Interleukin-1 Modulation of Human Placental Trophoblast Proliferation

“…The inhibitory effect was blocked by both IL-1 receptor antagonist (IL-1Ra) and antihuman IL-1<mml:math alttext="$eta$"> <mml:mi>&#x03B2;</mml:mi> </mml:math> monoclonal antibody. …”
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Therapeutic Use of Botulinum Toxin in Neurorehabilitation by Domenico Intiso

“…The botulinum toxins (BTX), type A and type B by blocking vesicle acetylcholine release at neuro-muscular and neuro-secretory junctions can result efficacious therapeutic agents for the treatment of numerous disorders in patients requiring neuro-rehabilitative intervention. …”
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Expandable Orbit Decay Prediction Using Continual Learning by Junhua He, Hua Wang, Haitao Wang, Xuankun Fang, Chengyi Huo

“…Generalization performance of machine learning techniques (MLTs) is blocked by the universal challenge known as catastrophic forgetting, resulting in limited improvement on PODP. …”
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Resveratrol-loaded metal-organic framework for mitochondria-targeted amplified CO gas therapy by Fengqin Wang, Yinfang Jiang, Yang Wang

“…RES acts as an ATPase inhibitor, disrupting the metabolism of the respiratory chain in tumor cell and thereby facilitating ATP-blocked metabolic therapy. In vitro experimental results demonstrate that the combination therapy, involving both RES drug and CO gas therapy, exhibits a synergistic effect against cancer cells. …”
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Genistein Ameliorated Vascular Endothelial Growth Factor-A (VEGF-A) and Estrogen Receptor-Alpha (ER-α) in Endometriosis Mice Model, In Vivo and In Silico by Sutrisno Sutrisno, Maharani Maharani

“…Molecular docking showed that genistein inhibited VEGF-A in several active site residues of VEGF-A, also blocked the ER-α protein in estradiol binding sites. …”
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Journal of a Frustrated Soul: John Henry Newman’s Dublin Diary (November 1853—March 1856) and the Perceived Failure of the Catholic University of Ireland by Pádraic Conway

“…One entry in particular raises the question whether and to what extent the bishops were actually committed to the Catholic University project or whether their primary concern was not the more negative one of blocking the efforts of the Queen’s Colleges. While this or very similar material had been reproduced in the Autobiographical Writings and picked up by early biographers such as Wilfrid Ward, it is given an enhanced impact when read in its original context in the Dublin journal. …”
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Phosphate Frustration: Treatment Options to Complement Current Therapies by Pablo E. Pergola

“…We present treatment options to complement current therapies including tenapanor, a novel sodium/hydrogen exchanger isoform 3 inhibitor that blocks the dominant paracellular phosphate absorption pathway and has been shown to reduce phosphate levels in several clinical trials.…”
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Optimizing Ontology Alignment through Linkage Learning on Entity Correspondences by Xingsi Xue, Chaofan Yang, Chao Jiang, Pei-Wei Tsai, Guojun Mao, Hai Zhu

“…Compact encoding mechanism does not need to store and maintain the whole population in the memory during the evolving process, and the utilization of linkage learning protects the chromosome’s building blocks, which is able to reduce the algorithm’s running time and ensure the alignment’s quality. …”
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The General Principle of the Warburg Effect as a Possible Approach for Cancer Immunotherapy: The Regulatory Effect of Plant Extracts Could Change the Game by Donika Ivanova, Severina Semkova, Boncho Grigorov, Milena Tzanova, Ana Georgieva, Dancho Danchev, Biliana Nikolova, Zvezdelina Yaneva

“…Because of the reported serious adverse effects of using synthetic ligands for PPARs in combination with chemotherapeutics, searches for less toxic and more active PPAR inhibitors, as well as blocking undesirable cellular PPAR-dependent processes, are in progress. …”
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Malware Analysis Using Visualized Image Matrices by KyoungSoo Han, BooJoong Kang, Eul Gyu Im

“…When the images are generated, we can reduce the overheads by extracting the opcode sequences only from the blocks that include the instructions related to staple behaviors such as functions and application programming interface (API) calls. …”
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Constitutive Expression of Functionally Active Protease-Activated Receptors 1 and 2 in Human Conjunctival Epithelial Cells by Timothy J. Nickel, Mohammad H. Kabir, Jaya Talreja, Daniel J. Stechschulte, Kottarappat N. Dileepan

“…Thrombin- and tryptase-induced HCEC activation was blocked by PAR1 and PAR2 neutralizing antibodies, respectively, and by specific enzyme inhibitors. …”
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Progress in Research on Metal Ion Crosslinking Alginate-Based Gels by Yantao Wang, Zhenpeng Shen, Huili Wang, Zhaoping Song, Dehai Yu, Guodong Li, Xiaona Liu, Wenxia Liu

“…Metal ion-induced alginate gelation shows different preferences for α-L-guluronic acid (G), β-D-mannuronic acid (M), and GM blocks. Some metal ions can also selectively bind to the carboxyl groups of guluronic acid. …”
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Mechanism of Support Optimization and Confined Blasting of Thick and Hard Rock with a Wedge-Structure Immediate Roof: A Case Study by Tong Zhao, Peilin Gong, Kaan Yetilmezsoy, Majid Bahramian, Changyou Liu, Xiaofei Gong

“…The length of confined blasting blocks and supporting intensity were calculated using a mechanical model for roof control in the strong strata behavior zone and less-strong strata behavior zone. …”
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Effective Variational Data Assimilation in Air-Pollution Prediction by Rossella Arcucci, Christopher Pain, Yi-Ke Guo

“…Numerical simulations are widely used as a predictive tool to better understand complex air flows and pollution transport on the scale of individual buildings, city blocks, and entire cities. To improve prediction for air flows and pollution transport, we propose a Variational Data Assimilation (VarDA) model which assimilates data from sensors into the open-source, finite-element, fluid dynamics model Fluidity. …”
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Both CD4+ and CD8+ Lymphocytes Participate in the IFN-γ Response to Filamentous Hemagglutinin from Bordetella pertussis in Infants, Children, and Adults by Violette Dirix, Virginie Verscheure, Françoise Vermeulen, Iris De Schutter, Tessa Goetghebuer, Camille Locht, Françoise Mascart

“…Filamentous hemagglutinin-specific IFN-γ secretion by circulating lymphocytes was blocked by anti-MHC-I or -MHC-II antibodies, suggesting that CD4+ and CD8+ T lymphocytes are involved in IFN-γ production. …”
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Discrimination of Melanoma Using Laser-Induced Breakdown Spectroscopy Conducted on Human Tissue Samples by Muhammad Nouman Khan, Qianqian Wang, Bushra Sana Idrees, Geer Teng, Xutai Cui, Kai Wei

“…The human melanoma and normal tissues are used in the form of formalin-fixed paraffin-embedded (FFPE) blocks as samples. The results demonstrated higher LIBS signal intensities of phosphorus (P), potassium (K), sodium (Na), magnesium (Mg), and calcium (Ca) in melanoma FFPE samples while lower signal intensities in normal FFPE tissue samples. …”
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Carbon Nanofoam by Pulsed Electric Arc Discharges by David Saucedo-Jimenez, Isaac Medina-Sanchez, Carlos Couder Castañeda

“…The pulsed electric arc discharge was established between two graphite electrodes with 22.8 kVA of power and 150 A DC current; the cathode was relatively motionless and was made of a pure carbon rod of 6 mm diameter, and the spinner anode was a pure carbon disc spinning at 600 rpm; over the disc was an annular cavity where the new catalytic mixture of 93.84/2.56/1.43/0.69/1.48 of C/Ni/Fe/Co/S molar fraction was deposited in a geometrically fixed way by 8 catalytic mixture blocks and 8 empty spaces, and the discharge frequency was 80 Hz. …”
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ECgMLP: A novel gated MLP model for enhanced endometrial cancer diagnosis by Md. Alif Sheakh, Sami Azam, Mst. Sazia Tahosin, Asif Karim, Sidratul Montaha, Kayes Uddin Fahim, Niusha Shafiabady, Mirjam Jonkman, Friso De Boer

“…Through a sequence of blocks, the ECgMLP architecture processes input images to remove unimportant patterns. …”
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Study on Disease Mechanism and Theoretical Quantification Method of Tunnel Structure by Yu Liu, Chun-an Tang, Peng-yu Wang, Yong-ping Guan, Shu-hong Wang

“…Most tunnel structures tend to have different degrees of structural damage such as leakage, concrete cracking, lining salinization, and falling blocks after the operation for a period. Compared with the diversity of tunnel disease detection methods, there are few studies on the methods of quantifying and evaluating the main structural diseases of the lining. …”
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The Hsf1-sHsp cascade has pan-antiviral activity in mosquito cells by Jieqiong Qu, Michelle Schinkel, Lisa Chiggiato, Samara Rosendo Machado, Gijs J. Overheul, Pascal Miesen, Ronald P. van Rij

“…Abstract Aedes mosquitoes transmit pathogenic arthropod-borne (arbo) viruses, putting nearly half the world’s population at risk. Blocking virus replication in mosquitoes is a promising approach to prevent arbovirus transmission, the development of which requires in-depth knowledge of virus-host interactions and mosquito immunity. …”
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