Knockdown of PTEN promotes colon cancer progression and induces M2 macrophage polarization in the colon cancer cell environment by Xu Han, Ting Yan, Lina Wang, Bin He, Huaxu Yu

“…Materials and Methods and Results: The expression of PTEN in colon cancer tissues and colon cancer cells was significantly lower than in precancerous tissues or CCD-18Co cells, and the decrease was most evident in SW620 cells. …”
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Carbonic Anhydrase IX Targeted Polyaspartamide fluorescent Probes for Tumor imaging by Zhang Y, Liu F, Shao C, Huang J, Yan G

“…Yu Zhang,1,2 Fan Liu,2,3,* Chuntao Shao,2,* Jun Huang,3 Guoping Yan1 1College of Chemical and Material Engineering, Quzhou University, Quzhou, Zhejiang Province, 324000, People’s Republic of China; 2School of Materials Science and Engineering, Wuhan Institute of Technology, Wuhan, 430205, People’s Republic of China; 3School of Chemical and Biomolecular Engineering, University of Sydney, NSW, 2006, Australia*These authors contributed equally to this workCorrespondence: Guoping Yan, Tel +86 570 8028560, Email guopingyan@qzc.edu.cnBackground: Precise intraoperative tumor delineation is essential for successful surgical outcomes. …”
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An Exploratory Study of Training Intensity in EEG Neurofeedback by Inês Esteves, Wenya Nan, Cristiana Alves, Alexandre Calapez, Fernando Melício, Agostinho Rosa

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HuoXueTongFu Formula Alleviates Intraperitoneal Adhesion by Regulating Macrophage Polarization and the SOCS/JAK2/STAT/PPAR-γ Signalling Pathway by Min Zhao, Yao-Yao Bian, Li-Li Yang, Yan-Qi Chen, Ya-Jie Wang, Yan-Ting Ma, Yu-Qiong Pei, Wen-Lin Li, Li Zeng

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The role of CO on initial oxidation behavior of α-U(001) surface: A first principles study by Longxian Li, Min Zhu, Yan Li, Yanru Ren, Longfei Pu, Chengxuan Peng

“…The CO molecules occur on the surface of uranium as a non-dissociative chemical. The mechanism of CO inhibiting the adsorption of O2 molecules stems from the fact that CO molecules occupy the optimal adsorption sites. …”
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Correlation between uterine microbiota and pregnancy outcomes of embryo transfer in overweight and obese women by Ying Yan, Ying Li, Lingling Wu, Yuxuan Zhang, Hong Guo, Yazhong Ji

“…At the genus level, the relative abundance of Lactobacillus in the Con group was 2.2 times higher than that in the OwOb group. The Alpha diversity in the OwOb group was significantly higher than in the Con group (p=0.028). …”
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Upregulated miR-206 Aggravates Deep Vein Thrombosis by Regulating GJA1-Mediated Autophagy of Endothelial Progenitor Cells by Yan Li, Jingping Ge, Yuanyuan Yin, Ruowen Yang, Jie Kong, Jianping Gu

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Therapeutic effects of Pueraria lobata (Willd.) Ohwi root and Hovenia dulcis Thunb. extracts on alcoholic liver disease: Network pharmacology and experimental validation by Zhendong Chen, Yu Yue, Hongyan An, Haisu Yan, Hyeok-Joo Park, Pei Lin

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Low-Intensity Transcranial Ultrasound Stimulation Inhibits Epileptic Seizures in Motor Cortex by Modulating Hippocampus Neural Activity by Na Pang, Qianqian Wang, Jiamin Pei, Hailin Zhang, Yi Yuan, Jiaqing Yan

“…Prior studies indicate that applying low-intensity transcranial ultrasound stimulation (TUS) to the hippocampus can suppress epileptic seizures. Nevertheless, it is unclear how TUS regulates hippocampal neural activity, and whether and how epileptic discharges in the motor cortex are suppressed by modulating hippocampal neural activity. …”
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New bitongling regulates gut microbiota to predict angiogenesis in rheumatoid arthritis via the gut-joint axis: a deep neural network approach by Yin Guan, Xiaoqian Zhao, Yun Lu, Yue Zhang, Yan Lu, Yue Wang

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An Exploratory Study of Intensive Neurofeedback Training for Schizophrenia by Wenya Nan, Feng Wan, Lanshin Chang, Sio Hang Pun, Mang I. Vai, Agostinho Rosa

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Causal relationship between 412 gut microbiota, 1,400 blood metabolites, and diabetic nephropathy: a randomized Mendelian study by Bo-Ning Cao, Cai-Yan Zhang, Zhen Wang, Yao-Xian Wang, Yao-Xian Wang

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A fiducial-assisted strategy compatible with resolving small MFS transporter structures in multiple conformations using cryo-EM by Pujun Xie, Yan Li, Gaëlle Lamon, Huihui Kuang, Da-Neng Wang, Nathaniel J. Traaseth

“…Furthermore, resolving more than one protein conformation within a sample, a major advantage of cryo-EM, represents an even greater degree of difficulty. …”
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D-mannose alleviates chronic periodontitis in rats by regulating the functions of neutrophils by Xue Li, Xueting Chen, Qingyu Zhu, Pengye Zhang, Shunxue Nan, Lei Lv, Shengcai Qi

“…To evaluate the protective effects of D-mannose against periodontal bone loss, methylene blue staining, hematoxylin and eosin (H&E) staining, and micro-CT scanning were utilized. Then, immunofluorescence (IF), Western Blot, and RT-PCR were applied to assess the expression levels of pro-inflammatory cytokines (IL-1β, IL-6, and IL-17), anti-inflammatory cytokine (IL-10), tumor necrosis factor-alpha (TNF-α), granulocyte colony-stimulating factor (G-CSF), granulocyte-macrophage colony-stimulating factor (GM-CSF), ten-eleven translocation 2 (TET2), and key glycolytic enzymes (HK1, HK2, PFKFB3), and to examine D-mannose’s impact on the recruitment and activation of neutrophils in the gingiva. …”
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High-dose dual therapy for Helicobacter pylori eradication inducing less impact on the gut microbiota by Jia-Lun Guan, Ting-Ting Xu, Ya Lin, Yan-Shuai Mo, Bi-Yu He, Ying-Ying Han, Ji-Yan Li, Su-Hong Xia, Ya-Ni Zhou, Jia-Zhi Liao, Pei-Yuan Li

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Heterothallism and potential hybridization events inferred for twenty-two yellow morel species by Xi-Hui Du, Dongmei Wu, Heng Kang, Hanchen Wang, Nan Xu, Tingting Li, Keliang Chen

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Predictive factors for clinical cure in the treatment of HBeAg(−) chronic hepatitis B or compensated cirrhosis: a prospective observational study by Yan-Qing Lv, Ru-Hua Guo, Kun-Yu Liu, Jia-Jie Li, Hui-Fan Ji

“…BackgroundSequential or combined treatment with nucleos(t)ide analogs (NAs) and pegylated interferon alpha-2b (Peg-IFN-α-2b) can improve the clinical cure rate. …”
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USP22 inhibits microglial M1 polarization by regulating the PU.1/NLRP3 inflammasome pathway by Ming-chen Yu, Xiao-lin Li, Ming-liang Ning, Zhen-zhong Yan, Wan-tao Yu

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Characterization of the Universal Flavor in Chinese Butter Hotpot by Multiple Mass Spectrometry Detection Technology by Menglu Yang, Yuan Mei, Haimei Lai, Yali Wang, Yuli Huang, Xueqing Zeng, Lihong Ge, Nan Zhao

“…Therefore, for the first time, multiple GC-Q-TOF/MS and GC-Orbitrap-MS methods were performed to explore the more 44 potential aroma compounds of butter hotpot, in which alpha-terpinyl, acetate, nonanal, piperitone, and (E)-lignstilde could further cause the differences in flavor intensity of spices aroma, smell of grease, and roasted, charred, and nutty (p<0.05). …”
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Inflammasomes in neurodegenerative diseases by Qianchen Wang, Songwei Yang, Xuan Zhang, Shanshan Zhang, Liping Chen, Wanxue Wang, Naihong Chen, Jiaqing Yan

“…In neurodegenerative diseases and neuroinflammation, the accumulation of misfolded proteins, such as beta-amyloid and alpha-synuclein, can lead to inflammasome activation, resulting in the release of interleukin (IL)-1β and IL-18. …”
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