Rehabilitation using virtual gaming for Hospital and hOMe-Based training for the Upper limb in acute and subacute Stroke (RHOMBUS II): results of a feasibility randomised controlle... by Cherry Kilbride, Tom Butcher, Meriel Norris, Nana Anokye, Alyson Warland, Karen Baker, Dimitrios A Athanasiou, Guillem Singla-Buxarrais, Jennifer Ryan, Francesca Gowing, Elmar Kal, Carole Pound, Victoria Stewart, Basaam Aweid, Arul Samiyappan

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What is the influence of single-entry models on access to elective surgical procedures? A systematic review by Deborah A Marshall, Zaheed Damani, Barbara Conner-Spady, Tina Nash, Henry Tom Stelfox, Tom W Noseworthy

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Primary prevention of sexually transmitted infections in Switzerland: practices of family physicians and their determinants—a national cross-sectional survey by Hanna Vautrin, Nicolas Senn, Christine Cohidon

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Open-label dose-extending placebos for opioid use disorder: a protocol for a randomised controlled clinical trial with methadone treatment by Annabelle M Belcher, Thomas O Cole, Aaron D Greenblatt, Stephen W Hoag, David H Epstein, Michael Wagner, Amy S Billing, Ebonie Massey, Kristen R Hamilton, Zofia K Kozak, Christopher J Welsh, Eric Weintraub, Emerson M Wickwire, Eric D Wish, Ted J Kaptchuk, Luana Colloca

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Incidence and contributing factors of dementia among people living with HIV in British Columbia, Canada, from 2002 to 2016: a retrospective cohort study by Rolando Barrios, Julio S G Montaner, Silvia Guillemi, Ni Gusti Ayu Nanditha, Viviane D Lima, Thomas L Patterson, Fidel Vila-Rodriguez, William G Honer, Jason Trigg, Hasan Nathani, Sara Shayegi-Nik, Weijia Yin, Alejandra Fonseca, Bronhilda T Takeh

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Development of a core outcome set and core measurement set for kangaroo mother care: a study protocol by Yuan Li, Xia Li, Qiong Chen, Ying Xin Li, Han Mei Peng, Xue Mei Guo, Xiao Wen Li, Yan Ling Hu, Xing Li Wan

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Development and design validation of a novel network meta-analysis presentation tool for multiple outcomes: a qualitative descriptive study by Lehana Thabane, Jason W Busse, Behnam Sadeghirad, Gordon H Guyatt, Mohit Bhandari, Romina Brignardello-Petersen, Fernando Kenji Nampo, Carlos A Cuello-Garcia, Raveendhara R Bannuru, Mark R Phillips, Yu Jia Guo, Sofia Bzovsky

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Factors associated with in-hospital mortality of newborns admitted to a special care newborn unit of a tertiary care hospital in southern Bangladesh: a retrospective cohort study by Md Mostafizur Rahman, Tahmina Zerin, Md Abdullah Saeed Khan, Md Golam Abbas, Aysha Haque, Mohammed Zahidul Alam, Ummay Thamima, Md Wahiduzzaman, Siddhartha Sankar Das

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Mitochondrial reactive oxygen species trigger metformin-dependent antitumor immunity via activation of Nrf2/mTORC1/p62 axis in tumor-infiltrating CD8T lymphocytes by Kazuhiro Kakimi, Hirokazu Matsushita, Masaaki Komatsu, Eiryo Kawakami, Mikako Nishida, Nahoko Yamashita, Taisaku Ogawa, Keita Koseki, Eiji Warabi, Tomoyuki Ohue, Katsuyuki Shiroguchi, Heiichiro Udono

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How do electronic risk assessment tools affect the communication and understanding of diagnostic uncertainty in the primary care consultation? A systematic review and thematic synt... by Sarah Gerard Dean, Joshua Feyi-Waboso, Mark Tarrant, Raff Calitri, Elizabeth Shephard, Alex Burns, Brian Donnelly

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Effect of novel accelerated intermittent theta burst stimulation on suicidal ideation in adolescent patients with major depressive episode: a randomised clinical trial by Dong Huang, Shuming Zhong, Xiaodong Song, Rongxu Zhang, Shunkai Lai, Yanbin Jia

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Transient lymphocyte count decrease correlates with oncolytic adenovirus efficacy in humans: mechanistic and biomarker findings from TUNIMO phase I trial by Tuomo Alanko, Akseli Hemminki, Víctor Cervera-Carrascón, Riikka Havunen, Kristian Taipale, Dafne C A Quixabeira, Jorma Sormunen, Katriina Peltola, Suvi Sorsa, Santeri A Pakola, Elise Jirovec, Lyna Haybout, Claudia Kistler, Tatiana V Kudling, Victor Arias, James H A Clubb, Mirte van der Heijden, Teijo Pellinen, Joao M Santos

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Geriatric nutrition in the surgical patient: an American Association for the Surgery of Trauma Critical Care and Geriatric Trauma Committees clinical consensus document by Adel Elkbuli, Deborah M Stein, Ruben Peralta, Aussama Khalaf Nassar, Tasce Bongiovanni, Joseph Cuschieri, Michael Steven Farrell, Abhijit Pathak, Rondi Gelbard, Randeep Jawa, Tanya Egodage, Tyler Putnam, Samrah Mitha

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Point-of-care tests, diagnostic uncertainty and antimicrobial stewardship in the ICU: procalcitonin or PCR to aid antibiotic-stop decisions – an observational cohort study by Luke Moore, Suveer Singh, Martine Nurek, Nabeela Mughal, Timothy Lau, Archit Singhal

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Parsimonious versus extensive bleeding score: can we simplify risk stratification after percutaneous coronary intervention and reduce bleeding events by de-escalation of the antipl... by Pascal Vranckx, Stephan Windecker, Marco Valgimigli, Neil O’Leary, Yoshinobu Onuma, Peter Damman, Eva Christine Ida Woelders, Kai Ninomiya, Denise Adriana Maria Peeters, Arnoud Willem Johannes van 't Hof, Patrick Washington J C Serruys, Robert-Jan Matthijs van Geuns

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Outcome evaluation and cost-effectiveness analysis for an integrated multidisciplinary diabetic limb salvage program: a combined observational and simulation study by Yan Sun, Xiaoli Zhu, Jaime Lin, John Abisheganaden, Zhiwen Joseph Lo, Lixia Ge, Joseph Molina, Elaine Tan, Huiling Liew, Jeremy Hoe, Gary Ang, Kai Qiang Low, Theophilus Yap, Nur Aberleen Syafirah Binte Azmi, Enming Yong, Tiffany Chew, Hui Yan Koo, Chelsea Law, Dexter Yak Seng Chan, Claris Shi, Julia Choo, Wai Han Hoi, Sadhana Chandraskear, Jo Ann Lim, Jemes Siow, Sabariah Binte Kaspon, Subramaniam Tavintharan, Daniel Chew

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Geographical accessibility of emergency neonatal care services in Ethiopia: analysis using the 2016 Ethiopian Emergency Obstetric and Neonatal Care Survey by Andrew Hayen, Getiye Dejenu Kibret, Daniel Demant

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Association of sildenafil use with age-related macular degeneration: a retrospective cohort study by Nicola Jaime Adderley, Krishnarajah Nirantharakumar, Anuradhaa Subramanian, Alastair K Denniston, Wen Hwa Lee, Ji Eun Diana Han, Jesse Coker

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Fluid balance and clinical outcomes in patients with aortic dissection: a retrospective case-control study based on ICU databases by Tao Chen, Peng Qiu, Yixuan Li, Xinwu Lu, Zhaoyu Wu, Zhijue Xu, Hongji Pu, Jiahao Lei, Zhuojing Zhang, Xinrui Yang, Ruihua Wang

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Monitoring for 5-aminosalicylate nephrotoxicity in adults with inflammatory bowel disease: prognostic model development and validation using data from the Clinical Practice Researc... by Abhishek Abhishek, Richard D Riley, Christian D Mallen, Guruprasad P Aithal, Georgina Nakafero, Matthew J Grainge, Maarten W Taal, Tim Card, Matthew D Stevenson

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