A fiducial-assisted strategy compatible with resolving small MFS transporter structures in multiple conformations using cryo-EM by Pujun Xie, Yan Li, Gaëlle Lamon, Huihui Kuang, Da-Neng Wang, Nathaniel J. Traaseth

“…This approach involves fusion of the last transmembrane domain helix of the target protein with the first helix of BRIL through a short poly-alanine linker to promote helicity. Combining this strategy with a BRIL-specific Fab, we elucidated four cryo-EM structures of the 42 kDa Staphylococcus aureus transporter NorA, three of which were derived from a single sample corresponding to inward-open, inward-occluded, and occluded conformations. …”
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Therapeutic effect and potential mechanism of Fufang Danshen dripping pills for stable coronary heart disease: a randomized controlled trial by Li-qin Meng, Li-qin Meng, Pei-ying Huang, Qing-min Li, Yu-chao Feng, Yu-chao Feng, Yu-chao Feng, Ding-jian Li, Guang-long Wu, Bo-wen Ao, Guo-chao Wu, Guo-xiong Zhang, Bo-jun Chen, Bo-jun Chen, Bo-jun Chen

“…Additionally, we evaluated the patients' Seattle Angina Questionnaire score, blood pressure, circulating levels of total cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, triglycerides, C-reactive protein, platelets, alanine aminotransferase, aspartate aminotransferase, serum creatinine, and fasting blood glucose as the secondary outcomes. …”
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Investigation of cardiotoxic effects of marbofloxacin by Devran Coşkun, Burak Dik, Yasemin Korkmaz, Rahmi Canbar, Ayşe Er, Enver Yazar

“…In addition, it is to determine the effects of marbofloxacin on the liver function [alkaline phosphatase (ALP), alanine aminotransferase (ALT), gamma glutamyltransferase (GGT), total protein], renal function [blood urea nitrogen (BUN, creatinine] and hemogram [white blood cell (WBC), red blood cell (RBC), platelet, hemoglobin, hematocrit] parameters.…”
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Hepatokine leukocyte cell‐derived chemotaxin 2 as a biomarker of insulin resistance, liver enzymes, and metabolic dysfunction‐associated steatotic liver disease in the general popu... by Keita Suzuki, Hiromasa Tsujiguchi, Akinori Hara, Yumie Takeshita, Hisanori Goto, Yujiro Nakano, Reina Yamamoto, Hiroaki Takayama, Atsushi Tajima, Tatsuya Yamashita, Masao Honda, Hiroyuki Nakamura, Toshinari Takamura

“…LECT2 levels also positively correlated with gamma‐glutamyl transferase levels (B = 0.01, P = 0.01) and alanine aminotransferase levels (B = 0.33, P = 0.02). …”
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The role of Ashwagandha in modulating gut parameters in dogs—a randomized double-blind placebo-controlled trial by Kala Kumar Bharani, Ashok Kumar Devarasetti, Rajendar Bobbili, Amit Khurana, Donga Durga Veera Hanuman, Roupesh Gudepu, Swapna Guda

“…Moreover, a significant decrease in important serum liver biomarkers (alanine transaminase [ALT], aspartate transaminase [AST]; p < 0.01 and p < 0.001 at day 60) was observed in the ARE-treated dogs compared to that in the placebo control group. …”
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Casein Kinases 2-dependent phosphorylation of the placental ligand VAR2CSA regulates Plasmodium falciparum-infected erythrocytes cytoadhesion. by Dominique Dorin-Semblat, Jean-Philippe Semblat, Romain Hamelin, Anand Srivastava, Marilou Tetard, Graziella Matesic, Christian Doerig, Benoit Gamain

“…Furthermore, using CRISPR/Cas9 we generated a parasite line in which phosphoresidue S1068 was changed to alanine. This mutation strongly impairs infected erythrocytes adhesion by abolishing VAR2CSA translocation to the surface of infected erythrocytes. …”
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Reperfusion injury or cytokine storm? Utilizing plasmapheresis in severe trauma-induced multiorgan failure: a case report by Gun Woo Kim, Suyeong Hwang, Kyoung Hoon Lim, Sung Hoon Cho

“…On postoperative day 2, marked increases were observed in levels of aspartate aminotransferase (8,600 U/L), alanine transaminase (6,690 U/L), creatine phosphokinase (26,817 U/L), and lactate dehydrogenase (7,398 U/L) levels. …”
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Clinical outcome of non-alcoholic fatty liver disease: an 11-year follow-up study by Steven Dooley, Juan Du, Xiaoping Tang, Lan Chen, Jinzhu Jia, Fujun Li, Yanyan Shi, Christoph Meyer, Zhongwei Zhu, Yanming Zhang, Roman Liebe, Keming Hu, Tingting Zhou, Huier Zhang, Hong-Lei Weng, Tong Huang

“…Except one male patient who developed cirrhosis, no patients with NAFLD progressed into severe liver disease.Conclusion Diabetes, hypertension and hyperuricaemia are the main clinical outcomes of NAFLD. Eleven years of NAFLD are not sufficient to cause severe liver disease. …”
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6 Şubat 2017, Mw=5.4 Ayvacık Depremi Öncesi ve Sonrası Temel Deprem Tehlike Parametrelerinin Analizi by Ayşe Gezer, Tolga Bekler

“…Saroz-Ayvacık-Edremit doğrultusunda alansal olarak deprem verisi yoğunluğu dikkate alındığında b-değerlerinin gerilmelerle ters orantılı olarak deprem öncesi artışı ve akabin-de de bu davranış azalımı 2014 ve 2017 depremleri ile kendisini göstermiştir.…”
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Pipeline for development of acylated peptide based CGRP receptor antagonist with extended half-life for migraine treatment by Jens Bjelke Kristensen, Lisbeth Elster, Morten Lundh, Borja Ballarín-González, Flora Alexopoulou, Martin Kræmer, Ditte Marie Jensen, Ulrike Leurs, Jens Christian Nielsen, Henrik H. Hansen, Kristian A. Haanes, Matilda Degn

“…An hαCGRP8-37 analogue conjugated with a C20 diacid at position 25 was subjected to an amino acid substitution scan to identify mutations that could further enhance hCGRP receptor antagonism. Substituting alanine with serine at position 36 resulted in a ~ 4 fold gain of potency. …”
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Gelibolu Yarımadası Savaş Arkeojeofiziği Çalışmaları: Şahindere Şehitliği ve Lone Pine Anıtı Örnek Bölgeleri by Cahit Yalçıner, Yunus Can Kurban, Erdem Gündoğdu, Mehmet Ali Yücel

“…Şahindere Şehitliğindeki ölçümler ile şehitlik alanın mevcut halinden çok daha geniş olduğu belirlenmiştir. …”
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Effects of Dietary Vitamin C on the Growth Performance, Biochemical Parameters, and Antioxidant Activity of Coho Salmon Oncorhynchus kisutch (Walbaum, 1792) Postsmolts by Cong-mei Xu, Hai-rui Yu, Ling-yao Li, Min Li, Xiang-yi Qiu, Xiao-qian Fan, Yan-lin Fan, Ling-ling Shan

“…Results showed that VC markedly improved the growth performance indexes and liver VC concentration, enhanced the hepatic and serum antioxidant activities, and increased the contents of serum alkaline phosphatase (AKP) activity, low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), and total cholesterol (TC) whereas decreased the serum aspartate aminotransferase (AST), alanine aminotransferase (ALT) activities, and triglyceride (TG) level. …”
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Kibar Feyzo ve Organize İşler Filmlerinde Merkezi İktidar ile Çevrenin Toplumsal Analizi by Koray Çankaya

“…Postmodern dönemle birlikte ise iktidarın toplumsal alandaki parçalanmasının bir sonucu olarak sosyo-kültürel alanın dokusuna nüfuz etmiş mikro iktidar pratiklerinden bahsetmek mümkün hale gelmiştir. …”
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Antioxidant Potential, Subacute Toxicity, and Beneficiary Effects of Methanolic Extract of Pomelo (Citrus grandis L. Osbeck) in Long Evan Rats by Md. Yousuf Ali, Nur-E Noushin Rumpa, Sudip Paul, Md. Sakib Hossen, E. M. Tanvir, Tareq Hossan, Moumoni Saha, Nadia Alam, Nurul Karim, Md. Ibrahim Khalil, Siew Hua Gan

“…However, rats which received 1000 mg/kg dose had a significant reduction in some serum parameters, including alanine transaminase (15.29%), alkaline phosphatase (2.5%), lactate dehydrogenase (15.5%), γ-glutamyltransferase (20%), creatinine (14.47%), urea (18.50%), uric acid (27.14%), total cholesterol (5.78%), triglyceride (21.44%), low-density lipoprotein cholesterol (40.74%), glucose (2.48%), and all atherogenic indices including cardiac risk ratio (24.30%), Castelli’s risk index-2 (45.71%), atherogenic coefficient (42%), and atherogenic index of plasma (25%) compared to control. …”
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The modern options of chronic hepatitis C antiviral therapy with daclatasvir: results of named patient program by V. T. Ivashkin, M. V. Mayevskaya, D. T. Abdurakhmanov, I. G. Bakulin, N. I. Geyvandova, M. L. Zubkin, S. N. Kizhlo, A. V. Kuznetsova, I. B. Latysheva, N. A. Mamonova, V. G. Morozov, O. I. Sagalova, Ye. V. Esaulenko, Ye. O. Lyusina

“…No significant elevation of alanine transaminase and aspartate aminotransferase activity, or bilirubin level were detected. …”
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Efficacy and safety of ondansetron orally soluble pellicle for preventing moderate- to high-emetic risk chemotherapy-induced nausea and vomiting by Lu Sun, Jia Ma, Yajuan Zhou, Xiaofang Ying, Gai Liang, Guoliang Pi, Ying Li, Yan Luo, Jianping Bi, Hanping He, Yi Peng

“…The most common adverse events were elevated levels of alanine transaminase (6.7%), elevated levels of aspartate transaminase (3.7%), fatigue (3.7%), and cough (2.5%). …”
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Cell-free DNA predicts all-cause mortality of sepsis-induced acute kidney injury by Feixiang Xu, Xiao Tan, Jianli Wang, Su Lu, Hailin Ding, Mingming Xue, Yumei Chen, Sheng Wang, Jie Teng, Yiqin Shi, Zhenju Song

“…Moreover, cfDNA was positively correlated with several baseline parameters, including serum creatine, aspartate aminotransferase, alanine aminotransferase, prothrombin time, and International Normalized Ratio.Conclusion High serum cfDNA level is associated with higher mortality among the S-AKI population, indicating that cfDNA is a valuable biomarker for S-AKI prognosis.…”
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Kentsel Açık Yeşil Alanların Kurakçıl Peyzaj Tasarımına Uygunluğunun Değerlendirilmesi: Tokat Kenti Örneği by Saliha Erdoğdu, Aysun Çelik, Venhar Melda Hassamancıoğlu, Güzella Yılmaz

“…Araştırma kent merkezindeki semt, mahalle ve cep parkı olarak gruplandırılan 124 açık-yeşil alanın kurakçıl peyzaj planlama ve tasarım ilkeleri esas alınarak belirlenmiş ölçütlerle değerlendirilmesine dayanmaktadır. …”
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Hepatoprotective Effects of Nasturtium Officinale and Allium Polyanthum Extracts on CCL4- Induced Hepatic Damage In Albino Rats by Shkar Rzgar K.Rostam, Zana Hassan Ibrahim, Rebaz Rebwar Mala, Soran Qadir Abdul

“…Aspartate aminotransferase (AST), Alanine aminotransferase (ALT), Alkaline phosphatase (ALP), Total serum bilirubin (TSB), Total protein (TP), Albumin (ALB) and malondialdehyde (MDA) were measured in serum at the end of the study. …”
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The efficacy of Artichoke leaf extract conjugated with organic zinc nanoparticles on growth, carcass traits and blood biochemical parameters of broilers by Elwy A. Ashour, Ahmed K. Aldhalmi, Mahmoud Kamal, Salem S. Salem, Samir A. Mahgoub, Abdulmohsen H. Alqhtani, Mahmoud Madkour, Ahmed A. Elolimy, Mohamed E. Abd El-Hack, Ayman A. Swelum

“…In addition, we found significant differences in total protein, albumin, and globulin levels between treatments, with the control group showing higher levels compared to the other two groups. The diet increased alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels and elevated cholesterol levels. …”
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