Structure-based identification of HNF4α agonists: Rosmarinic acid as a promising candidate for NAFLD treatment by Xi Chen, Xinqi Zhu, Gang Wu, Xiaobo Wang, Yu Zhang, Nan Jiang

“…Current lipid-lowering pharmacotherapies are associated with side effects, including hepatotoxicity, rhabdomyolysis, and decreased erythrocyte counts, underscoring the urgent need for safer therapeutic alternatives. Hepatocyte nuclear factor 4α (HNF4α) has been identified as a pivotal regulator of lipid metabolism, making it an attractive target for drug development. …”
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Computer-Aided Supporting Models of Customized Crack Propagation Sensors for Analysis and Prototyping by Paulina Kurnyta-Mazurek, Rafał Wrąbel, Artur Kurnyta

“…This paper briefly introduces a new type of sensor, called a Customized Crack Propagation Sensor (CCPS), which is an alternative for crack gauges, but with enhanced functional features and customizability. …”
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Biofabrication of copper oxide nanoparticles using Dalbergia sisso leaf extract for antibacterial, antibiofilm and antioxidant activities by Muhammad Hussnain Siddique, Maimona Sadia, Saima Muzammil, Muhammad Saqalein, Asma Ashraf, Sumreen Hayat, Saba Saba, Arif Muhammad Khan, Abeer Hashem, Graciela Dolores Avila-Qezada, Elsayed Fathi Abd-Allah

“…This problem has led to the development of alternative approaches to treat the diseases caused by these multidrug resistant bacteria (MDR). …”
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Low dose DNA methyltransferase inhibitors potentiate PARP inhibitors in homologous recombination repair deficient tumors by Romain Pacaud, Scott Thomas, Sibapriya Chaudhuri, Ann Lazar, Luika A. Timmerman, Pamela N. Munster

“…Thus we are seeking alternative therapeutics to enhance PARP-directed outcomes. …”
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Predictive models for the implementation of targeted reproductive management in multiparous cows on automatic milking systems by Fergus P. Hannon, Martin J. Green, Luke O'Grady, Chris Hudson, Anneke Gouw, Laura V. Randall

“…We discuss the advantages and limitations the integration of additional data sources imposes on model training and deployment and suggest alternative methods to improve performance while preserving model parsimony.…”
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Adipose Tissue-Derived Stromal Cells Induce a Highly Trophic Environment While Reducing Maturation of Monocyte-Derived Dendritic Cells by Morten Juhl, Bjarke Follin, Monika Gad, Jesper Larsen, Jens Kastrup, Annette Ekblond

“…Allogeneic cell-based therapies using adipose tissue-derived stromal cells (ASCs) offer an off-the-shelf alternative to autologous therapy. An underlying assumption is that ASC can modulate the immune response of the recipient. …”
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Management of Persistent Epistaxis Using Floseal Hemostatic Matrix vs. traditional nasal packing: a prospective randomized control trial by Scott Murray, Adrian Mendez, Alexander Hopkins, Hamdy El-Hakim, Caroline C. Jeffery, David W. J. Côté

“…Conclusions Floseal® (Baxter, USA) was demonstrated to be an effective, comfortable and cost-effective alternative treatment of persistent epistaxis when compared to traditional packing methods for patients referred to OHNS with a normal coagulation profile. …”
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Comparison of the two treatment methods in primary hyperparathyroidism due to solitary parathyroid adenoma, Ultrasound-guided percutaneous alcohol ablation vs. parathyroidectomy: a... by Mohammad Eslamian, Babak Tavakoli, Alireza Firouzfar, Alireza Pouramini, Bijan Iraj, Mohsen Kolahdouzan, Marjan Mansourian

“…PEA is an effective alternative to PTx, particularly in adenomas with a volume of less than 425.5 mm3 and a maximum diameter of 13.5 mm. …”
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Combined negative pressure wound therapy with new wound dressings to repair a ruptured giant omphalocele in a neonate: a case report and literature review by Shulin Hou, Zeyao Shi, Xiaowen Li, Ru Yang, Yan Song, Zhaolan Zeng

“…Conclusions NPWT is a safe and effective alternative therapy for the repair of giant omphalocele. …”
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CD36 inhibition enhances the anti-proliferative effects of PI3K inhibitors in PTEN-loss anti-HER2 resistant breast cancer cells by You-Yu Liu, Wei-Lun Huang, Sin-Tian Wang, Hui-Ping Hsu, Tzu-Ching Kao, Wei-Pang Chung, Kung-Chia Young

“…Therefore, seeking for alternative combination therapy needs urgent attentions in PTEN-loss anti-HER2 resistant breast cancer. …”
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Exploring phytochemical, antioxidant, and antimicrobial properties of Plumeria pudica Jacq. leaves by Kavan Shukla, Kunal N. Odedra, B. A. Jadeja

“…This shift entails exploring organic alternatives to traditional medicines, involving the extraction of superior phytochemicals from plants for enhanced biomedical applications in treating various diseases and conditions. …”
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The role of solar thermal hydrogen production technologies in future energy solutions: A review by Md. Shameem Hossain, Md. Nasirul Islam, Khaza Shahriar, Mohammad Mujtaba Hasan, Md. Sohag Hossain

“…This situation makes using non-renewable resources even more problematic, especially since hydrogen is often promoted as a clean energy alternative. Among renewable options for hydrogen production, solar-based methods have attracted considerable interest from researchers. …”
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RBMDC-Net: Effective Jaw Cyst Segmentation Network Using Residual Bottleneck and Multiscale Dilated Convolution by Huixia Zheng, Xiaoliang Jiang, Xu Xu, Zhenfei Yuan

“…Automatic segmentation of jaw cysts in cone-beam computed tomography (CBCT) scans plays a crucial role in clinical and treatment planning, and it provides an efficient alternative to labor-intensive manual procedures. However, cysts on pathological sections often present with irregular and complex morphology, as well as extremely similar to surrounding tissue, which poses a great challenge in achieving their accurate segmentation. …”
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Gedunin Mitigates <i>Cutibacterium acnes</i>-Induced Skin Inflammation by Inhibiting the NF-κB Pathway by Ju Kyoung Sim, Ye Ji Heo, Jin Hak Shin, Seon Sook Kim, Su Ryeon Seo

“…This study highlights gedunin’s promise as an alternative approach to managing <i>C. acnes</i>-induced skin inflammation.…”
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HUBUNGAN ANTARA MOTIVASI BELAJAR DENGAN PEMAHAMAN KONSEP FISIKA PESERTA DIDIK MAN BARAKA by Muhammad Amran Shidik

“…Data collection used two types of instruments namely non-test and each test to determine learning motivation with a total of 37 answers, each of which had 5 answer choices and students' understanding of concepts with a total of 26 items, each of which had five alternative answers. By using product evaluation analysis when the results of significance 0.008 <0.05 which mean that Ho was rejected and Ha was accepted. …”
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In Vitro Acaricidal Activity of Selected Medicinal Plants Traditionally Used against Ticks in Eastern Ethiopia by Jelalu Kemal, Tesfaheywet Zerihun, Sisay Alemu, Kedir Sali, Musa Nasir, Ashebr Abraha, Teka Feyera

“…Thus, all the tested plants could be used against Rhipicephalus (Boophilus) decoloratus and Rhipicephalus pulchellus as a potential alternative to substitute commercially available drugs. …”
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THE INSTITUTIONALIZATION OF GLOBAL STRATEGIES FOR THE TRANSFORMATION OF SOCIETY AND EDUCATION IN THE CONTEXT OF CRITICAL THEORY by Viktor V. Zinchenko

“…Critical social philosophy of education strives to provide a radical critique of existing models of education in the so-called Western models of democracy, creating progressive alternative models. In this context, the proposed integrative metatheory, which is based on classical and modern sources, concepts, aims for a comprehensive understanding and reconstruction of the phenomenon of education. …”
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Wind speed and direction on predicting wind energy availability for a sustainable ecosystem by B. Baranitharan, D. Sivakumar, M. Perarul Selvan

“…BACKGROUND AND OBJECTIVES: Overusing renewable resources for various purposes is making it necessary to use fewer non-renewable ones to generate energy. Finding alternative renewable energy sources is essential for energy production. …”
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Assessing Durability and Stability of Calcium Sulfoaluminate Cement-Stabilized Soils Under Cyclic Wet–Dry Conditions by Ayesha Rauf, Sung-Woo Moon, Alfrendo Satyanaga, Jong Kim

“…While the conventional approach to ground improvement involves the application of ordinary Portland cement (OPC) and lime for treating unstable soil, this research explores calcium sulfoaluminate (CSA) cement as an eco-friendly alternative with comparable efficacy and fewer adverse environmental effects. …”
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The simpler modified fried frailty scale predicts 2-year mortality in older adults with heart failure: a pilot study by Celalettin Küçük, Serdar Özkök, Gülistan Bahat, Ekrem Bilal Karaayvaz, Mustafa Altınkaynak, Alpay Medetalibeyoğlu, Mehmet Akif Karan

“…FRAIL scale, the Study of Osteoporosis Fractures (SOF) index, and Edmonton Frailty Scale (EFS) were alternatively used to study the correlation of SMFFS with different scales. …”
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