mTOR Modulates the Endoplasmic Reticulum Stress-Induced CD4+ T Cell Apoptosis Mediated by ROS in Septic Immunosuppression by Hao Wang, Jianwei Chen, Guangxu Bai, Wen Han, Ran Guo, Na Cui

“…Additionally, we constructed T cell-specific mTOR and TSC1 gene knockout mice to determine the role of mTOR in ROS-mediated, ERS-induced CD4+ T cell apoptosis. Results. Blocking ROS significantly suppressed the CD4+ T cell apoptosis associated with the reduction in ERS, as revealed by lower levels of GRP78 and CHOP. …”
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The Possible Potential Therapeutic Targets for Drug Induced Gingival Overgrowth by Tamilselvan Subramani, Vidhya Rathnavelu, Noorjahan Banu Alitheen

“…This review summarizes recent observations concerning the contribution of TGF-β, CTGF, IGF, PDGF, ET-1, Ang II, and mast cell chymase and tryptase enzymes to fibroblast activation in gingival fibrosis and the potential utility of agents blocking these proteins in affecting the outcome of drug-induced gingival overgrowth.…”
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Phenoxybenzamine in Complex Regional Pain Syndrome: Potential Role and Novel Mechanisms by Mario A. Inchiosa

“…Earlier treatments of CRPS syndromes were primarily focused on blocking sympathetic outflow to an affected extremity. …”
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Monitoring of radionuclides in carbon steel blooms produced by EAF process by Sofilić T., Barišić D., Sofilić U., Živković J.

“…At the same time the content of radionuclides in the other materials (ferroalloys, bauxite, fluorite, lime, coke, graphite electrodes, refractory blocks) used in the same steel making process was investigated. …”
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Application of Microbial Biopolymers as an Alternative Construction Binder for Earth Buildings in Underdeveloped Countries by Ilhan Chang, Minkyung Jeon, Gye-Chun Cho

“…., compressive strength) of biopolymer mixed soil blocks (i.e, both 1% xanthan gum and 1% gellan gum) satisfied the international criteria for binders used in earthen structures. …”
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Cardiac Pacing in Cienfuegos from 2005 to 2009 by Yanier Coll Muñoz, Brandy Viera González

“…The most common causes of implant were blocks the atrioventricular conduction and sinus node disease. …”
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An Analysis of spatial inequalities of Housing quality in middle textures neighboods of zanjan city by Mohsen Ahadnejad, Asghar Teymouri, Mahnaz Vaez livari, Hossein Tahmasebi Moghaddam

“…The information gathering method was used by the library method (set of statistical blocks of 1395 and detailed plan of 1394). Combined methods of the Tedim model and the geographic information system are used to analyze the data. …”
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Lyapunov stability analysis for M3C based fractional frequency transmission system utilizing generalized participation factors by Ziyue Duan, Yongqing Meng, Shuhao Yan, Lianhui Ning, Xiuli Wang, Xifan Wang

“…Additionally, the stability regions are compared for unveiling the pattern of the components interaction, when analyzing the dynamic characteristics of different blocks from the generalized system matrix individually with the overall analysis results. …”
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Stromal Derived Factor-1/CXCR4 Axis Involved in Bone Marrow Mesenchymal Stem Cells Recruitment to Injured Liver by Kuai Xiao Ling, Li Peng, Zhang Jian Feng, Cao Wei, Yuan Wei Yan, Shao Nan, Guan Cheng Qi, Wang Zhi Wei

“…In vivo, BMSCs migrated into injured liver which was partially blocked by AMD3100 or anti-CXCR4 antibody. Taken together, the results demonstrated that the migration of BMSCs was regulated by SDF-1/CXCR4 signaling which involved in BMSCs recruitment to injured liver.…”
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Danhong Huayu Koufuye Prevents Diabetic Retinopathy in Streptozotocin-Induced Diabetic Rats via Antioxidation and Anti-Inflammation by Wenpei Chen, Xiaolan Yao, Chenghao Zhou, Ziyang Zhang, Gang Gui, Baoqin Lin

“…Here, we investigated whether antioxidative and anti-inflammatory activities of DHK contributed to its therapeutic effect on DR in streptozotocin- (STZ-) induced diabetic rats. DHK significantly blocked the breakdown of the blood-retinal barrier (BRB) and increased the thickness of the inner nuclear layer (INL), as well as suppressed the swelling of the ganglion cell layer (GCL) in diabetic retinas. …”
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SP-1-activated LINC01016 overexpression promotes gastric cancer invasion and metastasis through inhibiting EIF4A3-mediated MMP9 mRNA decay by Ying Sun, Hui Zhang, Duan-bo Shi, Peng Gao

“…We determined that LINC01016 can blocks the binding of EIF4A3 to MMP9 mRNA, thereby inhibiting EIF4A3-mediated nonsense-mediated RNA decay (NMD), increasing MMP9 mRNA level and protein expression levels to promote tumor progression. …”
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Complementary Approaches to Postoperative Pain Management: A Review of Non-pharmacological Interventions by Emery Niyonkuru, Muhammad Asad Iqbal, Xu Zhang, Peng Ma

“…Alternatives like nonsteroidal anti-inflammatory drugs, N-methyl-d-aspartate (NMDA) receptor antagonists, and regional anesthesia techniques such as nerve blocks are utilized, but these also have limitations. …”
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A PAF receptor antagonist inhibits acute airway inflammation and late-phase responses but not chronic airway inflammation and hyperresponsiveness in a primate model of asthma by R. H. Gundel, C. D. Wegner, H. O. Heuer, L. G. Letts

“…In addition, oral WEB 2170 treatment in dual responder primates blocked the acute influx of neutrophils into the airways as well as the associated late-phase airway obstruction occurring 6 h after antigen inhalation. …”
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Postoperative Residual Neuromuscular Paralysis at an Australian Tertiary Children’s Hospital by Thomas Ledowski, Brendan O’Dea, Luke Meyerkort, Mary Hegarty, Britta S. von Ungern-Sternberg

“…Residual neuromuscular blockade (RNMB) is known to be a significant but frequently overlooked complication after the use of neuromuscular blocking agents (NMBA). Aim of this prospective audit was to investigate the incidence and severity of RNMB at our Australian tertiary pediatric center. …”
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The Role of PCNA Posttranslational Modifications in Translesion Synthesis by Montaser Shaheen, Ilanchezhian Shanmugam, Robert Hromas

“…Translesion synthesis is a special pathway that enables the replication fork to bypass blocking lesions. Proliferative Cell Nuclear Antigen (PCNA), which is an essential component of the fork, undergoes posttranslational modifications, particularly ubiquitylation and sumoylation that are critical for lesion bypass and for filling of DNA gaps which result from this bypass. …”
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Shaping Ability of Reciproc, UnicOne, and Protaper Universal in Simulated Root Canals by Etevaldo Matos Maia Filho, Cláudia de Castro Rizzi, Matheus Bandeca Coelho, Sara Freitas Santos, Luzia Mayanne Oliveira Costa, Ceci Nunes Carvalho, Rudys Rodolfo de Jesus Tavarez, Janir Alves Soares

“…The study aimed to compare the shaping effects, preservation of the original curvature, and transportation of the apical foramen of Reciproc (VDW, Munich, Germany), UnicOne (Medin, Nové Město na Moravě, Czech Republic), and Protaper Universal (Dentsply Maillefer, Ballaigues, Switzerland) in simulated root canals. Thirty resin blocks with simulated curved root canals were distributed into three groups (n=10), and prepared using Reciproc (RCp), UnicOne (UnO) and the Protaper Universal (PTu). …”
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DESIGNING AND EFFICIENCY EFFECT OF AUTOMATIC BALL-CLEANING SYSTEM FOR CONDENSER 180-KTsS-1 OF TURBINE Т-180/210-130-1 LMZ. Part 2 by Yu. A. Zenovich-Leshkevich-Ol’pinskiy, A. Yu. Naumov, A. Yu. Zenovich-Leshkevich-Ol’pinskaya

“…As a result of regular application of the ball-cleaning system the temperature difference of the condensers of all blocks Т-180/210-130-1 confined into the regulatory values and the cleanness coefficient of all three turbine units reached 0,85. …”
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The Immunoexpression of Glucocorticoid Receptors in Breast Carcinomas, Lactational Change, and Normal Breast Epithelium and Its Possible Role in Mammary Carcinogenesis by Raja Alyusuf, Javed Fayyaz Wazir, Urmil Prabha Brahmi, Abdul Rahman Fakhro, Moiz Bakhiet

“…Immunohistochemistry (IHC) for GRs was performed on archival formalin-fixed paraffin-embedded tissue blocks of 96 cases comprising 52 invasive carcinomas, 21 cases with lactational change, and 23 cases showing normal mammary tissue histology. …”
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Synergistic strategies for glioblastoma treatment: CRISPR-based multigene editing combined with immune checkpoint blockade by Xiaolin Liu, Xiao Liu, Xiaonan Luo, Maorong Zhu, Nannan Liu, Juan Li, Qi Zhang, Cheng Zou, Yuxin Wu, Zhengcong Cao, Shuangxin Ma, Weizhong Wang, Guangzhao Yang, Jintao Gu, Wei Liu, Meng Li, Anan Yin, Yalong He, Wei Lin

“…These modified EVs were then utilized to rejuvenate exhausted CD8+ T cells blocking PD-L1, resulting in significant therapeutic benefits for GBM treatment. …”
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Fast Image Registration for Spacecraft Autonomous Navigation Using Natural Landmarks by Yun-Hua Wu, Lin-Lin Ge, Feng Wang, Bing Hua, Zhi-Ming Chen, Feng Yu

“…CSA is based on image segmentation technology, aiming to find representative blocks, which will be allocated to different tasks to speed up the image registration progress. …”
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