Unveiling unexpected adverse events: post-marketing safety surveillance of gilteritinib and midostaurin from the FDA Adverse Event Reporting database by Tingting Jiang, Yanping Li, Ni Zhang, Lanlan Gan, Hui Su, Guiyuan Xiang, Yuanlin Wu, Yao Liu

“…The common AEs observed with gilteritinib included febrile neutropenia, pyrexia, anemia, and thrombocytopenia. Similarly, the prevalent AEs associated with midostaurin were nausea, vomiting, diarrhea, pyrexia, and febrile neutropenia. …”
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Evaluation of inflammation adjustment methods to assess iron deficiency using longitudinal data from norovirus human challenge trials. by Yi-An Ko, Parminder S Suchdev, Jiaxi Geng, Hanqi Luo, Melissa F Young, Anne M Williams

“…Correction factors (CF), the Biomarkers Reflecting Inflammation and Nutritional Determinants of Anemia (BRINDA) regression correction (BRC), and restricted cubic splines (RCS) were used to adjust the influence of inflammation on ferritin using alpha-1-acid glycoprotein (AGP) and/or C-reactive protein (CRP). …”
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The Effect of Pregnancy in the Hemoglobin Concentration of Pregnant Women: A Longitudinal Study by Berhanu Elfu Feleke, Teferi Elfu Feleke

“…Recommendation. Regular anemia screening intervention should be implemented after delivery.…”
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Desafíos apremiantes para enseñantes comprometidos con una educación en ciudadanía y derechos humanos desde los Modelos de Naciones Unidas by Matías Penhos

“…Con base en una referencia socio-comunitaria muy atenta a la articulación territorial, se han consagrado esfuerzos compartidos para alcanzar los resultados que se adecuan a las expectativas de los grupos estudiantiles. …”
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Case Report of Gastrointestinal Bleeding in an Adult with Chronic Visceral Acid Sphingomyelinase Deficiency by David Cassiman, Louis Libbrecht, Wouter Meersseman, Alexander Wilmer

“…At age 64 they had multiple hospital admissions for hematochezia (originally diagnosed as ischemic colitis) accompanied by hypotension (blood pressure 91/45 mmHg), anemia (hemoglobin 8.5g/dL, ref 12-16; INR 1.4, ref ≤1.2), and mild renal insufficiency (creatinine 1.33mg/dL, ref 0.51-0.95). …”
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A Rare Co-Occurrence of Triple Mutations in JAK2, CALR, and MPL in the Same Patient with Myelofibrosis by Sherine J. Thomas, D. P. Dash

“…The patient was started on treatment with hydroxyurea and aspirin with improvement in platelet count and resolution of anemia. Discussion. The clinical significance of the presence of multiple driver mutations in the same patient is not well understood at this time. …”
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Studying red cell distribution width in Iraqi persons with type 2 diabetes mellitus in Najaf City: a case-control study by Maysam Riyadh Mohammed Hussein Alaasam, Karrar Mohammed Abbas Al-buthabhak, Ahmed Mech, Shamim Riadh Mohammed Hussein

“…People with a history of anemia, renal failure, heart disease, hypertension, thyroid disorder, pregnancy, and conditions leading to chronic inflammation, such as rheumatoid arthritis, diabetic neuropathy, diabetic retinopathy, and diabetic nephropathy, were excluded from the study. …”
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Dapagliflozin improves diabetic kidney disease by inhibiting ferroptosis through β-hydroxybutyrate production by Yan Tian, Chenxia Zhou, Qun Yan, Ziyi Li, Da Chen, Bo Feng, Jun Song

“…The mitochondrial membrane potential (MMP), adenosine triphosphate (ATP) level, NAD+/NADH ratio (oxidized/reduced ratio of nicotinamide adenine dinucleotide), and lipid peroxidation were measured. …”
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Editorial by Amarilys Suárez Alfonso

“…Dar prioridad al trabajo decente en la economía rural en las agendas políticas nacionales e internacionales es indispensable para encontrar soluciones viables, a largo plazo, a los desafíos que enfrentan cientos de millones de personas el mundo. …”
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Presenting the Model of Eco-Leadership in Elementary Schools with an Interpretive Phenomenological Approach by Adel Zahed babolan, Seyyedmohammad Seyyedkalan

“…This research addresses the challenges and issues fronted by these agendas, aligning with recent Ministry of Education initiatives (since 2018) aimed at implementing environmental programs in schools. …”
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“Onde você mora?”: um estudo hodonímico dos logradouros do município de Farroupilha/RS by Jaqueline Biazus, Kleber Eckert

“…Sendo assim, o principal objetivo deste artigo é analisar, sob a perspectiva histórica, linguística e sociocultural, os nomes dados às ruas, avenidas e travessas do município de Farroupilha, localizado no Rio Grande do Sul. …”
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Impacto de la movilidad urbana en la calidad del aire de la zona metropolitana de San Luis Potosí, México. by Claudia Nalleli Hernández Cerda, Alfredo Ávila Galarza, Diana Gabriela Cerda Alonso

“…La calidad del aire es monitoreada en algunas ciudades del mundo, pero en América Latina y en particular en México, el número de ciudades atentas a esta afectación ambiental se reduce; mientras que los impactos negativos a la salud humana y a los ecosistemas aumentan. …”
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Epidemiological Characteristics and Family Relatives among Thalassemic Patients in Sulaimani City, Kurdistan Region, Iraq by Kamal Jalal Rashid

“…Patients with thalassemia suffer from chronic hemolytic anemia and its sequelae. A descriptive study was undertaken in Sulaimani Thalassemia and Congenital Blood Disease Center. …”
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Can smoking duration alone replace pack-years to predict the risk of smoking-related oncogenic mutations in non-small cell lung cancer? A cross-sectional study in Japan by Masahiko Ando, Yoshihiko Taniguchi, Akihiro Tamiya, Akihide Matsumura, Koichi Ogawa, Yasuhiro Koh, Hiroyasu Kaneda, Motohiro Izumi, Yoshiya Matsumoto, Kenji Sawa, Mitsuru Fukui, Naoki Yoshimoto, Akihito Kubo, Shun-ichi Isa, Hideo Saka, Tomoya Kawaguchi

“…Objective To investigate whether smoking duration alone can replace pack-years to predict the risk of oncogenic mutations in non-small cell lung cancer (NSCLC).Design A cross-sectional study using the baseline dataset from the Japan Molecular Epidemiology for Lung Cancer Study.Setting Forty-three medical institutions nationwide in Japan.Participants From July 2012 to December 2013, 957 patients with newly diagnosed stage I–IIIB NSCLC who underwent surgery were enrolled, and molecular analyses were performed on 876 samples (from 441 ever-smokers and 435 never-smokers).Main outcomes measured We calculated the area under the receiver operating characteristic curve (AUC) values using logistic regression to compare between the predictive values of smoking duration and pack-years for mutational frequencies in the v-Ki-ras2 Kirsten rat sarcoma (KRAS), tumour suppressor p53 (TP53), and epidermal growth factor receptor (EGFR) genes and for cytosine-to-adenine base substitution (C>A).Results For predicting KRAS mutations, the AUC values for smoking duration and pack-years were 0.746 (95% CI 0.682 to 0.800) and 0.759 (95% CI 0.700 to 0.810), respectively (p=0.058). …”
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Digestive enzymes activities in Oreochromis niloticus fed diet supplemented with recombinant growth hormone by Apriana Vinasyiam, Muhammad Agus Suprayudi, , Alimuddin

“…Kecernaan protein dan retensi protein bernilai lebih tinggi sementara laju ekskresi amonia bernilai lebih rendah pada ikan perlakuan. …”
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Comparative analysis of the primary structure and production of recombinant poly(ADP-ribose)polymerase 1 of long-lived Heterocephalus glaber by K. N. Naumenko, A. R. Nurislamov, K. D. Nazarov, V. S. Fishman, A. A. Popov, I. O. Petruseva, A. N. Evdokimov, O. I. Lavrik

“…PARP1 catalyzes the synthesis of poly(ADPribose) polymer (PAR) upon DNA damage using nicotinamide adenine dinucleotide (NAD+) as a substrate. This polymer covalently attaches to PARP1, which leads to its dissociation from the complex with damaged DNA and stimulation of the repair process. …”
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A Multicentric, Retrospective Efficacy and Safety Study of Nanosomal Docetaxel Lipid Suspension in Metastatic Castration-Resistant Prostate Cancer by Aseem Samar, Srikant Tiwari, Sundaram Subramanian, Nisarg Joshi, Jaykumar Sejpal, Mujtaba A. Khan, Imran Ahmad

“…The most common hematological AEs were anemia, lymphopenia, thrombocytopenia, and neutropenia whereas nausea, weakness, constipation, vomiting, and diarrhea were the most common (≥10%) nonhematological AEs. …”
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Humanizing processes after harm part 1: patient safety incident investigations, litigation and the experiences of those affected by Lauren Ramsey, Laura Sheard, Justin Waring, Siobhan McHugh, Ruth Simms-Ellis, Ruth Simms-Ellis, Gemma Louch, Katherine Ludwin, Jane K. O’Hara

“…Ultimately, elusive “organizational agendas” were prioritized above the needs of all affected.ConclusionsIncident investigations fail to acknowledge and address emotional distress experienced by all affected, resulting in compounded harm. …”
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Short- and Intermediate-Term Morbidity Following Total Pelvic Exenteration in Colorectal Cancer by Christopher Guske BS, Nusheen Immen BS, Devon Conant BS, Jose Laborde PhD, Joshua Linscott MD, PhD, Mitchell Hayes MD, Seyed Behzad Jazayeri MD, Adnan Fazili MD, Erin Siegel PhD, MPH, Sophie Dessureault MD, Julian Sanchez MD, Amalia Stefanou MD, Brandon Manley MD, Seth Felder MD

“…The most common complication overall was anemia requiring transfusion, while the most common major complication was pelvic abscess. …”
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The Relationship between Red Blood Cell Distribution Width and Incident Diabetes in Chinese Adults: A Cohort Study by Jialu Wang, Yanan Zhang, Yanping Wan, Zhuping Fan, Renying Xu

“…Sensitivity analysis generated similar results with prospective analyses after excluding aged participants, participants who are overweight and with obesity, participants with elevated blood pressure, participants with decreased eGFR, and those with anemia at baseline. Conclusions. High RDW was associated with high risk of developing diabetes in Chinese adults. …”
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