The role and underlying mechanism of dental pulp stem cell-derived exosomal miR-31 in the treatment of osteoarthritis by targeting mTOR to enhance chondrocyte autophagy levels by Guanglei Zhao, Jinyang Lyu, Xin Huang, Gangyong Huang, Feiyan Chen, Yibing Wei, Siqun Wang, Jun Xia, Jie Chen, Jingsheng Shi

“…The ability of DPSC-exosomes to partially regulate autophagy was blocked upon inhibition of miR-31. In brief, DPSC-exosomes have a chondroprotective role in a mouse osteoarthritis model. …”
Get full text

Possible Role of Large Fluid Intake in Delaying Formation of Encrustations and, thereby, Prolonging Working Life of Memokath Stent for Nearly 14 Years in a Spinal Cord Injury Patie... by Subramanian Vaidyanathan, Bakul M. Soni, Peter L. Hughes, Gupreet Singh

“…This case is also a reminder to health professionals that if a tetraplegic patient, in whom a Memokath stent has been deployed for treatment of detrusor-sphincter dyssynergia, presents with autonomic dysreflexia, encrustations blocking the lumen of the stent or calculus formation around the stent should be considered as possible reasons for autonomic dysreflexia.…”
Get full text

Modeling power system with distributed generation by B. A. Kosarev, V. K. Fedorov

“…The method of measuring the basic parameters of the system using the blocks U, I, P Measurement and Powergui is considered. …”
Get full text

Muscarinic Receptors Types 1 and 2 in the Preoptic-Anterior Hypothalamic Areas Regulate Ovulation Unequally in the Rat Oestrous Cycle by Yadira L. López-Ramírez, Kayro López-Ramírez, Isabel Arrieta-Cruz, Angélica Flores, Luciano Mendoza-Garcés, Raúl A. Librado-Osorio, Roger Gutiérrez-Juárez, Roberto Domínguez, María Esther Cruz

“…Muscarinic receptors types 1 (m1AChR) and 2 (m2AChR) in the preoptic and anterior hypothalamus areas (POA-AHA) were counted, and the effects of blocking these receptors on spontaneous ovulation were analysed throughout the rat oestrous cycle. …”
Get full text

Lactoferrin exhibits PEDV antiviral activity by interfering with spike-heparan sulfate proteoglycans binding and activating mucosal immune response by Peng Liu, Jinjiao Zuo, Hui Lu, Bin Zhang, Caihong Wu

“…It was hypothesized that lactoferrin can impede PEDV by blocking its binding to heparan sulfate proteoglycans (HSPG) on the surface of target cells, and molecular docking experiments was conducted to identify the binding sites between lactoferrin and HSPG. …”
Get full text

Myogenesis gone awry: the role of developmental pathways in rhabdomyosarcoma by Annika L. Gustafson, Annika L. Gustafson, Annika L. Gustafson, Adam D. Durbin, Kristin B. Artinger, Heide L. Ford, Heide L. Ford, Heide L. Ford

“…In FN-RMS, re-expression of MRFs, as well as other myogenic TFs, blocks terminal differentiation and holds cells in a proliferative, stem-cell-like state. …”
Get full text

An FPGA-Based Omnidirectional Vision Sensor for Motion Detection on Mobile Robots by Jones Y. Mori, Janier Arias-Garcia, Camilo Sánchez-Ferreira, Daniel M. Muñoz, Carlos H. Llanos, J. M. S. T. Motta

“…The overall architecture has been mapped onto a commercial low-cost FPGA device, using a hardware/software co-design approach, which comprises a Nios II embedded microprocessor and specific image processing blocks, which have been implemented in hardware. The background subtraction algorithm was also used to calibrate the system, allowing for accurate results. …”
Get full text

Bionic Silk Fibroin Film Promotes Tenogenic Differentiation of Tendon Stem/Progenitor Cells by Activating Focal Adhesion Kinase by Kang Lu, Xiaodie Chen, Hong Tang, Mei Zhou, Gang He, Zhisong Lu, Kanglai Tang

“…The TSPCs on SF films with a bionic microstructure exhibited a slender cell morphology, promoted the expression of tenogenic genes and proteins, such as SCX, TNC, TNMD, and COLIA1, and activated FAK. FAK inhibitors blocked the enhanced expression of tenogenic genes and proteins. …”
Get full text

Sarcoidosis: molecular mechanisms and therapeutic strategies by Danfeng Xu, Xiaohua Tao, Yibin Fan, Yan Teng

“…The current therapeutic strategies focus on blocking the formation and spread of granulomas to protect organ function and alleviate symptoms. …”
Get full text

Comparative Genomic Hybridization (CGH) in New World Monkeys (Primates) Reveals the Distribution of Repetitive Sequences in Cebinae and Callitrichinae by Vanessa Milioto, Vincenzo Arizza, Aiti Vizzini, Polina L. Perelman, Melody E. Roelke-Parker, Francesca Dumas

“…The CGH shows bright signals with balanced and imbalanced DNA involving different genome regions: such as predominantly repetitive DNA at centromeric positions, and interstitial distribution with extended blocks. Cross-species CGH demonstrated the origin of some heterochromatic regions and identified apomorphic heterochromatin expansion events. …”
Get full text

Comparison between the WNBA and WEL: differences and key performance indicators in top women basketball leagues by Jorge Lorenzo Calvo, Rafael Manuel Navarro Barragán, Carlos Serrano Luengo, Guillermo Muñoz Andradas

“…The results showed differences between the number of possessions per team, blocks and points between the leagues. Discussion: The comparison between the best teams showed differences in points, total rebounds and defensive rebounds. …”
Get full text

Orlistat ameliorates lipid dysmetabolism in high-fat diet-induced mice via gut microbiota modulation by Chengyan Huang, Yuanhui He, Ping Chai, Zongxin Liu, Sirui Su, Yanhui Zhang, Yuelan Luo, Shuiping Fu

“…Orlistat reduces obesity by inhibiting gastrointestinal lipases, thereby blocking the absorption and accumulation of triglycerides in the intestine. …”
Get full text

Effect of Motor Blockage on Transient Characteristics of Asymmetric Flow in a Double-suction Centrifugal Fan by S. Du, X. Wu, Z. Wang, W. Yang, Z. Yang, Z. Wang, W. Zhang

“…One of the two inlets of the double-suction fan is partially blocked by the motor, and the flow in the fan becomes asymmetric and non-uniform. …”
Get full text

IMPACTS OF REPLACING THE AMAZON RAINFOREST WITH PASTURE ON SOIL PROPERTIES by Sandra Cátia Pereira Uchôa, Sasha de Souza Farage, José Maria Arcanjo Alves, Carlos Henrique de Lima Matos, Ingridy do Nascimento Tavares, Valdinar Ferreira Melo

“…Soil samples were collected at two depths (0-0.10 m and 0.10-0.20 m) in four representative blocks of 1 ha in each system. Chemical, physical, and biochemical properties, and microbial and metabolic coefficients were analyzed. …”
Get full text

Acute ischemic stroke lesion segmentation in non-contrast CT images using 3D convolutional neural networks by A.V. Dobshik, S.K. Verbitskiy, I.A. Pestunov, K.M. Sherman, Yu.N. Sinyavskiy, A.A. Tulupov, V.B. Berikov

“…Our deep-learning approach is based on the popular 3D U-Net convolutional neural network architecture, which was modified by adding the squeeze-and-excitation blocks and residual connections. Robust pre-processing methods were implemented to improve the segmentation accuracy. …”
Get full text

Delta Cell Hyperplasia in Adult Goto-Kakizaki (GK/MolTac) Diabetic Rats by Lukáš Alán, Tomáš Olejár, Monika Cahová, Jaroslav Zelenka, Zuzana Berková, Magdalena Smětáková, František Saudek, Radoslav Matěj, Petr Ježek

“…Somatostatin analog octreotide completely blocked insulin secretion, impaired proliferation at low autocrine insulin, and decreased PPY secretion and mitochondrial DNA in INS-1E cells. …”
Get full text

Combining Region-Guided Attention and Attribute Prediction for Thangka Image Captioning Method by Fujun Zhang, Wendong Kang, Wenjin Hu

“…This predictor leverages feature maps from four different convolutional blocks within the region-guided module to incorporate more detailed information into the model. …”
Get full text

mRNA Expression of EgCHI1, EgCHI2, and EgCHI3 in Oil Palm Leaves (Elaeis guineesis Jacq.) after Treatment with Ganoderma boninense Pat. and Trichoderma harzianum Rifai by Laila Naher, Soon Guan Tan, Chai Ling Ho, Umi Kalsom Yusuf, Siti Hazar Ahmad, Faridah Abdullah

“…The five-month-old oil palm seedlings were treated with Gano-wood blocks inoculum and trichomulch. Expression of EgCHI1, EgCHI2, and EgCHI3 in treated leaves tissue was determined by real-time PCR. …”
Get full text

Effects of Activating Mutations on EGFR Cellular Protein Turnover and Amino Acid Recycling Determined Using SILAC Mass Spectrometry by Michael J. Greig, Sherry Niessen, Scott L. Weinrich, Jun Li Feng, Manli Shi, Ted O. Johnson

“…Often, the mutation directly affects a drug’s binding site, effectively blocking binding of the drug, but these mutations can have other effects such as changing the protein turnover half-life. …”
Get full text

Neuroprotective Effects of Bone Marrow Mesenchymal Stem Cells on Bilateral Common Carotid Arteries Occlusion Model of Cerebral Ischemia in Rat by Bagher Pourheydar, Sara Soleimani Asl, Mostafa Azimzadeh, Adel Rezaei Moghadam, Asghar Marzban, Mehdi Mehdizadeh

“…Adult male Wistar rats were divided into 5 groups: control, sham (surgery without blockage of common carotid arteries), ischemia (common carotid arteries were blocked for 30 min prior to reperfusion), vehicle (7 days after ischemia PBS was injected via the tail vein), and treatment (injections of BMSC into the tail veins 7 days after ischemia). …”
Get full text