Flow rate modulates focused ultrasound-mediated vascular delivery of microRNA by Stephanie He, Davindra Singh, Brandon Helfield

“…Focused ultrasound presents a non-viral, image-guided technique in which circulating intravascular microbubble contrast agents can reversibly enhance vascular permeability and gene penetration. …”
Get full text

Enhanced antitumor efficacy through sustained release of 5-fluorouracil from poly(trimethylene carbonate) membranes by Zongheng Wang, Zhipeng Hou, Shuguang Zhang, Shuangyi Ren, Liqun Yang, Qianshi Zhang

“…IntroductionCancer remains one of the deadliest diseases worldwide. 5-Fluorouracil (5-FU) is one of the most commonly used chemotherapeutic agents in clinical practice today, but its effectiveness is often hampered by rapid drug metabolism and systemic toxicity. …”
Get full text

Fungal Exposure and Low Levels of IL-10 in Patients with Sarcoidosis by Marjeta Terčelj, Sanja Stopinšek, Alojz Ihan, Barbara Salobir, Saša Simčič, Ragnar Rylander

“…The low serum IL-10 values at high fungal exposure suggest that fungal cell wall agents play a role in granuloma formation in sarcoidosis by inhibiting the secretion of the anti-inflammatory cytokine IL-10.…”
Get full text

An in-depth study of indolone derivatives as potential lung cancer treatment by Mohammed Er-rajy, Mohamed El fadili, Radwan Alnajjar, Sara Zarougui, Somdutt Mujwar, Khalil Azzaoui, Hatem A. Abuelizz, Belkheir Hammouti, Menana Elhallaoui

“…The ADMET analysis revealed that these compounds exhibited favourable drug-like properties, meeting nearly all the key pharmacological criteria required for potential therapeutic agents. Molecular docking studies of the most active compounds revealed strong interactions with critical amino acid residues in the PDK1 receptor’s binding site, underscoring their potential as effective PDK1 inhibitors. …”
Get full text

Recent advances in pancreatic α-cell transdifferentiation for diabetes therapy by Yanjiao Li, Yanjiao Li, Jinyu Zhu, Congyang Yue, Siyuan Song, Limin Tian, Yi Wang, Yi Wang, Yi Wang

“…As the global prevalence of diabetes mellitus rises, traditional treatments like insulin therapy and oral hypoglycemic agents often fail to achieve optimal glycemic control, leading to severe complications. …”
Get full text

G alleria mellonella in vitro model for chromoblastomycosis shows large differences in virulence between isolates by Dongmei Shi, Zhiya Yang, Wanqing Liao, Chen Liu, Liang Zhao, Huilin Su, Xiaodong Wang, Huan Mei, Min Chen, Yinggai Song, Sybren de Hoog, Shuwen Deng

“…Cladophialophora carrionii (C. carrionii) is one of the agents. However, the pathogenesis of C. carrionii is not fully investigated yet. …”
Get full text

Effects of Ozone Dissolved in Water on the Physicochemical Properties of Activated Carbons Applied in Drinking Water Treatment by Stanisław Biniak, Grzegorz Trykowski, Maciej Pakuła, Andrzej Świątkowski, Zofia Malinowska, Stanisław Popiel

“…The following procedures were applied to assess the effects of contact between each carbon and the oxidizing agents: thermogravimetry, alkalimetry, voltammetry, EDX and FT-IR methods to illustrate changes in the surface chemistry, and nitrogen low-temperature adsorption to show up any possible changes in the porous structure. …”
Get full text

β-Glucan-modified nanoparticles with different particle sizes exhibit different lymphatic targeting efficiencies and adjuvant effects by Wen Guo, Xinyue Zhang, Long Wan, Zhiqi Wang, Meiqi Han, Ziwei Yan, Jia Li, Ruizhu Deng, Shenglong Li, Yuling Mao, Siling Wang

“…The results also indicate that β-glucan-modified MSN, with a particle size of ∼100 nm, has a great potential as a vaccine delivery vehicle and immune adjuvant and offers a novel approach for the delivery of multiple therapeutic agents that target other lymph-mediated diseases.…”
Get full text

Escrever com Adília/Barthes sobre o que gostamos by Paulo Alberto da Silva Sales

“…Reflexão sobre como os poemas dos últimos livros-álbuns adilianos, sobretudo a partir de Manhã (2015) até os mais recentes Pardais (2022) e Choupos (2023), são permeados por resquícios de memória de leituras e de vivências da poeta-leitora-personagem, que escreve motivada pelo desejo em rememorar o outro por meio de si. …”
Get full text

Fatal Epstein-Barr Virus Reactivation in an Acquired Aplastic Anemia Patient Treated with Rabbit Antithymocyte Globulin and Cyclosporine A by Tohru Takahashi, Yumiko Maruyama, Mayuko Saitoh, Hideto Itoh, Mitsuru Yoshimoto, Masayuki Tsujisaki

“…One month after the start of ATG, persistent fever which was not responsive to antibiotics or antifungal agents developed and atypical lymphocytes emerged in peripheral blood. …”
Get full text

Phytochemical Test and Antibacterial Activity of Pranawija (Euchresta horsfieldii (Lesch.) Benn.) by Amalia Indah Prihantini, Krisnawati Krisnawati, Anita Apriliani Dwi Rahayu, Yosephin Martha Maria Anita Nugraheni, Gipi Samawandana

“…The result of the present study supports the investigation on potentiality of E. horsfieldii as alternative source for antibacterial agents.…”
Get full text

Virulence of Bacteria Causing Mastitis in Dairy Cows: A Literature Review by Xiaofang Tong, Herman W. Barkema, Diego B. Nobrega, Chuang Xu, Bo Han, Chenyibo Zhang, Jingyue Yang, Xiaoping Li, Jian Gao

“…The disease is associated with different bacterial agents, primarily Gram-positive cocci (e.g., <i>Staphylococcus</i> spp., <i>Streptococcus</i> spp.) and Gram-negative bacilli (e.g., <i>Escherichia coli</i>, <i>Klebsiella pneumoniae</i>). …”
Get full text

Gut Microbiota and its Metabolites in Pathogenesis of NAFLD by M. S. Reshetova, O. Yu. Zolnikova, V. T. Ivashkin, K. V. Ivashkin, S. A. Appolonova, T. L. Lapina

“…The results allow us to summarize the effects of microbial agents and their metabolites in the formation of changes in the liver parenchyma in the context of NAFLD. …”
Get full text

Subarachnoid Transplant of the Human Neuronal hNT2.19 Serotonergic Cell Line Attenuates Behavioral Hypersensitivity without Affecting Motor Dysfunction after Severe Contusive Spina... by Mary J. Eaton, Eva Widerström-Noga, Stacey Quintero Wolfe

“…Transplant of cells which make biologic agents that can modulate the sensory and motor responses after spinal cord injury (SCI) would be useful to treat pain and paralysis. …”
Get full text

Leveraging AI to automate detection and quantification of extrachromosomal DNA to decode drug responses by Kohen Goble, Aarav Mehta, Damien Guilbaud, Jacob Fessler, Jingting Chen, William Nenad, William Nenad, Christina G. Ford, Oliver Cope, Darby Cheng, William Dennis, Nithya Gurumurthy, Yue Wang, Kriti Shukla, Elizabeth Brunk, Elizabeth Brunk, Elizabeth Brunk, Elizabeth Brunk, Elizabeth Brunk

“…This pipeline is tailored to monitor ecDNA dynamics during drug treatment.ResultsOur approach effectively quantified ecDNA changes, providing a robust framework for analyzing the adaptive responses of cancer cells under therapeutic pressure.DiscussionThe pipeline not only serves as a valuable resource for automating ecDNA detection in metaphase FISH images but also highlights the role of ecDNA in facilitating swift and reversible adaptation to epigenetic remodeling agents such as JQ1.…”
Get full text

Prediction of OCT contours of short-term response to anti-VEGF treatment for diabetic macular edema using generative adversarial networks by Xueying Yang, Fabao Xu, Han Yu, Zhongwen Li, Xuechen Yu, Zhiwen Li, Li Zhang, Jie Liu, Shaopeng Wang, Shaopeng Liu, Jiaming Hong, Jianqiao Li

“…Anti-vascular endothelial growth factor (VEGF) agents are currently recognized as the first-line treatment. …”
Get full text

La science-fiction au prisme de l’intime : étude des séries Lupus et Aâma de Frederik Peeters (2002-2014) by Alain Boillat

“…The generic expectations created by the comic books of Peeters are discussed in particular on the basis of the cover images and the first panels of the albums. The emphasis is on the gap established by Peeters with certain conventions of the genre, since introspection and everyday life are in both series privileged on exoticism and spectacular: introspection is superimposed on spatial exploration. …”
Get full text

Radioterapia guiada por PET-PSMA en cáncer de próstata: experiencia en el escenario curativo y en el salvamento by Juan C. Galvis, María Caicedo-Martínez, José L. Poveda-Matiz, Camilo Giedelman, Jaime A. Cajigas, Daniela Villada-Flórez

“…M&eacute;todos: Realizamos un estudio observacional retrospectivo de pacientes con c&aacute;ncer de pr&oacute;stata localizado remitidos para radioterapia. …”
Get full text

Plant Adaptability to Improved Dredged Sediment by Shoulong Zhang, Rixiong Mo, Haorong Shi, Yuanzhen Li, Yaoyao Zhou, Chenhao Wang, Guanlong Yu

“…This study used dredged sludge, composted pig manure, and sawdust as raw materials, and supplemented them with composite biological agents to prepare improved soil. Plant adaptability to the improved soil was comprehensively evaluated using factors such as seed germination index (GI). …”
Get full text

Studies of the Antiproliferative Activity of Ruthenium (II) Cyclopentadienyl-Derived Complexes with Nitrogen Coordinated Ligands by Virtudes Moreno, Julia Lorenzo, Francesc X. Aviles, M. Helena Garcia, João P. Ribeiro, Tânia S. Morais, Pedro Florindo, M. Paula Robalo

“…Four cationic ruthenium(II) complexes with the formula [Ru(η5-C5H5)(PPh3)2]+, with L=5-phenyl-1H-tetrazole (TzH) 1, imidazole (ImH) 2, benzo[1,2-b;4,3-b′] dithio-phen-2-carbonitrile (Bzt) 3, and [5-(2-thiophen-2-yl)-vinyl]-thiophene-2-carbonitrile] (Tvt) 4 were prepared and characterized in view to evaluate their potentialities as antitumor agents. Studies by Circular Dichroism indicated changes in the secondary structure of ct-DNA. …”
Get full text