The development and evaluation of a tublysine-based antibody-drug conjugate with enhanced tumor therapeutic efficacy by Huihui Guo, Hongsheng Xie, Yuanyuan Huang, Junxiang Jia, Xiangfei Kong, Qingliang Yang, Shun Gai, Wenjun Li, Lu Bai, Lingli Zhang, Xiaoxiao Chen, Zhicang Ye, Hangbo Ye, Linyao Zhao, Yifang Xu, Yong Du, Xiuzhen Zhang, Miaomiao Chen, Xiaomai Zhou, Robert Y. Zhao

“…Antibody-drug conjugates (ADCs) offer targeted cancer therapy by delivering cytotoxic agents directly to tumor cells. However, challenges such as relapse, resistance, and diverse patient needs drive ongoing innovation in ADC development. …”
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Angiotensin Inhibition Reduces the Risk of Subarachnoid Hemorrhage in Patients With Hypertension by Mohammad Hossein Abbasi, Colleen M. Brensinger, Emily K. Acton, Christopher G. Favilla, Jan‐Karl Burkhardt, Scott E. Kasner

“…Conclusion Treatment of hypertension with ACEI/ARBs was associated with a lower risk of SAH than other types of antihypertensive agents, particularly with longer courses of therapy.…”
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Identification and expression analysis of P-type ATPase IIIA subfamily in Puccinia Striiformis f. sp. tritici by Yingjie Sun, Hong Tao, Hong Han, Yiping Zou, Yingyu Xue, Shiwen Chen, Fei Tao

“…This study not only identifies a target and direction for the development of new, efficient, and environmentally friendly control agents for wheat stripe rust but also establishes a foundation for analyzing its pathogenic mechanisms.…”
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Analysis of drug release models from biodegradable nanomodified chitosan based materials by М. О. Кумеда, Л. Б. Суходуб, Л. Ф. Суходуб

“…Selected C60 nanoparticles are widely used as antibacterial agents and can strengthen the structure of composites. …”
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Comparison of the somatic growth of juvenile sea urchin Paracentrotus lividus (Lamarck, 1816) fed with experimental and commercial pre-growth diets by Noelia Tourón Besada, Estefanía Paredes, Damián Costas

“…Las dietas experimentales se prepararon con harina de atún (HA) o de insectos (HI), utilizando gelatina de cerdo (HA-G, 31,3% proteína; HI-G, 31,6%) o Agar (HA-A, 21,8%; HI-A, 21,6%) como agente gelificante; las dietas comerciales tuvieron H 21,8% de proteína, N 20,95% y la macroalga 8,2%. …”
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Poly-ADP ribose polymerase (PARP) inhibitor regimens for platinum-sensitive ovarian cancer in randomized, double-blind, phase III controlled trials: protocol for a systematic revie... by Xiaolian Peng, Jie Liu

“…However, there is insufficient comprehensive evidence regarding the comparison of different agents. To evaluate and compare the efficacy and side effects of various PARP inhibitors.MethodsWe plan to conduct a network meta-analysis that includes randomized, double-blind, controlled phase III trials of Niraparib, Rucaparib, Olaparib, or Veliparib in patients with Platinum-sensitive ovarian cancer. …”
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Treatment of a mutant KRAS lung cancer cell line with polyisoprenylated cysteinyl amide inhibitors activates the MAPK pathway, inhibits cell migration and induces apoptosis. by Matthew D Gregory, Kweku Ofosu-Asante, Jassy Mary S Lazarte, Pablo E Puente, Nada Tawfeeq, Nadine Belony, Yong Huang, Ite A Offringa, Nazarius S Lamango

“…Polyisoprenylated Cysteinyl amide Inhibitors (PCAIs) constitute a group of potential cancer therapy agents that we designed to specifically disrupt and suppress hyperactive G-protein signaling, such as that caused by mutated RAS proteins. …”
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Cuidado de enfermería en paciente posoperatorio de revascularización miocárdica en la unidad de cuidados intensivos: estudio de caso by Ángela Patricia Dávila Gamboa, Julieth Ximena Guerrero Córdoba, Norma Viviana Moreno Montenegro, Claudia Amanda Chaves

“… El infarto agudo de miocardio es considerado una de las primeras causas de mortalidad a nivel regional, nacional y mundial; los factores de riesgo se convierten en el agente causal de esta patología. Por ello, cuando un paciente enferma, requiere de un tratamiento quirúrgico, como la revascularización miocárdica, donde la atención y manejo se hace en la unidad de cuidados intensivos (UCI), con el fin de garantizar su supervivencia. …”
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The Role of SGLT2 Inhibitors in Heart Failure: A Systematic Review and Meta-Analysis by Vasiliki Tsampasian, Ranu Baral, Rahul Chattopadhyay, Maciej Debski, Shruti S Joshi, Johannes Reinhold, Marc R Dweck, Pankaj Garg, Vassilios S Vassiliou

“…This systematic review and meta-analysis aim to provide a concise evaluation of all the available evidence for the use of these agents in patients with heart failure (HF) regardless of their baseline diabetes status. …”
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EVALUACIÓN DEL EMPLEO DE POLVO DE HOJAS SECAS DE MORINGA EN UN SAZONADOR by Belkis Julia Fonseca Medina, Caridad Curbelo Hernández

“…Conclusiones: Es posible realizar la sustitución total del COADTEC por PHSM en el sazonador marca ԵoQue sin que se afecte la calidad sensorial establecida en las especificaciones de la norma cubana para condimentos, con beneficio económico y sustitución de importación.…”
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Assessing the Efficacy of Broad-Spectrum Antibiotics in Controlling Bacterial Contamination in the In Vitro Micropropagation of Ginger (Zingiber officinale Rosc) by Selam Tewelde, Subban Patharajan, Zenebe Teka, Desta Berhe Sbhatu

“…Hence, this article reports the finding of a study that aimed at testing the (a) effectiveness of three sterilization agents, namely, 0.25% w/v RBK (composed of ridomile, bayleton, and kocide at 1 : 1 : 1 ratio), 0.50% v/v NaOCl, and 70% v/v ethanol at three different treatment times in combination with 0.25% HgCl2; (b) efficacy of four broad-spectrum antibiotics and their combinations in controlling bacterial contaminants of ginger shoot tip explants and in vitro micropropagation media; and (c) effects of the antibiotics on the shooting performances of the explants of the cultivar. …”
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Impedance mapping with high-density microelectrode array chips reveals dynamic heterogeneity of in vitro epithelial barriers by Alessandra Venz, Bastien Duckert, Liesbet Lagae, Saeedeh Ebrahimi Takalloo, Dries Braeken

“…This method could thus, in principle, enable detection of tissue barrier disrupting and modifying agents with higher specificity. Epithelial barrier function assays benefit from using HD-MEA impedance sensors due to their increased informativity and resolution, which will be of great value in future organ-on-chip platforms.…”
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Antifungal, toxicological, and colorimetric properties of Origanum vulgare, Moringa oleifera, and Cinnamomum verum essential oils mixture against Egyptian Prince Yusuf Palace deter... by Asmaa Alhussein Mohamed, Mahgoub A. Ahmed, Abdallah S. Korayem, Samah H. Abu-Hussien, Wael Bakry Rashidy

“…Abstract The increasing demand for sustainable alternatives to conventional antifungal agents has prompted extensive research into the antifungal properties of plant essential oils (EOs). …”
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lncRNA-KCNQ1OT1: A Potential Target in Exosomes Derived from Adipose-Derived Stem Cells for the Treatment of Osteoporosis by Shan-zheng Wang, Jun Jia, Chang-hong Chen

“…KCNQ1OT1-Exos have a more significant inhibitory effect compared to ADSCs-Exos by the function of sponging miR-141-5p, suggesting that KCNQ1OT1-Exos can be promising agents in osteoporosis treatment.…”
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Factors affecting arteriovenous access patency after percutaneous transluminal angioplasty in chronic haemodialysis patients under vascular access monitoring and surveillance: a si... by Chung-Kuan Wu, Der-Cherng Tarng, Chia-Hsun Lin, Jyh-Gang Leu, Chih-Yu Yang

“…Among patients with PTA, those with acute myocardial infarction, high ferritin level or arteriovenous graft (AVG) had a significantly higher risk of reintervention post-PTA (p<0.05). …”
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¿Qué necesitan los centros y las familias para poder forjar una alianza? La perspectiva del profesorado de Educación Infantil y Primaria by Esperanza-María Ceballos-Vacas, Diego Hervella-Fariñas, Beatriz Rodríguez-Ruiz

“…Respecto a los centros, en primer lugar, el profesorado alude a la necesidad de una normativa para regular la relación centro escolar-familia, si bien la circunscribe a las obligaciones de las familias, incluso con consecuencias punitivas. …”
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Tormenta de Polvo: reflexiones de un día de campo en la Patagonia by Javier Grosso

“…El agua que ocupaba la zona, ahora desierta, impidió el crecimiento de vegetales que actúan como sostén del suelo, actuando ella misma como agente retensivo al otorgar peso a las partículas. …”
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Traducción y validez de la Escala de creencias sobre el uso de mascarillas para prevenir el contagio de la COVID-19 by Henry Santa-Cruz-Espinoza, Natalia Mavila Guzmán Rodríguez, Patricia Ibeth Tirado Bocanegra, Jessica Esther Mendo Zelada, Geraldine Vanessa Morales Domínguez

“…El modelo fue verificado y obtuvo índices de ajuste aceptables (χ² = 154 gl = 46; p < 0,01; CFI = 0,96; TLI = 0,942; RMSEA = 0,602). …”
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Descripción de la asociación entre la periodontitis y la COVID-19 by Elizabeth Gregorio Duliep, Yamirka de la Caridad Rodríguez Guerra, Grisel Díaz Montalvo, Esperanza Zoe González Rodríguez

“…En su patogenia pueden participar los virus; agentes infecciosos únicos en biología, entre ellos el SARS-CoV-2 causante de la COVID-19. …”
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Elevated POSTN expression predicts poor prognosis and is associated with radioresistance in cervical cancer patients treated with radical radiotherapy by Cui-qin Huang, Wen-tao Xiao, Xiang-rong Yao, Zhi-min Li, Jun-yan He

“…Drug sensitivity analysis suggested that high POSTN expression may be linked to resistance to multiple chemotherapeutic agents. Furthermore, weighted correlation network analysis (WGCNA) and gene set enrichment analysis (GSEA) identified EMT as a top enriched pathway in patients with high POSTN expression, suggesting it may play a critical role in radiotherapy resistance. …”
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