Design, synthesis, SAR and ADMET analyses of the novel class of synthetic 7-amino[1,2,5]oxadiazolo[3,4-b]pyridine-6-carboxylate derivatives with vasorelaxant activity by Anatolii Varenyk, Roman Vydzhak, Svitlana Panchishin, Irina Ivanova, Victor Zhirnov, Volodymyr Brovarets

“…The results obtained highlight the considerable potential for further development of this class of compounds as vasoactive agents.…”
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Problems and possibilities of studying malting quality in barley using molecular genetic approaches by N. V. Trubacheeva, L. A. Pershina

“…About one-third of the world’s barley crop is used for malt production to meet the needs of the brewing industry. …”
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Metabolomic approach to search for fungal resistant forms of <i>Aegilops tauschii</i> Coss. from the VIR collection by T. V. Shelenga, L. L. Malyshev, Yu. A. Kerv, T. V. Diubenko, A. V. Konarev, V. I. Horeva, M. K. Belousova, M. A. Kolesova, N. N. Chikida

“…For instance, genes that determine resistance to rust agents in common wheat were successfully introgressed from Ae. tauschii into the genome of T. aestivum L. …”
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Advances in Cell and Immune Therapies for Melanoma by Tanase Timis, Sanda Buruiana, Delia Dima, Madalina Nistor, Ximena Maria Muresan, Diana Cenariu, Adrian-Bogdan Tigu, Ciprian Tomuleasa

“…The incidence rate of cutaneous melanoma is on the rise worldwide, due to increased exposure to UV radiation, aging populations, and exposure to teratogen agents. However, diagnosis is more precise, and the increased number of new cases is related to the improved diagnosis tools. …”
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NIR-triggered programmable nanomotor with H2S and NO generation for cascading oncotherapy by three-pronged reinforcing ICD by Jinlong Zhang, Quan Jing, Longlong Yuan, Xianhui Zhou, Duolong Di, Jinyao Li, Dong Pei, Zhongxiong Fan, Jun Hai

“…Gas therapy (GT) and/or phototherapy have been recently employed as immunogenic cell death (ICD) agents for activating immunotherapy, whereas the effective activation of sufficient immune responses remains an enormous challenge in such single therapeutic modality. …”
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Real-world clinical evidence of oral semaglutide on metabolic abnormalities in subjects with type 2 diabetes: a multicenter retrospective observational study (the Sapporo-Oral SEMA... by Sho Furusawa, Hiroshi Nomoto, Chiho Oba-Yamamoto, Jun Takeuchi, Miki Ito, Hiroyoshi Kurihara, Shin Aoki, Aika Miya, Hiraku Kameda, Akinobu Nakamura, Tatsuya Atsumi

“…Efficacy was also confirmed in the subgroup switched from other anti-hyperglycemic agents, including dipeptidyl peptidase-4 inhibitors. …”
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Incidence and risk of endocrine and metabolic abnormalities linked to PARP inhibitors in solid tumors: a meta-analysis by Shunlian Fu, Pingjin Zou, Zengyi Fang, Xinxiang Zhou, Junyang Chen, Cuicui Gong, Li Quan, Bing Lin, Qiu Chen, Jinyi Lang, Meihua Chen

“…Abstract Background Poly (ADP-ribose) polymerase inhibitors (PARPi) serve as crucial therapeutic agents in solid tumor treatment. Preclinical investigations suggest a potential protective function of PARPi against endocrine and metabolic impairments. …”
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Nina Façon şi tentaţia omului activ by Ana Bazac

“…Dopo un’introduzione sull’importanza della filosofia nell’opera di Nina Façon, in seguito a una breve analisi del concetto di attività – con insistenza sui suoi legami con la nozione di soggetto e con il motivo di Prometeo come modello culturale – la relazione ricorda alcune caratteristiche dell’uomo attivo, così come ritrovate negli studi di Nina Façon. …”
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Cortina d’Ampezzo 1956 tra organizzazione sportiva e relazioni internazionali by Gherardo Bonini, Franco Cervellati, Marcello Marchioni

“…Oltre alla possibile problematicità legata al funzionamento degli impianti e alla gestione dei Giochi, il Comitato organizzatore si confrontò con alcune controversie sul piano delle relazioni internazionali. …”
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Insights into the mechanisms of serplulimab: a distinctive anti-PD-1 monoclonal antibody, in combination with a TIGIT or LAG3 inhibitor in preclinical tumor immunotherapy studies by Yizhou Zhang, Ruicheng Wei, Ge Song, Xinyi Yang, Mengli Zhang, Wei Liu, Aiying Xiong, Xuehan Zhang, Qianhao Li, Wan-Jen Yang, Chencheng Han, Rui Liu, Chen Hu, Qingyu Wang, Jun Zhu, Yongqiang Shan

“…With more than 20 anti-PD-1/PD-L1 antibodies currently marketed, anti-PD-1 therapy has become a cornerstone of tumor immunotherapy. These agents, however, exhibit notable disparities in their characteristics and clinical performance. …”
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The Influence of Ficus deltoidea in Preserving Alveolar Bone in Ovariectomized Rats by N. I. Omar, B. Baharin, S. F. Lau, N. Ibrahim, N. Mohd, A. Ahmad Fauzi, N. Muhammad, N. M. Fernandez

“…Treatment of the rats commenced two weeks after ovariectomy—the OVXP rats that served as positive control received Premarin® (64.5 μg/kg body weight), while OVXF rats were given F. deltoidea (800 mg/kg body weight); both agents were administered orally for two months. The negative control group of rats (OVXN) and the SO group received deionized water, also administered via oral gavage. …”
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Rappresentazioni contemporanee per il progetto di paesaggio by Sara Colaceci

“… Questo saggio affronta le tematiche inerenti alla rappresentazione contemporanea per il progetto di paesaggio tramite alcune esperienze significative sviluppate dagli anni ’90 del XX secolo ad oggi, nati dalla collaborazione di architetti, di paesaggisti, di artisti tra i quali Yves Brunier, Enric Miralles, Inside Outside (studio fondato da Petra Blaisse), Mark Smout, Laura Allen, Teresa Moller Landscape Studio (studio fondato da Teresa Moller), Openfabric (studio fondato da Francesco Garofalo), 08014 arquitectura (studio fondato da Adrià Guardiet e Sandra Torres), Mir (studio fondato da Mats Andersen e Trond Greve Andersen). …”
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Diagnostics and treatment of pancreatic exocrine insufficiency: clinical guidelines of the Russian gastroenterological association by V. T. Ivashkin, I. V. Mayev, A. V. Okhlobystin, S. A. Alekseyenko, Ye. V. Beloborodova, Yu. A. Kucheryavy, T. L. Lapina, A. S. Trukhmanov, I. B. Khlynov, M. V. Chikunova, A. A. Sheptulin, O. S. Shifrin

“…Digestive enzymes should be taken at the beginning of the meal, in the case of incomplete response it can be recommended to use antisecretory agents. Patient should be consulted by nutritionist, no significant limitation of fat intake is recommended. …”
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Nationwide observational study of incidence, management and outcome of spontaneous coronary artery dissection: a report from the Swedish Coronary Angiography and Angioplasty regist... by Per Tornvall, Eva Swahn, Dimitrios Venetsanos, Troels Yndigegn, Sofia Sederholm Lawesson, Lena Jonasson, Nina Johnston, Henrik Wilander, Christos Pagonis, Christian Dworeck, Thomas Kellerth

“…The use of antithrombotic agents was similar between the groups and there was no difference regarding outcomes, 10.9% vs 13.4%, p=0.75. …”
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Actividad de recubrimientos de quitosano, nanopartículas de quitosano y ZnO contra hongos aislados e identificados molecularmente de frutas con potencial de exportación en la zona... by Gerardo Juan Francisco Cruz, Rosa Liliana Solís-Castro, John Rimaycuna, José Luis Solís, Mónica Marcela Gómez, Rubén Alfaro

“…Los recubrimientos en base a quitosano y NPs de quitosano y ZnO tienen un potencial de uso como agente antifúngico en frutas de exportación.…”
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Venetoclax-based salvage therapy as a bridge to transplant is feasible and effective in patients with relapsed/refractory AML by Julia M. Unglaub, Richard F. Schlenk, Jan Moritz Middeke, Stefan W. Krause, Sabrina Kraus, Hermann Einsele, Michael Kramer, Sven Zukunft, Joseph Kauer, Simon Renders, Elena Katelari, Christoph Schliemann, Caroline Pabst, Thomas Luft, Peter Dreger, Christoph Röllig, Martin Bornhäuser, Carsten Müller-Tidow, Tim Sauer

“…Abstract: The B-cell lymphoma 2 inhibitor venetoclax (VEN) in combination with hypomethylating agents has been approved for first-line treatment of patients with acute myeloid leukemia (AML) ineligible for intensive treatment. …”
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Relevance of plant growth-promoting bacteria in reducing the severity of tomato wilt caused by Fusarium oxysporum f. sp. lycopersici by altering metabolites and related genes by Waquar Akhter Ansari, Ram Krishna, Sarvesh Pratap Kashyap, Khalid Mashay Al-Anazi, Mohammad Abul Farah, Durgesh Kumar Jaiswal, Akhilesh Yadav, Mohammad Tarique Zeyad, Jay Prakash Verma

“…This study’s results reveal that PGPB strains can be utilized as biocontrol agents (BCAs) to enhance tomato resistance against Fusarium wilt.…”
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Syntheses, structures and anticancer activities of CuII and ZnII complexes containing 1,1′-[(3-fluorophenyl)methylene]bis[3-(3-fluorophenyl)imidazo[1,5-a]pyridine] by Hai Le Thi Hong, Hau Nguyen Van, Duong Hoang Tuan, Hung Tran Quang, Tuan Dang Thanh, Luc Van Meervelt

“…The results suggest that CuII and ZnII complexes of T4 show potential as cancer treatment agents.…”
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Exploring the role of ELOVLs family in lung adenocarcinoma based on bioinformatic analysis and experimental validation by Zihan Wang, Wenjing Cui, Long Liang, Jingge Qu, Yuqiang Pei, Danyang Li, Ying Luo, Yue Zhang, Yifan Qiu, Yongchang Sun

“…Meanwhile, patients with low-ELOVL6 expression were more sensitive to the 4 representative chemotherapeutic agents. In vitro, we revealed that interfering with ELOVL6 could influence the viability, proliferation, migration capacity and fatty acid metabolism of LUAD cells (A549 and H1299). …”
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Targeting of the HER2/HER3 signaling axis overcomes ligand‐mediated resistance to trastuzumab in HER2‐positive breast cancer by Satomi Watanabe, Kimio Yonesaka, Junko Tanizaki, Yoshikane Nonagase, Naoki Takegawa, Koji Haratani, Hisato Kawakami, Hidetoshi Hayashi, Masayuki Takeda, Junji Tsurutani, Kazuhiko Nakagawa

“…The effects of these agents were then evaluated in vivo using BT474‐HRG and an intrinsic heregulin‐expressing and HER2‐positive JIMT‐1 xenograft models. …”
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