Patient-derived follicular lymphoma spheroids recapitulate lymph node signaling and immune profile uncovering galectin-9 as a novel immunotherapeutic target by Cèlia Dobaño-López, Juan García Valero, Ferran Araujo-Ayala, Ferran Nadeu, Fabien Gava, Carla Faria, Marine Norlund, Renaud Morin, Pascale Bernes-Lasserre, Fabian Arenas, Marta Grau, Cristina López, Irene López-Oreja, Neus Serrat, Ares Martínez-Farran, Lluís Hernández, Heribert Playa-Albinyana, Rubén Giménez, Silvia Beà, Elías Campo, Jean-Michel Lagarde, Armando López-Guillermo, Laura Magnano, Dolors Colomer, Christine Bezombes, Patricia Pérez-Galán

“…FL-PDLS recapitulates the most relevant B-cell transcriptional pathways present in FL-LN (proliferation, epigenetic regulation, mTOR, adaptive immune system, among others). The T cell compartment in the FL-PDLS preserves CD4 subsets (follicular helper, regulatory, and follicular regulatory), also encompassing the spectrum of activation/exhaustion phenotypes in CD4 and CD8 populations. …”
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Reliability of Schirmer and Phenol Red Thread test value on dry eye patients by Urvashni Nirghin, Tharuna Govender, Yeshalya Hirachund, Rorisang Mosololi, Hlengiwe Nxumalo, Sumaya Patel, Philani Zwane, Khathutshelo P. Mashige

“…Novesin (0.4%) was instilled into the right eye of each participant, followed by the administration of the ST and PRT, 5 min apart, then re-administered after a 10-min interval. …”
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De fil palatial en aiguille patrimoniale. La soierie du cabinet de repos du petit appartement de Napoléon Ier à Versailles. by Laureen Gressé-Denois

“…To illustrate this rich future, this article looks at five aspects of agency through the biography of the colourfully embroidered gros de Tours white brocaded silk from the resting room in the emperor’s private apartments. From its creation as part of Napoleon’s recovery plan, and its replacement after 1815 for reasons of economy, to its ornamentation, which conveys a symbolic message, the history of the silks was initially shaped by economic and political intentions. …”
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Winter tick sharing between ungulates in the Greater Yellowstone Ecosystem and implications for apparent competition by Troy Koser, Alynn Martin, Alyson Courtemanch, Laura Thompson, Benjamin Wise, Gary Fralick, Sarah Dewey, Amy Girard, Brandon Scurlock, Jared Rogerson, Kennan Oyen, Paul Cross

“…Our analysis of 2793 informative single‐nucleotide polymorphisms showed genetic differentiation among tick populations that were only ~75 km apart, but fewer differences among ticks from elk or moose in the same locality, suggesting sharing of winter ticks across host species. …”
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Inhibition of Extracellular Calcium Influx Results in Enhanced IL-12 Production in LPS-Treated Murine Macrophages by Downregulation of the CaMKKβ-AMPK-SIRT1 Signaling Pathway by Xin Liu, Ning Wang, Yuanfeng Zhu, Yongjun Yang, Xiaoli Chen, Shijun Fan, Qian Chen, Hong Zhou, Jiang Zheng

“…Activated macrophages are the primary sources of IL-12, a key cytokine bridging innate and adaptive immunity. However, macrophages produce low amounts of IL-12 upon stimulation and the underlying regulatory mechanism remains unclear. …”
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Reprogramming the tumor immune microenvironment using engineered dual-drug loaded Salmonella by Dinh-Huy Nguyen, Sung-Hwan You, Hien Thi-Thu Ngo, Khuynh Van Nguyen, Khang Vuong Tran, Tan-Huy Chu, So-young Kim, Sang-Jun Ha, Yeongjin Hong, Jung-Joon Min

“…Here, we show that SAM-FC induces functional reprogramming of the tumor immune microenvironment by activating both the innate and adaptive arms of the immune system and can be used for targeted delivery of multiple immunotherapeutic payloads for the establishment of potent and long-lasting antitumor immunity.…”
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Bir Kadınlık Deneyimi Olarak Menopoz by Aslı Merve Çıtak

“…Nitel araştırma deseninin benimsendiği çalışma, menopozu deneyimlemiş katılımcılarla derinlemesine görüşmeler yapılmış, amaçlı ve kolayda örneklem tekniklerinden yararlanılan çalışmada, temalaştırma yöntemi ve betimsel analiz gerçekleştirilmiştir. …”
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Evaluation of the implementation of governmental policies and actions to create healthy food environments in Burkina Faso by Viviane Aurélie Tapsoba, Ella WR Compaore, Augustin Nawidimbasba Zeba, Jerome Winbetourefa Some, Julien Soliba Manga, Adama Diouf, Jean-Claude Moubarac, Stefanie Vandevijvere, Mamoudou H Dicko

“…The tool has two components (policy and infrastructure support), thirteen domains and fifty-six good practice indicators adapted to the Burkina Faso context. Setting: Burkina Faso. …”
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Reservoir ecological health assessment Methods: A systematic review by Esi Esuon Biney, Charles Gyamfi, Anthony Yaw Karikari, Deborah Darko

“…Recommendations for future research include the development of more robust ecological health indicators and enhanced data integration techniques such as multimetric indices, functional trait-based indices, and resilience indicators that assess traditional metrics like water quality and biodiversity and incorporate measures of ecosystem function, services, resilience, and adaptive capacity. The SLR also recommended a comprehensive and integrated approach for future reservoir studies that combine physicochemical analyses, trophic state indices, species composition and diversity measurements, bioindicator assessments, statistical analyses, and physical habitat evaluations. …”
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Evaluation of Patients with Parkinson’s Disease in Intensive Care Units: A Cohort Study by Álvaro Réa-Neto, Bruna C. Dal Vesco, Rafaella S. Bernardelli, Aline M. Kametani, Mirella C. Oliveira, Hélio A. G. Teive

“…Compared with patients in the NPD group, those in the PD group were more frequently admitted with lower level of consciousness and increased APACHE II severity score but required less frequently vasoactive drugs. …”
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Temperature and Humidity Monitoring in Hydroponic Cultivation Based on Internet of Things: Dataset Development for Smart Agriculture by Simon Prananta Barus, Jeriko Ichtus Seo

“…The research method includes literature study, hardware development using NodeMCU ESP8266 microcontroller and DHT11 sensor, web-based software development with JavaScript on the Front-End side, PHP on the Back-End side, Apache as Web Server, and MySQL as database management system (DBMS), as well as the implementation stage, integration, system testing and report writing. …”
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Interaction between arbuscular mycorrhizal fungi and dark septate endophytes in the root systems of Populus euphratica and Haloxylon ammodendron under different drought conditions... by Huimei Wang, Huimei Wang, Hengfang Wang, Hengfang Wang, Shengtao Wei, Shengtao Wei, Li Sun, Li Sun, Li Sun, Linlin Cheng, Linlin Cheng

“…This study demonstrates the interaction between AMF and DSE with the host plants P. euphratica and H. ammodendron as well as their effects on the adaptation of host plants to the desert environment, which can provide a basis for strengthening desert vegetation management.…”
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Çocuk Kitapları Yetişkinlere Ne Söylüyor? by Ferah Burgul Adıgüzel, Canan Aslan

“…Araştırma, temel nitel araştırma yaklaşımına göre desenlemiştir.Araştırmanın çalışma grubu, kendi ilgi ve isteği doğrultusunda çocuk edebiyatı ürünleri okuyangönüllü 221 yetişkindir. Grup, amaçlı örnekleme yöntemlerinden ölçüt örnekleme yoluylabelirlenmiştir. …”
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Distinct neural computations scale the violation of expected reward and emotion in social transgressions by Ting Xu, Lei Zhang, Feng Zhou, Kun Fu, Xianyang Gan, Zhiyi Chen, Ran Zhang, Chunmei Lan, Lan Wang, Keith M. Kendrick, Dezhong Yao, Benjamin Becker

“…Abstract Traditional decision-making models conceptualize humans as adaptive learners utilizing the differences between expected and actual rewards (prediction errors, PEs) to maximize outcomes, but rarely consider the influence of violations of emotional expectations (emotional PEs) and how it differs from reward PEs. …”
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Sürdürülebilirlik ve Kurumsal Reklam İlişkisi Bağlamında Göstergebilimsel Bir Analiz by Mert Susur, Ömer Aydınlıoğlu

“…Sürdürülebilirlik, mevcut doğal kaynakların bilinçli kullanılmasıyla gelecek nesillere aktarılması olarak tanımlanmaktadır. Bu çalışmanın amacı, bir ticari ürün veya hizmet ile ilgili olmaktan ziyade, kuruluş hakkında hedef kitlelere bilgi vermek amacıyla kullanılan kurumsal reklamlarda son yıllarda kuruluşlar tarafından büyük önem verilen çevresel sürdürülebilirlik kavramının ne şekilde ele alındığını, ne gibi göstergeler eşliğinde izleyicilere sunulduğunu, örnekleme alınan markanın kurumsal reklamları üzerinden detaylı bir biçimde ele almak ve analiz etmektir. …”
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Okuma Kültürü Edindirme Sürecine Yönelik Bir Eylem Araştırması by Mustafa Şahin, İzzet Şeref

“…Amaç: Bu çalışmanın amacı, araştırmacılar tarafından planlanan okuma grubu temelli okuma etkinliklerinin lise öğrencilerinin okuma kültürü edinme, okuma beceri ve alışkanlıklarını geliştirme süreçlerine olan etkilerini ortaya koymaktır. …”
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Sex-Specific Differences in the Pathophysiology of Hypertension by Hannah Zhang, Pawan K. Singal, Amir Ravandi, Inna Rabinovich-Nikitin

“…In brief, estrogen promotes subcutaneous fat deposition over visceral fat and increases in mass via adaptive hyperplasia rather than pathogenic hypertrophy. …”
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Acquired vulnerability against EGF receptor inhibition in gastric cancer promoted by class I histone deacetylase inhibitor entinostat by Tamara Zenz, Robert Jenke, Denys Oliinyk, Sandra Noske, René Thieme, Tim Kahl, Ines Gockel, Florian Meier-Rosar, Achim Aigner, Thomas RH Büch

“…Since previous studies in other tumor entities showed a downregulation of EGFR by HDACi, our findings thus indicate essential differences in the adaptive response of gastric carcinoma cells. Moreover, our results provided the basis for combined entinostat + EGFR inhibitor (erlotinib) treatment, and indeed we demonstrate synergistic effects in combination therapy studies. …”
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Vegetation Dynamics and Sensitivity Responds to Climate Change in the Upstream of the Yellow River, China by XiangYu Lan, RuoWei Li, Xin Wang, TianCai Zhou, YunHui Li, JieJi Duo, Jian Sun

“…Our study is helpful to adaptive ecosystem management under ongoing climate change.…”
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Impact of Inappropriate Empiric Antimicrobial Therapy on Mortality of Septic Patients with Bacteremia: A Retrospective Study by Saoraya Lueangarun, Amorn Leelarasamee

“…There were 229 cases, mean age (SD) of 63.5 (17.2) years and mean (SD) APACHE II score of 24.7 (6.8). The prevalence of first-dose and 24-hour inappropriate antimicrobials was 29.7% and 25.3%, respectively. …”
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