Early Markers of Liver Fibrosis in Children with Beta-thalassaemia Major: A Cross-sectional Study by Himani Aggarwal, Monica Verma, Shuchi Bhalla, Dinkar Yadav, Kapil Bhalla, Abhishek Soni

“…Non invasive tools like APRI, FIB-4, and the biomarker YKL-40 show promise as alternatives to biopsy and elastography, enabling earlier detection and intervention.…”
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Exploring anticancer, antioxidant, and antimicrobial potential of Aspergillus flavus, a fungal endophyte isolated from Dillenia indica leaf callus by Ashish Gupta, Brajesh Chandra Pandey, Mohd Yaseen, Renu Kushwaha, Madhavenda Shukla, Pratima Chaudhary, Partha Pratim Manna, Aparna Singh, Ida Tiwari, Gopal Nath, Nishi Kumari

“…Their extensive studies are required to develop an alternative of plant less production of valuable compounds.…”
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Optimasi Proses Klasterisasi di MySQL DBMS dengan Mengintegrasikan Algoritme MIC-Kmeans Menggunakan Bahasa SQL dalam Stored Procedure by Issa Arwani

“…With the advantages of the MIC-Kmeans algorithm, the method was chosen as an alternative algorithm to be integrated in the DBMS using SQL  for a clustering. …”
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Evaluation of Six Novel Protein Sources on Apparent Digestibility in Pacific White Shrimp, Litopenaeus vannamei by Xiaoyue Li, Yongkang Chen, Chaozhong Zheng, Shuyan Chi, Shuang Zhang, Beiping Tan, Shiwei Xie

“…To conclude, newly developed protein sources such as single-cell protein (CAP, BPM, and CM) showed great potential as a fishmeal alternative, and insect protein meals (TM and BSFLM) were less effective for shrimp compared to the CD. …”
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Self-Management Strategies for Low Back Pain Among Horticulture Workers: Protocol for a Type II Hybrid Effectiveness-Implementation Study by Kim Dunleavy, Heidi Liss Radunovich, Jason M Beneciuk, Boyi Hu, Yang Yang, Janeen McCormick Blythe, Kelly K Gurka

“…If self-management is effective, mitigating pain positively impacts quality of life, productivity, and retention, while increasing the use of nonpharmacological alternatives to opioids addresses an important public health issue. …”
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ANALISIS PERANCANGAN STRUKTUR BETON BERTULANG UNTUK FUNGSI RENTAL OFFICE 30 LANTAI DENGAN PENEKANAN SISTEM RIGID FRAME BERKANTILEVER by Reinhart Bunadi, Nasruddin Junus, Imriyanti Imriyanti

“…The cantilevered slab support structure is given two alternatives, namely model 1 and model 2. For earthquake loads, model 1 is more stable at 3.2% -10.39% of model 2. …”
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Nisin A-producing Lactococcus cremoris formulations for pre- and post-milking teat disinfection modulate the bovine milk microbiota by Alessandra Gazzola, Camilla Ceccarani, Bianca Castiglioni, Filippo Biscarini, Stefano Morandi, Tiziana Silvetti, Renata Piccinini, Milena Brasca, Paola Cremonesi

“…Since the agents commonly used for pre- and post-dipping can affect the udder health by modifying milk microbiota, alternative products are needed. This study aimed to evaluate the effect of the use of pre- and post-dipping formulations containing the fermented broth of Nisin A-producing Lactococcus cremoris FT27 strain (treated group, TR) on the abundance and biodiversity of milk microbiota as compared to iodine-based commercial disinfectants (control group, CTR) during a three-month trial. …”
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Current trends of unicompartmental knee arthroplasty (UKA): choosing between robotic-assisted and conventional surgeries and timing of procedures by Kelvin S. C. Cheung, Kai Chun Augustine Chan, Amy Cheung, Ping Keung Chan, Michelle Hilda Luk, Kwong Yuen Chiu, Henry Fu

“…For patients with bilateral unicompartmental OA, biUKA was shown to be a safe and effective alternative to unilateral operations. Trial Registration Registered (HKU/ HA HKW IRB; Ref No: 24–373).…”
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Preference for HIV testing among community residents in Yunnan Province, China: results from a discrete choice experiment by Jingwen Yang, Chenquan Qiu, Renhai Tang, Wenbin Dong, Enlong Yao, Huyunzhao Wang, Shuwen Lin, Minyang Xiao, Zuyang Zhang, Jin Niu, Liru Fu, Lijun Song, Xuehua Li, Yuhua Shi, Xiaowen Wang

“…The participants were asked to make nine choices between two unlabelled alternatives that differed in seven attributes: distance to the testing venue, confidentiality, institution, administrator, support services, testing days, and testing cost. …”
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Confronting food insecurity through agricultural interventions: the Farmer FIRST program in India by Purushothaman Venkatesan, Nilakandan Sivaramane, Ch Srinivasa Rao, Ramanujam Venkattakumar, Sethuraman Sivakumar, Palanisamy Mooventhan, Rajarshi Roy Burman, Bommu Kalyani, Lalitha Navya Challa

“…However, at the micro level, particularly for farmers who produce their food and are secure in terms of availability, yield increases from the selected interventions under FFP served as an alternative measure. Purchasing power was assessed by the additional income generated to buy food during the off-season. …”
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ارزیابی امکان‌پذیری تهدید بر دارایی‌های آب و فاضلاب شهری در مواجهه با سوانح انسان‌ساخت عمدی (مطالعه موردی: شهر همدان)... by سعید گیوه چی, علی وجدانی نوذر, بهرام ملک محمدی

“…در این تحقیق باهدف اصلی ارزیابی امکان‌پذیری تهدید بر دارایی‌های آب و فاضلاب شهر همدان در مواجهه با سوانح انسان‌ساخت عمدی، موضوع با استفاده از روش ترکیبی SECA-GIS[1] مورد ارزیابی قرار گرفت، نتایج نشان می‌دهد در این شهر از بین معیارهای ارزیابی تهدیدات؛ شدت تهدید با وزن 1844/0، بزرگی تهدید با وزن 1780/0 و سابقه وقوع با وزن 1674/0 به ترتیب اولویت اول تا سوم را به خود اختصاص داده و همچنین از بین تهدیدات سوانح انسان‌ساخت عمدی به‌طورکلی شورش و اغتشاش رتبه اول، حمله هوایی و موشکی رتبه دوم و خرابکاری رتبه سوم را کسب نموده است، لیکن با نگاهی به دسته‌بندی انواع سوانح انسان‌ساخت عمدی؛ حمله هوایی و موشکی (با عاملیت دشمن خارجی) و شورش و اغتشاشات (با عاملیت دشمن داخلی) در منطقه موردمطالعه در رتبه اول قرار دارند و برحسب جذابیت دارایی‌های زیرساخت آب و فاضلاب از دید دشمن؛ تصفیه‌خانه‌هایآب شهر با کسب امتیاز 5072/4 در سطح بحرانی در مواجهه با حملات هوایی و موشکی قرارگرفته که نیازمند انجام اقدامات پیشگیرانه و دفاعی است. [1] Simultaneous Evaluation of Criteria and Alternatives - Geographic Information System…”
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Pembrolizumab hybrid dosing is non-inferior to flat dosing in advanced non-small cell lung cancer: a real-world, retrospective bicenter cohort study by Egbert F Smit, Willemijn S M E Theelen, Michiel M Smeenk, Vincent van der Noort, Jeroen M A Hendrikx, Hanieh Abedian Kalkhoran

“…Background Immune checkpoint inhibitors (ICIs) have revolutionized cancer treatment but come with high costs. Alternative ICI dosing strategies could reduce costs without losing efficacy. …”
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Contribution of cuproptosis and immune-related genes to idiopathic pulmonary fibrosis disease by Chengji Jin, Jia Li, Qiaoyu Li, Lipeng Zhang, Shaomao Zheng, Qiong Feng, Yongjie Li, Yu Zheng, Qiuli Nie, Jin Liang, Jing Wang, Jing Wang

“…BackgroundIdiopathic pulmonary fibrosis (IPF) is a degenerative respiratory condition characterized by significant mortality rates and a scarcity of available treatment alternatives. Cuproptosis, a novel form of copper-induced cell death, has garnered attention for its potential implications. …”
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Reticulocyte hemoglobin content: a new frontier in iron deficiency diagnostics for major surgical patients by Suma Choorapoikayil, Mischa J. Kotlyar, Lisa Kawohl, Paul P. Pratz, Denana Mehic, Peter Kranke, Florian Rumpf, Lea V. Blum, Jan A. Kloka, Kai Zacharowski, Vanessa Neef, Patrick Meybohm

“…Conclusion This study highlights the potential of Ret-He as a promising alternative marker for diagnosing ID in patients undergoing major surgery, particularly in cases of elevated ferritin levels or non-anemic patients. …”
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A randomised controlled implementation trial of the feasibility and effectiveness of school staff delivery of a selective substance use and mental health program during the COVID-1... by Lucinda Grummitt, Kirsty Rowlinson, Joanne Cassar, Chloe Conroy, Louise Birrell, Lexine Stapinski, Emma Louise Barrett, Julia Macauley, Maree Teesson, Nicola C. Newton, Erin V. Kelly

“…However, concerns around feasibility may limit teacher-led application of the program in the Australian context. Alternative approaches, such as delivery by dedicated personnel within schools without a teaching load, may be critical in implementing such evidence-based interventions at scale. …”
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Phase transitions, Dirac and Weyl semimetal states in Mn1−x Ge x Bi2Te4 by A. M. Shikin, N. L. Zaitsev, T. P. Estyunina, D. A. Estyunin, A. G. Rybkin, D. A. Glazkova, I. I. Klimovskikh, A. V. Eryzhenkov, K. A. Kokh, V. A. Golyashov, O. E. Tereshchenko, S. Ideta, Y. Miyai, Y. Kumar, T. Iwata, T. Kosa, K. Kuroda, K. Shimada, A. V. Tarasov

“…Model calculations of the influence of local magnetic ordering in AFM $$\textrm{Mn}_{1-x} \textrm{Ge}_x \textrm{Bi}_2 \textrm{Te}_4$$ were carried out by alternating Mn layers with Ge-doped layers and showed that the magnetic Weyl semimetal state in this system is reachable at a Ge concentration of approximately 40% without application of any external magnetic fields.…”
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Autologous osteoperiosteal transplantation achieves comparable repair effect and superior interface integration to autologous osteochondral transplantation in porcine osteochondral... by Shuai Yang, En Deng, Linxin Chen, Yanbin Pi, Anhong Wang, Linghui Dai, Hongjie Huang, Xiaoning Duan, Xin Fu, Jiying Zhang, Qinwei Guo, Weili Shi

“…Additionally, autologous osteoperiosteal transplantation (AOPT) has emerged as a promising alternative with comparable clinical efficacy. However, a notable gap in the literature exists regarding the specific repair process by the periosteal graft. …”
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Modulatory effect of Echium plantagineum oil on the n-3 LC-PUFA biosynthetic capacity of chicken (Gallus gallus) by Jesús Villora, José Antonio Pérez, Nieves Guadalupe Acosta, Deiene Rodríguez-Barreto, Pedro Juan Alonso, Mónica B. Betancor, Alexandr Torres, Sergio Álvarez, Covadonga Rodríguez

“…Emerging evidence suggest that local plants like those including in Echium genus, rich in SDA and with a balanced LA/ALA ratio, could offer a more sustainable and efficient alternative to traditional ALA sources in poultry production.…”
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Path model explaining the association between fear of falling and health-related quality of life in (pre-)frail older adults by Tjard Sattler, Sophie Gottschalk, Hans-Helmut König, Tobias Braun, Gisela Büchele, Michael Denkinger, Tim Fleiner, Corinna Nerz, Kilian Rapp, Martina Schäufele, Christian Werner, Judith Dams

“…The proposed model should be tested on an alternative sample, using longitudinal data, and extended to include additional explanatory factors (e.g. activity avoidance). …”
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Four-dimensional flow magnetic resonance imaging for noninvasive diagnosis of clinically significant portal hypertension and high-risk gastroesophageal varices in patients with cir... by Jiachen Ji, Yi Xiang, Jinghui Dong, Hanyu Jiang, Tianyi Xia, Yunduo Li, Mengmeng Zhang, Changchun Liu, Xijun Gong, Bo Jin, Wen Shen, Gangfeng Zhu, Jianming Cai, Rui Li, Xiaolong Qi

“…Four-dimensional (4D) flow magnetic resonance imaging (MRI) provides comprehensive flow information and is a promising alternative. This study evaluated the efficacy of 4D flow MRI as a noninvasive method for diagnosing CSPH and high-risk varices in patients with liver cirrhosis. …”
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