Pharmacokinetic Evaluation of [C]CEP-32496 in Nude Mice Bearing BRAF Mutation-Induced Melanomas by Cuiping Jiang MMSc, Lin Xie MD, PhD, Yiding Zhang BSc, Masayuki Fujinaga PhD, Wakana Mori MSc, Yusuke Kurihara PhD, Tomoteru Yamasaki PhD, Feng Wang MD, PhD, Ming-Rong Zhang MD, PhD

“…These were followed by PET scans and biodistribution studies on nude mice bearing subcutaneous A375 cell-induced melanoma. [ 11 C]CEP-32496 showed high binding affinity for BRAF V600E -positive A375 melanoma cells and densely accumulated in the respective tissue sections; this could be blocked by the BRAF V600E selective antagonist sorafenib and by unlabeled CEP-32496. …”
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Assessing dynamic coastal vulnerability to climate hazards: A geospatial approach in Kakinada District, Andhra Pradesh, India by Ganni Satya Venkata Sai Aditya Bharadwaz, Indrajit Pal, Chitrini Mozumder, Mokbul Morshed Ahmad

“…Thondangi and Kakinada urban were identified as the most vulnerable blocks, requiring urgent adaptation and mitigation strategies. …”
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Soluble Epoxide Hydrolase Inhibitor and 14,15-Epoxyeicosatrienoic Acid-Facilitated Long-Term Potentiation through cAMP and CaMKII in the Hippocampus by Han-Fang Wu, Yi-Ju Chen, Su-Zhen Wu, Chi-Wei Lee, I-Tuan Chen, Yi-Chao Lee, Chi-Chen Huang, Chung-Hsi Hsing, Chih-Wei Tang, Hui-Ching Lin

“…We found that pharmacological inhibition of sEH to stabilize endogenous EETs and exogenous 14,15-EET significantly increased the field excitatory postsynaptic potential (fEPSP) response in the CA1 area of the hippocampus, while additionally enhancing high-frequency stimulation- (HFS-) induced long-term potentiation (LTP) and forskolin- (FSK-) induced LTP. sEH inhibitor (sEHI) N-[1-(oxopropyl)-4-piperidinyl]-N’-[4-(trifluoromethoxy) phenyl)-urea (TPPU) and exogenous 14,15-EET increased HFS-LTP, which could be blocked by an N-methyl-D-aspartate (NMDA) receptor subunit NR2B antagonist. …”
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Gap junction intercellular communications regulates activation of SARM1 and protects against axonal degeneration by Wen Jie Zhu, Jun Liu, Wan Hua Li, Zhi Ying Zhao, Chongquan Huang, Jian Yuan Yang, Hon Cheung Lee, Yong Juan Zhao

“…It is activated by nicotinamide mononucleotide (NMN) to produce a calcium messenger, cyclic ADP-ribose (cADPR). This activity is blocked by elevated NAD level. Here, we verified this metabolic regulation in somatic HEK-293T cells by overexpressing NMN-adenyltransferase to elevate cellular NAD, which resulted not only in inhibition of their own SARM1 from producing cADPR but, surprisingly, also in the 5–10 neighboring wildtype cells in mixed cultures via connexin (Cx)-43. …”
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Accumulation Mechanism of Marine Shale Gas Reservoir in Anticlines: A Case Study of the Southern Sichuan Basin and Xiuwu Basin in the Yangtze Region by Kun Zhang, Yan Song, Shu Jiang, Zhenxue Jiang, Chengzao Jia, Yizhou Huang, Ming Wen, Weiwei Liu, Pengfei Wang, Xin Li, Tianlin Liu, Xuelian Xie, Chang’an Shan, Xiaoxue Liu, Xin Wang

“…This paper focuses on typical shale blocks in the southern Sichuan Basin and shale in the Upper Ordovician and the Lower Silurian. …”
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Chronic NaAsO2 exposure promotes migration and invasion of prostate cancer cells by Akt/GSK-3β/β-catenin/TCF4 axis-mediated epithelial-mesenchymal transition by Zhi-Hui Zhang, Hai-Xin Yan, Ming-Dong Liu, Feng-Wen Niu, Kai Yao, Shi-Yao Feng, Xi Li, Yuan-Hua Chen, Dong-Dong Xie

“…Ly294002, a selective phosphatidylinositol 3-kinase (PI3K)/Akt inhibitor, suppressed the β-catenin/TCF4 complex activation and EMT through blocking Akt-mediated GSK-3β inactivation in the ''disruption complex'' in chronic NaAsO2 exposed DU145 and PC-3 cells. …”
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Productive performance in Italian Mediterranean buffaloes after partially replacing dietary starch with simple sugars by Roberta Matera, Gabriele di Vuolo, Giuseppina Pedota, Luca de Luise, Mariateresa Marra, Luca Borzacchiello, Ludovica Capoluongo, Gianluca Neglia

“…The two groups were maintained in separate paddocks throughout the study, which lasted 120 days. …”
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Automated Internal Defect Identification and Localization Based on a Near-Field SAR Millimeter-Wave Imaging System by Quoc Cuong Bui, Weizhi Lin, Qiang Huang, Gyung-Su Byun

“…Experiments were conducted using 3D-printed blocks with synthetic defects to demonstrate the detection capability of the proposed system. …”
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Facial expression recognition through muscle synergies and estimation of facial keypoint displacements through a skin-musculoskeletal model using facial sEMG signals by Lun Shu, Victor R. Barradas, Zixuan Qin, Yasuharu Koike

“…Muscle synergies are groups of muscles that show coordinated patterns of activity, as measured by their sEMG signals, and are hypothesized to form the building blocks of human motor control. We then trained two classifiers for the facial expressions based on extracted features from the sEMG signals and the synergy activation coefficients of the extracted muscle synergies, respectively. …”
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Hematopoietic stem cell discovery: unveiling the historical and future perspective of colony-forming units assay by Nur Afizah Yusoff, Zariyantey Abd Hamid, Siti Balkis Budin, Izatus Shima Taib

“…Thus, stem cells are considered as the building blocks of tissues and organs in which they reside. …”
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Long-Term Safety and Effectiveness of Canakinumab in Patients with MKD/HIDS: Interim Analysis of the RELIANCE Registry by Prasad T. Oommen, Tilmann Kallinich, Juergen Rech, Norbert Blank, Julia Weber-Arden, Jasmin B. Kuemmerle-Deschner

“…Conclusion Data from this interim analysis of a unique registry of patients with a rare disease support the long-term safety and effectiveness of the IL-1-blocking agent canakinumab for the treatment of MKD/HIDS.…”
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Optimization of Development Strategies and Injection-Production Parameters in a Fractured-Vuggy Carbonate Reservoir by Considering the Effect of Karst Patterns: Taking C Oilfield i... by Mengqin Li, Qi Wang, Chao Yao, Fangfang Chen, Qinghong Wang, Jing Zhang

“…In the northern facing karst fractured-vuggy units, there are two main types of remaining oil: well-spacing type and local-blocking type, and the reasonable development strategies are affected by reservoir morphology and the connectivity of structure patterns. …”
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RESULTS OF EXPEDITIONS CARRIED OUT BY KRYMSK EXPERIMENT BREEDING STATION OF VIR TO COLLECT WILD AND RUN-WILD FRUIT AND BERRY PLANTS IN SOUTHERN REGIONS OF RUSSIA by G. V. Eremin, V. N. Podorozhnyi

“…In particular, the Republic of Crimea, especially its steppe zone, has been experiencing a real ecological disaster since 2016 because of water deficiency due to the drying up of the North-Crimean Canal after it has been blocked by Ukraine. All this makes it urgent to search for and collect wild and run-wild plant species in their natural habitats, and con­serve them in controlled conditions at VIR’s branches.  …”
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Hematohidrosis in Pediatric Practice  – a Case Report and Review of the Literature by Oksana Matsyura, Lesya Besh, Svitlana Jefimova, Khrystyna Slivinska-Kurchak, Sergiy Gerasymov

“…Capillary endothelial cells are known to contain β2-adrenoceptors, which, through the modulation of nitric oxide release, cause endothelium-dependent vasodilation. Blocking β-adrenoceptors (for example, propranolol) prevents excessive vasodilation of blood vessels and, accordingly, their rupture and blood flow to the sweat gland.We managed to find out that the patient’s bloody sweat was a manifestation of a separate pathological phenomenon, and not one of the symptoms of another disease. …”
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Zinc Supplementation Prevented Type 2 Diabetes-Induced Liver Injury Mediated by the Nrf2-MT Antioxidative Pathway by Lechu Yu, Yuanyuan Liu, Yichun Jin, Tinghao Liu, Wenhan Wang, Xuemian Lu, Chi Zhang

“…A mechanistic study showed that MT deficiency blocked zinc supplementation-induced hepatic protection under the condition of type 2 diabetes. …”
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Factors affecting arteriovenous access patency after percutaneous transluminal angioplasty in chronic haemodialysis patients under vascular access monitoring and surveillance: a si... by Chung-Kuan Wu, Der-Cherng Tarng, Chia-Hsun Lin, Jyh-Gang Leu, Chih-Yu Yang

“…Significant between-group differences were observed for β-adrenergic blocking agents (with PTA, 49.8%; without PTA, 37.5%; p, 0.007) and ADP inhibitors (with PTA, 23.8%; without PTA, 11.2%; p<0.001). …”
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A Low Dose of Naloxone Added to Ropivacaine Prolongs Femoral Nerve Blockade: A Randomized Clinical Trial by Seung Cheol Lee, Jeong Ho Kim, So Ron Choi, Sang Yoong Park

“…Femoral nerve blocks (FNBs) are used as safe and useful procedures to control severe postoperative pain from total knee arthroplasty (TKA). …”
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Proliferin-1 Ameliorates Cardiotoxin-Related Skeletal Muscle Repair in Mice by Hiroki Goto, Aiko Inoue, Limei Piao, Lina Hu, Zhe Huang, Xiangkun Meng, Yusuke Suzuki, Hiroyuki Umegaki, Masafumi Kuzuya, Xian Wu Cheng

“…An enzyme-linked immunosorbent assay revealed that rPLF-1 suppressed the levels of plasma tumor necrosis factor-α and interleukin-1β in CTX mice. PLF-1 blocking accelerated CTX-related muscle damage and dysfunction. …”
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Hybrid Carbohydrate–Lipid Nanocarriers: In Vitro Efficacy Gene-Rated by Association of UV-Absorbers and Raspberry Polyphenols Rich-Fraction by Nicoleta Badea, Diego Samayoa, Alina Moroşan, Cristina Ott, Ioana Lacatusu

“…To establish the performance profile of antioxidant activity, release of active substances, sun blocking action, and photostability, in vitro studies were conducted. …”
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Combination Blockade of the IL6R/STAT-3 Axis with TIGIT and Its Impact on the Functional Activity of NK Cells against Prostate Cancer Cells by S. González-Ochoa, M. C. Tellez-Bañuelos, A. S. Méndez-Clemente, A. Bravo-Cuellar, G. Hernández Flores, L. A. Palafox-Mariscal, J. Haramati, E. J. Pedraza-Brindis, K. Sánchez-Reyes, P. C. Ortiz-Lazareno

“…Finally, the disruption of the IL6R/STAT-3 axis in prostate cancer cells and the blocking of TIGIT on NK-92 were observed to increase the cytotoxicity of NK-92 cells against DU145 cells through an increase in sFasL, granzyme A, granzyme B, and granulysin. …”
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