Lopinavir and Ritonavir have High Affinity Toward the SARS-CoV-2 S-protein Receptor-binding Domain Sequenced in Brazil by Aline Diogo Marinho, Helyson Lucas Bezerra Braz, João Alison de Moraes Silveira, Danilo Galvão Rocha, Roberta Jeane Bezerra Jorge, Geanne Matos de Andrade

“…Lopinavir exhibited a binding affinity of −9.8 kcal/mol, forming interactions with residues PHE168, GLY167, SER176, GLN175, GLU166, LEU134, LEU137, TYR171, PHE138, LEU174, and PHE172. …”
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Genomic characterization and molecular predictive biomarkers for chemotherapy in patients with metastatic triple-negative breast cancer treated in a real-world setting by Erik Olsson, Henrik Lindman, Evangelos Digkas, Viktoria Thurfjell, Haidar Mir Ali, Ute Krüger, Anna-Karin Wennstig, Marie Sundqvist, Antonios Valachis

“…Altered genes and pathways were correlated with overall survival (OS) and evaluated regarding their association with real-world progression-free survival (rwPFS) in patients treated with different chemotherapy agents. Occurrence of alterations were compared between patients with exceptional response and rapid progression to chemotherapy. …”
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Ethanol Extracts of Solanum lyratum Thunb Regulate Ovarian Cancer Cell Proliferation, Apoptosis, and Epithelial-to-Mesenchymal Transition (EMT) via the ROS-Mediated p53 Pathway by Chen Zhang, Zheming Li, Jie Wang, Xuelu Jiang, Mengting Xia, Jianfen Wang, Shenyi Lu, Shouye Li, Hanmei Wang

“…In summary, this study illustrated the anticancer effects of SLT on ovarian cancer cells, suggesting that SLT may have the potential to provide basic evidence for the discovery of antiovarian cancer agents.…”
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Haploidentical hematopoietic stem cell transplantation using post-transplant cyclophosphamide in patients with inborn errors of immunity: Experience in a reference center in Colomb... by Diego Medina, Jhonier Orlando Castro, David Esteban Castro, Estefanía Beltrán, Eliana Manzi, Alexis Antonio Franco, Manuela Olaya

“…Twelve out of sixteen patients developed acute graft-versus-host disease. Out of these, 3 corresponded to grades III-IV. …”
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Behavior of soil aggregates in reclaimed farmland with different restoration durations: Mediating factors and mechanisms by Zhaoxinyu Liu, Junying Li, Lina Gao, Xinju Li, Wen Song, Luofan Li, Yulong Zang, Gengdi Zhang

“…In the early stages of reclamation, inorganic cementing agents were crucial for maintaining RMS aggregation and SOC sequestration. …”
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Prognostic factors of thalamic and thalamopeduncular low-grade gliomas in children: A systematic review and recommendations for surgical management by Jana Táborská, Adéla Bubeníková, Petr Skalický, Jakub Táborský, David Horváth, Michal Zápotocký, Ondřej Bradáč, Vladimír Beneš, 3rd

“…Given the excellent long-term outlook of these patients, the extent of resection should not be pursued at the risk of neurological function since additional therapeutic possibilities are available today, such as molecular-targeted agents.…”
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Crise du sport scolaire et universitaire au Sénégal : des conflits personnels et institutionnels aux carences financières, infrastructurelles et organisationnelles by Mouhamed Dit Momar Talla NDONGO, Danty Patrick DIOMPY, Souleymane DIALLO

“…A cela s’ajoutent une insuffisance des ressources allouées à la base et des carences infrastructurelles et organisationnelles. …”
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Discovery of mutated oncodriver genes associated with glioblastoma originated from stem cells of subventricular zone through whole exome sequence profile analysis, and drug repurpo... by Arnob Sarker, Burhan Uddin, Reaz Ahmmed, Sabkat Mahmud, Alvira Ajadee, Md. Al Amin Pappu, Md. Abdul Aziz, Md. Nurul Haque Mollah

“…Finally, overexpressed oncodriver genes guided top-ranked six drug agents (Irinotecan, Imatinib, etoposide, pazopanib, trametinib and cabozanitinib) were recommended against GBM through molecular docking study. …”
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A systematic review on gut microbiota in type 2 diabetes mellitus by Serena Chong, Serena Chong, Mike Lin, Mike Lin, Deborah Chong, Slade Jensen, Slade Jensen, Slade Jensen, Namson S. Lau, Namson S. Lau, Namson S. Lau

“…Aims/hypothesisThe gut microbiota play crucial roles in the digestion and degradation of nutrients, synthesis of biological agents, development of the immune system, and maintenance of gastrointestinal integrity. …”
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Consequences of Surface Composition and Aggregation Conditions of Ag Nanoparticles on Surface-Enhanced Raman Scattering (SERS) of Pesticides by Marcelo José dos Santos Oliveira, Gilia Cristine Marques Ruiz, Rafael Jesus Gonçalves Rubira, Santiago Sanchez-Cortes, Carlos José Leopoldo Constantino, Leonardo Negri Furini

“…This highlights the specific nuances in detection depending on the method of Ag synthesis and the nature of the aggregating agents used.…”
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Antimicrobial and anti-quorum sensing activities of giant fennel (ferula elaeochytris korovin) from the hatay region by Enis Fuat Tüfekci, Anfal Alkateeb, Sarah Akar, Orhan Çorum, Yasemin Çelik Altunoğlu, Mehmet Cengiz Baloğlu, Muammer Kiraz, Nilay Çöplü

“…<p> <b>Conclusion:</b> This study shows that the root extract of F. elaeochytris Korovin may be a good candidate to develop antistaphylococcal and anti-QS agents.…”
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Experimental Study on Impermeability Law of Aquiclude Reconstructed by Mudstone of External Dump in Arid Zone by Li Ma, Chendong Liu, Yinli Bi, Suping Peng, Kaisheng Jiang, Hui Zhang, Qiang Luo, Fei Xue, Tianxin Xu, Tianxiang Li, Jing Wu, Jiahao Tian, Dongxu Zhang

“…XRD diffraction experiments are used to determine the composition of red mudstone including kaolinite mineral, quartz, potash feldspar, albite, and illite. The moisture content of the red mudstone is 4.16% as measured by the indoor drying experiment. …”
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Very first real-world data on zongertinib use in non-small cell lung cancer patients with HER2 mutations: A brief report by Oliver Illini, Anna Sophie Lang-Stöberl, Hannah Fabikan, Christoph Weinlinger, Arschang Valipour, Maximilian J. Hochmair

“…Introduction: Treatment options for HER2-mutant patients with non-small cell lung cancer (NSCLC) are limited. New agents, including zongertinib, a HER2-selective tyrosine kinase inhibitor (TKI), are being investigated in clinical trials. …”
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Toxicological effects of the environmental pollutant perfluoronanoic acid on the ground-dwelling arthropod Solenopsis invicta by Wenxuan Wang, Mingrong Liang, Yangting Ou, Xiangrui Wang, Yunbo Song, Huimei Chen, Jingxin Hong, Yuling Liang, Yongyue Lu

“…Perfluorononanoic acid (PFNA), widely employed in surfactants, coatings, plastics, corrosion inhibitors, and fire-extinguishing agents, is less regulated than PFOS or PFOA but displays higher bioaccumulation and potential toxicity. …”
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Assisted Egg White Biogenic Synthesis for Elaboration of ZnO Nanoparticles by Elena Andreea Vijan, Ecaterina Magdalena Modan, Sorin Georgian Moga, Denis Aurelian Negrea, Adriana-Gabriela Schiopu, Mihai Oproescu, Daniela Istrate

“…Additionally, the proteins in egg white act as capping agents, stabilizing the nanoparticles and preventing their aggregation. …”
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Alcance das intervenções em atividade física na saúde pública de Santa Catarina by Felipe Fank, Daniel Rogério Petreça, Fabio Araujo Almeida, Giovana Zarpellon Mazo

“…Das IAF, 56,3% atendem menos de 100 usuários, com maior participação do público adulto e idoso. Destaca-se o agente comunitário de saúde como a estratégia de recrutamento dos participantes para as IAF (95,3%) e “ter indicação ou autorização do médico” como critério para participação (79,2%). …”
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The role of adipose tissue cell elements in the regulation of the nitroxidergic system and possible ways of pharmacological modulation by I. F. Bielenichev, S. O. Maslennikov, N. V. Dobrelia, O. S. Khromov, M. L. Holovakha, V. P. Ryzhenko, O. O. Brek

“…Isolated fragments of the popliteal arteries (PA) and intrapulmonary artery (IPA) were cleared of perivascular adipose tissue (PVAT-) or left uncleaned (PVAT+) and cut into rings. The simulation of acute hypoxia with further study of medical agents were performed. …”
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Septoriablotch epidemic process on spring wheat varieties by E. Yu. Toropova, O. A. Kazakova, V. V. Piskarev

“…Septorialeaf and ear  blotch of spring wheat is widespread in West Siberia and the Trans-Urals, causing a decrease in yield by up to 50 %  or more with the deterioration in grain quality. The causative agents of the disease are P. nodorum, Septoria tritici,  and P. avenaef. sp. triticae, and the species ratio varied across the regions and varieties, and within plant organs.  …”
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STANDARDIZATION OF CLINICAL PHARMACIST FUNCTIONAL RESPONSIBILITIES IN HOSPITAL SETTING IN UKRAINE AND ABROAD by Andriy Zimenkovsky, Х.І. Макух, Myroslava Sekh, Marta Zayats

“…The results of the survey revealed that the practical functions of clinical pharmacists in national healthcare facilities extend far beyond the administration of antimicrobial agents as defined by legislation. They also encompass the practical implementation of 26 additional functions. …”
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Efficacy of various combined treatment regimens in patients with stable effort angina, functional classes II-III by Svetlana G. Dorofeeva, Eugenia N. Konoplya, Oksana V. Mansimova

“…Results: The combined treatment with using the above-mentioned pharmacological agents resulted in a statistically significant improvement in cycle ergometry indicators: Mexicor made it possible to increase the threshold load power by 43.0% and the total load power – by 70.3%. …”
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