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1761
Developing and validating a drug recommendation system based on tumor microenvironment and drug fingerprint
Published 2025-01-01“…Clinical application was assessed using The Cancer Genome Atlas (TCGA) dataset, with Best Overall Response (BOR) serving as the clinical efficacy measure. …”
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1762
Key regions aberrantly connected within cerebello-thalamo-cortical circuit and their genetic mechanism in schizophrenia: an fMRI meta-analysis and transcriptome study
Published 2025-01-01“…Gene annotation analysis was performed to identify genes over-expressed in these regions by using the Allen Human Brain Atlas, followed by a set of gene functional feature analyses. 19 studies (1333 patients and 1174 healthy controls) were included in this meta-analysis. …”
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1763
Potential biomarkers and immune infiltration linking endometriosis with recurrent pregnancy loss based on bioinformatics and machine learning
Published 2025-02-01“…Moreover, immune cell infiltration was estimated using CIBERSORTx, and the Cancer Genome Atlas (TCGA) database was employed to elucidate the role of key genes in endometrial carcinoma (EC).Results26 common differentially expressed genes (DEGs) were screened in both diseases, three of which were identified as common core genes (MAN2A1, PAPSS1, RIBC2) through the combination of WGCNA, PPI network, and machine learning-based feature selection. …”
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1764
Single-cell sequencing uncovers the mechanistic role of DAPK1 in glioma and its diagnostic and prognostic implications
Published 2025-01-01“…However, the precise role and underlying mechanisms of DAPK1 in gliomas remain inadequately understood.MethodsWe performed analyses on RNA-seq and microarray datasets from The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO), in addition to single-cell RNA sequencing (scRNA-seq) data from glioma patients available in GEO. …”
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1765
Comprehensive Analysis of the Mechanism of Anoikis in Hepatocellular Carcinoma
Published 2024-01-01“…This paper’s data (TCGA-HCC) were retrieved from the database of the Cancer Genome Atlas (TCGA). Differential gene expression with prognostic implications for anoikis was identified by performing both the univariate Cox and differential expression analyses. …”
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1766
Providing an Anti-Marketing Model to Prevent Criminal Behaviors in Online and Digital Businesses
Published 2024-06-01“…Ultimately, employing ATLAS.ti software, “the anti-marketing model aimed at preventing criminal behaviors in the online business environment” was derived. …”
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1767
Single-cell transcriptomics reveals novel chondrocyte and osteoblast subtypes and their role in knee osteoarthritis pathogenesis
Published 2025-02-01“…Therefore, this study constructed a bipedal postmenopausal KOA mouse model to better understand how the interplay between subchondral bone remodeling and cartilage degeneration contributes to KOA development. A single-cell atlas of the osteochondral composite tissue was established. …”
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1768
Basal-Supported Oral Therapy with Sitagliptin Counteracts Rebound Hyperglycemia Caused by GLP-1 Tachyphylaxis
Published 2014-01-01“…Their GLP-1 analog-based therapy was switched to BOT with insulin glargine plus sitagliptin and other medications. The primary outcomes were whether switching of therapy was associated with a change of hemoglobin A1c (HbA1c) and whether weight gain occurred. …”
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1769
Activin levels correlate with lymphocytic infiltration in epithelial ovarian cancer
Published 2024-09-01“…Immune gene expression profile was further explored within the TCGA‐OV cohort derived from The Cancer Genome Atlas (TCGA). Immunohistochemical analysis was performed to evaluate activin A and T‐cell markers CD8 and FoxP3 at the protein level. …”
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1770
Expression of CSTF2 in oral squamous cell carcinoma and its relationship with immune infiltration and poor prognosis
Published 2025-02-01“…However, its specific association with patient prognosis and immune cell infiltration in OSCC remains insufficiently understood.MethodsTo assess the expression levels and prognostic implications of CSTF2 in OSCC, comprehensive data were acquired from The Cancer Genome Atlas (TCGA) and subsequently normalized. Immunohistochemical staining of tissue microarrays was performed to analyze CSTF2 expression in the OSCC samples. …”
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1771
Identification of Survival Risk and Immune-Related Characteristics of Kidney Renal Clear Cell Carcinoma
Published 2022-01-01“…A series of information such as RNA sequence, clinical data, and tumor mutation burden (TMB) of KIRC patients were downloaded through The Cancer Genome Atlas (TCGA). Next, combining the survival information and gene expression data of TCGA and Gene Expression Omnibus (GEO), we established an immune gene-related prognosis model (IGRPM) and analyzed it. …”
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1772
Single-cell transcriptomes of dissecting the intra-tumoral heterogeneity of breast cancer microenvironment
Published 2024-12-01“…Conclusion We constructed a comprehensive single-cell transcriptome atlas of 54,055 cells from 4 malignant and 4 nonmalignant patients, providing insights into the mechanisms underlying breast cancer progression and the development of potential therapeutic strategies in breast cancer.…”
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1773
Predicting Outcomes in Esophageal Squamous Cell Carcinoma Using scRNA‐Seq and Bulk RNA‐Seq: A Model Development and Validation Study
Published 2025-01-01“…Methods A total of 8, 99, and 140 individuals from The Gene Expression Omnibus database, The Cancer Genome Atlas database, and the Memorial Sloan Kettering Cancer Center, respectively, were encompassed in the investigation. …”
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1774
Tumour DNA methylation markers associated with breast cancer survival: a replication study
Published 2025-01-01“…Candidate methylation sites (N = 22) and signatures (N = 3) potentially associated with breast cancer survival were identified from five prior studies that used The Cancer Genome Atlas (TCGA) methylation dataset, which shares key characteristics with the MCCS: comparable sample size, tissue type (formalin-fixed paraffin-embedded; FFPE), technology (Illumina HumanMethylation450 array), and participant characteristics (age, ancestry, and disease subtype and severity). …”
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1775
Heterogeneous Acupuncture Effects of Taixi (KI3) on Functional Connectivity in Healthy Youth and Elder: A Functional MRI Study Using Regional Homogeneity and Large-Scale Functional...
Published 2020-01-01“…Regional homogeneity (ReHo) and large-scale FC analysis using Power 264 atlas were utilized to analyze the changes of brain spontaneous activity. …”
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1776
Apoptosis antagonizing transcription factor expression and its validation as a potential diagnostic and prognostic biomarker in oral squamous cell carcinoma
Published 2025-01-01“…This study aimed to investigate the expression of apoptosis antagonizing transcription factor (AATF) in OSCC, examine its correlation with clinicopathological features, assess its prognostic implications, and explore its potential role in OSCC progression.MethodsExpression profiles and clinical data of OSCC patients were obtained from The Cancer Genome Atlas (TCGA). Immunohistochemical analysis on tissue microarrays was performed to assess AATF expression in OSCC. …”
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1777
Conceptualización y Práctica de la Comunicación Responsable Universitaria: la perspectiva de los DirCOM sobre su ejercicio
Published 2022-10-01“…Las categorías y códigos de análisis se definieron a priori mediante una sistematización deductiva aplicada al software Atlas.Ti (v.8). Resultados: Los expertos muestran concordancia respecto a la definición de la Comunicación Responsable y plantean la necesidad de contemplar sus rasgos como parte de la Comunicación Pública que ejercen en la dinámica universitaria. …”
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1778
Single-cell sequencing provides clues about the developmental genetic basis of evolutionary adaptations in syngnathid fishes
Published 2025-02-01“…We created a single-cell RNA sequencing atlas of Gulf pipefish embryos to understand the developmental basis of four traits: derived head shape, toothlessness, dermal armor, and male pregnancy. …”
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1779
Efeito da burocracia no custo de transação econômica na Pró-Reitoria de Administração da Universidade Federal Rural do Semi-Árido
Published 2020-05-01“…Os dados foram tratados, atendendo aos preceitos da análise de conteúdo; para isso, primeiramente, transcreveu-se a entrevista, que posteriormente foi importada para o Software Atlas ti 8.0. Logo após, fez-se o trabalho de codificação que, com a finalização, empregou-se a categorização dos dados, com o propósito de criar famílias de acordo com as dimensões estudadas. …”
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1780
Training and onboarding initiatives in high energy physics experiments
Published 2025-02-01“…In this article we document the current analysis software training and onboarding activities in several High Energy Physics (HEP) experiments: ATLAS, CMS, LHCb, Belle II and DUNE. Fast and efficient onboarding of new collaboration members is increasingly important for HEP experiments. …”
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