PPAR-γ Regulates Trophoblast Differentiation in the BeWo Cell Model by Khrystyna Levytska, Sascha Drewlo, Dora Baczyk, John Kingdom

“…We report a novel negative autoregulatory mechanism between PPAR-γ activity and expression and show that blocking PPAR-γ activity induces cell proliferation at the expense of differentiation, while these remain unaltered following treatment with the agonist rosiglitazone. …”
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Molecular Mechanism of Macrophage Activation by Red Ginseng Acidic Polysaccharide from Korean Red Ginseng by Se Eun Byeon, Jaehwi Lee, Ji Hye Kim, Woo Seok Yang, Yi-Seong Kwak, Sun Young Kim, Eui Su Choung, Man Hee Rhee, Jae Youl Cho

“…According to pharmacological evaluation with specific enzyme inhibitors, Western blot analysis of intracellular signaling proteins and inhibitory pattern using blocking antibodies, ERK, and JNK were found to be the most important signaling enzymes compared to LPS signaling cascade. …”
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Mesenchymal Stem Cell-Educated Macrophages Ameliorate LPS-Induced Systemic Response by Yaoqin Hu, Chaojin Qin, Guoping Zheng, Dengming Lai, Huikang Tao, Yan Zhang, Guanguan Qiu, Menghua Ge, Lanfang Huang, Lina Chen, Baoli Cheng, Qiang Shu, Jianguo Xu

“…ASCs also reduced the levels of LPS-induced proinflammatory cytokines in vitro which were mimicked by IL-10 and blocked by antibodies for IL-10 and IL-10 receptor supporting the notion that educated macrophages exert their anti-inflammatory effects via IL-10-dependent mechanisms.…”
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Bovine Tooth Discoloration Induced by Endodontic Filling Materials for Primary Teeth by Samantha Rodrigues Xavier, Katerine Jahnecke Pilownic, Andressa Heberle Gastmann, Mariana Silveira Echeverria, Ana Regina Romano, Fernanda Geraldo Pappen

“…Material and Methods. Dentine-enamel blocks were prepared from 75 bovine teeth, assorted in five experimental groups (n=15). …”
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Case report: Bevacizumab-induced cerebrovascular events: a case series report and literature review by Ke Chen, Boyang Jiang, Boyang Jiang, Huiping Yan, Huiping Yan, Liu Yang, Liu Yang, Zheling Chen, Zheling Chen

“…However, VEGF can maintain the normal function of vascular endothelial cells. Blocking the VEGF pathway can lead to endothelial dysfunction, and the anti-VEGF mechanism of bevacizumab will inevitably lead to a series of thrombotic events and bleeding events. …”
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Curcumin Protects Neonatal Rat Cardiomyocytes against High Glucose-Induced Apoptosis via PI3K/Akt Signalling Pathway by Wei Yu, Wenliang Zha, Zhiqiang Ke, Qing Min, Cairong Li, Huirong Sun, Chao Liu

“…In addition, LY294002 blocked the effects of curcumin on cardiomyocytes exposure to high glucose. …”
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Pre-martensite and bainite reactions: A thermal stability study by Aleksandra Królicka, José Antonio Jimenez, Francisca G. Caballero

“…However, a clear refinement of the retained austenite blocks of the steel treated below Ms was observed. …”
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Selective state models are what you need for animal action recognition by Edoardo Fazzari, Donato Romano, Fabrizio Falchi, Cesare Stefanini

“…By transforming the state-of-the-art MSQNet model with Mamba blocks, we achieve significant reductions in computational requirements: up to 90% fewer Floating point OPerations and 78% fewer parameters compared to MSQNet. …”
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Cerium-based nanoplatform for severe acute pancreatitis: Achieving enhanced anti-inflammatory effects through calcium homeostasis restoration and oxidative stress mitigation by Tingyi Luo, Yujing Tang, Wangcheng Xie, Zhilong Ma, Jian Gong, Yonggui Zhang, Tingsong Yang, Xuyang Jia, Jia Zhou, Zhengyu Hu, Lin Han, Qigang Wang, Zhenshun Song

“…A single low dose of the nanoplatform (1.5 mg kg−1) significantly reduced pancreatic necrosis in SAP rats, effectively ameliorated oxidative stress in the pancreas, improved mitochondrial dysfunction, reduced the proportion of apoptotic cells, and blocked the systemic inflammatory amplification cascade, resulting in the alleviation of systemic inflammation. …”
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Engineered biomimetic cisplatin-polyphenol nanocomplex for chemo-immunotherapy of glioblastoma by inducing pyroptosis by Xinyan Hao, Yucheng Tang, Wenjie Xu, Ming Wang, Jiayi Liu, Yongjiang Li, Jun He, Yanjin Peng, Pengcheng Sun, Dehua Liao, Xiongbin Hu, Tiantian Tang, Min Zhou, Ruyue Han, Jiemin Wang, João Conde, Daxiong Xiang, Junyong Wu

“…Additionally, BV2 microglial cells were engineered to overexpress programmed death-1 (PD-1), and the membrane is employed for nanocomplex coating, effectively blocking the CDDP-induced upregulation of programmed death ligand 1 (PD-L1). …”
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Super-Resolution Reconstruction of Motor Long-Wave Infrared Images Based on Improved USR-Net by Darong Zhu, Ziyan Sun, Fangbin Wang

“…The method first applies adaptive Wiener filtering to eliminate environmental noise and subsequently incorporates a spatial attention mechanism (SA) within the residual blocks of the USR-Net to enhance edge feature extraction. …”
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Physical and functional characterization of whey protein-lignin biocomposite films for food packaging applications by Yihong Deng, Sierra Kolodjski, Grace Lewis, Gary Onan, Youngmi Kim

“…Adding lignin enhanced specific film properties: alkaline lignin increased glass transition temperature, opacity, UV blocking capacity, and antioxidant properties, while reducing flexibility. …”
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Pore-Scale Investigation on the Plugging Behavior of Submicron-Sized Microspheres for Heterogeneous Porous Media with Higher Permeability by Yafei Liu, Jingwen Yang, Tianjiang Wu, Yanhong Zhao, Desheng Zhou, Shun Liu

“…For the purpose of examining the plugging performance of submicron-sized microspheres in high-permeability porous media, systematic investigations were implemented incorporating macroscale blocking rate tests using core samples and pore-scale water migration analysis via nuclear magnetic resonance (NMR). …”
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Caffeoylquinic Acid Derivatives Extract of Erigeron multiradiatus Alleviated Acute Myocardial Ischemia Reperfusion Injury in Rats through Inhibiting NF-KappaB and JNK Activations by Zhifeng Zhang, Yuan Liu, Xuecong Ren, Hua Zhou, Kaishun Wang, Hao Zhang, Pei Luo

“…Our results suggested that cardioprotective effect of AE could be due to suppressing myocardial inflammatory response and blocking NF-κB and JNK activation pathway. Thus, caffeoylquinic acids might be the active compounds in E. multiradiatus on myocardial ischemia and be a potential natural drug for treating myocardial I/R injury.…”
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Abrogation of mercuric chloride-induced nephritis in the Brown Norway rat by treatment with antibodies against TNFα by A. Molina, F. Sánchez-Madrid, T. Bricio, A. Martín, E. Escudero, V. Alvarez, F. Mampaso

“…Treatment with anti-TNF-α antiserum had preventative effects as it reduced the urinary protein levels to close to the normal range and also blocked the influx of inflammatory cells in the renal glomeruli and interstitium, but circulating anti-GBM and lineal glomerular IgG deposits were unmodified. …”
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Design and Optimization of a Coherent Beamforming Network for an Aperiodic Concentric Ring Array by Armando Arce, Enrique Stevens-Navarro, Marco Cardenas-Juarez, Ulises Pineda-Rico, Jorge Simon, Marco A. Panduro

“…A complete antenna system in a monobeam configuration with a coherent network based on grouped inputs (blocks) per ring for an aperiodic concentric ring array with beam scanning and beam shaping properties is synthesized and analyzed. …”
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Comparing the Effect of Intrathecal Injection of Pethidine with That of Bupivacaine on Hemodynamics in Hip Surgery: A Double Blinded Clinical Trial by Seyed Babak Mojaveraghili, Sina Hassannasab, Mansour Deylami, Tahereh Chavoshi, Avasadat Mirkatouli, Nasser Behnampour

“…Given the relative advantages observed about intrathecal injection of pethidine, including fewer side effects, and longer postoperative analgesia, in combination with effective sensory, motor, and sympathetic blocks, we sought to compare the influence of intrathecal injection of pethidine and bupivacaine on the hemodynamics of patients. …”
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Deep Learning for Predicting Spheroid Viability: Novel Convolutional Neural Network Model for Automating Quality Control for Three-Dimensional Bioprinting by Zyva A. Sheikh, Oliver Clarke, Amatullah Mir, Narutoshi Hibino

“…Spheroids serve as the building blocks for three-dimensional (3D) bioprinted tissue patches. …”
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Brain Responses during the Anticipation of Dyspnea by M. Cornelia Stoeckel, Roland W. Esser, Matthias Gamer, Christian Büchel, Andreas von Leupoldt

“…We induced dyspnea using resistive-load breathing in healthy subjects during functional magnetic resonance imaging. Blocks of severe and mild dyspnea alternated, each preceded by anticipation periods. …”
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Effects of post-processing on the microstructural evolution and mechanical behaviour of an additively manufactured AlSi10Mg alloy by R. Ramesh, Saurabh Gairola, R. Jayaganthan, M. Kamaraj

“…AlSi10Mg alloy finds critical applications in the automotive sector, such as in cylinder heads, engine blocks, and wheels. Such applications often require intricate parts that can be fabricated only through additive manufacturing. …”
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