Mahan Abbasian, Rama Krishna Narla, Joseph R. Piccotti, Katie Stamp, Ho Cho, Kandasamy Hariharan

“…As a result of the detuned CD47 affinity, CC-96673 selectively binds to CD20-expressing cells, blocking the interaction of CD47 with SIRPα. This increased selectivity of CC-96673 over monospecific anti-CD47 approaches allows for the use of wild-type IgG1 Fc, which engages activating crystallizable fragment gamma receptors (FcγRs) to fully potentiate macrophages to engulf and destroy CD20+ cells, while sparing CD47+CD20− normal cells. …”
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Development of indicators to measure health system capacity for quality abortion care in 10 countries: a rapid assessment of a measurement framework and indicators by Leopold Ouedraogo, Katy Footman, Fahdi Dkhimi, Bela Ganatra, Mohamed Ali, Antonella Lavelanet, Souleymane Zan, Shikha Bansal, Karima Gholbzouri, Eman Aly, Nilmini Hemachandra, Laurence Läser, Ulrika Rehnstrom Loi, Dina Gbenou, Yelmali Hien, Asmani Chilanga, Hayfa Elamin, Priya Karna, Laurence Codjia, Heidi Bart Johnston, Ghislaine Glitho Alinsato, Sithembile Dlamini-Nqeketo, Lisa Hedman, Md Khurshid Alam Hyder, Theopista John, Amrita Kansal, Belete Mihretu, Pamela Amaka Onyiah, Sikander Qais, Ellen Thom, Meera Upadhyay, Qudsia Uzma

“…After implementing the indicators for baseline and annual project monitoring, project staff from 10 teams assessed each indicator using 4 criteria: validity, feasibility, usefulness and importance.Results We identified 30 indicators aligning with 5 of the 6 WHO health system building blocks (excluding service delivery): 6 indicators in leadership and governance, 5 in health workforce, 6 in health information, 8 in access to medicines and health products and 5 in health financing. …”
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Nicotinic α7 receptors on cholinergic neurons in the striatum mediate cocaine-reinforcement, but not food reward by Michael Fritz, Michael Fritz, Michael Fritz, Priscila Batista Rosa, Daniel Wilhelms, Daniel Wilhelms, Maarit Jaarola, Johan Ruud, David Engblom, Anna M. Klawonn, Anna M. Klawonn, Anna M. Klawonn, Anna M. Klawonn

“…Cocaine induction of striatal immediate early gene expression of cFos, FosB, Arc and EGR2 was blocked in α7 nAChR-ChATCre mice, demonstrating the importance of α7 nAChRs on cholinergic neurons for striatal neuronal activity changes. …”
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Multi-institutional evaluation comparing guidance from International Ki67 Working Group vs National Health Commission of China on immunohistochemistry-based Ki67 assessment alongsi... by Yin Wang, Jiarui Zou, Qinghua Cao, Guihong Dai, Panhong Fan, Xue Gong, Jinyan Jiang, Yanqing Kong, Chao Liu, Chunhui Liu, Chenjia Lu, Meiren Li, Zhiqiang Lang, Yang Lin, Yan Peng, Haiyan Shi, Yuhuan Wang, Jiu Wang, Bichen Xie, Bing Yang, Guohua Yu, Cuiping Zhang, Hengming Zhang, Luting Zhou, Zilan Zhang, Zhenli Zhu, Junmei Hao

“…They were evaluated in this multi-institutional study alongside the results from the Quantitative Dot Blot (QDB) method.MethodsThree alternative adjacent sections from 40 primary ER+ breast cancer resection blocks were randomly assigned a number from 1 to 120 for Ki67 staining and reviewed by 21 pathologists, while the other three alternative sections were sent for QDB analysis of Ki67 protein levels. …”
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Loss of Type 2 Bone Morphogenetic Protein Receptor Activates NOD‐Like Receptor Family Protein 3/Gasdermin E‐Mediated Pyroptosis in Pulmonary Arterial Hypertension by Xiao‐ting Tian, Zhou‐yang‐fan Peng, Yu‐si Wu, Yuan‐yuan Cao, Xue‐chun Li, Ying Li, Si‐Yuan Tang, Alex F. Chen, Xiao‐hui Li

“…Knockout of NLRP3 or short hairpin RNA interference of GSDME in animal models can alleviate the development of pyroptosis, accompanied with improved endothelial integrity, vascular remodeling, and right ventricular systolic pressure. Blocking BMPR2 is sufficient to induce NLRP3 upregulation and release of inflammatory factor IL‐1β (interleukin‐1β) in pulmonary arterial endothelial cells. …”
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Use of a wearable device to improve sleep quality by Susan L. Moore, Susan L. Moore, Evan P. Carey, Kristyna Finikiotis, Kelsey L. Ford, Richard D. Zane, Richard D. Zane, Katherine K. Green

“…Among the subjective secondary outcomes, 100% of participants felt the device blocked environmental noise, 86% reported falling asleep more easily, 76% felt they stayed asleep longer, and 82% felt overall sleep quality was improved. …”
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