Blockade of 4-1BB and 4-1BBL Interaction Reduces Obesity-Induced Skeletal Muscle Inflammation by Ngoc Hoan Le, Chu-Sook Kim, Thai Hien Tu, Hye-Sun Choi, Byung-Sam Kim, Teruo Kawada, Tsuyoshi Goto, Taesun Park, Jung Han Yoon Park, Rina Yu

“…Conversely, disruption of the interaction between 4-1BB and its ligand (4-1BBL) with blocking antibody decreased the release of inflammatory cytokines from cocultured muscle cells/macrophages. …”
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Economic Evaluations of Health Service Interventions Targeting Patients with Multimorbidities: A Scoping Literature Review by Lucia Ferrara, Vittoria Ardito, Valeria D. Tozzi, Rosanna Tarricone

“…The search strategy was built around three keyword blocks: service interventions, multimorbidity, economic evaluations. …”
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The Visual and Quantitative Study of the Microoccurrence of Irreducible Water at the Pore and Throat System in a Low-Permeability Sandstone Reservoir by Using Microcomputerized Tom... by Xiaoyu Gu, Chunsheng Pu, Hai Huang, Nasir Khan, Jing Liu, Yanlong He, Cheng Jing, Feifei Huang, Aojiang Qi

“…However, 25.5% of the throats are blocked by the irreducible water which cut off the crude oil drainage channels.…”
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Characterization of Bozitinib as a potential therapeutic agent for MET-amplified gastric cancer by Hang Lin, Lingzhi Qu, Hudie Wei, Ming Guo, Xiaojuan Chen, Qianmeng Lin, Huajun Zhang, Shuyan Dai, Yongheng Chen

“…Bozitinib demonstrates a strong effect on MET-amplified gastric cancer cells by blocking the c-Met signaling pathway, leading to the inhibition of cell proliferation and survival, as well as the induction of G0/G1 phase arrest and apoptosis. …”
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The Effect of an Acidic Food-Simulating Environment on the Shear Bond Strength of Self-Ligating Brackets with Different Base Designs by Ahmad Sheibaninia, Sepehr Sepasi, Mohammad Ali Saghiri, Setareh Sepasi

“…Freshly extracted first maxillary premolars (n=160) were embedded in resin blocks. A conventional stainless steel bracket, Equilibrium 2, and three types of self-ligating brackets, Speed, In-Ovation R, and Damon 3MX, were bonded to teeth and exposed to distilled water (groups 1, 3, 5, and 7) or acetic acid 3% (groups 2, 4, 6, 8) for 12 weeks. …”
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Activation of MEK1/2/Nrf-2 Signaling Pathway by Epstein-Barr Virus-Latent Membrane Protein 1 Enhances Autophagy and Cisplatin Resistance in T-Cell Lymphoma by Xintao Jia, Qiuyu He, Mei Zeng, Yuhua Chen, Yan Liu

“…Inhibition of MEK1/2/Nrf-2 blocked the promoting effects of LMP1 on lymphoma cell resistance. …”
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Evaluating the antagonist effect of naltrexone implant via opioid challenge tests with escalating doses of hydromorphone injection in former heroin dependent patients by Wei Qu, Xuyi Wang, Chongyang Dong, Tao Zhang, Shugui Yin, Zhijun Sun, Shiqiang Wang, Anni Guo, Wei Hao

“…The findings indicate that the NXT-IMP effectively blocks the agonistic effects of hydromorphone in a dose-dependent manner.…”
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Effects of uncut refuge management on grassland arthropods – A systematic review by Kitti Révész, Róbert Gallé, Jean-Yves Humbert, Péter Batáry

“…We found several potential drivers behind these patterns, including refuge shape – most commonly strips or blocks – and refuge proportion, typically 10–25 % of the area. …”
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Fatal Renal Failure in a Spinal Cord Injury Patient with Vesicoureteric Reflux Who Underwent Repeated Ureteric Reimplantations Unsuccessfully: Treatment Should Focus on Abolition o... by Subramanian Vaidyanathan, Bakul Soni, Kottarathil Abraham Abraham, Peter Hughes, Gurpreet Singh

“…Angiotensin-converting enzyme inhibitors or angiotensin-receptor-blocking agents should be prescribed even in the absence of hypertension when a spinal cord injury patient develops vesicoureteral reflux and proteinuria.…”
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Comparison of Growth Traits and Yields Components of five Chickpeas Genotypes (Cicer arietinum L.) at Bakrajo/ Sulaymaniyah Conditions by Jalal Omer Ahmed, Dara Yara Mohammad, Anwar Rashid Abdulla, Chnar Hama Noori Meerza

“…Experimentation was laid out in a randomized complete blocks design (RCBD) with three replications applied. …”
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Micro-CT Analysis of Y-TZP Copings Made by Different CAD/CAM Systems: Marginal and Internal Fit by Rafaella Caramori Saab, Leonardo Fernandes da Cunha, Carla Castiglia Gonzaga, Amanda Mahammad Mushashe, Gisele Maria Correr

“…The master models were then scanned for the production of copings from specific yttrium oxide partially stabilized tetragonal zirconia polycrystal ceramic blocks of each system (n=10): Cerec/inCoris Zi, Sirona; Cercon/Cercon base, Dentsply; Ceramill/Ceramill Zi, Amann Girrbach; and Lava/Lava Frame Zirconia, 3M ESPE. …”
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HMGB1 Acts in Synergy with Lipopolysaccharide in Activating Rheumatoid Synovial Fibroblasts via p38 MAPK and NF-κB Signaling Pathways by Zheng-Wen He, Yang-Hua Qin, Zhi-Wei Wang, Yan Chen, Qian Shen, Sheng-Ming Dai

“…Both blockers of TLR4 and RAGE significantly inhibited the synergistic effects of HMGB1-LPS on the production of IL-6 and MMPs, but blocking antibodies to TLR2 failed. HMGB1-LPS synergistically increased intracellular levels of phosphorylated p38 and phosphorylated IκB. …”
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Anthropometrics Analysis of Mental Foramen and Accessory Mental Foramen in Zambian Adult Human Mandibles by Balakrishnan Subramanian, Severine N. Anthony, Lumamba Mubbunu, Chitinti Hachombwa, Majuto S. Mlawa, Mudhihiri M. Majambo, Rajab M. Sasi

“…The mental foramen (MF) and accessory mental foramen (AMF) are the strategically important landmarks during surgical interventions and anaesthetic nerve blocks procedures involving the mental nerve. The study aimed at evaluating anthropometrics of MF and AMF in Zambian adult human mandibles and it was cleared for ethics from TDRC Ethics Review Committee (Reg. …”
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Targeted Inhibition of the miR-199a/214 Cluster by CRISPR Interference Augments the Tumor Tropism of Human Induced Pluripotent Stem Cell-Derived Neural Stem Cells under Hypoxic Con... by Yumei Luo, Xuehu Xu, Xiuli An, Xiaofang Sun, Shu Wang, Detu Zhu

“…We first developed a baculovirus-delivered CRISPR interference (CRISPRi) system that sterically blocked the E-box element in the promoter of the miR-199a/214 cluster with an RNA-guided catalytically dead Cas9 (dCas9). …”
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5-HT7R enhances neuroimmune resilience and alleviates meningitis by promoting CCR5 ubiquitination by Zhenfang Gao, Yang Gao, Yuxiang Li, Jie Zhou, Ge Li, Shun Xie, Ruiyan Jia, Lanying Wang, Ziying Jiang, Meng Liang, Chunxiao Du, Yaqiong Chen, Yinji Liu, Lin Du, Cong Wang, Shuaijie Dou, Zhonglin Lv, Lubin Wang, Renxi Wang, Beifen Shen, Zhiding Wang, Yunfeng Li, Gencheng Han

“…Mechanistically, the Fluoxetine-5-HT7R axis induces proteasome-dependent degradation of CCR5 via mTOR signaling, and then recruits STUB1, an E3 ubiquitin ligase, to initiate K48-linked polyubiquitination of CCR5 at K138 and K322, promotes its proteasomal degradation. STUB1 deficiency blocks 5-HT7R-mediated CCR5 degradation. Conclusion: Our results reveal a neuroimmune pathway that balances anti-infection immunity via happiness neurotransmitter receptor and suggest the 5-HT7R-CCR5 axis as a potential target to promote neuroimmune resilience.…”
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Multiple Immunosuppressive Effects of CpG-c41 on Intracellular TLR-Mediated Inflammation by Wancheng Liu, Xuejiao Yang, Ning Wang, Shijun Fan, Yuanfeng Zhu, Xinchuan Zheng, Yan Li

“…Therefore, research into blocking TLR activation to treat these disorders has become a hot topic. …”
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Enhanced multiscale human brain imaging by semi-supervised digital staining and serial sectioning optical coherence tomography by Shiyi Cheng, Shuaibin Chang, Yunzhe Li, Anna Novoseltseva, Sunni Lin, Yicun Wu, Jiahui Zhu, Ann C. McKee, Douglas L. Rosene, Hui Wang, Irving J. Bigio, David A. Boas, Lei Tian

“…Additionally, we show that DS preserves geometry in 3D on cubic-centimeter tissue blocks, allowing for visualization of meso-scale vessel networks in the white matter. …”
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Experimental Study on Shear Behavior and Failure Mechanism of Bolted Heterogeneous Rock Joints under Different Anchorage Conditions by Xianzhen Cheng, Hengjie Luan, Yujing Jiang, Sunhao Zhang, Chuanyang Jia

“…The shear dislocation between the blocks under shear load results in the interaction between the bolt and surrounding media. …”
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Multitasking: does task-switching add to the effect of dual-tasking on everyday-like driving behavior? by Piesie A. G. Asuako, Robert Stojan, Otmar Bock, Melanie Mack, Claudia Voelcker-Rehage

“…The tasks were presented either in separate blocks or in intermixed order (conditions: repetitive vs. switching). …”
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Floods’ Impact on Cities’ Critical Infrastructure: A Case Study on Dubai by Diaa Addeen Abuhani, Raghad Aldamani, Imran Zualkernan, Reem Alali, Himanshu Grover

“…The main road connecting both sides of the area was completely blocked due to the floods with distant alternative connections while critical infrastructure was mainly concentrated on one of the two sides only. …”
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