Effectiveness and safety of metformin in 51 675 patients with type 2 diabetes and different levels of renal function: a cohort study from the Swedish National Diabetes Register by Katarina Eeg-Olofsson, Soffia Gudbjörnsdottir, Ann-Marie Svensson, Björn Eliasson, Linus Schioler, Björn Zethelius, Nils Ekström, Jan Cederholm, Junmei Miao Jonasson

“…Objective To evaluate the effectiveness and safety of metformin use in clinical practice in a large sample of pharmacologically treated patients with type 2 diabetes and different levels of renal function.Design Observational study between July 2004 and December 2010, mean follow-up 3.9 years.Setting Hospital outpatient clinics and primary care in Sweden.Participants 51 675 men and women with type 2 diabetes, registered in the Swedish National Diabetes Register, and on continuous glucose-lowering treatment with oral hypoglycaemic agents (OHAs) or insulin.Main outcome measures Risks of cardiovascular disease (CVD), all-cause mortality and acidosis/serious infection, associated with each treatment regimens, were analysed in all patients and in subgroups with different estimated glomerular filtration rate (eGFR) intervals. …”
Get full text

Similar Clinical and Surgical Outcomes Achieved with Early Compared to Late Anti-TNF Induction in Mild-to-Moderate Ulcerative Colitis: A Retrospective Cohort Study by Christopher Ma, Candace L. Beilman, Vivian W. Huang, Darryl K. Fedorak, Karen Wong, Karen I. Kroeker, Levinus A. Dieleman, Brendan P. Halloran, Richard N. Fedorak

“…Background. Biologic agents targeting tumor necrosis factor alpha are effective in the management of ulcerative colitis (UC), but their use is often postponed until after failure of other treatment modalities. …”
Get full text

Activity of Antiseptics Against <i>Pseudomonas aeruginosa</i> and Its Adaptation Potential by Tomasz M. Karpiński, Marzena Korbecka-Paczkowska, Mark Stasiewicz, Aleksandra E. Mrozikiewicz, Donald Włodkowic, Judyta Cielecka-Piontek

“…Conclusions: Antiseptics like OCT, CHX, and partially PVI can be critical in quick antibacterial action on infected wounds, while agents such as PHMB might be reserved for cases where prolonged contact times are possible. …”
Get full text

MSC-EVs and UCB-EVs promote skin wound healing and spatial transcriptome analysis by Ruonan Li, Haotian Wang, Xiaolong Wang, Yanbin Yang, Kai Zhong, Xuemei Zhang, Heping Li

“…They can be considered promising new agents for promoting skin wound healing.…”
Get full text

Quality of tiger shrimp artificial feed using various dosages of seaweed (Gracilaria gigas) meal as binder by Edison Saade, Siti Aslamyah, Nur Insana Salam

“… The quality of an artificial feed particularly the stability of the feed in the water is highly determined by binding agents. The objective of this study was to determine the optimum dosage of seaweed, Gracilaria gigas meal as binder.  …”
Get full text

Redox-Modulating Capacity and Effect of Ethyl Acetate Roots and Aerial Parts Extracts from <i>Geum urbanum</i> L. on the Phenotype Inhibition of the <i>Pseudomonas aeruginosa</i> Las/RhI Quorum Sensing System by Lyudmila Dimitrova, Milka Mileva, Almira Georgieva, Elina Tzvetanova, Milena Popova, Vassya Bankova, Hristo Najdenski

Subjects: Get full text

Compatibility and antimicrobial activity of silver nanoparticles synthesized using Lycopersicon esculentum peels by Esraa Ali, Samah H. Abu-Hussien, Esraa Hesham, Shimaa Ahmed, Habiba Mostafa, Ahmed Gamal, Salwa M. El-Sayed, Bahaa Hemdan, Ashraf Bakry, Naglaa M. Ebeed, Hesham Elhariry, Ahmed Galal, Basma T. Abd-Elhalim

“…Abstract Nanoparticles have gained worldwide attention as a new alternative to chemical control agents due to their special physiochemical properties. …”
Get full text

Disrupting USP39 deubiquitinase function impairs the survival and migration of multiple myeloma cells through ZEB1 degradation by Jessy Sirera, Saharnaz Sarlak, Manon Teisseire, Alexandrine Carminati, Victoria J. Nicolini, Coline Savy, Patrick Brest, Thierry Juel, Christophe Bontoux, Marcel Deckert, Mickael Ohanna, Sandy Giuliano, Maeva Dufies, Gilles Pages, Frederic Luciano

“…Despite advancements with proteasome inhibitors, immunomodulatory agents, and CD38-targeting antibodies, MM remains largely incurable due to resistant clones and frequent relapses. …”
Get full text

Global insights into MRSA bacteremia: a bibliometric analysis and future outlook by Jia-Yi Lin, Jia-Yi Lin, Jia-Kai Lai, Jia-Kai Lai, Jian-Yi Chen, Jian-Yi Chen, Jia-Yu Cai, Jia-Yu Cai, Zhan-Dong Yang, Zhan-Dong Yang, Liu-Qingqing Yang, Liu-Qingqing Yang, Liu-Qingqing Yang, Ze-Tao Zheng, Ze-Tao Zheng, Xu-Guang Guo, Xu-Guang Guo, Xu-Guang Guo

“…The journal with the most publications is Antimicrobial Agents and Chemotherapy, while the most cited global publication is Vincent JL’s article “Sepsis in European Intensive Care Units: Results of the SOAP Study” published in Critical Care Medicine in 2006. …”
Get full text

Assessment of 3-Cyanobenzoic Acid as a Possible Herbicide Candidate: Effects on Maize Growth and Photosynthesis by Luiz Henryque Escher Grizza, Isabela de Carvalho Contesoto, Ana Paula da Silva Mendonça, Amanda Castro Comar, Ana Paula Boromelo, Ana Paula Ferro, Rodrigo Polimeni Constantin, Wanderley Dantas dos Santos, Rogério Marchiosi, Osvaldo Ferrarese-Filho

“…As a result, the identification of novel herbicidal agents with low toxicity targeting C4 plants becomes imperative. …”
Get full text

Quels usages de la bibliotheque au Maroc  by Anouk Cohen

“…Un patrimoine, nous le verrons, davantage véhiculé par l’esthétique propre aux ouvrages qui le portent que par leur contenu. A cette fonction esthétique de la bibliothèque s’ajoute un rôle distinctif, chaque individu en effet, au travers de sa bibliothèque racontant son histoire relative à une mémoire singulière.…”
Get full text

Protocol for the DisCoVeRy trial: multicentre, adaptive, randomised trial of the safety and efficacy of treatments for COVID-19 in hospitalised adults by Florence Ader, Jean-François Timsit, Yazdan Yazdanpanah, François-Xavier Lescure, Laetitia Moinot, Christelle Delmas, Hélène Espérou, Laurent Abel, Benjamin Leveau, Vinca Icard, Toni Alfaiate, Linda Wittkop, Charles Burdet, France Mentré, Marion Schneider, Nathan Peiffer-Smadja, Julien Poissy, Lila Bouadma, Bruno Lina, Florence Morfin-Sherpa, Maude Bouscambert, Alexandre Gaymard, Gilles Peytavin, Jeremie Guedj, Claire Andrejak, Cedric Laouenan, Drifa Belhadi, Axelle Dupont, Basma Basli, Anissa Chair, Samira Laribi, Julie Level, Marie-Capucine Tellier, Aline Dechanet, Dominique Costagliola, Sandrine Couffin-Cadiergues, Juliette Saillard, Claire Fougerou, Carole Cagnot, Soizic Le Mestre, Delphine Lebrasseur-Longuet, Ventzislava Petrov-Sanchez, Alpha Diallo, NoéMie Mercier, Sarah Tubiana, Benjamin Hamze, Ambre Gelley, Marion Noret, Eric D’Ortenzio, Oriane Puechal, Caroline Semaille

“…The objective of the trial is to evaluate the clinical efficacy and safety of different investigational re-purposed therapeutics relative to Standard of Care (SoC) in patients hospitalised with COVID-19.Methods and analysis DisCoVeRy is a phase III, open-label, adaptive, controlled, multicentre clinical trial in which hospitalised patients with COVID-19 in need of oxygen therapy are randomised between five arms: (1) a control group managed with SoC and four therapeutic arms with re-purposed antiviral agents: (2) remdesivir + SoC, (3) lopinavir/ritonavir + SoC, (4) lopinavir/ritonavir associated with interferon (IFN)-β−1a + SoC and (5) hydroxychloroquine + SoC. …”
Get full text

Development of a latency model for HIV-1 subtype C and the impact of long terminal repeat element genetic variation on latency reversal by Shreyal Maikoo, Robert-Jan Palstra, Krista L. Dong, Tokameh Mahmoudi, Thumbi Ndung'u, Paradise Madlala

“…By enriching for latently infected cells, and treating them with different latency reversing agents, we developed an HIV-1C latency model that demonstrated that the HIV-1C consensus LTR has lower reactivation potential compared to its HIV-1B counterpart. …”
Get full text

Prophylactic phage administration provides a time window for delayed treatment of vancomycin-resistant Enterococcus faecalis in a murine bacteremia model by Wei-Xiao Wang, Jiao-Yang Yu, Xiu-Zhen Chen, Xiu-Zhen Chen, Shi-Yong Fu, Hui Li, Peng-Cheng Yi, Yun-Yao Ren, Shuang-Lin Gu, Jing-Han Gao, Jing Fan, Yan-Mei Sun, Jie Feng, Shi-Wei Wang, Wei Chen, Wei Chen

“…Its in vitro bactericidal and antibiofilm activities were evaluated, along with its synergy with antimicrobial agents. In vitro safety and protective efficacy were assessed using a mouse bacteremia model. …”
Get full text

Comprehensive analysis of metabolomics and transcriptomics reveals varied tepal pigmentation across Gloriosa varieties by Yue Sun, Pinli Hu, Yanan Jiang, Zhenzhen Wang, Jiaxing Chang, Yiwei Zhou, Haojing Shao

“…Anthocyanins serve as the principal coloring agents in the orange, red and purple tepals of Gloriosa. …”
Get full text

PrEP15-19 Choices: an implementation study protocol of HIV prevention with oral and long-acting injectable cabotegravir PrEP in real-world settings among sexual and gender minority... by Inês Dourado, Eliana Miura Zucchi, Laio Magno, Alexandre D Grangeiro, Márcia Thereza Couto, Mateus Westin, Eduardo Oliveira, Maria Mercedes Escuder, Dirceu Greco, Thais Regis Aranha Rossi, Fabiane Soares, Lorenza Dezanet, Paula Massa, Priscilla Caires, Ricardo de Paula Vasconcelos, Unaí Tupinambas, Beo Leite, Joilson Nascimento Paim, Guilherme Barreto Campos, Lucas Miranda Marques, Nathalia Suzart, Suilan Pedreira, DulceAurélia deSouza Ferraz, Dyemison Pinheiro, Eliane Sala, Raphaella Goulart, Ana Paula Silva, Erica Dumont Pena, Gabriella Jomara daSilva, Marília Greco, Matheus dePaula Alves

“…Safe and effective long-acting agents for pre-exposure prophylaxis (PrEP) for HIV infection are needed to increase preventive options among sexual and gender minority adolescents.Methods and analysis This is a multisite, prospective implementation study of three PrEP modalities (LAI-PrEP, event-driven (ED) and daily oral), using a mixed-method design with quantitative and qualitative approaches. …”
Get full text

Diagnostic Accuracy of Detective Flow Imaging Endoscopic Ultrasonography for Evaluating Blood Flow Within Mural Nodules of Intraductal Papillary Mucinous Neoplasms by Kazuki Endo, Haruo Miwa, Kazuya Sugimori, Kozue Shibasaki, Shoichiro Yonei, Yugo Ishino, Shotaro Tsunoda, Hayato Yoshimura, Akihiro Funaoka, Hiromi Tsuchiya, Ritsuko Oishi, Yuichi Suzuki, Satoshi Komiyama, Takashi Kaneko, Manabu Morimoto, Kazushi Numata, Shin Maeda

“…<b>Background/Objectives:</b> Detective flow imaging (DFI) endoscopic ultrasonography (EUS) can identify the microvascular flow imaging of a mural nodule (MN) in an intraductal papillary mucinous neoplasm (IPMN) without the use of contrast agents. This retrospective study evaluated the diagnostic accuracy of DFI-EUS and its ability to evaluate the blood flow of MNs in IPMNs. …”
Get full text

New Information and Communication Technologies for climate services: Evidence from farmers in Ada East District, Ghana by Rebecca Sarku, Famous Addi, Emmanuel M.N.A.N. Attoh

“…Building farmers’ digital literacy is crucial for maximising the benefits of ICT-based CIS.Agricultural extension services can modernise their practices by integrating new ICT-based CIS into their outreach programs. Extension agents can use mobile apps, social media, and other digital platforms to disseminate weather information, offer real-time advice, and engage with farmers more effectively. …”
Get full text

Caracterización genética de aislamientos de SARS-CoV-2 en las diferentes etapas pandémicas de COVID-19 en Cuba by Liuber Yans Machado Zaldívar, Enrique Noa Romero, Laura Sofía López Rizo, Madeline Blanco de Armas, Nibaldo Luis González Sosa, Juliet Enríquez Puertas, Dania Romay Franchi, María Teresa Pérez Guevara, Danay Carrillo Valdés, Marta Dubed Echevarría, Otto Cruz Sui, Mireida Rodríguez Acosta

“…Posibilita evaluar in vitro e in vivo los candidatos vacunales y agentes terapéuticos desarrollados por la industria biofarmacéutica cubana.…”
Get full text

Caractérisation de l’habitat des bonobos dans la province de Bolobo : premiers résultats de l’analyse de la structure de la forêt by Flora Pennec, Victor Narat, Sarah Bortolamiol, Sabrina Krief

“…Cependant, des paramètres qualitatifs doivent être ajoutés pour améliorer la distinction de classes d'habitats comme les forêts marécageuses et les forêts mixtes matures, qui sont confondues par leurs paramètres quantitatifs. …”
Get full text