Venetoclax plus low-intensity chemotherapy for adults with acute lymphoblastic leukemia by Marlise R. Luskin, Shai Shimony, Julia Keating, Eric S. Winer, Jacqueline S. Garcia, Richard M. Stone, Elias Jabbour, Yael Flamand, Kristen Stevenson, Jeremy Ryan, Zhihong Zeng, Anthony Letai, Marina Konopleva, Nitin Jain, Daniel J. DeAngelo

“…Venetoclax was given for 21 days with each cycle of mini–hyper-CVD (mini-HCVD; cyclophosphamide, vincristine, dexamethasone alternating with methotrexate and cytarabine). There were no dose-limiting toxicities at dose level 1 (DL1; n = 3, 400 mg/d) or DL2 (n = 6, 600 mg/d); DL2 was the recommended phase 2 dose and explored further (n = 10). …”
Get full text

Initial treatment of steroid-sensitive idiopathic nephrotic syndrome in children with mycophenolate mofetil versus prednisone: protocol for a randomised, controlled, multicentre tr... by Burkhard Toenshoff, Martin Konrad, Steffen Luntz, Anja Sander, Peter F Hoyer, Rasmus Ehren, Marcus R Benz, Jorg Doetsch, Alexander Fichtner, Jutta Gellermann, Dieter Haffner, Britta Höcker, Bärbel Kästner, Markus J Kemper, Uwe Querfeld, Lutz T Weber

“…The aim of the INTENT study (Initial treatment of steroid-sensitive idiopathic nephrotic syndrom in children with mycophenolate mofetil versus prednisone: protocol for a randomised, controlled, multicentre trial) is to show that an alternative treatment regimen with mycophenolic acid is not inferior regarding sustainment of remission, but with lower toxicity compared with treatment with glucocorticoids only.Methods and design The study is designed as an open, randomised, controlled, multicentre trial. 340 children with a first episode of steroid-sensitive nephrotic syndrome and who achieved remission by a standard prednisone regimen will be enrolled in the trial and randomised to one of two treatment arms. …”
Get full text

Phytochemical Profiling, GC-MS Analysis and Antibacterial Activity of Sida acuta leave Extracts Against Helicobacter pylori by Kamoldeen Ajijolakewu, Ayobami Elias Ajadi, S A Ayoola, Sheriffdeen Issa Bale, Taiwo Ayodeji Sorunke, Saheed Abayomi Onifade, Tomisin Oyawoye

“…Full Abstract: Helicobacter pylori is a major cause of ulcers, and increasing resistance to standard antibiotics underscores the need for alternative treatments.  Sida acuta, a plant with medicinal properties, was examined in this study for its potential antibacterial effects.  …”
Get full text

Short-term caloric restriction or resveratrol supplementation alters large-scale brain network connectivity in male and female rats by Judith R. A. van Rooij, Judith R. A. van Rooij, Monica van den Berg, Monica van den Berg, Tamara Vasilkovska, Johan Van Audekerke, Johan Van Audekerke, Lauren Kosten, Daniele Bertoglio, Daniele Bertoglio, Mohit H. Adhikari, Mohit H. Adhikari, Marleen Verhoye, Marleen Verhoye

“…Unfortunately, poor compliance hinders the success of this approach. A proposed alternative is resveratrol (Rsv), a CR-mimetic known to promote brain health. …”
Get full text

Multiplanar Semicircular New-Generation Implant System Developed for Proximal Femur Periprosthetic Fractures: A Biomechanical Study by Ahmet Burak Satılmış, Ahmet Ülker, Zafer Uzunay, Tolgahan Cengiz, Abdurrahim Temiz, Mustafa Yaşar, Tansel Mutlu, Uygar Daşar

“…It withstood higher physiological loads, offered better structural stability, and could be an alternative to existing fixation systems in clinical practice. …”
Get full text

Changes in Alcohol Consumption During and After the Covid-19 Pandemic From 2020 to 2023 in a Prospective Cohort of Italian Adults by Sonia Cerrai, Giulia Carreras, Filippo Monti, Chiara Stival, Alessandra Lugo, Cristina Bosetti, Silvia Biagioni, Tiziana Fanucchi, Giuseppe Gorini, Andrea Amerio, Luisa Mastrobattista, Claudia Mortali, Anna Odone, Sabrina Molinaro, Luc Smits, Silvano Gallus, the “Lost in Italy” and “Lost in Toscana” Study Investigators

“…It was more frequent among individuals with anxiety or depressive symptoms (OR 1.24; 95% CI, 1.12–1.37), those using psychotropic drugs (OR 1.99; 95% CI, 1.69–2.35) and users of conventional and/or alternative nicotine products (OR 3.67; 95% CI, 3.00–4.48). …”
Get full text

Long non-coding RNA OSTM1-AS1 promotes renal cell carcinoma progression by sponging miR-491-5p and upregulating MMP-9 by Jun-Feng Chen, Sha-Zhou Ye, Ke-Jie Wang, Xiang-yu Meng, Bin-bin Yang, Ke Rong Wu, Qi Ma

“…Therefore, this axis could represent a promising alternative therapeutic target for RCC treatment.…”
Get full text

Classification performance and reproducibility of GPT-4 omni for information extraction from veterinary electronic health records by Judit M. Wulcan, Kevin L. Jacques, Mary Ann Lee, Samantha L. Kovacs, Nicole Dausend, Lauren E. Prince, Jonatan Wulcan, Sina Marsilio, Stefan M. Keller

“…Using GPT-4o to automate information extraction from veterinary EHRs is a viable alternative to manual extraction, but requires validation for the intended setting to ensure accuracy and reliability.…”
Get full text

Guar, jantar, wheat straw, and rice hull composts as replacements for peat in muskmelon transplant production by Ghulam Mustafa, Muhammad Arif Ali, Donald Smith, Timothy Schwinghamer, John R. Lamont, Niaz Ahmed, Sajjad Hussain, Muhammad Arshad

“…Economic constraints paired with concerns over the sustainability of peat mining have necessitated the replacement of peat with renewable and regionally abundant alternatives. The aim of this study was to develop from composts complete or partial substitutes for peat. …”
Get full text

Computational Fluid Dynamics Analysis of Nasal Airway Changes after Treatment with C-Expander by Wang Xiao, Siling Liu, Yanqin Lu, Lei Lei, Ning Liu, Xiaoping Shen, Yuhong He, Ousheng Liu

“…For patients suffering from maxillary width deficiency and respiratory disorders, a C-expander may be an alternative method to treat the disease.…”
Get full text

Lipoxin A4 yields an electrophilic 15-oxo metabolite that mediates FPR2 receptor-independent anti-inflammatory signaling by Adolf Koudelka, Gregory J. Buchan, Veronika Cechova, James P. O’Brien, Emily R. Stevenson, Crystal E. Uvalle, Heng Liu, Steven R. Woodcock, Steven J. Mullett, Cheng Zhang, Bruce A. Freeman, Stacy L. Gelhaus

“…Moreover, synthetic LXA4 and the membrane-permeable 15-oxo-LXA4 methyl ester, which rapidly de-esterified to 15-oxo-LXA4, displayed no ligand activity for the putative LXA4 receptor FPR2. Alternatively, 15-oxo-LXA4, an electrophilic α,β-unsaturated ketone, alkylates nucleophilic amino acids and can modulate redox-sensitive transcriptional regulatory protein and enzyme function. 15-oxo-LXA4 activated nuclear factor (erythroid related factor 2)-like 2-regulated expression of anti-inflammatory and repair genes and inhibited NF-κB-regulated pro-inflammatory mediator expression. …”
Get full text

Endoscopic retrograde cholangiopancreatography combined with extracorporeal shock wave lithotripsy for the removal of large gallbladder stones: a pilot study by Liang Zhu, Jinli He, Zhenzhen Yang, Xi Huang, Junbo Hong, Xiaojiang Zhou, Youxiang Chen, Guohua Li

“…Abstract Background Endoscopic gallbladder-preserving cholecystolithotomy (EGPC) has become an alternative option for treating cholecystolithiasis. …”
Get full text

Transcanalicular laser-assisted and external dacryocystorhinostomy anatomical and functional success in primary acquired nasolacrimal duct obstruction: systematic review and meta-a... by Khalid W. Helmi, Ahmed S. Abdulhamid, Mohammed S. Alomari, Ali S. Alsudais, Badran S. Alqurashi, Abdullah Alsharif, Abdulrahman H. Alzahrani, Abdulrahman M. Bahalaq, Mohammed F. Qutub, Hashem S. Almarzouki

“…This systematic review and meta-analysis aimed to measure the ability of transcanalicular dacryocystorhinostomy (TC-DCR) as an alternative approach to PANDO compared to traditional external dacryocystorhinostomy (EX-DCR). …”
Get full text

Nature and Origin of Mineralizing Fluids in Hyperextensional Systems: The Case of Cretaceous Mg Metasomatism in the Pyrenees by Benoît Quesnel, Marie-Christine Boiron, Michel Cathelineau, Laurent Truche, Thomas Rigaudier, Gérard Bardoux, Pierre Agrinier, Michel de Saint Blanquat, Emmanuel Masini, Eric C. Gaucher

“…The first hypothesis is by far the most realistic one considering the numerous occurrences of Trias formations nearby, their deformation during the extension, and the drainage of the expulsed brines as evidenced by the high-salinity fluid inclusions found all around the deposit. Alternatively, the exhumation of the mantle is considered as a major source of heat and stress that favored brine migration along the major shear zones. …”
Get full text

Association between chiropractic spinal manipulative therapy and benzodiazepine prescription in patients with radicular low back pain: a retrospective cohort study using real-world... by Jeffery A Dusek, Robert James Trager, Zachary A Cupler, Kayla J DeLano, Jaime A Perez

“…Serious aetiologies of low back pain, structural deformities, alternative neurological lesions and absolute benzodiazepine contraindications were excluded. …”
Get full text

Evaluating the dual impact of microbial activity and aged refuse layers on landfill leachate clogging: An experimental and LCA perspective by Zhaobin Li, Waifan Tang, Shulun Mak, Siukei Lam, Qingwen Li

“…Future research should explore alternative materials and configurations to optimize both clogging control and environmental performance, promoting more sustainable landfill drainage management strategies.…”
Get full text

Combined effects of alginate based active edible coatings and irradiation treatment on the quality characteristics of Beef Meat at 2°C by Samir Smeti, Souha Tibaoui, Hayet Ben Haj Koubaier, Atef Lakoud, Naziha Atti

“…This finding highlights their potential as a powerful and effective alternative to irradiation treatments, offering a natural solution for the food industry to improve product quality and safety.…”
Get full text

The Effects on Knee Swelling, Range of Motion and Pain using a Commercially Available Hot/Cold Contrast Device in a Rehabilitation and Sports Medicine Setting by Kevin E Wilk, Robert E Mangine, James Tersakjs, Kimberly Hasselford

“…# Background and Purpose Contrast therapy consists of alternating thermotherapy and cryotherapy repeatedly to assist in the management of acute, subacute, and chronic musculoskeletal conditions. …”
Get full text

Housing Price Forecasting Using AI (LSTM) by Hossein Ziyadi, Erfan Salavati, Mohammad Mahdi Lotfi Heravi

“…Besides that, being confronted with real estate price shocks and price fluctuations in alternative markets, determining the best time for the investment may come up as a big challenge for any investor. …”
Get full text

An Improved Bio-Inspired Material Generation Algorithm for Engineering Optimization Problems Including PV Source Penetration in Distribution Systems by Mona Gafar, Shahenda Sarhan, Ahmed R. Ginidi, Abdullah M. Shaheen

“…Also, the application of IMGO in PV parameter estimation achieved a reduction in computational errors of 27.8% while maintaining superior optimization stability compared to alternative methods.…”
Get full text