Pathological Microenvironment‐Remodeling Nanoparticles to Alleviate Liver Fibrosis: Reversing Hepatocytes‐Hepatic Stellate Cells Malignant Crosstalk by Ling‐Feng Zhang, Wen‐Qi Deng, Xing‐Huan Wang, Qing‐Wen Huang, Su‐Qing Liang, Ze‐Quan Ding, Liang Qi, Yi Wang, Tian‐Jiao Zhou, Lei Xing, Jai‐Woo Lee, Yu‐Kyoung Oh, Hu‐Lin Jiang

“…Herein, a malignant crosstalk‐blocking strategy is prompted to remodel vicious cellular interplay and reverse pathological microenvironment to put an end to liver fibrosis. …”
Get full text

The Design and Development of an Atraumatic Soft Robotic Surgical Retractor by Gavril Yong En Tan, Shaun Mahesh Buxani, Benjamin Wee Keong Ang, Chao Yu Chen, Raye Chen Hua Yeow, Hung Leng Kaan

“…The study presents a comprehensive evaluation, including bending angle, blocked force measurements, actuation time efficiency, and a comparative analysis with traditional stainless steel Langenbeck retractors. …”
Get full text

Effect of SIS3 on Extracellular Matrix Remodeling and Repair in a Lipopolysaccharide-Induced ARDS Rat Model by Qiong Liang, Qiqing Lin, Yueyong Li, Weigui Luo, Xia Huang, Yujie Jiang, Chunyan Qin, Jin Nong, Xiang Chen, Suren Rao Sooranna, Liao Pinhu

“…These findings indicate that SIS3, or the blocking of TGF-β/Smad3 pathways, could influence remodeling of the ECM and this may serve as a therapeutic strategy against ARDS.…”
Get full text

Antihypertensive effect of sinapine extracted from rapeseed meal in 2K1C hypertensive rats by Gaoyuan Yang, Lin Zhu, Yu Wang, Yang Yu, Xiaoguang Liu, Jingbo Xia, Yunjie Yang, Huiguo Wang, Baomin Feng

“…Furthermore, sinapine effectively inhibited ACE activation, increased NO levels, and blocked L-type calcium channels. Sinapine has an antihypertensive function and achieves this process through multiple targets.…”
Get full text

Off-Design Considerations through the Properties of Some Pressure-Ratio Line of Radial Inflow Turbines by N. Binder, X. Carbonneau, P. Chassaing

“…Nevertheless, a simple performance prediction analysis is proposed for blocked mass flow operation.…”
Get full text

Dominant Modes of Tropospheric Ozone Variation over East Asia from GOME Observations by Yi Liu, Yuli Zhang, Yong Wang, Chuanxi Liu, Zhaonan Cai, Paul Konopka, Rolf Müller

“…The principal component of EOF1 (PC1) suggested that photochemical ozone production together with Brewer-Dobson circulation and subtropical westerly jet plays important roles in modulating the seasonal variation of the TOVMR; ozone-rich air produced by photochemical processes was transported from the stratosphere to the troposphere by BD circulation and this ozone-rich air was then blocked by the subtropical westerly jet and accumulated north of the jet. …”
Get full text

Molecular characterization of siderophore biosynthesis in Paracoccidioides brasiliensis by Marielle Garcia Silva, Juliana Santana de Curcio, Mirelle Garcia Silva-Bailão, Raisa Melo Lima, Mariana Vieira Tomazett, Aparecido Ferreira de Souza, Vanessa Rafaela Milhomem Cruz-Leite, Nicolau Sbaraini, Alexandre Melo Bailão, Fernando Rodrigues, Maristela Pereira, Relber Aguiar Gonçales, Célia Maria de Almeida Soares

“…Furthermore, SidA activity was reduced in the presence of FOB, suggesting that P. brasiliensis blocks siderophores biosynthesis and can explore siderophores in the environment to scavenge iron. …”
Get full text

IL-1β Suppresses the Formation of Osteoclasts by Increasing OPG Production via an Autocrine Mechanism Involving Celecoxib-Related Prostaglandins in Chondrocytes by Yusuke Watanabe, Aki Namba, Yukiko Aida, Kazuhiro Honda, Hideki Tanaka, Naoto Suzuki, Hideo Matsumura, Masao Maeno

“…OPG and RANKL expression increased with IL-1β; whereas M-CSF expression decreased. Celecoxib blocked the stimulatory effect of IL-1β. Conditioned medium from IL-1β-treated chondrocytes decreased TRAP staining in RAW264.7 cells. …”
Get full text

Antibodies from a Patient with Type 1 Diabetes and Celiac Disease Bind to Macrophages that Express the Scavenger Receptor CD163 by Brigitte Sonier, Alexander Strom, Gen-Sheng Wang, Christopher Patrick, Jennifer A Crookshank, Majid Mojibian, Amanda J MacFarlane, Fraser W Scott

“…Blood monocytes and macrophage-like cells in human duodenum were also labelled with the enriched antibodies. Blocking studies revealed that binding to CD163+ macrophages was not due to cross-reactivity with anti-Glo-3A antibodies, but rather to non-Glo-3A antibodies co-purified during antibody enrichment. …”
Get full text

Hydrothermal Synthesis and Characterization of Sodalite from Feldspar Mesawa Minerals by Ida Ifdaliah Amin, Abdul Wahid Wahab, Paulina Taba, Rino R. Mukti, Giovanno Alvin S, Bulkis Musa, Hijrah A. Azis

“…This research proves that the Mesawa feldspar mineral sample contains type 6 secondary building units, the same blocks as zeolite analcime and cancrinite, so it has the potential as an adsorbent for heavy metals and as a catalyst alternative …”
Get full text

Effect of sex on the weight gain of calves (Bubalus bubalis) reared in silvopastoral systems during the dry season by Efraín Chacón Condori, Luis A. de la Cruz-Cruz

“…After weaning, the animals were abruptly separated and placed in 15 38-hectare paddocks with silvopastoral systems and rotational grazing in pastures with native and introduced grasses and natural shade. …”
Get full text

Disrupting EDEM3‐induced M2‐like macrophage trafficking by glucose restriction overcomes resistance to PD‐1/PD‐L1 blockade by Shaoyong Peng, Minshan Wu, Qian Yan, Gaopo Xu, Yumo Xie, Guannan Tang, Jinxin Lin, Zixu Yuan, Xiaoxia Liang, Ze Yuan, Jingrong Weng, Liangliang Bai, Xiaolin Wang, Huichuan Yu, Meijin Huang, Yanxin Luo, Xiaoxia Liu

“…Conclusions Our study suggests that blocking EDEM3‐induced M2‐like macro phage trafficking by FMD plus 2‐DG is a promising and effective strategy to overcomeresistance to checkpoint blockade therapy offeringhope for improved treatment outcomes. …”
Get full text

Quais et ouvrages portuaires romains de Rouen/Rotomagus (Seine-Maritime) by Marie-Clotilde Lequoy

“…This structure presents a mixed external facing, made of medium and large limestone blocks, masoned with clay and sections of oak placed vertically about 1 m to 1.20 m apart from one another. …”
Get full text

Exploring the evolution of global beef trade network patterns based on complex network analysis by Qianqian Wang, Wangfang Xu, Rongzhu Cheng

“…Additionally, the analysis identifies clustering and regionalization characteristics within the global beef trade blocks.DiscussionThese findings highlight the evolving dynamics of global beef trade, emphasizing the roles of key countries and the structural shifts in the trade network. …”
Get full text

Influence of shortest path algorithms on energy consumption of multi-core processors by A. A. Prihozhy, O. N. Karasik

“…The classical Floyd-Warshall algorithm (FW) consumed up to twice as much energy, and the blocked homogeneous (BFW) and heterogeneous (HBFW) algorithms consumed up to 52.2 % and 21.2 % more energy than GEA. …”
Get full text

Government support for the agro-industrial complex: the experience of a programme-oriented approach in Australia by Yu. P. Maidanevych, N. S. Sergienko, Yu. V. Gnezdova

“…The Australian experience in implementing the Smart Farms programme is presented in the context of programme blocks with an analysis of the technologies used; key approaches in organising the selection of the programme participants and the risks of its realisation are highlighted. …”
Get full text

Controlling Dielectric and Magnetic Properties of PVdF/Magnetite Nanocomposite Fibre Webs by A. P. Venugopal, O. Cespedes, S. J. Russell

“…Vibrating sample magnetometer (VSM) magnetisation measurements indicated a blocking temperature above 300 K suggesting ferrimagnetic rather than superparamagnetic behaviour as a result of Fe3O4 nanoparticle agglomeration within fibres.…”
Get full text

Leiomodin creates a leaky cap at the pointed end of actin-thin filaments. by Dmitri Tolkatchev, Garry E Smith, Lauren E Schultz, Mert Colpan, Gregory L Helms, John R Cort, Carol C Gregorio, Alla S Kostyukova

“…Our structural data indicate that the leiomodin/tropomyosin complex only forms at the pointed end of thin filaments, where the tropomyosin N-terminus is not blocked by an adjacent tropomyosin protomer. This discovery provides evidence supporting the debated mechanism where leiomodin and tropomodulin regulate thin filament lengths by competing for thin filament binding. …”
Get full text

Studies of biofilms and phenotypic characteristics of Candida fungi by E. M. Lenchenko, N. P. Sachivkina

“…The search and testing of multilevel algorithms for biofilm identification when exposed to chemotherapeutic and disinfectant drugs for blocking the synthesis or destruction of the intercellular matrix in the development of superficial, deep and systemic candidiasis of animals are relevant for developing and improving diagnostic and antiepidemic measures. …”
Get full text

Research on the Deformation Law and Stress Distribution Characteristics of Overburden under the Influence of Multiple Faults by Yaobin Qi, Weijian Yu, Desun Yu, Hanxiao Guo, Bao Pan

“…But as the working face continues to advance, the blocking effect of the roof plastic zone above the goaf on the transmission of the behind abutment pressure of the working face begins to appear and continues to increase, leading to a decrease in the peak stress at the lower strata of F1. …”
Get full text