Integrative bioinformatic approach reveals novel melatonin-related biomarkers for Alzheimer’s disease by Hua-xiong Zhang, Dilmurat Hamit, Qing Li, Xiao Hu, San-feng Li, Fu Xu, Ming-yuan Wang, Guo-qing Bao, Hong-yan Li

“…Abstract Background: Melatonin (MLT) can improve mitophagy, thereby ameliorating cognitive deficits in Alzheimer’s disease (AD) patients. …”
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Emodin Ameliorates Intestinal Dysfunction by Maintaining Intestinal Barrier Integrity and Modulating the Microbiota in Septic Mice by Mina Zhang, Bo Lian, Rui Zhang, Yuhong Guo, Jingxia Zhao, Shasha He, Yunjing Bai, Ning Wang, Yan Lin, Xuerui Wang, Qingquan Liu, Xiaolong Xu

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Colorectal cancer in Lynch syndrome families: consequences of gene germline mutations and the gut microbiota by Xuexin Wang, Zhijun Zheng, Dongliang Yu, Xiaojue Qiu, Ting Yang, Ruoran Li, Jing Liu, Xin Wang, Peng Jin, Jianqiu Sheng, Nan Qin, Na Li, Junfeng Xu

“…We enrolled 72 individuals from 9 LS families across six provinces in China and employed 16S rRNA gene amplicon sequencing to analyze the fecal microbiota components among LS-related CRC patients (AS group), their spouses (BS group), mutation carriers without CRC (CS group), and non-mutation carriers (DS group) using alpha and beta diversity indices. …”
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Fluoride exposure, personal susceptibility and osteoarticular degeneration: Evidence from farmers in the Yellow River Basin of Henan Province by Zichen Feng, Long Sun, Shu Niu, Bin Liu, Ruijie Ba, Guoqing Wang, Qing Sun, Chunxiang Li, Yan Wang, Fangfang Yu, Guoyu Zhou, Yue Ba

“…Osteoarticular degeneration (OAD) is an important issue. Excessive fluoride can damage osteoarticular health. Besides, personal susceptibility (including genetic factors, physiological characteristics, and lifestyle) also contributes to osteoarticular development significantly. …”
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Okra juice used for rapid wound healing through its bioadhesive and antioxidant capabilities by Biao Zhang, Yuanqiang Li, Kaijie Wu, Liqi Wei, Yining Chen, Yuan Zhang, Yiping Ren, Tianshu Zou, Pengcheng Yu, Hongxia Ma, Rui Chen, Xin Liu, Yan Cheng

“…The levels of pro-inflammatory tumor necrosis factor alpha (33.17 %) and Interleukin-6 (46.73 %) were significantly reduced. …”
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Luteolin Pretreatment Attenuates Hepatic Ischemia-Reperfusion Injury in Mice by Inhibiting Inflammation, Autophagy, and Apoptosis via the ERK/PPARα Pathway by Yuhui Jiang, Wenjuan Yang, Jiameng Ding, Jie Ji, Liwei Wu, Yuanyuan Zheng, Yan Li, Ziqi Cheng, Jie Zhang, Qiang Yu, Jiao Feng, Jingjing Li, Jianye Wu, Yingqun Zhou, Chuanyong Guo

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Tumor Necrosis Factor Receptor Superfamily, Member 1B Haplotypes Increase or Decrease the Risk of Inflammatory Bowel Diseases in a New Zealand Caucasian Population by Lynnette R. Ferguson, Dug Yeo Han, Claudia Huebner, Ivonne Petermann, Murray L. Barclay, Richard B. Gearry, Alan McCulloch, Pieter S. Demmers

“…Interactions between TNF-alpha and TNF-alpha receptor play a fundamental role in inflammatory response. …”
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Thermal sensitivity and niche plasticity of generalist and specialist leaf-endophytic bacteria in Mangrove Kandelia obovata by Rajapakshalage Thashikala Nethmini, Huaxian Zhao, Lianghao Pan, Xinyi Qin, Jiongqing Huang, Qing He, Xiaofang Shi, Gonglingxia Jiang, Qinghua Hou, Qingxiang Chen, Xiaolei Li, Ke Dong, Lingling Xie, Nan Li

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Engineered macrophage nanoparticles enhance microwave ablation efficacy in osteosarcoma via targeting the CD47-SIRPα Axis: A novel Biomimetic immunotherapeutic approach by Xiongfa Ji, Xin Qian, Guowen Luo, Wenjie Yang, Wenhan Huang, Zehua Lei, Jiaqi Zhou, Guoqing Zhong, Jielong Zhou, Nan Liu, Limin Ma, Mei Li, Xiangmei Liu, Shuilin Wu, Yu Zhang

“…This study developed an innovative nanotherapeutic approach by utilizing genetically engineered macrophage membranes with M1 polarization, stably overexpressing signal regulatory protein alpha (SIRPα), to encapsulate microwave-responsive nano-Prussian blue (SIRPα-M@nanoPB) nanoparticles. …”
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Increased Nuclear Transporter KPNA2 Contributes to Tumor Immune Evasion by Enhancing PD-L1 Expression in PDAC by Kai-Xia Zhou, Shan Huang, Li-Peng Hu, Xue-Li Zhang, Wei-Ting Qin, Yan-Li Zhang, Lin-Li Yao, Yanqiu Yu, Yao-Qi Zhou, Lei Zhu, Jianguang Ji, Zhi-Gang Zhang

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Shenlian (SL) Decoction, a Traditional Chinese Medicine Compound, May Ameliorate Blood Glucose via Mediating the Gut Microbiota in db/db Mice by Rui-xi Sun, Wei-jun Huang, Yao Xiao, Dou-dou Wang, Guo-hua Mu, He Nan, Bo-ran Ni, Xiao-qiang Huang, Hsuan-chuan Wang, Yi-fan Liu, Qiang Fu, Jin-xi Zhao

“…In this study, results demonstrated that SL decoction had a better hypoglycemic effect and β cell protection effect than either ginseng or Coptis chinensis. Alpha diversity analysis showed that all interventions with ginseng, Coptis, and SL decoction could reverse the increased diversity and richness of gut microbiota in db/db mice. …”
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Pancreatic cancer cells infiltrate nerves through TGFbeta1-driven perineural epithelial-to-mesenchymal-like transdifferentiation by Theresa Krauss, Ibrahim Halil Gürcinar, Ulrike Bourquain, Maren Hieber, Evelyn N. Krohmer, Nan Wu, Sergey Tokalov, Rüdiger Goess, Carmen Mota Reyes, Dieter Saur, Helmut Friess, Güralp O. Ceyhan, Ihsan Ekin Demir, Okan Safak

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A broadly neutralizing antibody against the SARS-CoV-2 Omicron sub-variants BA.1, BA.2, BA.2.12.1, BA.4, and BA.5 by Zhe Chen, Leilei Feng, Lei Wang, Li Zhang, Binyang Zheng, Hua Fu, Fengdi Li, Ligai Liu, Qi Lv, Ran Deng, YanLi Xu, Yongfeng Hu, Jianhua Zheng, Chuan Qin, Linlin Bao, Xiangxi Wang, Qi Jin

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Chronic cannabis use differentially modulates neural oscillations serving the manipulate versus maintain components of working memory processing by Peihan J. Huang, Jake J. Son, Yasra Arif, Jason A. John, Lucy K. Horne, Mikki Schantell, Seth D. Springer, Maggie P. Rempe, Hannah J. Okelberry, Abraham D. Killanin, Ryan Glesinger, Anna T. Coutant, Thomas W. Ward, Madelyn P. Willett, Hallie J. Johnson, Elizabeth Heinrichs-Graham, Tony W. Wilson

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mRNA vaccines with RBD mutations have broad-spectrum activity against SARS-CoV-2 variants in mice by Xiaoming Liang, Yuxia Yuan, Junbin Wang, Cong Tang, Yun Yang, Yanan Zhou, Hao Yang, Qing Huang, Wenhai Yu, Haixuan Wang, Yuhuan Yan, Dongdong Lin, Yanwen Li, Xuena Du, Longhai Yuan, Wenqi Quan, Daoju Wu, Shuaiyao Lu

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Enterotype Bacteroides Is Associated with a High Risk in Patients with Diabetes: A Pilot Study by Jiajia Wang, Wenjuan Li, Chuan Wang, Lingshu Wang, Tianyi He, Huiqing Hu, Jia Song, Chen Cui, Jingting Qiao, Li Qing, Lili Li, Nan Zang, Kewei Wang, Chuanlong Wu, Lin Qi, Aixia Ma, Huizhen Zheng, Xinguo Hou, Fuqiang Liu, Li Chen

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First report of the invasive snail Pomacea canaliculata in Kenya by Alan G. Buddie, Ivan Rwomushana, Lisa C. Offord, Simeon Kibet, Fernadis Makale, Djamila Djeddour, Giovanni Cafa, Koskei K. Vincent, Alexander M. Muvea, Duncan Chacha, Roger K. Day

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Soluble and cell-based markers of immune checkpoint inhibitor-associated nephritis by Sandra M Herrmann, Riley Fadden, Ryan J Sullivan, Kerry L Reynolds, Harish Seethapathy, Meghan E Sise, Shruti Gupta, Alexandra-Chloe Villani, Qiyu Wang, Daiana Moreno, Destiny Harden, R Neal Smith, Ivy A Rosales, Robert B Colvin, Sarah Chute, Lynn D Cornell, Nancy J Yang, Sara Barmettler, Sophia Wells, Jocelyn Farmer

“…Because ICIs block immune checkpoint pathways that include cytotoxic T lymphocyte antigen 4 (CTLA4), we hypothesized that biomarkers of immune dysregulationpreviously defined in patients with congenital CTLA4 deficiency, including elevated soluble interleukin-2 receptor alpha (sIL-2R) and flow cytometric cell-based markers of B and T cell dysregulation in peripheral blood may aid the diagnosis of ICI-nephritis.Methods A retrospective cohort of patients diagnosed with ICI-nephritis was compared with three prospectively enrolled control cohorts: ICI-treated controls without immune-related adverse events, patients not on ICIs with hemodynamic acute kidney injury (hemodynamic AKI), and patients not on ICIs with biopsy proven acute interstitial nephritis from other causes (non-ICI-nephritis). sIL-2R level and flow cytometric parameters were compared between groups using Wilcoxon rank sum test or Kruskal-Wallis test. …”
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Nanobody-thioesterase chimeras to specifically target protein palmitoylation by Chien-Wen Kuo, Caglar Gök, Hannah Fulton, Eleanor Dickson-Murray, Samuel Adu, Emily K. Gallen, Sheon Mary, Alan D. Robertson, Fiona Jordan, Emma Dunning, William Mullen, Godfrey L. Smith, William Fuller

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Effects of rumen fluid transplantation on the fecal flora of yaks by Man Zhang, Man Zhang, Man Zhang, Yan Li, Yumin Li, Yumin Li, Yumin Li, Chenxu Cheng, Chenxu Cheng, Chenxu Cheng, Shatuo Chai, Shatuo Chai, Shatuo Chai, Yingkui Yang, Yingkui Yang, Yingkui Yang, Xun Wang, Xun Wang, Xun Wang, Shuxiang Wang, Shuxiang Wang, Shuxiang Wang

“…After this, yak feed intake was recorded daily; yaks were weighed on days 1, 30, and 60 of the formal trial; and yak feces were collected directly from the ground on days 1, 4, 7, 14, 30, and 60 to compare the microbial composition of the feces using 16S rRNA sequencing data.ResultsThe results showed that rumen fluid transplantation significantly increased the alpha diversity of fecal microflora (P < 0.05), and on day 30 of the experiment, both the operational taxonomic unit (OTU) and Shannon index were significantly higher in the RT group than the CON group (P < 0.05). …”
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