Defining candidate drug characteristics for Long-QT (LQT3) syndrome by Aslak Tveito, Glenn T. Lines, Pan Li, Andrew McCulloch

“…In such models, the effects of a drug can be treated as alterations in on- and off rates between open and inactivated states on one hand, and blocked states on the other hand. Our aim is to compute the rates specifying a drug in order to: (a) restore the steady-state open probability of the mutant channel to that of normal wild type channels; and (b) minimize the difference between whole cell currents in drugged mutant and wild type cells. …”
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An Inductive Link-Based Wireless Power Transfer System for Biomedical Applications by M. A. Adeeb, A. B. Islam, M. R. Haider, F. S. Tulip, M. N. Ericson, S. K. Islam

“…The system is composed of two primary blocks: an inductive power transfer unit and a backward data communication unit. …”
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Effect of Feature Size on Defects, Microstructure, and Mechanical Properties of Selective Laser Melted AlSi10Mg Lattice Structure by Chengkuan Peng, Junfeng Qi, Sheng Zhou, Sanqiang Yang, Ran Tao, Heng Shao, Weining Li

“…This work optimized the process parameters based on large-size metal blocks (20 mm) and then fabricated submillimeter features with a size of 0.4~1.0 mm. …”
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Morphological comparison for the dorsal fin of Chrysichthys auratus, Synodontis schall, and Synodontis serratus (Teleosti: Siluriformes) collected from the Lake Nasser and the Rive... by Farrag Mahmoud M. S., Jawad Laith A., Park Joo M.

“…In S. schall and S. serratus, the posterior blocking process of the large specimens has a wavy edge, while in S. serratus, it is curved in young individuals and straight in larger specimens.…”
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Positive feedback loop involving AMPK and CLYBL acetylation links metabolic rewiring and inflammatory responses by Wenke Wang, Boquan Wu, Mingjun Hao, Sichong Chen, Ruiting Cong, Wenjie Wu, Pengbo Wang, Qiaoyi Zhang, Pengyu Jia, Yuequn Song, Bo Liu, Siyao Qu, Jian-Fei Pei, Da Li, Naijin Zhang

“…Here, we demonstrated that the metabolic reprogramming in inflammatory macrophages depended on the acetylation of CLYBL, a citramalyl-CoA lyase, at lysine 154 (K154), and blocking CLYBL-K154 acetylation restricted the release of pro-inflammatory factors. …”
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An adaptive intrusion detection and prevention system for Internet of Things by Sheikh Tahir Bakhsh, Saleh Alghamdi, Rayan A Alsemmeari, Syed Raheel Hassan

“…Once the proposed IDPIoT receives the packet, it examines the behavior, the packet is suspected, and it blocks or drops the packet. The main goal is accomplished by implementing one essential part of security, which is intrusion detection and prevention system.…”
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Macroscopic Profile Modification and Microscopic Displacement Mechanism of Weak Gel Flowing in Porous Media by Jian Wang, Bo Kang, Liehui Zhang, Beata Joanna Darowska, Peng Xu

“…Although the high permeable layer was not completely blocked, the oil recovery improved as a result of weak gel movement by continuous water flooding. …”
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A Hybrid Ant Colony Optimization Algorithm for Multi-Compartment Vehicle Routing Problem by Ning Guo, Bin Qian, Rong Hu, Huai P. Jin, Feng H. Xiang

“…First, a probabilistic model is designed to guide the algorithm search towards high-quality regions or solutions by considering both similar blocks of customers and customer permutations. Then, a heuristic rule is presented to generate initial individuals to initialize the probabilistic model, which can drive the search to the high-quality regions faster. …”
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Dominant Large-Scale Atmospheric Circulation Systems for the Extreme Precipitation over the Western Sichuan Basin in Summer 2013 by Yamin Hu, Panmao Zhai, Lihong Liu, Yang Chen, Yanju Liu

“…The configurations of WPSH and TC in the tropic and the blocking and trough in the midhigh latitudes play important roles during the EPPs over the WSB. …”
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Mibefradil and Flunarizine, Two T-Type Calcium Channel Inhibitors, Protect Mice against Lipopolysaccharide-Induced Acute Lung Injury by Limei Wan, Weibin Wu, Shunjun Jiang, Shanhe Wan, Dongmei Meng, Zhipeng Wang, Jiajie Zhang, Li Wei, Pengjiu Yu

“…Recent studies have illuminated that blocking Ca2+ influx into effector cells is an attractive therapeutic strategy for lung injury. …”
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Rhein Reduces Fat Weight in db/db Mouse and Prevents Diet-Induced Obesity in C57Bl/6 Mouse through the Inhibition of PPARγ Signaling by Yu Zhang, Shengjie Fan, Na Hu, Ming Gu, Chunxiao Chu, Yiming Li, Xiong Lu, Cheng Huang

“…Using diet-induced obese (DIO) C57BL/6 mice, we identified that rhein blocked high-fat diet-induced obesity, decreased fat mass and the size of white and brown adipocytes, and lowered serum cholesterol, LDL cholesterol, and fasting blood glucose levels in the mice. …”
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Oil drop face mask for sinus relief by Nur Hanisah Razali, Faten Elina Kamaruddin, Ainol Mardhiyah Rahmat, Nur Rifhan A. Rahim, Siti Noorhaslina Abd Halim, Hafizuddin Md Dali, Muhammad Haris Naqiuddin Muda

“…: Acute sinusitis is an infection caused by a virus that can lead to a congested or blocked nose, pain or pressure around your face, head, and eyes, loss of smell and taste, bad breath, ear pain, and headache. …”
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Non‐Reciprocity, Metastability, and Dynamic Reconfiguration in Co‐Assembly of Active and Passive Particles by Ahmed Al Harraq, Ruchi Patel, Jin Gyun Lee, Ope Owoyele, Jaehun Chun, Bhuvnesh Bharti

“…The combination of reciprocal and non‐reciprocal interactions between synthetic building blocks remains largely unexplored. Here, out‐of‐equilibrium assemblies of non‐motile isotropic passive and metal‐patched motile active particles are formed by overlapping bulk interactions with directed self‐propulsion. …”
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Case Study of Ground-Based Glaciogenic Seeding of Clouds over the Pyeongchang Region by Ha-Young Yang, Ki-Ho Chang, Sanghee Chae, Eunsil Jung, Seongkyu Seo, Jin-Yim Jeong, Jung-Ho Lee, Yonghun Ro, Baek-Jo Kim

“…In one case that did not show changes after seeding, it is analyzed that a sufficient cloud depth was not supplied to the seeding region due to the blocking effect of the Taebaek Mountains.…”
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Management recommendations to reduce cardiac risk in chronic epilepsy by Trudy D. Pang, Richard L. Verrier, Steven C. Schachter

“…Attention is drawn to the arrhythmogenic risks associated with antiseizure medications (ASMs) with sodium channel blocking properties that can disrupt cardiac conduction and repolarization and predispose to ventricular and atrial arrhythmias. …”
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Skin Testing to Identify Safe Drugs for Patients with Rocuronium-Induced Anaphylaxis by Manzo Suzuki, Hajime Kawase, Azusa Ogita, Hiroyasu Bito

“…Among patients who develop anaphylaxis during anesthesia, anaphylaxis caused by a neuromuscular blocking agent has the highest incidence. In patients who developed IgE-mediated anaphylaxis, and cross-reactivity among NMBAs is a concern in subsequent anesthetic procedures. …”
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ATP-Sensitive Potassium Channel Currents in Eccentrically Hypertrophied Cardiac Myocytes of Volume-Overloaded Rats by Zikiar V. Alvin, Richard M. Millis, Wissam Hajj-Mousssa, Georges E. Haddad

“…Treatment of the control myocytes with the KATP agonist cromakalim increased pA/pF significantly. This increase was blocked by the KATP antagonist glibenclamide. Treatment of the hypertrophied myocytes from volume-overloaded animals with cromakalim and in the presence and absence of glibenclamide did not change pA/pF significantly. …”
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RETRACTED ARTICLE: hERG1 channels modulate integrin signaling to trigger angiogenesis and tumor progression in colorectal cancer by Olivia Crociani, Francesca Zanieri, Serena Pillozzi, Elena Lastraioli, Matteo Stefanini, Antonella Fiore, Angelo Fortunato, Massimo D'Amico, Marika Masselli, Emanuele De Lorenzo, Luca Gasparoli, Martina Chiu, Ovidio Bussolati, Andrea Becchetti, Annarosa Arcangeli

“…This signaling pathway has novel features in that the integrin- and hERG1-dependent activation of HIF (i) is triggered in normoxia, especially after CRC cells have experienced a hypoxic stage, (ii) involves NF-kB and (iii) is counteracted by an active p53. Blocking hERG1 switches this pathway off also in vivo, by inhibiting cell growth, angiogenesis and metastatic spread. …”
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The Effect of Chewing Simulation on Flexural Strength of Different Lithium Disilicate Ceramics by Alsulimani O, Yousief SA, Al-Dabbagh RA, Attar EA, Bukhary DM, Algamaiah H, Musawa K, Subahi A, Abuzinadah SH, Alhaddad AJ, Alqahtani WMS, Emam ANM, Alqhtani MA, Elmarakby AM

“…The study’s findings suggest that Initial Lisi blocks should not be used for posterior teeth restorations. 2. …”
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Multi-phase attention network for face super-resolution. by Tao Hu, Yunzhi Chen

“…The IRAG consists of residual channel attention blocks (RCAB) and an integrated attention module (IAM). …”
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