Natural Killer Cell-Secreted IFN-γ and TNF-α Mediated Differentiation in Lung Stem-like Tumors, Leading to the Susceptibility of the Tumors to Chemotherapeutic Drugs by Kawaljit Kaur, Angie Perez Celis, Anahid Jewett

“…NK cells’ supernatants or IFN-γ and TNF-α-induced tumor differentiation was blocked when we used antibodies against IFN-γ and TNF-α. …”
Get full text

Prediction of the critical stress to crack initiation associated to the investigation of fatigue small crack by D. Marhabi, N. Benseddiq, G. Mesmacque, Z. Azari, J.M. Nianga

“…Indeed its evolution can be blocked by a microstructural barrier (grain boundary, for example). …”
Get full text

Early stroke behavior detection based on improved video masked autoencoders for potential patients by Meng Wang, Guanci Yang, Kexin Luo, Yang Li, Ling He

“…On the basis of establishing the masking mechanism for adjacent frames and pixel blocks within these sequences, The EPBR-PS employes pipeline mask strategy to extract spatiotemporal features effectively. …”
Get full text

A biomechanical study of locking spongious screws and failure rates are higher than expected in plate fixation by Fatih Parmaksizoglu, Onur Cetin, Sinan Kilic, Yener Ince

“…The moment of separation of the screws from the bone blocks was noted. In the first study using PCF15 bone model, in Group 1, the pull-out force has an average of 606.82 N. …”
Get full text

Golgin Subfamily A Member 5 Is Essential for Production of Extracellular Matrix Proteins during TGF-β1-Induced Periodontal Ligament-Fibroblastic Differentiation by Hyun-Jin Kim, Seong-Min Kim, Min-Jeong Choi, Young-Joo Jang

“…When the TGF-β1 signaling pathway was blocked or GOLGA5 was depleted by siRNA, the levels of extracellular matrix (ECM) proteins, such as type I collagen and fibronectin, decreased in PDL-fibroblastic progenitors. …”
Get full text

Extracellular CIRP Upregulates Proinflammatory Cytokine Expression via the NF-kappaB and ERK1/2 Signaling Pathways in Psoriatic Keratinocytes by Xiu Zhang, Shengbang Wang, Wei Wang, Liumei Song, Shuo Feng, Jingping Wang, Tong Kang, Peiwen Yang, Ning Wang, Pengju Yang, Ruimin Bai, Yongping Shao, Yan Zheng

“…We then found that the above effects of eCIRP could be blocked by C23 in both normal keratinocytes and M5-stimulated psoriatic keratinocytes. …”
Get full text

Disastrous Mechanism of Water Discharge in Abandoned Gob above the Stope in Mining Extra-Thick Coal Seam by Haixiao Lin, Feng Yang, Zhengzheng Cao, Yue Wang, Xiaojian Jiao

“…The seepage in the fractures in the high key stratum experiences the process of increase, decrease, and stabilization, related with the stretching and extrusion deformation between the high key stratum blocks. Compared with other fractures, the flow rates in the No.2 and No.4 fractures in the far field key lay are larger, because the fractures are in the tension state, forming the “saddle-shaped” flow pattern. …”
Get full text

Utilization of bauxite residue as fine aggregate for the development of structural concrete: An approach towards sustainable construction materials by Gali Kusumanjali, S. Tejas, Amit Chatterjee, Dinakar Pasla

“…Applications extend to self-compacting concrete, where red mud acts as a viscosity-modifying agent, and in the production of concrete blocks and pavers for non-structural uses. These applications not only address environmental concerns associated with red mud disposal but also promote the development of innovative and eco-friendly construction materials.…”
Get full text

What makes health systems resilient? An analytical framework drawing on European learnings from the COVID-19 pandemic based on a multitiered approach by Thomas Czypionka, Markus Kraus, Miriam Reiss, Monika Riedel

“…Both sections are further divided into six building blocks that were adapted from the WHO health system framework: governance and leadership, information and research, financing, physical resources, human resources, and service delivery. …”
Get full text

The Synergistic Effect of TRPV1 on Oxidative Stress-Induced Autophagy and Apoptosis in Microglia by Tingting Huang, Yao Lin, Qiongyi Pang, Weimin Shen, Xiang Chen, Fengxia Tu

“…However, the effect of TRPV1’s inhibitor on oxidative stress and apoptosis was not obvious when the autophagy was blocked. These findings suggested that TRPV1 may exhibit antioxidative and antiapoptosis effect on OGD/R-induced microglia. …”
Get full text

Site-selective photo-crosslinking for the characterisation of transient ubiquitin-like protein-protein interactions. by Zac Sandy, Zijuan Wang, Deepak Behera, Benjamin M Foster, Finlay A Martin, Kira Brüninghoff, Kathleen M Cain, Wolfgang Dörner, Maria Jose Cabello-Lobato, Josep V Forment, Matthew J Cliff, Igor Larrosa, Perdita Barran, Duncan L Smith, Henning D Mootz, Christine K Schmidt

“…Non-covalent protein-protein interactions are one of the most fundamental building blocks in cellular signalling pathways. Despite this, they have been historically hard to identify using conventional methods due to their often weak and transient nature. …”
Get full text

Extracellular Cardiolipin Modulates Select Immune Functions of Astrocytes in Toll-Like Receptor (TLR) 4-Dependent Manner by Taryn E. Murray, Tyler J. Wenzel, Svetlana Simtchouk, Bridget K. Greuel, Julien Gibon, Andis Klegeris

“…Furthermore, CL alone increases the secretion of monocyte chemoattractant protein (MCP)-1 by astrocytic cells, which is blocked by the TLR 4-specific antagonist TAK-242. …”
Get full text

The Mechanisms of Medial Pedicle Wall Violation: Insertion Method Is as Important as Correct Cannulation of the Pedicle by Cengiz Isik, Kamil Cagri Kose, Mustafa Erkan Inanmaz, Suleyman Murat Tagil, Hakan Sarman

“…We used 100 lumbar pedicles of cadavers. Special wooden blocks were produced to simulate a fixed angle fault after a correct pedicle cannulation. …”
Get full text

Static and Dynamic Routing, Fiber, Modulation Format, and Spectrum Allocation in Hybrid ULL Fiber-SSMF Elastic Optical Networks by Kangao Ouyang, Fengxian Tang, Zhilin Yuan, Jun Li, Yongcheng Li

“…Moreover, in the dynamic traffic demand scenario, the SU strategy remarkably surpasses the other strategies in terms of the lightpath blocking probability.…”
Get full text

A Multiscale Structural Analysis of Soft and Hard Coal Deposits in Deep High-Gas Coal Seams by Anying Yuan, Guangsheng Fu, Junling Hou

“…It was found that the majority of the examined specimens were characterized by scaly structures without blocks larger than 50 mm. The hard coal was observed to be mainly massive with only a small part being clastic. …”
Get full text

Rancang Bangun Website Akademik dengan Penyimpanan Sertifikat Digital Menggunakan Teknologi Blockchain by Windra Swastika, Hermawan Wirasantosa, Oesman Hendra Kelana

“…For scalability testing, it is estimated that 10 million blocks require a storage capacity of 22.6 GB to become a node or miner on this blockchain network. …”
Get full text

Revealing systematic changes in the transcriptome during the transition from exponential growth to stationary phase by Hyun Gyu Lim, Ye Gao, Kevin Rychel, Cameron Lamoureux, Xuwen A. Lou, Bernhard O. Palsson

“…We find that (i) the transition to the stationary phase accompanies common transcriptome changes, including increased stringent responses and reduced production of cellular building blocks and energy regardless of the limiting element; (ii) condition-specific changes are strongly associated with transcriptional regulators (e.g., Crp, NtrC, CysB, Cbl) responsible for metabolizing the limiting element; and (iii) the shortage of each limiting element differentially affects the production of amino acids and extracellular polymers. …”
Get full text

MicroRNA-101-3p Suppresses mTOR and Causes Mitochondrial Fragmentation and Cell Degeneration in COPD by Lei Fang, Xinggang Wang, Ming Zhang, Petra Khan, Michael Tamm, Michael Roth

“…Thus, reactivation mTOR or blocking miR-101-3p presents a potential new strategy for COPD therapy.…”
Get full text

Dataset of noise signals generated by smart attackers for disrupting state of health and state of charge estimations of battery energy storage systemsMendeley by Alaa Selim, Huadong Mo, Hemanshu Pota

“…These signals are designed to disrupt the State of Charge (SoC) and State of Health (SoH) estimation blocks within Unscented Kalman Filters (UKF). The low-magnitude noise signals are specifically crafted to be stealthy, evading easy detection while still effectively causing malfunctions in the estimation processes. …”
Get full text

Targeted Enrollment in Russian Universities: Current State, Problems and Solutions by Yu. S. Ezrokh

“…To overcome them, the article provides recommendations grouped into 4 blocks: 1) increasing the transparency of the system for selecting potential candidates for targeted training; 2) increasing the attractiveness of the target recruitment, entailing an increase in the educational potential of target applicants; 3) improving the quality of training target students; 4) control and strategic development of the targeted enrollment system in Russia.…”
Get full text