Melatonin attenuates MPP+-induced autophagy via heat shock protein in the Parkinson’s disease mouse model by Yinli Guo, Chengbo Liu

“…Background This study investigates the protective properties of melatonin in an in vivo Parkinson’s disease (PD) model, focusing on the underlying mechanisms involving heat shock proteins (HSPs). Methods Twelve adult male C57BL/6 mice were randomly divided into four groups (normal control, melatonin control, Parkinson’s model, and melatonin treatment; n = 3 per group) and housed in a single cage. 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) was injected intraperitoneally in the Parkinson’s model and treatment groups to establish a subacute PD model, while controls received saline. …”
Get full text

Global, regional and national burdens of bipolar disorders in adolescents and young adults: a trend analysis from 1990 to 2019 by Yifan Chen, Long Sun, Meiqi Wang, Yunxi Zhong, Xiaoying Su, Qixiu Li, Ziming Shao

“…In the past three decades, there has been an increase in incidence, prevalence and YLDs in both males and females. The largest increase in incidence between 1990 and 2019 was observed in those aged 20–24 years old (from 51.76 per 100 000 population (95% UI: 26.81 to 87.20) in 1990 to 58.37 per 100 000 population (95% UI: 30.39 to 98.55) in 2019; AAPC 0.42 (95% CI: 0.38 to 0.47)). …”
Get full text

Assessment of Food Safety and Food Handling Practice Knowledge among College of Basic Education Students, Kuwait by Fatemah Ashkanani, Wafaa Husain, Maryam A Al Dwairji

“…The students with the highest FSK scores were generally male and they cook by themselves all the time or sometimes (p=0.018 and p=0.002, resp.). …”
Get full text

From posts to practice: Instagram's role in veterinary dairy cow nutrition education—How does the audience interact and apply knowledge? A survey study by M. Lamanna, E. Muca, G. Buonaiuto, A. Formigoni, D. Cavallini

“…In terms of gender distribution, there was a female majority in the general population (59.8%) and a male majority among students (73.3%). Most responders were from Italy, with Emilia-Romagna contributing significantly. …”
Get full text

The Relationship between Routine Blood Parameters and the Prognosis of COVID-19 Patients in the Emergency Department by Birsen Ertekin, Mehmet Yortanlı, Ozan Özelbaykal, Ali Doğru, A. Sadık Girişgin, Tarık Acar

“…Of all patients, the mean age was 67 years and 51.8% were males. There was a significant difference between the two groups in terms of age, gender, length of hospital stay, need for mechanical ventilation, white blood cell, neutrophil, lymphocyte, monocyte, eosinophil, platelet counts, CRP, ferritin, procalcitonin values, NLR, MLR, and PLR (p<0.001 for all). …”
Get full text

Primary Hyperparathyroidism-Phosphaturic Mesenchymal Tumour: An Unusual Association and a Probable Syndrome by Gwendolyn Fernandes, Avanika, Gloria Khumanthem

“…The association of primary Hyperparathyroidism (pHPT) with PMT is extremely rare, with only two cases reported in the literature to date. A 51-year-old male presented in a bedridden state with multiple episodes of fractures throughout his skeleton over six years. …”
Get full text

Urban-Rural Dimension of Falls and Associated Risk Factors among Community-Dwelling Older Adults in West Java, Indonesia by Susiana Nugraha, Sabarinah Prasetyo, Indri Hapsari Susilowati, Tri Budi W. Rahardjo

“…Furthermore, the multiple logistic regression analysis showed that the male gender (OR = 0.29, 95%CI [0.09–0.88]), chronic illness (OR = 3.25, 95%CI [1.24–8.53]), and visual impairment (OR = 3.6, 95%CI [1.52–8.54]) were associated with fall among older adults in urban areas. …”
Get full text

A retrospective study on potential drug‒drug interactions in patients with severe asthma receiving biological therapy: a single-center experience by Mirna Momcilovic, Petra Turcic, Franka Butkovic, Sanja Popovic Grle

“…Results 60 adult patients, 60% female and 40% male, with median age of 56.2 years, were enrolled. …”
Get full text

Rosiglitazone, a Ligand to PPARγ, Improves Blood Pressure and Vascular Function through Renin-Angiotensin System Regulation by María Sánchez-Aguilar, Luz Ibarra-Lara, Leonardo Del Valle-Mondragón, María Esther Rubio-Ruiz, Alicia G. Aguilar-Navarro, Absalom Zamorano-Carrillo, Margarita del Carmen Ramírez-Ortega, Gustavo Pastelín-Hernández, Alicia Sánchez-Mendoza

“…We carried on experiments in normotensive (Sham) and aortic coarctation (AoCo)-induced hypertensive male Wistar rats. Both sham and AoCo rats were treated 7 days with vehicle (V), RGZ (5 mg/kg/day), or RGZ+BADGE (120 mg/kg/day) post-coarctation. …”
Get full text

Cardiac Gene Therapy With Phosphodiesterase 2A Limits Remodeling and Arrhythmias in Mouse Models of Heart Failure by Rima Kamel, Aurélia Bourcier, Jean Piero Margaria, Valentin Jin, Audrey Varin, Agnès Hivonnait, Françoise Mercier‐Nomé, Delphine Mika, Alessandra Ghigo, Flavien Charpentier, Vincent Algalarrondo, Emilio Hirsch, Rodolphe Fischmeister, Grégoire Vandecasteele, Jérôme Leroy

“…Methods and Results C57BL/6 male mice were injected with serotype 9 adeno‐associated viruses encoding for PDE2A. …”
Get full text

Long-Term Anatomic and Functional Outcomes after Macular Hole Surgery by Karolina Kaźmierczak, Joanna Stafiej, Joanna Stachura, Paweł Żuchowski, Grażyna Malukiewicz

“…Forty-four eyes of 40 patients (28 females and 12 males) were examined. The examination included visual acuity, optical coherence tomography, and colour vision testing. …”
Get full text

Prevalence and Risk Factors of Trypanosomosis in Dromedary Camels in the Pastoral Areas of the Guji Zone in Ethiopia by Gossa Alemu, Rahmeto Abebe

“…No significant statistical difference was found between the two districts, and male and female camels (P>0.05). Statistically, the mean packed cell volume was significantly lower (P<0.05) in parasitemic camels (26.5%±7) as compared with aparasitemic camels (33.9%±9.1). …”
Get full text

Effects of a Total Motion Release (TMR®) Protocol for the Single Leg Squat on Asymmetrical Movement Patterns by Nickolai JP Martonick, Craig P McGowan, Russell T Baker, Lindsay W Larkins, Jeff G Seegmiller, Joshua P Bailey

“… # METHODS Twenty participants (10 female, 10 male) with self-identified bilateral differences of 10 points or greater on the TMR® scoring scale were recruited for the study. …”
Get full text

Single-center experience and evaluation of rare ıntracranial abscesses in childhood by Nihal Yildiz, Zeynep Gökçe Gayretli Aydin

“…Results The study included a total of 23 patients, 9 (39.1%) of whom were male, with a mean age at diagnosis of 79.3 ± 65.4 months. …”
Get full text

Electrochemical skin conductance to assess peripheral neuropathy in rheumatic diseases with or without type 2 diabetes using sudoscan by Osama M. I. Mohamed, Nagwa M. M. Ali, Mohammed O. Ibrahim, Dana Sarmini, Farah Ibrahim, Mariam Al Hosany

“…There were 55 females (67.9%), and 26 males (32.1%) attended an ambulatory healthcare clinic in Abu Dhabi, UAE. …”
Get full text

The efficacy of an allosteric modulator of the alpha 7 nicotinic acetylcholine receptor in a murine model of stroke by Katherine Hernandez, Nathan Jones, Sterling B. Ortega

“…Using a murine transient middle cerebral artery occlusion (tMCAO) model, we sought to evaluate the neurotherapeutic efficacy of a positive allosteric modulator of the alpha7 nicotinic acetylcholine receptor (α7-nAChR), PNU-120596 (PNU), specifically examining whether PNU would modulate stroke-induced neurological dysfunction and neuropathology, with modulation of neuroinflammation as a possible mechanism.MethodsYoung male C57BL/6J mice received a subcutaneous injection of 20mg/kg of vehicle (DMSO) or PNU-120596 immediately after reperfusion, and infarct area and Bederson score were analyzed 24 hours post-stroke. …”
Get full text

Evaluating catastrophic health expenditures among patients with long bone fractures in Ghana's major teaching hospitals: a hospital-based analysis by Alexis D. B. Buunaaim, Michel Adurayi Amenah, Dominic Konadu-Yeboah, Richard Baidoo, Amgbo Asare, Wilfred Larbi Addo, Claude Martin

“…Results The incidence of CHE was highest at the 10% income threshold (53.21%) and decreased with higher thresholds. Male patients incurred higher average OOP payments ($343.68) than females ($271.63), and patients with tibia fractures faced the highest financial burden. …”
Get full text

How climate change is shaping young people’s health: a participatory, youth co-led study from Bangladesh, Guatemala and Nigeria by Jessie Pinchoff, Karen Austrian, Eno-Obong Etetim, Damilola Babatunde, Eleanor Blomstrom, Sigma Ainul, Toyin Olamide Akomolafe, Brian Medina Carranza, Angel Del Valle

“…In Nigeria, respondents discussed health effects of extreme heat, and how droughts were shifting women into more traditionally male roles in agriculture and income-generating activities, increasing the perceived risk of household tensions and gender-based violence. …”
Get full text

Assessment Of Awareness Level and Perception In Usage Of Plastic Bags And Its Hazards Among Secondary School Students by Mohi Ud Din, Zain Arif, Hafiz Usama Naveed, Maryam Tauseef, Nouman Yaseen, Talha Mahboob

“…A sample size of 377 was calculated through Raosoftware comprising 53.6% male and 46.4% female students. Ethical approval was taken with the number ERC/ID/47. …”
Get full text

Simultaneous Pheochromocytoma, Paraganglioma, and Papillary Thyroid Carcinoma without Known Mutation by Lorena Rasquin, Janna Prater, Jane Mayrin, Corrado Minimo

“…We report a case of pheochromocytoma/paraganglioma and PTC with negative testing for common mutations. Case. 32-year-old male with incidental liver mass during laparoscopy for acute appendicitis. …”
Get full text