The efficacy and safety of a taxane-based chemotherapy regimen combined with a PD-1 inhibitor in HNSCC: a multicenter real-world study by Min Ouyang, Hanquan Sun, Xiaoyu Liu, Haijun Wu, Feilong Deng, Erdong Shen, Guozheng Peng, Hanbing Wu, Yinshan Zhao, Hui Xiong, Bin Liu, Shasha He, Ying Hu, Ping Liu

“…Regarding safety, during treatment anemia was observed in 97 patients, leukopenia in 64, neutropenia in 33, thrombocytopenia in 28, transaminase elevation in 46, hypothyroidism in 46 patients, and one patient stopped taking the medication due to a serious adverse reaction. …”
Get full text

Factors Associated with Maternal Near Miss among Women Admitted in West Arsi Zone Public Hospitals, Ethiopia: Unmatched Case-Control Study by Fikadu Nugusu Dessalegn, Feleke Hailemichael Astawesegn, Nana Chea Hankalo

“…The major maternal near-miss morbidities were severe obstetric hemorrhage (32.5%), pregnancy-induced hypertensive disorders (31.3%), and obstructed labor (26.3%), followed by 6.3% and 3.8% of severe anemia and pregnancy-induced sepsis, respectively. …”
Get full text

Comprehensive safety evaluation of isatuximab in multiple myeloma using disproportionality analysis of FAERS and meta-analysis of randomized controlled trials by Muhammed Favas Karimbanathottathil, Beema T Yoosuf, M Mamatha, Dipika Bansal

“…AEs commonly observed with isatuximab therapy included neutropenia, pneumonia, infusion-related reactions, thrombocytopenia, acute kidney injury, and anemia. In our meta-analysis of three RCTs involving 1,258 patients, 659 (52.4%) in the isatuximab treatment group experienced 1,135 AEs, with 58% classified as grade three or higher. …”
Get full text

Migration, environnement et gentrification rurale en Montagne limousine by Frédéric Richard, Julien Dellier, Greta Tommasi

“…Se distinguent, entre autres, les entrées par la population, les migrations d’aménités ou encore par la gentrification rurale (Smith, 1998 ; M. …”
Get full text

Effect of schistosomiasis and soil-transmitted helminth infections on physical fitness of school children in Côte d'Ivoire. by Ivan Müller, Jean T Coulibaly, Thomas Fürst, Stefanie Knopp, Jan Hattendorf, Stefanie J Krauth, Katarina Stete, Aurélie A Righetti, Dominik Glinz, Adrien K Yao, Uwe Pühse, Eliézer K N'goran, Jürg Utzinger

“…<h4>Background</h4>Schistosomiasis and soil-transmitted helminthiasis are important public health problems in sub-Saharan Africa causing malnutrition, anemia, and retardation of physical and cognitive development. …”
Get full text

Determinants of Preterm Birth among Women Who Gave Birth in Amhara Region Referral Hospitals, Northern Ethiopia, 2018: Institutional Based Case Control Study by Abebayehu Melesew Mekuriyaw, Muhabaw Shumye Mihret, Ayenew Engida Yismaw

“…Thus, putting emphasis for prevention of obstetric and gynecologic complications such as anemia, premature rupture of membrane and abortion would decrease the incidence of preterm birth. …”
Get full text

TIGIT inhibitor M6223 as monotherapy or in combination with bintrafusp alfa in patients with advanced solid tumors: a first-in-human, phase 1, dose-escalation trial by Wei Gao, Ping Hu, Aung Naing, Meredith McKean, Anthony Tolcher, Lillian L Siu, Keyvan Tadjalli-Mehr, Anja Victor, Emilia Richter, Marco A F Nogueira Filho, Thomas Kitzing, Stephan Gleicher, Daniel Holland

“…Additional objectives included pharmacokinetics, pharmacodynamics and clinical activity (NCT04457778).Results Two dose-limiting toxicities were observed: grade 3 adrenal insufficiency (Part 1A: M6223 900 mg every 2 weeks) and grade 3 anemia (Part 1B: M6223 300 mg, only BA related). MTD was not reached. …”
Get full text

Phase 3 Study of Talazoparib Plus Enzalutamide Versus Placebo Plus Enzalutamide as First‐Line Treatment in Patients With Metastatic Castration‐Resistant Prostate Cancer: TALAPRO‐2... by Nobuaki Matsubara, Hideaki Miyake, Hiroji Uemura, Atsushi Mizokami, Hiroaki Kikukawa, Takeo Kosaka, Kazuo Nishimura, Motonobu Nakamura, Kazuki Kobayashi, Atsushi Komaru, Yuko Mori, Shigeyuki Toyoizumi, Natsuki Hori, Yoshiko Umeyama, Hirotsugu Uemura

“…The safety profile of talazoparib plus enzalutamide was similar between Japanese patients and the overall all‐comers population; no new safety signals were identified. Anemia was the most common grade 3/4 treatment‐emergent adverse event (55%) and cause of talazoparib discontinuation (12%). …”
Get full text

Long-term safety of dexamethasone sodium phosphate encapsulated in autologous erythrocytes in pediatric patients with ataxia telangiectasia by Mary Kay Koenig, Vincenzo Leuzzi, Riadh Gouider, Riadh Gouider, Eppie M. Yiu, Eppie M. Yiu, Barbara Pietrucha, Asbjørg Stray-Pedersen, Susan L. Perlman, Steve Wu, Trudy Burgers, Rupam Borgohain, Rukmini Mridula Kandadai, Isabelle Meyts, Giorgia Bucciol, Anaita Udwadia-Hegde, Ravi Yadav, Donna Roberts, Aaron Dane, Maureen Roden, Dirk Thye, Biljana Horn, Howard M. Lederman, William P. Whitehouse

“…Notable adverse events included transient pruritus reported in 23 (34%) patients and findings of low serum iron reported in 27 (40%) patients, while at baseline one fifth of patients had low serum iron. Anemia was reported in 9 (13%) patients. The mean hemoglobin level changed by −0.8 ± 1.0 g/dL after 6 months of therapy without subsequent decline. …”
Get full text

Evaluation of Treatment Patterns and Maintenance Dose Titration Among Patients With Crohn’s Disease Initiating Biologics With 3 Years of Follow-Up by Ruizhi Zhao, Zhijie Ding, Parul Gupta, Laurence Gozalo, Robert Bruette, Victor M. Johnson, Keshia Maughn, Yihang Liu, Sumesh Kachroo

“…Common comorbidities (>10%) included anemia, anxiety, depression, and hypertension. Persistence over 3 years’ follow-up was highest for UST (61.4%) patients, followed by VDZ (58.0% ), ADA (52.1% , and IFX (48.1%). …”
Get full text

Phase II clinical trial assessing the addition of hyperthermia to salvage concurrent chemoradiotherapy for unresectable recurrent head and neck cancer in previously irradiated pati... by Kai-Lin Yang, Mau-Shin Chi, Chung-Yu Hao, Hui-Ling Ko, Yi-Ying Huang, Ren-Hong Wu, Hung-Chih Lai, Ying-Chu Lin, Sheng-Po Hao, Kwan-Hwa Chi

“…Grade 3–4 leucopenia, anemia, thrombocytopenia accounted for 14.3%, 14.3%, and 8.6%, respectively. …”
Get full text

Pooling the complex survey data across the 64 lower and middle-income countries: A study on antibiotic usage in under-five children by Md Fakrul Islam, Prosenjit Basak Arka, Mahfuzer Rohman, Md Sabbir Hossain, Md Rashed Babu, Hasin Anupama Azhari, Md Jamal Uddin

“…On the other hand, Cameroon (0.3 %), Armenia (4.0 %), and Mauritania (6.1 %) had the lowest. …”
Get full text

First-in-human dose escalation trial to evaluate the clinical safety and efficacy of an anti-MAGEA1 autologous TCR-transgenic T cell therapy in relapsed and refractory solid tumors by Ignacio I Wistuba, Mamta Kalra, Linus Backert, Martin Wermke, Edwin R Parra, Jason John Luke, Apostolia M Tsimberidou, Sebastian Bunk, Mohammad B Hossain, Andrea Mayer-Mokler, Arun Satelli, Norbert Hilf, Steffen Walter, Cedrik M Britten, Van K Morris, Tobias A W Holderried, Winfried H Alsdorf, Katrin Wetzko, Borje S Andersson, Sandra Grund-Gröschke, Katrin Aslan, Anantha Marisetty, Swapna Satam, Jens Hukelmann, M Alper Kursunel, Karine Pozo, Andreas Acs, Melissa Baumeister, Claudia Wagner, Oliver Schoor, Ali S Mohamed, Delfi Krishna

“…The most common grade 3–4 adverse events were cytopenias, that is, neutropenia (81.3%), lymphopenia (75.0%), anemia (50.0%), thrombocytopenia (50.0%) and leukopenia (25.0%). 13 patients experienced cytokine release syndrome, including one grade 3 event. …”
Get full text

Interactions between NAD+ metabolism and immune cell infiltration in ulcerative colitis: subtype identification and development of novel diagnostic models by Linglin Tian, Huiyang Gao, Tian Yao, Tian Yao, Yuhao Chen, Linna Gao, Jingxiang Han, Lanqi Zhu, He Huang, He Huang, He Huang

“…Growing evidence highlights the pivotal role of nicotinamide adenine dinucleotide (NAD+) metabolism in UC pathogenesis, prompting our investigation into the subtype-specific molecular underpinnings and diagnostic potential of NAD+ metabolism-related genes (NMRGs).MethodsTranscriptome data from UC patients and healthy controls were downloaded from the GEO database, specifically GSE75214 and GSE87466. …”
Get full text

Bonding performance of universal adhesive systems with dual-polymerising resin cements to various dental substrates: in vitro study by Shunsuke Takano, Rena Takahashi, Tomoko Tabata, Chen Zeng, Masaomi Ikeda, Yasushi Shimada

“…Enamel, dentin, zirconia (Katana Zirconia UTML), LDS (IPS e.max CAD CEREC), and resin blocks (Katana Avencia P Block) were used as substrates. The universal adhesive was applied to all bonding surfaces, followed by resin cement application in micro-bore Tygon tubes and light curing for 40 s. …”
Get full text

Adaptation for Staphylococcus aureus to hosts via insertion mutation in the accessory gene regulator agrC gene: decreased virulence and enhanced persistence capacity by Jiawei Chen, Yun Wu, Ying Zhu, Li Zhang, Yingchun Xu, Yali Liu

“…The genomic comparison between strains 23B and 23H revealed that 23B had a single adenine base insertion at position 923 in the agrC gene, leading to a functional loss of the encoded AgrC. …”
Get full text

Policitemia en pacientes con enfermedad renal crónica en hemodiálisis by Cristhian Adolfo Vizcarra Vizcarra

“…Introducción: Los pacientes con enfermedad renal crónica cursan con anemia, la cual es menos frecuente en ciudades por encima de los 1000 metros de altitud sobre el nivel del mar. …”
Get full text

Caracterización de pacientes con esplenopatía quirúrgica no traumática by Jan González Ramos, Zoe Quintero Delgado, Annia Quintana Marrero

“…El tratamiento quirúrgico más utilizado fue la esplenectomía total, y la parcial en el mayor porcentaje a los que presentaban anemia drepanocítica y β-talasemia. El criterio clínico-hematológico que más motivó la cirugía fue la trombocitopenia en el 50 % de los casos. …”
Get full text

Parasitological and clinical correlates of Plasmodium–Schistosoma mansoni co-infection and its determinants among Plasmodium-infected patients in the Wolaita Zone, South Ethiopia r... by Kemal Mohamed, Tariku Belay, Ahmed Zeynudin

“…Plasmodium–Schistosoma mansoni co-infected with a heavy intensity of Schistosoma mansoni had the highest parasitemia and was also significantly associated with malaria attack. In addition, anemia was associated with the presence of Plasmodium–Schistosoma mansoni co-infection. …”
Get full text

RNA stability is regulated by both RNA polyadenylation and ATP levels, linking RNA and energy metabolisms in Escherichia coli by Charlotte Roux, Marvin Ramos-Hue, Marjorie Audonnet, Marie-Pierre Duviau, Sébastien Nouaille, Agamemnon J. Carpousis, Sandrine Laguerre, Eliane Hajnsdorf, Muriel Cocaign-Bousquet, Laurence Girbal

“…RNA polyadenylation is catalyzed by poly(A) polymerases, which use ATP as a substrate to add adenine to the 3′ end of RNAs, which can alter their stability. …”
Get full text