Humoral and Cellular Immune Regulation in Albino Rat Exposed to Glyphosate and Aluminum Phosphide by Ujuamala Ezeani, Onyemaechi Afonne, Michael Ezeani

“…The potential effects of this exposure on humoral and cellular immune processes are yet to be fully understood.Methods: The expression and potential regulation of T cells, specifically CD4+ helper T cells and CD8+ cytotoxic T lymphocytes, were evaluated in groups of male and female albino rats treated with oral distilled water; a low dose of glyphosate (1000 mg/kg/day); a high dose of glyphosate (3500 mg/kg/day); a low dose of ALP (1.1 mg/kg/day); and a high dose of ALP (5.0 mg/kg/day). …”
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<i>Chlamydia trachomatis</i> Serovars from the C-Complex and the B- and C-Related Complexes Are Significantly More Pathogenic than Those from the B-Complex in C3H/HeN but Not in BA... by Sukumar Pal, Jennifer R. Carmichael, Delia F. Tifrea, Olga Tatarenkova, Luis M. de la Maza

“…To determine the pathogenicity and its impact on fertility, at week seven post-infection, female mice were caged with male mice. In the C3H/HeN mice, significant differences in vaginal shedding and fertility were observed between serovars from the B-complex (D and E) and those from the C-complex (H, I, J) and B- and C-related complexes (G, F, and K). …”
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Nephropathy in Hypertensive Animals Is Linked to M2 Macrophages and Increased Expression of the YM1/Chi3l3 Protein by Paula Andréa Malveira Cavalcante, Natalia Alenina, Alexandre Budu, Leandro Ceotto Freitas-Lima, Thaís Alves-Silva, Juan Sebastian Henao Agudelo, Fatimunnisa Qadri, Niels Olsen Saraiva Camara, Michael Bader, Ronaldo Carvalho Araújo

“…Bone marrow cells were isolated from the femurs and tibia of male FVB/N (control) and transgenic hypertensive animals that overexpressed the rat form of angiotensinogen (TGM(rAOGEN)123, TGM123-FVB/N). …”
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Parental divorce's long shadow: Elevated stroke risk among older Americans. by Mary Kate Schilke, Philip Baiden, Esme Fuller-Thomson

“…The association between parental divorce and stroke was not dependent on sex; however, compared to females, males had 1.47 times higher odds of having a stroke (AOR = 1.47, 95% CI = 1.11-1.93). …”
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The incidence of radiologically verified community-acquired pneumonia requiring hospitalisation in adults living in southern Sweden, 2016-2018: a population-based study by Elisabeth Rünow, Frida Valeur, Gustav Torisson, Karin Hansen, Christian Theilacker, Kristian Riesbeck, Jonas Ahl

“…Among those aged 80 years and older, hospitalization rate was 17 times higher vs those aged 18–64 years, yielding an IRR 17.4 (95% CI: 15.4–19.7). Males aged ≥ 80 years had a 57% increased risk of CAP requiring hospitalization compared to women ≥ 80 years, resulting in an IRR of 1.57 (95% CI: 1.33–1.85). …”
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Exploratory Network Meta Regression Analysis of Stroke Prevention in Atrial Fibrillation Fails to Identify Any Interactions with Treatment Effect. by Sarah Batson, Alex Sutton, Keith Abrams

“…These covariates included the proportion of patients with a previous stroke, proportion of males, mean age, the duration of study follow-up and the patients underlying risk of ischaemic stroke.…”
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MicroRNA-451a is a candidate biomarker and therapeutic target for major depressive disorder by Yan Chen, Yun Liu, Ming Xiao, Chun Wang, Panpan Hu, Qiuchen Cao, Hu Feng, Jingfan Xu, Weixi Feng, Huaiqing Sun, Huachen Ding, Junying Gao

“…Background Increasing evidence supports the role of microRNAs (miRNAs) in major depressive disorder (MDD), but the pathophysiological mechanism remains elusive.Aims To explore the mechanism of microRNA-451a (miR-451a) in the pathology and behaviours of depression.Methods Abnormal miRNAs such as miR-451a reported previously in the serum of patients with MDD were screened and then confirmed in a mouse model of depression induced by chronic restraint stress (CRS). Eight-week-old male C57BL/6 mice had miR-451a overexpression in the medial prefrontal cortex (mPFC) via adeno-associated virus serotype 9 vectors encoding a pri-mmu-miR-451a-GFP fusion protein followed by behavioural and pathological analyses. …”
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English Teaching Achievement Prediction by Big Data Analysis under Deep Intervention by Junfang Guo

“…There is only a 1% difference in the final grade failure rate between male and female students. The effect of gender on teaching performance is less pronounced. (3) As the number of practice questions increases, the rate of failing grades decreases. …”
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Endobronchial Lipoma: A Rare Cause of Bronchial Stenosis or Obstruction by Jian Chen, Tao Xin, Lei Pan, Yan Li, Weisheng Qian, Jin Wei, Yan Yan, Yan Wang, Faguang Jin, Hua Jiang

“…Among the patients reviewed, nine were histopathologically diagnosed with EL, comprising seven males and two females. All EL patients exhibited noticeable symptoms, including cough (in eight patients), dyspnea (in six patients), fever (in three patients), expectoration (in two patients), chest pain (in two patients), hemoptysis (in one patient), and fatigue (in one patient). …”
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Synchronous Occurrence of Splenic Pleomorphic Mantle Cell Lymphoma and Esophageal Adenocarcinoma with Overexpression of BCL1 Protein by Dominik Dabrowski, Roberto F. Silva, Michael Constantinescu, Rodney E. Shackelford, Nestor Dela Cruz, Eric X. Wei

“…We report a case of synchronic MCL and an esophageal tumor in an elderly male patient. Morphologically, the tumors were classified as splenic pleomorphic MCL and adenocarcinoma of the esophagus occurring concurrently. …”
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Post-Implant Global Longitudinal Strain as a Predictor of Pacing-Induced Cardiomyopathy in Patients with Preserved Ejection Fraction Undergoing Pacemaker Placement by Sung Soo Kim, Hyung Wook Park, Hyung Ki Jeong

“…Results: A total of 71 patients (28 males, mean age 73.1 years) were included. Following PPM implantation, significant declines in both EF and GLS were noted, especially in those with PICM. …”
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Do cash or digital payment modalities affect community health worker performance? – a case study of a remote refugee settlement in Western Uganda by Michael T Wagaba, David Musoke, Charles Opio, Arthur Bagonza, Juliet Aweko, Hajarah Nakitende, Alex Mulyowa, Michael Ediau, Peter Waiswa, Elizabeth Ekirapa-Kiracho

“…For digital payments, being male (APR 0.58; CI: 0.34–0.98), serving longer than 9 years (APR 0.87; CI: 0.82–0.93), and being allocated more than 60 households per month (APR 0.31; CI: 0.19–0.52) were negatively associated with CHW performance. …”
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Paraoxonase and Arylesterase Activities, Lipid Profile, and Oxidative Damage in Experimental Ischemic Colitis Model by Ethem Unal, Cengiz Eris, Bülent Kaya, Hafize Uzun, Faruk Cavdar, Murat Yildar, Ali Riza Kiziler, Birsen Aydemir, Pembegul Gunes, Riza Kutanis, Izzet Titiz

“…In the present study, since PON1 is known as an HDL-associated antioxidant enzyme that inhibits the oxidative modification of LDL and oxidative stress plays a role in the pathogenesis of mesenteric ischemia, we investigated the changes in PON1 activity and lipid profile in an experimental ischemic colitis model. Methods. Forty male Wistar albino rats were divided into two groups: the control group (N=15) and the experimental group (N=25). …”
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Assessing the relationship between the distress levels in patients with irreversible terminal delirium and the good quality of death from the perspective of bereaved family by Pei Zhou, Cheng Tang, Jingyi Wang, Chunhua Zhang, Jun Zhong

“…Result A total of 263 subjects were enrolled. More males (63.5%) participated than females (36.5%), the mean age was 75.35 ± 13.90 years. …”
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Impact of sperm DNA fragmentation index on assisted reproductive outcomes: a retrospective analysis by Bin Yang, Leizhen Xia, Rufei Deng, Liping Wu, Zhiqin Zhang, Xingwu Wu, Tao Ding, Yan Zhao, Jialyu Huang, Jialyu Huang, Zhihui Huang

“…Multivariate logistic regression analyses were conducted to control for potential confounders.ResultsThe DFI value was negatively correlated with semen quality in males. High DFI affected the blastocyst formation rate (56.44%, 55.32%, 53.72%, respectively; P=0.045) and the rate of transferable embryos (3.97 ± 2.71, 3.90 ± 2.7, 3.38 ± 2.4, respectively; P&lt;0.001); however, no significant difference in pregnancy outcomes was observed among the three groups. …”
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Religious Practices and Its Impacts on a Sustainable Urban Environment in Nigeria: The Way Forward by Timothy Oyebamiji Ogunbode, Funke Elizabeth Oyekan

“…The test showed 67.6% at a significance level of p < 0.001 The results showed that 52.6% were of secondary school level, 52.2 were of Christian faith, and 61.6% were also of the male gender who were mostly in the age category of 46 to 65 years. …”
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Low Citrate Synthase Activity Is Associated with Glucose Intolerance and Lipotoxicity by Yosra Alhindi, Lobke M. Vaanholt, Mustafah Al-Tarrah, Stuart R. Gray, John R. Speakman, Catherine Hambly, Bader S. Alanazi, Brendan M. Gabriel, Arimantas Lionikas, Aivaras Ratkevicius

“…During HFD feeding, glucose tolerance of mice decreased progressively and to a greater extent in B6.A females compared to B6 females, with males showing a similar trend. Body weight and fat gain did not differ between B6.A and B6 mice. …”
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Powassan Encephalitis: A Case Report from New York, USA by Danielle A. Bazer, Matthew Orwitz, Nicholas Koroneos, Olga Syritsyna, Elizabeth Wirkowski

“…The patient is a 62-year-old male with a past history of a right putamen infarct, hepatitis C, hypertension, and substance abuse who presented due to acute onset altered mental status, dysarthria, and left-sided facial droop. …”
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Flavouring group evaluation 418 (FGE. 418): 3‐[3‐(2‐isopropyl‐5‐methyl‐cyclohexyl)‐ureido]‐butyric acid ethyl ester by EFSA Panel on Food Additives and Flavourings (FAF), Laurence Castle, Monica Andreassen, Gabriele Aquilina, Maria Bastos, Polly Boon, Biagio Fallico, Reginald FitzGerald, Maria Jose Frutos Fernandez, Bettina Grasl‐Kraupp, Ursula Gundert‐Remy, Rainer Gürtler, Eric Houdeau, Marcin Kurek, Henriqueta Louro, Patricia Morales, Sabina Passamonti, Romualdo Benigni, Kevin Chipman, Eugenia Cordelli, Gisela Degen, Karl‐Heinz Engel, Paul Fowler, Maria Carfí, Gabriele Gagliardi, Agnieszka Mech, Salvatore Multari, Carla Martino

“…In this study, the Panel considered that the NOAEL is 777 and 923 mg/kg bw per day (the highest dose tested) for male and female rats, respectively. Considering the lowest NOAEL of 777 mg/kg bw per day, as a reference point, adequate margins of exposure of 55 × 103 and 21 × 103 were calculated for adults and children, respectively, when considering the chronic APET dietary exposure estimates. …”
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Satisfactory Functional Outcome and Significant Correlation with the Length of Haglund’s Deformity after Endoscopic Calcaneoplasty: A Minimum 4-Year Follow-Up Study by Hossam Fathi Mahmoud, Walid Feisal, Fahmy Samir Fahmy

“…Seventeen patients (21 feet) with a mean age of 44.7 ± 5.1 years were included in this study. Six females and 11 males underwent endoscopic calcaneoplasty. Clinical outcome evaluation included the assessment of the visual analog scale (VAS) and the American Orthopedic Foot and Ankle Society score (AOFAS). …”
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