Elucidation of the mechanism of berberine against gastric mucosa injury in a rat model with chronic atrophic gastritis based on a combined strategy of multi-omics and molecular bio... by Lisheng Chen, Lisheng Chen, Xin Wang, Xin Wang, Jianyu Li, Lijuan Zhang, Wenbin Wu, Shizhang Wei, Wenjun Zou, Yanling Zhao, Yanling Zhao

“…Integrating transcriptomics and metabolomics analyses indicated that BBR directly regulated Carnitine C3:0, LPC (0:0/20:3), L-Glutamic Acid and FFA (15:0) by acting on SLC25A20, PNLIPRP1, PLA2G4C, GSR, GFPT2, GCLM, CTPS1, ACSL1, ACOT4 and ACOT2. 16S rRNA sequencing revealed that BBR could restore the balance of gut microbiota dysbiosis by significantly regulating the relative abundance of unclassified_Muribaculaceae and Lactobacillus_johnsonii.ConclusionThis study demonstrated that BBR alleviates CAG through the regulation of the MAPK signaling pathway, metabolic disorders and gut microbiota dysbiosis, thereby revealing the complex mechanism of BBR in relation to alleviating CAG from multiple levels and perspectives.…”
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Investigation of Hydro-Geochemical Characteristics of Groundwater In Port Harcourt City, Nigeria: Implication for Use and Vulnerability by HO Nwankwoala, GJ Udom

“…The analytical results present the abundance of the ions in the following order: Mg > Ca > Na > K = Cl > SO4 > HCO3 > NO3. …”
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Effects of saffron-grape intercropping on saffron flower number and rhizosphere microbial community by Yuanyuan Tao, Guifen Zhou, Xingchang Zhang, Mengqing Feng, Liqin Li, Xiaodong Qian

“…The intercropping led to a higher relative abundance of bacterial genera such as Sphingomonas and Streptomyces, as well as fungal genera including Acremonium, Llyonectria, Penicillium, Cadophora, Plectosphaerella, and Tetracladium. …”
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Prolonged oral coenzyme Q10-β-cyclodextrin supplementation increases skeletal muscle complex I+III activity in young Thoroughbreds by M.F. Rooney, C.E. Curley, J. Sweeney, M.E. Griffin, R.K. Porter, E.W. Hill, L.M. Katz

“…Skeletal muscle mitochondrial ETC combined complex I+III enzyme activity (indirect measurement of CoQ10 content) was assessed spectrophotometrically and normalised to mitochondrial abundance. Horses accepted supplementation with no adverse effects. …”
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The Campylobacter jejuni BumS sensor phosphatase detects the branched short-chain fatty acids isobutyrate and isovalerate as direct cues for signal transduction by Nestor Ruiz, Jiawei Xing, Igor B. Zhulin, Chad A. Brautigam, David R. Hendrixson

“…Here, we expanded the repertoire of cues sensed by BumS to the branched-short chain fatty acids isobutyrate and isovalerate that are also abundant in the lower intestines. Both isobutyrate and isovalerate are potent, direct cues for BumS, whereas butyrate is an indirect cue. …”
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A 16-week randomized controlled trial of a fish oil and whey protein-derived supplement to improve physical performance in older adults losing autonomy-A pilot study. by Anne-Julie Tessier, Julia Lévy-Ndejuru, Audrey Moyen, Marissa Lawson, Marie Lamarche, Joseé A Morais, Amritpal Bhullar, Francis Andriamampionona, Vera C Mazurak, Stéphanie Chevalier

“…<h4>Conclusion</h4>Because of low eligibility, the pilot study was interrupted and deemed non-feasible; adherence to rigorous study assessments and to supplements was adequate except for long-term fish oil. The non-amended protocol may be applied to populations with greater functional capacity.…”
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Upper circumpolar deep water influences microbial functional gene composition and diversity along the southern Central Indian Ridge and eastern Southwest Indian Ridge by Sheryl Oliveira Fernandes, Dhiraj Paul, Surya Prakash Lankalapalli, Srinivas Rao Arvapalli, Vidya PJ, John Kurian Palayil

“…Availability of hydrothermally derived substrates in plumes detected along the ridges triggered an increase in the abundance of genes encoding for remediation of polycyclic aromatics, nitrate reduction, and arsenic and mercury resistance. …”
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High-throughput untargeted metabolomics reveals metabolites and metabolic pathways that differentiate two divergent pig breeds by S. Bovo, M. Bolner, G. Schiavo, G. Galimberti, F. Bertolini, S. Dall’Olio, A. Ribani, P. Zambonelli, M. Gallo, L. Fontanesi

“…The molecular data were analysed using a bioinformatics pipeline specifically designed for identifying differentially abundant metabolites between the two breeds in a robust and statistically significant manner, including the Boruta algorithm, which is a Random Forest wrapper, and sparse Partial Least Squares Discriminant Analysis (sPLS-DA) for feature selection. …”
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The Growth and Yield of Shallots and Melons Based on the Interseasonal Windbreaks Cropping System in Anticipation of Climate Change by Saparso, Sudarmaji Arief, Bachtiar Musthafa Muhammad, Tamad

“…In addition, it is necessary to add soil amendments such as manure and clay to improve soil structure. …”
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Disruption of Gut Microbiota and Associated Fecal Metabolites in Collagen-Induced Arthritis Mice During the Early Stage by Wu D, Yin M, Cao D, Zhang X, Zhu Y, Wei Y, Li Y, Wen C, Zhou J

“…Correlation analysis showed significant correlations between specific gut microbial abundances and fecal metabolite levels. Especially, SCFAs were strongly associated with Bifidobacterium, Alistipes, Ruminococcus, Anaerotruncus, and Allobaculum.Conclusion: These findings suggest that collagen immunization leads to disruption of gut microbiome and induces changes of fecal metabolites in mice, which may play a key role in early development of RA in CIA mice.Keywords: gut microbiota, fecal metabolites, short-chain fatty acids, preclinical stage, collagen-induced arthritis…”
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NALCN expression is down-regulated and associated with immune infiltration in gastric cancer by Xuewei Li, Xuewei Li, Na Wu, Chen Wang, Beibei Pei, Xiaoyan Ma, Jun Xie, Jun Xie, Wenhui Yang

“…Immunofluorescence staining confirmed that B cells and CD8 T cells were more abundant in GC tumor tissues with high NALCN expression, whereas Th17 and Th2 cells were less prevalent. …”
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A phase 1b clinical trial to determine the safety, tolerability and immunogenicity of simian adenovirus and poxvirus vectored vaccines against Mycobacterium avium complex subspecie... by Jeremy Sanderson, Jeremy Aboagye, Rebecca Makinson, Katerina Rapi, Samuel Provstgaard-Morys, Lisa Stockdale, Alison Lawrie, Isabelle Lanigan, Nishat Halim, Abdel Douiri, Emily Greenlay, Rayka Malek, Emma Gray, Lindsey West, Fatima El Oulidi, Paul Ian Cross, Michael Stallibrass, Sarah C. Gilbert, Adrian V.S. Hill, Katie J. Ewer

“…The Sponsor was involved in protocol development, trial conduct, including data monitoring and analysis, and the preparation of this manuscript in line with the Medicines for Human Use (Clinical Trials) Regulations 2004 and amendments.…”
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Evaluation of hydro-chemical facies and surface water quality dynamics using multivariate statistical approaches in Southern Nigeria by E. A Ubuoh, F. U Nwogu, E. Q Ossai-Abeh, J. C Ikwuemesi, A. O Oke, J. D Umoh

“…Result of surface water recorded mean pH ranges from 4.8 for wet season and 5.3 for dry season, above the WHO, and during dry season TDS, Mg2+, Pb, and Cd were above the WHO limits, respectively. Abundance of cation and anion in surface water was in a decreasing trend of: HCO3 > Ca2+ > Mg2+ > Cl− > Na+ > SO4 2− > K + > NO3 −. …”
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Effects of Different Tea Varieties on the Quality of Enshi Yulu Tea by WANG Huanhuan, QIN Muxue, HU Xingming, YUAN Liping, QIN Xinxue, YU Zhi, ZHENG Shibing, ZHANG Qiang, NI Dejiang, CHEN Yuqiong

“…Among them, alcohols were the most abundant. Analysis of relative odor activity values (rOAV) revealed that linalool, phenylethanol, geraniol, jasmine, trans-β-ionone and nonanal were the major contributors to the characteristic aroma of the 10 Yulu teas. …”
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Effect of Dendrobium Officinale on Radioactive Oral Mucositis of Nasopharyngeal Carcinoma and Changes of Oral Microecology by Jiaying Yang MM, Yuancai Liu MM, He Yao MM, Mengying Sun MM, Yangbo Tong MM, Guanjun Ma MM, Zhuo Chen MD, Xiang Qian MD, Aiqin Zhang MD

“…The use of Dendrobium officinale in nasopharyngeal carcinoma patients with radiotherapy-induced oral mucositis showed little difference in microbial diversity and abundance, but there were significant differences among oral bacteria genera. …”
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Using genomics to explore the epidemiology of vancomycin resistance in a sewage system by Emilie Egholm Bruun Jensen, Saria Otani, Ivan Liachko, Benjamin Auch, Frank M. Aarestrup

“…Only vanHAX and vanHBX genes were differentially abundant in Lynetten. Analyses of eight contigs suggested limited variations in the flanking regions. …”
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Protein Level and Infantile Diarrhea in a Postweaning Piglet Model by Jing Gao, Jie Yin, Kang Xu, Hui Han, ZeMin Liu, ChenYu Wang, TieJun Li, YuLong Yin

“…The diarrhea-related mRNA abundances were analyzed by real-time PCR; the results showed that HP treatment markedly decreased the expression of aquaporin (AQP, P<0.05) and the tight junction protein (P<0.05), but increased inflammatory cytokines (P<0.01) than those in control group. …”
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Petrogenesis of REE-rich two-mica granite from the Indosinian Xiekeng pluton in South China Block with implications for REE metallogenesis by Defu Zhang, Defu Zhang, Tingting Lv, Xiangaung Wang, Xiangaung Wang, Mingxuan Cao, Xiquan Chen, Xiquan Chen, Yongwen Zhang, Liangxin Gong

“…The Xiekeng pluton is rich in total rare earth elements, with abundant rare earth minerals such as apatite, monazite, xenotime, fluocerite, and bastnäsite, showing geochemical characteristics similar to those of typical Indosinian ion-adsorption REE deposit host rocks, indicating potential for the formation of ion-adsorption REE deposits.…”
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Immune profiling of human vestibular schwannoma secretions identifies TNF-α and TWEAK as cytokines with synergistic potential to impair hearing by Sasa Vasilijic, Richard Seist, Zhenzhen Yin, Lei Xu, Konstantina M. Stankovic

“…Among these, TWEAK was notably abundant, with levels exceeding those in normal nerve tissue, elevated in patients with non-serviceable hearing and strongly linked to poor hearing in patients with TNF-α high-secreting tumors. …”
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The effects of citral on the intestinal health and growth performance of American bullfrogs (Aquarana catesbeiana) by Xiaoting Zheng, Qiuyu Chen, Xueying Liang, Jingyi Xie, Alfredo Loor, Hongbiao Dong, Jinlong Yang, Jiasong Zhang

“…Citral also modulated the intestinal microbiota, increasing the relative abundance of beneficial bacteria such as Cetobacterium at 1–2 mL/kg (P < 0.05). …”
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