Ethyl Lactate Ameliorates Hepatic Steatosis and Acute‐on‐Chronic Liver Injury in Alcohol‐Associated Liver Disease by Inducing Fibroblast Growth Factor 21 by Yang Jiang, Shuang Wei, Shiming Shen, Yuxiao Liu, Weitong Su, Dong Ding, Zengpeng Zheng, Haokai Yu, Tingting Zhang, Qiuli Yang, Jiuxiang Zhao, Yi Shen, Xia Fang, Liangcai Lin, Dongguang Xiao, Aoyuan Cui, Qin Wan, Yadong Zhang, Yu Li, Cuiying Zhang

“…Importantly, FGF21 deficiency in hepatocytes blocks the downregulation of lipogenesis by ethyl lactate and exacerbates alcoholic steatosis, inflammation and liver injury. …”
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Extracts of Coreopsis tinctoria Nutt. Flower Exhibit Antidiabetic Effects via the Inhibition of α-Glucosidase Activity by Wujie Cai, Lijing Yu, Yu Zhang, Li Feng, Siyuan Kong, Hongsheng Tan, Hongxi Xu, Cheng Huang

“…We found that the extracts blocked the increase of fasting blood glucose, serum triglyceride (TG), insulin, leptin, and liver lipid levels and prevented the development of glucose tolerance impairment and insulin resistance in the C57BL/6 mice induced by a high-fat diet. …”
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A Subanesthetic Dose of Isoflurane during Postconditioning Ameliorates Zymosan-Induced Neutrophil Inflammation Lung Injury and Mortality in Mice by Hui Wang, Jing Fan, Nan-lin Li, Jun-tang Li, Shi-fang Yuan, Jun Yi, Ling Wang, Jiang-hao Chen, Yong-gang Lv, Qing Yao, Ting Wang, Yu-cai Wang, Rui Ling

“…Consistent with these in vivo observations, in vitro studies confirmed that ISO blocked NF-κB and iNOS activation in primary mouse neutrophils challenged by ZY. …”
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Pterostilbene antagonizes homocysteine-induced oxidative stress, apoptosis and lipid deposition in vascular endothelial cells by Qiao Jiang, Li Wang, Xu Si, Yuanyuan Bian, Weijia Zhang, Huijun Cui, Hailong Gui, Ye Zhang, Bin Li, Dehong Tan

“…LY294002 pretreatment partially reversed the protective effect of Pte by blocking the PI3K/Akt pathway. Moreover, Pte reduced lipid deposition in human umbilical vein endothelial cells (HUVECs). …”
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15-Lipoxygenase-1 Is Involved in the Effects of Atorvastatin on Endothelial Dysfunction by Peng Zhang, Xin Xing, Chunxiao Hu, Hui Yu, Qian Dong, Guanglei Chang, Shu Qin, Jian Liu, Dongying Zhang

“…Immunohistochemistry and western blotting showed that atorvastatin increased the expression of cellular adhesion molecules (CAMs) but decreased the expression of endothelial nitric oxide synthase (eNOS); these effects of atorvastatin were blocked by ALOX15 overexpression. In human umbilical venous endothelial cells (HUVECs), silencing of ALOX15 enhanced the effects of atorvastatin on endothelial function. …”
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Low Concentrations of Corticosterone Exert Stimulatory Effects on Macrophage Function in a Manner Dependent on Glucocorticoid Receptors by He-Jiang Zhong, Hai-Yan Wang, Ce Yang, Jian-Yun Zhou, Jian-Xin Jiang

“…However, these effects were not observed at a high concentration of corticosterone (3 μM). Furthermore, blocking GR activity inhibited 150 nM corticosterone-enhanced chemotaxis and phagocytosis of macrophages. …”
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Curcumin-enhanced NIR-II-responsive gold nanobipyramids for targeted HSP 90 inhibition by Zhenying Diao, Youcheng Liang, Yong Liu, Dou Zhang, Long Qiu, Jianbo Sun, Qiaoyou Lu, Yanlei Liu, Daxiang Cui, Ting Yin

“…Under the irradiation of NIR-II light, the obtained GNBs-Cur blocked the expression of HPS90 and inhibited related antiapoptotic pathways, thus enhancing the mild PTT of GNBs under 1064 nm laser irradiation. …”
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Productive and monetary efficiency of radish and coriander intercropping under organic management by Gerlani Alves Silva, Francisco Bezerra Neto, Jailma Suerda Silva de Lima, Elizangela Cabral dos Santos, Vitor Abel da Silva Lino, Francisca Karla Kelly da Silva Lino, Jéssica Paloma Pinheiro da Silva, Erivan Alves da Silva

“…The experimental design used was randomized blocks, with treatments arranged in a 4 × 4 factorial scheme with four replications. …”
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Efficient guided inpainting of larger hole missing images based on hierarchical decoding network by Xiucheng Dong, Yaling Ju, Dangcheng Zhang, Bing Hou, Jinqing He

“…Firstly, the structural priors extracted from the encoding layer are utilized to guide the first decoding layer, while residual blocks are employed to extract deep-level image features. …”
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Impact of Jupiter’s Heating and Self-shadowing on the Jovian Circumplanetary Disk Structure by Antoine Schneeberger, Olivier Mousis

“…The existence of these shadows in Jupiter’s CPD may have influenced the composition of the building blocks of the Galilean moons, potentially shaping their formation and characteristics. …”
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Epidemiology of sickle cell disease in tribal population of Southern Rajasthan, India by Anil Purohit, Ramesh K. Huda, Suman S. Mohanty, Bontha V. Babu

“…Methods A cross-sectional study was conducted in two blocks of southern Rajasthan to determine the prevalence of Sickle Cell Trait (SCT) and SCD. …”
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Lymphatic platelet thrombosis limits bone repair by precluding lymphatic transporting DAMPs by Yangkang Zheng, Lin Cong, Li Zhao, Pengyu Wang, Lianping Xing, Junling Liu, Hao Xu, Ning Li, Yongjian Zhao, Luying Yuan, Qi Shi, Xueqing Sun, Qianqian Liang, YongJun Wang

“…Furthermore, we identify that lymphatic platelet thrombosis (LPT) blocks the draining lymphoid sinus and LVs, causes LDI, and inhibits fracture healing in male mice, which can be rescued by a blood thinner. …”
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Leptin Inhibits the Proliferation of Vascular Smooth Muscle Cells Induced by Angiotensin II through Nitric Oxide-Dependent Mechanisms by Amaia Rodríguez, Javier Gómez-Ambrosi, Victoria Catalán, Ana Fortuño, Gema Frühbeck

“…The inhibitory effect of leptin on Ang II-induced VSMC proliferation was attenuated. Conclusion. Leptin blocks the proliferative response to Ang II through NO-dependent mechanisms. …”
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Compact low-noise GeV-scale electron-positron pair spectrometer by Jaehyun Song, Youhwan Noh, Mohammad Mirzaie, Calin Ioan Hojbota, Hyeong-il Kim, Seongmin Lee, Junho Won, Chiwan Song, Woosuk Bang

“…We investigated the arrangement of magnet blocks using Geant4 simulations to enhance energy resolution over a wide spectral range from MeV to GeV. …”
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Repetitive Transcranial Magnetic Stimulation of Dorsolateral Prefrontal Cortex Affects Performance of the Wisconsin Card Sorting Task during Provision of Feedback by Ji Hyun Ko, Oury Monchi, Alain Ptito, Michael Petrides, Antonio P. Strafella

“…Early functional neuroimaging studies of tasks evaluating executive processes, such as the Wisconsin card sorting task (WCST), only assessed trials in blocks that may contain a large amount of different cognitive processes. …”
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Fabrication of Zn and Ti-loaded Carbon-silica Composite Derived from Gelatin Template for the Photodegradation of Methylene Blue by Maria Ulfa, Ika Uswatun Hasanah, Ida Setiarini

“…The nitrogen adsorption-desorption curves revealed both micropores and mesopores of TiO2/CSNs and ZnO/CSNs where the surface area reduced due to the blocking pore after impregnation. Moreover, ZnO/CSNs verified a higher degradation percentage against methylene blue than that of TiO2/CSNs. …”
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Exergo-economic analysis of multi HDH system integrated with evaporative crystallizer for zero liquid discharge by Osman Shamet, Dahiru U. Lawal, Suhaib M. Alawad, Mohamed Antar, Syed M. Zubair

“…Capital costs analysis shows that HDH blocks account for $547,245, representing almost 92.18 % of the total cost, while the air heater and crystallizer contribute 35 % and 26 %, respectively, to exergy destruction. …”
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World Climate Research Programme lighthouse activity: an assessment of major research gaps in solar radiation modification research by Jim M. Haywood, Olivier Boucher, Chris Lennard, Trude Storelvmo, Simone Tilmes, Daniele Visioni

“…These issues have led to increasing interest in so-called “Solar Radiation Modification” whereby the global mean temperature of the Earth is reduced by either blocking a small fraction of sunlight from reaching it or by increasing the Earth’s albedo to reflect a small proportion of incident sunlight back out to space. …”
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Posttranslational Nitration of Tyrosine Residues Modulates Glutamate Transmission and Contributes to N-Methyl-D-aspartate-Mediated Thermal Hyperalgesia by Carolina Muscoli, Concetta Dagostino, Sara Ilari, Filomena Lauro, Micaela Gliozzi, Erlisa Bardhi, Ernesto Palma, Vincenzo Mollace, Daniela Salvemini

“…The broader implication of our findings reinforces the notion that free radicals may contribute to various forms of pain events and the importance of the development of new pharmacological tool that can modulate the glutamate transmission without blocking its actions directly.…”
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Effects of a Pain Catastrophizing Induction on Sensory Testing in Women with Chronic Low Back Pain: A Pilot Study by Chloe J. Taub, John A. Sturgeon, Kevin A. Johnson, Sean C. Mackey, Beth D. Darnall

“…Forty women with chronic low back pain were assigned in blocks to an experimental condition, either a psychologist-led 10-minute pain catastrophizing induction or a control (10-minute rest period). …”
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