I-SPY COVID adaptive platform trial for COVID-19 acute respiratory failure: rationale, design and operations by Carolyn S Calfee, Michael A Matthay, Paul Henderson, Martin Eklund, Laura J Esserman, Chirag Patel, Angela Haczku, Michelle Jung, Tony Oliver, Alessio Crippa, Andrea Discacciati, Kathleen D Liu, Ellen L Burnham, Nuala J Meyer, Fady A Youssef, Derek W Russell, Julie Lang, Kevin W Gibbs, Daniel C Files, Sheetal Gandotra, Purnema Madahar, Nathan K Cobb, Timothy E Albertson, Rajiv Sonti, John P Reilly, Alejandra Jauregui, Iván García, Luis E Huerta, Daniel Clark Files, Neil R Aggarwal, Adam L Asare, Jeremy R Beitler, Paul A Berger, George Cimino, Melissa H Coleman, Paul T Henderson, Caroline A G Ittner, Kashif T Khan, Jonathan L Koff, Mary LaRose, Joe Levitt, Ruixiao Lu, Jeffrey D McKeehan, Karl W Thomas, Aaron M Mittel, Albert F Yen, Alexis E Suarez, Alexis L Serra, Alpesh N Amin, Amanda Rosen, Amy L Dzierba, Anna D Barker, Ariel R Weisman, Brian M Daniel, Brian M Morrissey, Caroline AG Ittner, Chayse Jones, Christina Creel-Bulos, Christina M Angelucci, Diana Ng, Fredy Chaparro-Rojas, Gavin H Harris, Harsh V Barot, Heny Su, Jacqueline B Sutter, Jamal Dodin, Jerry S Lee, John Kazianis, Joshua F Detelich, Julie E Lang, Justin Muir, Katarzyna Gosek, Katherine L Nugent, Kimberly Yee, Laura G Rodrigues, Laura R Macias, Lindsey A Orr, Lindsie L Boerger, Lissette Rosario-Remigio, Lucia Kufa, Maged Tanios, Maria B Reyes, Max W Adelman, Maya M Juarez, Michelle Meyers, Mitchell P Sternlieb, Neil Aggarwal, Nilam S Mangalmurti, Patrice Jones, Paul L Saban, Peter S Marshall, Philiip A Robinson, Philip Yang, Rahul Nair, Richard Anthony Lee, Richard G Wunderink, Romina Wahab, Roxana A Lupu, Santhi I Kumar, Sara C Auld, Scott Fields, Se Fum Wong, Skyler J Pearson, Spencer Whealon, Timothy F Obermiller, Anita Darmanian, John Schicchi, Esmeralda Martinez, Farjad Sarafian, Julie Nguyen, Bethany Weiler-Lisowski, Jaime Wyatt, Daniel Blevins, Marylee Melendrez, Brenda Lopez, Hiwet Tzehaie, Omowunmi Amosu, Austin Simonson, Erin Hardy, Brett Lindgren, Gregory Peterfreund, Leigha Landreth, Lisa Parks

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Comparing propofol anaesthesia guided by Bispectral Index monitoring and frontal EEG wave analysis with standard monitoring in laparoscopic surgery: protocol for the ‘EEG in Genera... by Luzius A Steiner, Salome Dell-Kuster, Bettina U Gruber, Valerie Girsberger, Lukas Kusstatscher, Simon Funk, Anita Luethy, Lien Jakus, Julien Maillard, Christoph S Burkhart

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Evaluating the use of coronary artery calcium scoring as a tool for coronary artery disease (CAD) risk stratification and its association with coronary stenosis and CAD risk factor... by Afrose Liaquat, Ameerdad Khan, Saeed Ullah Shah, Hania Iqbal, Safa Iqbal, Atif Iqbal Rana, Habib Ur Rahman

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Rapid corticosteroid taper versus standard of care for immune checkpoint inhibitor induced nephritis: a single-center retrospective cohort study by Ryan Sullivan, Riley Fadden, Kerry L Reynolds, Meghan D Lee, Harish Seethapathy, Ian A Strohbehn, Sophia H Zhao, Genevieve M Boland, Meghan E Sise

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Use of machine learning in osteoarthritis research: a systematic literature review by Francis Berenbaum, Jérémie Sellam, David Klatzmann, Atul J Butte, Karine Louati, Encarnita Mariotti-Ferrandiz, Marie Binvignat, Valentina Pedoia

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Cluster analysis of post-COVID-19 physical and mental health outcomes 3–6 months after SARS-CoV-2 infection: results of the French Prospective ALCOVID Cohort Study by Philippe Halfon, Laurent Chiche, Hervé Pegliasco, Stanislas Rebaudet, Thomas Escoda, Hervé Faralli, Frédéric Cohen

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Lessons learnt from a scientific peer-review training programme designed to support research capacity and professional development in a global community by Ella August, Tamrat Endale, Julie M Buser, Kirby L Morris, Veronica Millicent Dzomeku, Yolanda R Smith

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Does candidate race influence simulated patient ratings in standardised assessments of clinical practice? A single-blinded randomised study in UK medical schools by Celia Brown, Amir H Sam, Rachel Westacott, Mark Gurnell, Sarah Khavandi, Malcolm Reed, Ann Sebastian, Kerry Badger

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Novel role of microphthalmia-associated transcription factor in modulating the differentiation and immunosuppressive functions of myeloid-derived suppressor cells by Yoon Kyung Jeon, Aram Lee, Haesun Park, Soyoung Lim, Jihyun Lim, Jaemoon Koh, Young Yang, Myeong-Sok Lee, Jong-Seok Lim

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Intimate partner violence among women of reproductive age during the COVID-19 pandemic in Ethiopia: a systematic review and meta-analysis by Gizachew Yilak, Alemayehu Sayih Belay, Aychew Kassie, Befkad Derese Tilahun, Ambaw Abebaw Emrie, Mulat Ayele, Eyob Shitie Lake, Legese Fekede Abza

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Keratoconus disease classification with multimodel fusion and vision transformer: a pretrained model approach by Shokufeh Yaraghi, Toktam Khatibi

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Blood coagulation system in patients with chronic kidney disease: a prospective observational study by Xi Yang, Yang Wang, Ri-bao Wei, Ting-yu Su, Meng-jie Huang, Ping Li, Xiang-mei Chen, Ping Di, Qing-ping Li

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The relationship between physician burnout and quality of healthcare in terms of safety and acceptability: a systematic review by Sarah Bonato, Carolyn S Dewa, Desmond Loong, Lucy Trojanowski

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Effectiveness of physical activity counselling provided for people with type 2 diabetes mellitus in primary healthcare in North Karelia, Finland: a register-based evaluation study by Tiina Laatikainen, Tuula Marketta Martiskainen, Marja-Leena Lamidi, Mika Venojärvi, Heikki Tikkanen

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Xpert Ultra stool testing to diagnose tuberculosis in children in Ethiopia and Indonesia: a model-based cost-effectiveness analysis by Peter J Dodd, Nyashadzaishe Mafirakureva, Rina Triasih, Debebe Shaweno, Jens Levy, Eveline Klinkenberg, Petra de Haas, Ineke Spruijt, Nastiti Kaswandani, Ahmed Bedru, Melaku Gebremichael, Edine W Tiemersma

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Young adults’ cigarillo risk perceptions, attention to warning labels and perceptions of proposed pictorial warnings: a focus group study by Michelle Jeong, Olivia A Wackowski, Stefanie K Gratale, Andrew A Strasser, Cristine D Delnevo, Zeinab Safi, Anupreet Sidhu

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Population-based survey of the prevalence and types of glaucoma in Bangladesh by Bipul Kumer De Sarker, Sheikh M A Mannaf, Siddiqur Rahman, Md Shafiqul Islam, Md Mizanur Rahman, M Nazrul Islam, Salma Parvin

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Benefits and harms of pregabalin in the management of neuropathic pain: a rapid review and meta-analysis of randomised clinical trials by Igho J Onakpoya, Elizabeth T Thomas, Joseph J Lee, Ben Goldacre, Carl J Heneghan

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Tumor-associated neutrophils and macrophages interaction contributes to intrahepatic cholangiocarcinoma progression by activating STAT3 by Jian Zhou, Jia Fan, Zhiqiang Hu, Jia Li, Zhengjun Zhou, Pengcheng Wang, Rongqi Sun, Haoyang Xin, Chubin Luo, Shaolai Zhou

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Relationship between obesity indicators and hypertension–diabetes comorbidity among adults: a population study from Central China by Li Li, Ling Li, Ying Wang, Wenwen Wu, Xiaodong Tan, Fen Yang, Jinru Yang, Yifan Wu, Donghan Sun, Ziling Ni, Yaofei Xie

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