Activation of FGD5-AS1 Promotes Progression of Cervical Cancer through Regulating BST2 to Inhibit Macrophage M1 Polarization by Guokun Liu, Xuan Du, Li Xiao, Qing Zeng, QianLing Liu

“…Loss of BST2 induced M1 macrophage polarization while blocking M2 macrophage polarization. For another, we demonstrated that FGD5-AS1-triggered M2 macrophage polarization was remarkably reversed by miR-129-5p via suppressing BST2. …”
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Surface Treatment of Rammed Earth Heritage Sites Using MICP Technology: An Investigation of Rainwater Erosion Resistance via Indoor Experiments and In Situ Testing by Liang Liu, Yun Zhang, Wanting Chen, Haiying Cao, Lianjun Guo, Lingling Zheng, Tianli Li, Rong Shu, Dongdong Li

“…At lower concentrations of the cementation solution, calcium carbonate crystals are merely adsorbed by soil particles without blocking the pores. Due to the high compressibility of rammed earth, which results in lower porosity, a higher concentration of the cementation solution leads to rapid pore clogging by excessive calcium carbonate crystals, which accumulate on the surface to form a white crust layer. …”
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Enhancing anthropometric proficiency: Effect of a structured training program on skills of Anganwadi workers in rural areas of Raebareli District, Uttar Pradesh by Mukesh Shukla, Abhay Singh, Sourabh Paul, Mritunjay Kumar, Ravinder Singh Bedi

“…Settings and Design: A community-based interventional study, was conducted among 162 AWWs, 73 from Salon and 89 from Rahi development blocks of Raebareli district. Methods and Material: The skills of AWWs in anthropometric measurement domains (weight, height/length, and mid-upper arm circumference) were assessed using a pre-tested observatory checklist both before and after the training sessions. …”
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Activating CD137 Signaling Promotes Sprouting Angiogenesis via Increased VEGFA Secretion and the VEGFR2/Akt/eNOS Pathway by Bo Li, Yue Zhang, Runting Yin, Wei Zhong, Rui Chen, Jinchuan Yan

“…Additionally, activating CD137 signaling promoted endothelial secretion of VEGFA, while blocking CD137 signaling attenuated VEGFA secretion. …”
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Persistence of the Immune Response to an Intramuscular Bivalent (GI.1/GII.4) Norovirus Vaccine in Adults by Geert Leroux-Roels, Robert L. Atmar, Jakob P. Cramer, Ian Escudero, Astrid Borkowski

“…Results: For single-dose 15/50 recipients (N = 105), GI.1-specific and GII.4c-specific histoblood-group antigen-blocking (HBGA) antibodies appeared to have persisted to 5 years, waning from a peak at 4 to 8 weeks, and plateauing above baseline after 3 years. …”
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Design of a humanized CD40 agonist antibody with specific properties using AlphaFold2 and development of an anti-PD-L1/CD40 bispecific antibody for cancer immunotherapy by Kun Du, He Huang

“…Building upon this, we created a novel bispecific antibody (anti-PD-L1/CD40 bispecific antibody, referred to as ''BA4415'') designed to activate CD40 signaling specifically in the context of PD-L1 while simultaneously blocking PD-1/PD-L1 signaling. Results from functional evaluations using effector cells revealed the superior biological activity of BA4415 compared to the combination of each monoclonal antibody. …”
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Recombinant short TNF-BD protein from smallpox virus is pharmacologically active in an experimental septic shock model by I. P. Gileva, S. N. Yakubitskiy, I. V. Kolosova, S. N. Shchelkunov

“…These proteins compete with cellular receptors for cytokine binding, thus blocking the antiviral immune response. In particular, the G2R gene of VARV encodes the TNF decoy receptor, VARV-CrmB protein. …”
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Organic matter from biofilter nitrification by high performance size exclusion chromatography and fluorescence excitation-emission matrix by E.N. Hidayah, W.L. Lai, O.H. Cahyonugroho, F. Rizqa

“…According to chromatography with carbon and ultraviolet detector, the main characteristics of organic matter shifted from building blocks aromatic compounds with percentage peak area of carbon/ultraviolet detector: 31%/53% to 14%/27.5% to humic-like substances with percentage peak area of carbon/ultraviolet detector 21%/17% to 27%/46.5% during nitrification. …”
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In Vitro Effect of Acidic Solutions and Sodium Fluoride on Surface Roughness of Two Types of CAD-CAM Dental Ceramics by Elham Farhadi, Hamid Kermanshah, Shiva Rafizadeh, Reza Saeedi, Ladan Ranjbar Omrani

“…Materials and Methods. 40 blocks of Vitablocs Mark II and IPS e.max CAD (5 × 5 × 3) were prepared. …”
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A Line of Sight/Non Line of Sight Recognition Method Based on the Dynamic Multi-Level Optimization of Comprehensive Features by Ziyao Ma, Zhongliang Deng, Zidu Tian, Yingjian Zhang, Jizhou Wang, Jilong Guo

“…The DMOCF model improves the expression ability of the deep model by adding a res2 module to the time delay neural network (TDNN), so that fine-grained feature information such as weak reflections or noise in the signal can be deeply understood by the model, enabling the network to realize layer-level feature processing by adding Squeeze and Excitation (SE) blocks with adaptive weight adjustment for each layer. …”
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The Effect of an Educational Intervention Based on the Health Belief Model on the Level of Breastfeeding Self-efficacy in Mothers Referring to Qazvin Health Centers: A Randomized C... by fatemeh mohammadi, mahdi ranjbaran, hamed bigdeli, zinat jourabchi

“…Through the random allocation method of 4 blocks, the participants were assigned to either the intervention group or the control group. …”
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Baicalein inhibits PRRSV through direct binding, targeting EGFR, and enhancing immune response by Jing Wu, Qi Lu, Jing Hou, Yueqin Qiu, Min Tian, Li Wang, Kaiguo Gao, Xuefen Yang, Zongyong Jiang

“…Baicalein inhibited the entry of PRRSV by blocking EGFR phosphorylation and the downstream PI3K-AKT signaling pathway. …”
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The Endocannabinoid, Anandamide, Acts as a Novel Inhibitor of LPS-Induced Inflammasome Activation in Human Gastric Cancer AGS Cell Line: Involvement of CB1 and TRPV1 Receptors by Sahar Sadat Sedeighzadeh, Hamid Galehdari, Mohammad Reza Tabandeh, Mehdi Shamsara, Ali Roohbakhsh

“…Exposure to AEA (10 μM, 24 h) before or after inflammation induction downregulated the expression of inflammasome components and attenuated inflammasome activation as demonstrated by cleavage of caspase 1 and matured IL-1β secretion, although AEA pretreatment showed more reducing effects on the inflammasome activation. In addition, blocking of CB1R and TRPV1R by application of AM-251 and AMG-9810 antagonists remarkably reversed the observed effects of AEA and revealed that NLRP3, NLRC4, and IL-1β genes were mainly regulated via CB1R, while TRPV1R could only regulate the expression of IL-1β and IL-18 genes. …”
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Oral Cancer Stem Cell-Derived Small Extracellular Vesicles Promote M2 Macrophage Polarization and Suppress CD4+ T-Cell Activity by Transferring UCA1 and Targeting LAMC2 by Lan Wu, Sai Ye, Yilin Yao, Chenping Zhang, Wei Liu

“…We previously reported that miR-134 blocks the expression of its targeting protein LAMC2 via the PI3K/AKT pathway and inhibits cancer stem cell (CSC) migration and invasion in oral squamous cell carcinoma (OSCC). …”
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Systemic Crisis in the US-Turkish Relations Under the Presidency of D. Trump by A. A. Davydov

“…During the first one, for the United States Turkey was one of the key countries that was blocking the Soviet expansion southward towards the Persian Gulf and the Suez Canal. …”
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Failure Mechanisms and the Control of a Longwall Face with a Large Mining Height within a Shallow-Buried Coal Seam by Haijun Wang, Yingjie Liu, Yuesong Tang, Hao Gong, Guoliang Xu

“…The medium and higher sections of the coal wall display a dynamic failure mode, while the broken coal blocks, given their initial speed, threaten the safety of coal miners. …”
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Effects of Different Organic Fertilizers on Yield and Yield-Related Characteristics in Black Cumin (Nigella sativa L.) Cultivation Under the Ecological Conditions of Tokat, Türkiye... by Abdulkadir Acar, Yasin Bedrettin Karan

“…The experiment was designed using a split plot arrangement in a randomized complete blocks design with three replications. The main plots were assigned to five organic fertilizer types: Leonardite, Vermicompost, Solid Humus, Chicken Manure and Sheep Manure, while the subplots included in the same way in all fertilizer forms four fertilizer doses (0, 150, 300 and 600 kg/da). …”
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Le lieu-dit des « Trois-Piliers » : un ensemble à caractère monumental du iiie s. apr. J.-C. dans la périphérie nord-est de Reims/Durocortorum ? by Philippe Rollet, Émilie Jouhet

“…And while the cladding courses are perfectly horizontal, the internal blocking is composed of small limestone fragments, bound with a tile mortar. …”
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3-MA attenuates collagen-induced arthritis in vivo via anti-inflammatory effect and autophagy inhibition by Chong Feng, Zi-rou Wang, Chen-yu Li, Xiang-yu Zhang, Xin-xing Wang

“…A recent study showed autophagy modulation may be a novel strategy in the treatment of RA. 3-Methylademine (3-MA), is the most widely used autophagy inhibitor, which blocks autophagy at the initiation and maturation stages. …”
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Prospects for mine geological work in the intelligence age: Architecture of the intelligent geological guarantee technology system for mine exploitation by Yucheng XIA, Xueyang SUN, Lintian MIAO, Chen GUO, Rongjun DU

“…., the intelligent management subsystem for fundamental geological survey information, the intelligent prediction and early warning subsystem for geologic hazards in mines, the intelligent monitoring, prediction, and early warning subsystem for ecosystems in mining areas, the intelligent identification subsystem for favorable mining blocks, and the transparent mining face subsystem), as well as their core modules. …”
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