Cardiovascular risk associated with glucagon-like peptide-1 receptor agonists versus other conventional glucose-lowering drugs in patients with type-2 diabetes: protocol for a nati... by François Schiele, Mikael Mazighi, Nicolas Danchin, Igor Sibon, Gilles Lemesle, Kamel Mohammedi, Laurent Fauchier, Bruno Detournay, Alexandre Caron, Corinne Emery, Camille Nevoret, Lucile Vigié, Christine Massien

“…Sodium-glucose transport protein 2 inhibitors (SGLT-2i) will be excluded as comparators, as this class of oral hypoglycaemic agents just started in 2020 to be marketed in France.Methods and analysis The Système National des Données de Santé is a comprehensive nationwide administrative healthcare database in France that covers approximately 67 million people.Several cohorts of adult patients with T2D initiating any GLP1-RA in dual or triple therapies, as recommended by the French Health authorities, will be identified in this database over the period 2016–2021. …”
Get full text

Performance of a hybrid capture-based target enrichment next-generation sequencing for the identification of respiratory pathogens and resistance-associated genes in patients with... by Wei-Yu Hsu, Ting-Wei Kao, Hsin-Ching Cho, Sheng-Yuan Ruan, Tai-Fen Lee, Yu-Tsung Huang, Jung-Yien Chien

“…In conclusion, RPIP can sensitively profile respiratory pathogens and is a promising tool for detecting multiple microorganisms and AMR-associated genes in patients with severe pneumonia.IMPORTANCESensitive pathogen detection is pivotal for timely treatment by tailoring adequate antimicrobial agents. Unlike conventional phenotypic approach, novel measures using molecular interrogation appear promising. …”
Get full text

Comment prendre en compte les mobilités saisonnières du bétail dans l’estimation de la charge animale d’un territoire sud-sahélien ? by Yanoussa Yakoubou Alzouma, Pierre Hiernaux, Mahamane Larwanou, Maguette Kaire, Issa Garba, Amadou Adamou Kalilou, Sambo Bode, Mahaman Maaouia Abdou Moussa, Harouna Abdou Bawa

“…Résultats : le cheptel du territoire était composé de 22 028 bovins, 19 597 caprins et 22 374 ovins auxquels s’ajoutent ceux des pasteurs étrangers. Les mesures de poids vifs saisonniers ont permis d’exprimer cette charge en unité de bétail tropical, à savoir 0,38, 0,28 et 0,23UBT/ha en saison des pluies, en saison sèche et fraîche et en saison chaude respectivement. …”
Get full text

Examining the therapeutic potential and side effects of calcium channel blockers in mortality and morbidity of patients with stroke: A systematic review of pre-clinical and clinica... by Sevak Hatamian, Asad Abdi, Fatemeh Sadat Seyedi Asl, Armin Tafazolimoghadam, Arian Tavasol, Seyed Ali Mousavi Nejad, Reza Madadi, Zohre Tajabadi, Mina Dehghani, Najmeh Ahmadpoor, Mobina Fathi, Mohammadreza Hajiesmaeili, Navid Nooraei

“…One study showed favorable and unfavorable outcomes compared to other antihypertensive agents. Stroke was reported in two studies following CCB overdose. …”
Get full text

Du passage des cultures aux identités plurielles: bandes dessinées et romans graphiques sino-francophones by Jean-Baptiste Bernard

“…À titre d’exemple, Chen Jiang Hong, auteur et illustrateur d’albums pour la jeunesse, transmet aussi bien la culture traditionnelle de la Chine que l’histoire qui l’a mené à vivre en France. …”
Get full text

Clinical Features at Onset and Genetic Characterization of Pediatric and Adult Patients with TNF-α Receptor—Associated Periodic Syndrome (TRAPS): A Series of 80 Cases from the AIDA... by Carla Gaggiano, Antonio Vitale, Laura Obici, Giampaolo Merlini, Alessandra Soriano, Ombretta Viapiana, Marco Cattalini, Maria Cristina Maggio, Giuseppe Lopalco, Davide Montin, Masen Abdel Jaber, Lorenzo Dagna, Raffaele Manna, Antonella Insalaco, Matteo Piga, Francesco La Torre, Virginia Berlengiero, Viviana Gelardi, Luisa Ciarcia, Giacomo Emmi, Piero Ruscitti, Francesco Caso, Rolando Cimaz, José Hernández-Rodríguez, Paola Parronchi, Ludovico Luca Sicignano, Elena Verrecchia, Florenzo Iannone, Jurgen Sota, Salvatore Grosso, Carlo Salvarani, Bruno Frediani, Roberto Giacomelli, Maria Antonietta Mencarelli, Alessandra Renieri, Donato Rigante, Luca Cantarini

“…Both NSAIDs and colchicine were used as monotherapy more frequently in the LP group compared to the HP group (p<0.01). Biologic agents were prescribed to 49 (61%) patients; R92Q subjects were more frequently on NSAIDs monotherapy than other patients (p<0.01); nevertheless, they required biologic therapy in 53.1% of cases. …”
Get full text

Salomé, reine d’Angleterre : destins esthétiques de la Salomé d’Oscar Wilde (Aubrey Beardsley, Charles Bryant, Ken Russell) by Tristan Grünberg

“…Personnage hautement ambivalent, elle incarne ces valeurs chères à l’Esthétisme britannique, cultivant le goût du paradoxe, de la métamorphose, de l’ambiguïté morale et sexuelle. …”
Get full text

Comparative evaluation of sensititre YeastOne and VITEK2 antifungal susceptibility tests with CLSI broth microdilution method of clinical Cryptococcus isolates in Taiwan by Tzu-Ping Weng, Shin-Wei Wang, Shih-Ting Lo, Shu-Li Su, Ming-I Hsieh, Pei-Jane Tsai, Pei-Fang Tsai, Chi-Jung Wu, Nan-Yao Lee, Wen-Chien Ko, Po-Lin Chen

“…The essential agreements between SYO and CLSI BMD were >90% to most antifungal agents except ITC in C. neoformans isolates (64%) and AMB in C. gattii group (67%). …”
Get full text

Durvalumab and tremelimumab in patients with advanced rare cancer: a multi-centre, non-blinded, open-label phase II basket trialResearch in context by Abha A. Gupta, Anna Tinker, Derek Jonker, Rahma Jamal, Hal Hirte, Eric W. Winquist, Quincy Chu, Christian Kollmannsberger, Ralph Wong, Thierry Alcindor, Torsten O. Nielsen, Ming Tsao, Tricia R. Cottrell, Diane Provencher, John Hilton, Monika K. Krzyżanowska, Christine Elser, Sebastien Hotte, Joana Sederias, Siwei Zhang, Wei Tu, Janet Dancey

“…We sought to determine the objective response rate of combination durvalumab (D) plus tremelimumab (TM) in parallel cohorts of patients with carefully selected rare cancer types in which these agents had not previously been evaluated in phase II trials and for which there was clinical or biological rationale for dual immune checkpoint inhibitor therapy to be active. …”
Get full text

Dry eye syndrome before corneal refractive surgery: the prevalence and pathogenesis-oriented therapy by N.V. Maychuk, I.S. Malyshev, M.R. Obraztsova

“…To relieve the sterile inflammatory response, the patients received a course of steroids as anti-inflammatory agents followed by cyclosporin A. An eye gel was recommended for the long-lasting overnight hydration of the corneal epithelium and its faster renewal. …”
Get full text

Wild grasses as the reservoirs of infection of rust species for winter soft wheat in the Northern CaucasusWild grasses as the reservoirs of infection of rust species for winter sof... by E. I. Gultyaeva, L. A. Bespalova, I. B. Ablova, E. L. Shaydayuk, Zh. N. Khudokormova, D. R. Yakovleva, Yu. A. Titova

“…The purpose of these studies is to characterize the virulence of P. triticina, P. graminis, P. striiformis on wild cereals and to assess the specialization of causative agents to winter wheat in the North Caucasus. Infectious material represented by leaves with urediniopustules of leaf, stem and stripe rusts was collected from wild cereals (Poa spp., Bromus spp.) in the Krasnodar Territory in October–November 2019. …”
Get full text

Diagnostics and treatment of gastroesophageal reflux disease: clinical guidelines of the Russian gastroenterological association by V. T. Ivashkin, I. V. Mayev, I. . A.s. Trukhmanov, Ye. K. Baranskaya, O. B. Dronova, O. V. Zayratyants, R. G. Sayfutdinov, A. A. Sheptulin, T. L. Lapina, S. S. Pirogov, Yu. A. Kucheryavy, O. A. Storonova, D. N. Andreyev

“…Nowadays PPIs are considered as the most effective and safe agents for GERD treatment. PPIs are applied for the long­term baseline treatment (no less than 4-8 wks) and maintenance therapy (6-12 months). …”
Get full text

Relaciones entre el recuento de células somáticas, test de mastitis California, conductividad eléctrica y el diagnóstico de mastitis subclínicas en cabras lecheras by V.H. SUAREZ, G.M. MARTINEZ, V. GIANRE, L. CALVINHO, A. RACHOSKI, M. CHAVEZ, A. SALATIN, S. OROZCO, V. SANCHEZ, E. BERTONI

“…El estudio muestra que tanto el CCS (línea de corte <1000000) como el CMT (0, T, 1) pueden ser usados para monitorear la presencia de mastitis subclínicas, teniendo en cuenta que presentan una E buena y alto VP negativo (98%) para el diagnóstico de ubres sanas y una S aceptable para detectar infecciones (especialmente patógenos mayores), siempre que se tengan en cuenta el diagnóstico bacteriológico, la recurrencia de los diagnósticos y otros factores no infecciosos ligados al aumento del CCS en las cabras.…”
Get full text

Prolonged use of selective immunosuppressants in glacoma drainage surgery: experimental in vivo study by V.N. Germanova, E.V. Karlova, L.T. Volova, N.N. Sarbaeva, I.F. Nefedova, M.V. Radaykina

“…Radaykina²</b> </p> <p> <b>¹Samara State Medical University, Samara, Russian Federation</b> </p> <p> <b>²Eroshevskiy Eye Hospital, Samara, Russian Federation</b> </p> <p> <b>³REAVIZ Medical University, Samara, Russian Federation</b> </p> <p> <i><b>Background</b>: anti-inflammatory and antiproliferative agents are among tools to prevent postoperative scarring. …”
Get full text

La desnutrición infantil en la comunidad wichí y sus representaciones sociales: un abordaje desde la teoría de los campos de Bourdieu by María Paula Costas Czarnescki, Carolina Antonela Curti, Mónica Patricia Millán, Maria Emilce Romero Talló, Andrea Paula Cravero Bruneri

“…Resultados: En el CS se observaron desigualdades en las disposiciones de los agentes sociales de acuerdo con los capitales puestos en juego. …”
Get full text

Second-line treatment patterns and outcomes in advanced HCC after progression on atezolizumab/bevacizumab by Meng Wu, Claudia A.M. Fulgenzi, Antonio D’Alessio, Alessio Cortellini, Ciro Celsa, Giulia F. Manfredi, Bernardo Stefanini, Y. Linda Wu, Yi-Hsiang Huang, Anwaar Saeed, Angelo Pirozzi, Tiziana Pressiani, Lorenza Rimassa, Martin Schoenlein, Kornelius Schulze, Johann von Felden, Yehia Mohamed, Ahmed O. Kaseb, Arndt Vogel, Natascha Roehlen, Marianna Silletta, Naoshi Nishida, Masatoshi Kudo, Caterina Vivaldi, Lorenz Balcar, Bernhard Scheiner, Matthias Pinter, Amit G. Singal, Joshua Glover, Susanna Ulahannan, Fredrich Foerster, Arndt Weinmann, Peter R. Galle, Neehar D. Parikh, Wei-Fan Hsu, Alessandro Parisi, Hong Jae Chon, David J. Pinato, Celina Ang

“…Findings from this study show that patients who continued active treatment had improved post-progression survival compared to those who received best supportive care, and medication regimens incorporating tyrosine kinase inhibitors as well as immunotherapy agents were active. These results can help inform clinicians of possible treatment options for patients who progress after frontline atezolizumab plus bevacizumab while we await maturing data from randomized-controlled trials.…”
Get full text

National monitoring of antibiotic resistance of pathogens causing community-acquired urinary tract infections in Russia: results of the multicenter epidemiological study «DARMIS -2... by Kozlov R.S., Palagin I.S., Ivanchik N.V., Trushin I.V., Dekhnich A.V., Edelstein M.V., Perepanova T.S., Belashova M.A., Nastausheva T.L., Ivanova I.A., Valiullina I.R., Momotova A.A., Shirokova T.M., Kotov S.V., Pul'bere S.A., Petrova L.V., Eremeeva A.V., Popov S.V., Zhukov V.A., Suhorukova M.V., Plugin P.S., Nikitina I.V., Vityazeva V.P., Zlobnaya K.A., Ibishev H.S., Naboka Yu.L., Kuz'min I.V., Petrov S.B., Slesarevskaya M.N., Savicheva A.M., Husnutdinova T.A., Moskvitina E.N., Andronova T.I., Dolzhenko E.V., Sholomova L.A., Burasova E.G., Lupyreva E.G., Malyavin A.I., Sidorova R.K., Mihajlichenko A.O., Kataeva E.I., Shamaeva S.H., Ahremenko Ya.A., Portnyagina U.S., Ershova M.G.

“…The study included 1098 isolates obtained from the urine of children and adults of both sexes of all age groups with acute and exacerbation of recurrent community-acquired UTIs, including pregnant women with asymptomatic bacteriuria. …”
Get full text

Paesaggi della memoria della Grande Guerra (1914-1918) Un cambiamento paradigmatico nella ricerca turistica sull’heritage di guerra by Myriam Jansen-Verbeke, Wanda George

“…L’inclusione nella survey di un numero di questioni aperte concernenti i valori, le esperienze, le memorie di circa 2.400 rispondenti (in 61 paesi), ha prodotto un database enorme, che consente di identificare alcune variabili rilevanti nel processo di turisticizzazione di paesaggi di guerra del passato. …”
Get full text

La Città Metropolitana in Italia: nuovi spazi di dialogo e relazione tra città e montagna by Federica Corrado, Erwin Durbiano

“…I casi significativi analizzati sono: il Piano Strategico per Aosta e la sua montagna a cura della Regione Valle d'Aosta e l'esperienza del Piano Strategico dei Comuni dell'Alto Canavese (Piano Strategico per i Comuni dell'Alto Canavese Alpino, all'interno del Città Metropolitana di Torino).L’analisi ha permesso così l’identificazione di alcune questioni-chiave del rapporto città-montagna: la costruzione di mutual benefit tra città e montagna; la definizione di una visione policentrica del territorio urbano-montano; l’interterritorialità come dispositivo per costruire un’identità metro-montana.…”
Get full text

L’approccio multidisciplinare al trattamento del dolore cronico pediatrico: analisi qualitativa mediante focus group by Aldana Paola Ercolano, Sabrina Galvan, Tessa Louise Marchesan, Alessia Gavioli, Gerardo Papa, Mariarita Todaro, Lidia Berforini D’Aquino, Alessia Zanatta, Andrea Vianello

“…Tuttavia, sono emerse alcune criticità, come il limitato coinvolgimento precoce dei professionisti della riabilitazione e la necessità di un coordinamento migliore tra le diverse figure professionali. …”
Get full text