γ-Secretase Inhibitor Alleviates Acute Airway Inflammation of Allergic Asthma in Mice by Downregulating Th17 Cell Differentiation by Weixi Zhang, Xueya Zhang, Anqun Sheng, Cuiye Weng, Tingting Zhu, Wei Zhao, Changchong Li

“…Th17 cell differentiation requires Notch signaling. γ-Secretase inhibitor (GSI) blocks Notch signaling; thus, it may be considered as a potential treatment for allergic asthma. …”
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Activation of CD147 with Cyclophilin A Induces the Expression of IFITM1 through ERK and PI3K in THP-1 Cells by Ju-Young Kim, Ho Kim, Kyoungho Suk, Won-Ha Lee

“…CD147-induced expression of IFITM1 was blocked by inhibitors of ERK, PI3K, or NF-κB, but not by inhibitors of p38, JNK, or PKC. …”
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Hierarchical Structures from Inorganic Nanocrystal Self-Assembly for Photoenergy Utilization by Yun-Pei Zhu, Tie-Zhen Ren, Tian-Yi Ma, Zhong-Yong Yuan

“…The general strategies for the synthesis of hierarchical structures assembled from nanobuilding blocks are elaborated. The well-defined hierarchical structures provide new opportunities for optimizing, tuning, and/or enhancing the properties and performance of these materials and have found applications in photoenergy utilization including photodegradation, photocatalytic H2 production, photocatalytic CO2 conversion, and sensitized solar cells, and these are discussed illustratively.…”
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A Lightweight Laser Chip Defect Detection Algorithm Based on Improved YOLOv7-Tiny by HU Wei, ZHAO Jumin, LI Dengao

“…[Methods] By employing a lightweight convolutional neural network as the feature extraction backbone and integrating multi-branch reparameterized convolution blocks, this algorithm not only significantly reduces resource consumption but also enhances feature representation capabilities. …”
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Simulation of Particle-Fluid Interaction in Fractal Fractures Based on the Immersed Boundary-Lattice Boltzmann Method by Shenggui Liu, Songlei Tang, Jinkuang Huang, Mindong Lv, Yingjun Li

“…With increasing particle grading composition, the blocking effect of particles on fracture flow also increases with increasing particle proportion.…”
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Density Functional Study of Electronic and Structural Properties of Gold-Cadmium Selenide/Telluride Nanoclusters by Shimeles T. Bulbula, Hagos W. Zeweldi

“…Semiconductor nanowires are one class of building blocks that show promise for application in nanoscale electronics. …”
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Chromatographic and Spectral Analysis of Two Main Extractable Compounds Present in Aqueous Extracts of Laminated Aluminum Foil Used for Protecting LDPE-Filled Drug Vials by Samuel O. Akapo, Sajid Syed, Anicia Mamangun, Wayne Skinner

“…Lower molecular weight compounds that might be associated with the “building blocks” of these compounds were not detected in the aqueous extracts.…”
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The Real-Time-Based Assessment of the Microbial Killing by the Antimicrobial Compounds of Neutrophils by J. T. Atosuo, E.-M. Lilius

“…Taurine, the known HOCl scavenger, blocked the killing by MPO. When E. coli-lux was incubated with neutrophils, similar killing kinetics was recorded as in H2O2/MPO experiments. …”
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The Immune Response to Tumors as a Tool toward Immunotherapy by F. Pandolfi, R. Cianci, D. Pagliari, F. Casciano, C. Bagalà, A. Astone, R. Landolfi, C. Barone

“…This can be achieved by blocking pathways limiting the immune response, such as CTLA-4 or Tregs. …”
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Diabetes Mellitus and Increased Tuberculosis Susceptibility: The Role of Short-Chain Fatty Acids by Ekta Lachmandas, Corina N. A. M. van den Heuvel, Michelle S. M. A. Damen, Maartje C. P. Cleophas, Mihai G. Netea, Reinout van Crevel

“…This anti-inflammatory effect was independent of butyrate’s well-characterised inhibition of HDAC activity and was not accompanied by changes in Toll-like receptor signalling pathways, the eicosanoid pathway, or cellular metabolism. In contrast blocking IL-10 activity reversed the effects of butyrate on Mtb-induced inflammation. …”
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TNF-α as a Therapeutic Target in Acute Pancreatitis — Lessons from Experimental Models by Giuseppe Malleo, Emanuela Mazzon, Ajith K. Siriwardena, Salvatore Cuzzocrea

“…Given the importance of TNF-α in the pathogenesis of acute pancreatitis, investigators have regarded blocking the action of this mediator as an attractive treatment option. …”
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Nonfragile H∞ Stabilizing Nonlinear Systems Described by Multivariable Hammerstein Models by Zeineb Rayouf, Chekib Ghorbel, Naceur Benhadj Braiek

“…First, the parameters of linear and nonlinear blocks characterizing the multivariable Hammerstein model structure are separately estimated by using a subspace identification algorithm. …”
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Coordinated conformational changes in P450 decarboxylases enable hydrocarbons production from renewable feedstocks by Wesley Cardoso Generoso, Alana Helen Santana Alvarenga, Isabelle Taira Simões, Renan Yuji Miyamoto, Ricardo Rodrigues de Melo, Ederson Paulo Xavier Guilherme, Fernanda Mandelli, Clelton Aparecido Santos, Rafaela Prata, Camila Ramos dos Santos, Felippe Mariano Colombari, Mariana Abrahão Bueno Morais, Rodrigo Pimentel Fernandes, Gabriela Felix Persinoti, Mario Tyago Murakami, Leticia Maria Zanphorlin

“…Abstract Fatty acid peroxygenases have emerged as promising biocatalysts for hydrocarbon biosynthesis due to their ability to perform C-C scission, producing olefins - key building blocks for sustainable materials and fuels. These enzymes operate through non-canonical and complex mechanisms that yield a bifurcated chemoselectivity between hydroxylation and decarboxylation. …”
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Laboratory Measurement and Interpretation of the Changes of Physical Properties after Heat Treatment in Tight Porous Media by Yili Kang, Mingjun Chen, Lijun You, Xiangchen Li

“…Prevention of water blocking and optimization of multiscale flow channels will increase gas production of tight reservoirs. …”
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Enhanced high-energy proton radiation hardness of ZnO thin-film transistors with a passivation layer by Yongsu Lee, Hae-Won Lee, Su Jin Kim, Jeong Min Park, Byoung Hun Lee, Chang Goo Kang

“…In this study, significantly enhanced radiation hardness of Al2O3-passivated ZnO TFTs against high-energy protons with energies of up to 100 MeV is obtained owing to the passivation layer blocking interactions with external reactants, thereby maintaining the chemical stability of the thin-film semiconductor. …”
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6-Bromoindole- and 6-Bromoindazole-Based Inhibitors of Bacterial Cystathionine γ-Lyase Containing 3-Aminothiophene-2-Carboxylate Moiety by Roman A. Novikov, Dmitry N. Platonov, Alexander Yu. Belyy, Konstantin V. Potapov, Maxim A. Novikov, Yury V. Tomilov, Olga I. Kechko, Tatiana A. Seregina, Anastasia S. Zemskaya, Pavel N. Solyev, Vladimir A. Mitkevich

“…Their syntheses are based on 6-bromoindole, 6-bromoindazole and methyl 5-(bromomethyl)-3-((ethoxycarbonyl)amino)thiophene-2-carboxylate as the main building blocks, assembling the rest of the heterocyclic system on their basis at the nitrogen atom. …”
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Shield Equipment Optimization and Construction Control Technology in Water-Rich and Sandy Cobble Stratum: A Case Study of the First Yellow River Metro Tunnel Undercrossing by Fei Ye, Nan Qin, Xiang Gao, Xue-yong Quan, Xian-zhuo Qin, Bing Dai

“…It was completed after successfully overcoming several construction challenges, including strata with a high proportion of large-sized sandy cobble stratum being saturated, large-scale sand pits along the bank of the Yellow River, and a combination of boulders and erratic blocks of rock. Given the difficulties in constructing the tunnel, this paper summarizes the scheme employed to transform the cutter and cutter head design to be applicable to sandy cobble stratum and the key technology used to form the slurry film to facilitate crossing the sand pits in a systematic way. …”
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A platform for Bioengineering Tissue Membranes from cell spheroids by Quang Bach Le, Hariharan Ezhilarasu, Weng Wan Chan, Alok Tanala Patra, Priya Murugan, Shashaank Abhinav Venkatesh, Yean Kai Tay, Shin Ru Lim, Ahmad Amirul Abdul Rahim, Jia Sheng Zach Lee, Xuezhi Bi, Deepak Choudhury

“…Cell spheroids are essential building blocks for engineering tissues like cartilage, bone, liver, cardiac, pancreatic, and neural tissues, but controlling their fusion and organisation is challenging. …”
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Transcriptome and DNA Methylome Dynamics during Triclosan-Induced Cardiomyocyte Differentiation Toxicity by Guizhen Du, Mingming Yu, Lingling Wang, Weiyue Hu, Ling Song, Chuncheng Lu, Xinru Wang

“…After TCS treatment, the differentiation process was significantly blocked and spontaneous beating rates of CMs were also decreased. …”
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Rosiglitazone Restores Endothelial Dysfunction in a Rat Model of Metabolic Syndrome through PPARγ- and PPARδ-Dependent Phosphorylation of Akt and eNOS by Zhigang Zhao, Zhidan Luo, Peijian Wang, Jing Sun, Hao Yu, Tingbing Cao, Yinxing Ni, Jing Chen, Zhencheng Yan, Daoyan Liu, Zhiming Zhu

“…Importantly, this effect was blocked by either inhibition of PPARγ or PPARδ. In cultured endothelial cells, acute treatment with rosiglitazone increased the phosphorylation of Akt and eNOS and the production of NO. …”
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