Targeting the activated allosteric conformation of the endothelin receptor B in melanoma with an antibody-drug conjugate: mechanisms and therapeutic efficacy by Amaury Herbet, Marie Hautière, Frédéric Jean-Alphonse, Delphine Vivier, Christophe Leboeuf, Narciso Costa, Aloïse Mabondzo, Guilhem Bousquet, Franck Denat, Eric Reiter, Didier Boquet

“…Abstract Background Endothelin 1 receptors are one of the drivers of tumor progression in many cancers. Inhibition of their signaling pathways with antagonist drugs has been the subject of numerous clinical trials, but the results have not met expectations probably due to the high endothelin concentrations in the tumor microenvironment and their unusually high affinity for their receptors. …”
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Evaluating the role of environmental advertising on the use of eye movements towards the brand by Seyed Hamid Mir Motahari, Sina Nematizadeh, Seyed Abbas Heydari

“…According to open coding, the concepts related to the consequences of the model have been extracted, then according to the back and forth movement between the themes and concepts, the main categories have been extracted and named, and accordingly, the consequences are divided into three parts related to the competitive advantage, value-creating, and promotion of strategic marketing decisions are classified as the consequences of Ambient advertising based on the use of eye tracking. …”
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Beyond Current Frontiers of Electrocatalysis by Aleksandar Zeradjanin

“…One of the key reasons why the transition to renewable energy sources is progressing slowly is the low efficiency of processes at electrified interfaces where electricity is converted and stored as chemical energy. The challenge behind low efficiency is sluggish electrochemical conversion reactions. …”
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Thermoelectric Characterization of Electronic Properties of GaMnAs Nanowires by Phillip M. Wu, Waldomiro Paschoal, Sandeep Kumar, Christian Borschel, Carsten Ronning, Carlo M. Canali, Lars Samuelson, Håkan Pettersson, Heiner Linke

“…However, the unusually large thermopower suggests that additional mechanisms must be considered as well.…”
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Persistent Cryptococcal Brain Infection despite Prolonged Immunorecovery in an HIV-Positive Patient by Tom Wingfield, Jo Baxter, Amit Herwadkar, Daniel du Plessis, Tom J. Blanchard, F. Javier Vilar, Anoop Varma

“…Although initially treated for relapsing cryptococcal immune reconstitution syndrome, a brain biopsy taken 17 months after initial presentation showed budding Cryptococci. Conclusion. This unusually protracted case highlights the difficulties in differentiating relapsing cryptococcal meningitis from immune reconstitution and raises questions concerning the optimum timing of initiation of combined antiretroviral therapy in such patients.…”
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Expanding Network Analysis Tools in Psychological Networks: Minimal Spanning Trees, Participation Coefficients, and Motif Analysis Applied to a Network of 26 Psychological Attribut... by Srebrenka Letina, Tessa F. Blanken, Marie K. Deserno, Denny Borsboom

“…Using these techniques, we investigate how the network of different psychological concepts is organized, which attribute is most central, and what the role of intelligence in the network is relative to other psychological variables. …”
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Stability Analysis of the New Section in Raising the Existing Composite Wala Dam Using Finite Element Methods by Dima A. Husein Malkawi, Abdallah I. Husein Malkawi

“…The Wala dam was raised uniquely and unusually, which raises concerns about its stability and safety. …”
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Země Koruny české a Svatá říše římská v raném novověku by Petr Vorel

“… This study is an extended version of the paper presented at the 47th conference of German historiographers in Dresden in October 2008. …”
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Competitive strategies of internationalization, searching and creating markets by O. V. Mickhailov

“…The combination of specialization (concerning products and know-how) and global broadening of the market/niche has diversity advantages, including of economies on scale, experience curve and temporal monopolization of the market niche.The strategy of revealing and creating new markets and market niches can form and create not only big companies, but middle and small enterprises, having unusually initiatives, invention initiatives, creation capabilities in finding and creating the new markets/niches. …”
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The world’s most venomous spider is a species complex: systematics of the Sydney funnel-web spider (Atracidae: Atrax robustus) by Stephanie F. Loria, Svea-Celina Frank, Nadine Dupérré, Helen M. Smith, Braxton Jones, Bruno A. Buzatto, Danilo Harms

“…Morphological variability and venom diversity in this species appear to be unusually high, raising questions about species concepts and diversity in these spiders. …”
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EIGHT MINERAL SPECIES IN ONE CRYSTAL: UNIQUE ZONATION OF POLYCHROME TOURMALINE FROM THE KRUTAYA VEIN (MALKHAN PEGMATITE FIELD, TRANSBAIKALIA, RUSSIA) by A.V. Kasatkin, О.S. Vereshchagin, L.A. Gorelova, D.I. Belakovskiy

“…A unique unusually Mn-rich concentrically zoned polychrome crystal from the cavity of granite pegmatite of the Krutaya vein within the Malkhan pegmatite field (Transbaikalia) is studied. …”
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Mechanisms linking river flow regime and riparian hardwood establishment by Steven F. Railsback, John H. Bair

“…These results indicate that the conventional conceptual model of establishment is incomplete. …”
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Epistemic Roots, Universal Routes and Ontological Roofs of African “Ritual Archives”: Disciplinary Formations in African Thought by Oluwatoyin Vincent Adepoju

“…His focus is Africa and its Diaspora, but his thought resonates with implications far beyond Africa, into contexts of struggle for plurality of vision outside and even within the West, the global dominance of whose central theoretical constructs inspires Falola’s essay. …”
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A Two-Fluid Conditional Averaging Paradigm for the Theory and Modeling of Turbulent Premixed Combustion by Vladimir L. Zimont

“…It is a more suitable conceptual framework that is likely to be more convenient in the long run than the traditional Favre averaging method. …”
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