In Vitro Evaluation of a Stable Monomeric Gold(II) Complex with Hematoporphyrin IX: Cytotoxicity against Tumor and Kidney Cells, Cellular Accumulation, and Induction of Apoptosis by Georgi Momekov, Dilyan Ferdinandov, Spiro Konstantinov, Sonja Arpadjan, Daniela Tsekova, Galina Gencheva, Panayot R. Bontchev, Margarita Karaivanova

“…A comparative assessment of both agents against the human kidney cell line 293T has shown that [Au(II)Hp-2H.…”
Get full text

Retrovirus Entry by Endocytosis and Cathepsin Proteases by Yoshinao Kubo, Hideki Hayashi, Toshifumi Matsuyama, Hironori Sato, Naoki Yamamoto

“…Retroviruses include infectious agents inducing severe diseases in humans and animals. …”
Get full text

Advances in lysosomal escape mechanisms for gynecological cancer nano-therapeutics by Heng Wei, Yingying Hao, Jin Zhang, Yue Qi, Chong Feng, Chen Zhang

“…Mechanisms such as the proton sponge effect, where NPs induce osmotic swelling and rupture of the lysosomal membrane, and membrane fusion, which facilitates the release of therapeutic agents directly into the cytoplasm, are explored in detail. …”
Get full text

Colorimetric Sensor Based on β-Cyclodextrin-Functionalized Silver Nanoparticles for Zidovudine Sensitive Determination by Farhad Ghanizadeh Gerayeli, Farnaz Hosseini, Zohreh Bagheri, Amir Savardashtaki, Zahra Shabaninejad, Ali Mohammad Amani, Sohrab Najafipour

“…Due to the ability of forming various molecular bonds, silver nanoparticles (AgNPs) are widely used for the detection of large range of agents, including drugs. In this study, we synthesized AgNP-modified β-cyclodextrin (β-CD) using green synthesis for the sensitive and selective zidovudine (ZDV) determination. …”
Get full text

New Triterpenoids from the Leaves of <i>Heritiera littoralis</i> and Their Anti-Inflammatory Activity by Chenyang Ren, Xiaoqin Liang, Rui Pi, Jiwen Xin, Bo Yang, Qingfang Zheng, Yanqin Li, Jun Li, Yanjun Zhang

“…The triterpenoids from <i>H. littoralis</i> could be served as potential candidates for the development of new anti-inflammatory agents.…”
Get full text

Potential application of proteolysis targeting chimera (PROTAC) modification technology in natural products for their targeted protein degradation by Guliang Yang, Haiyan Zhong, Xinxin Xia, Zhiwen Qi, Chengzhang Wang, Shiming Li

“…Proteolysis targeting chimera (PROTAC) is a type of bifunctional chimeric molecules that can directly degrade the binding proteins targeted by bioactive molecules in an ubiquitin-proteasome pathway. As the agents in protein degradation dependent on ubiquitin ligase, the bifunctional molecule connects the target protein ligand and E3 ligase ligand together via an appropriate linker. …”
Get full text

Treatment of irritable bowel syndrome: the past, present and future by V. T. Ivashkin, Ye. A. Poluektova, O. S. Lyashenko, D. V. Reykhart

“…Spasmolytics, laxatives or antidiarrheal agents are traditionally applied for treatment of IBS patients according to leading symptom. …”
Get full text

hpvPDB: An Online Proteome Reserve for Human Papillomavirus by Satish Kumar, Lingaraja Jena, Sangeeta Daf, Kanchan Mohod, Peyush Goyal, Ashok K. Varma

“…The molecular understanding of HPV proteins has significant connotation for understanding their intrusion in the host and designing novel protein vaccines and anti-viral agents, etc. Genomic, proteomic, structural, and disease-related information on HPV is available on the web; yet, with trivial annotations and more so, it is not well customized for data analysis, host-pathogen interaction, strain-disease association, drug designing, and sequence analysis, etc. …”
Get full text

Comprehensive Management of Polycystic Ovary Syndrome: The Role of Metformin in Addressing Metabolic and Endocrine Dysregulation by Martyna Kaźmierczak, Jakub Parys, Agnieszka Mikosińska, Patrycja Kałuziak, Marta Jajaczak, Maciej Mossakowski, Aleksandra Witek, Mateusz Litwin, Stanisław Jesionek

“…Additional therapeutic strategies, including non-pharmacological measures and other pharmacological agents, play a vital role in a comprehensive treatment plan for PCOS. …”
Get full text

Antimicrobial Evaluation of Bacterial Isolates from Urine Specimen of Patients with Complaints of Urinary Tract Infections in Awka, Nigeria by Perpetua A. Ekwealor, Malachy C. Ugwu, Ifeanyi Ezeobi, George Amalukwe, Belinda C. Ugwu, Ugochukwu Okezie, Catherine Stanley, Charles Esimone

“…The antibacterial activities of the tested agents were in the order of Augmentin < Ceftazidime < Cefuroxime < Cefixime < Gentamicin < Ofloxacin < Ciprofloxacin < Nitrofurantoin. …”
Get full text

The Interactions between Insulin and Androgens in Progression to Castrate-Resistant Prostate Cancer by Jennifer H. Gunter, Amy A. Lubik, Ian McKenzie, Michael Pollak, Colleen C. Nelson

“…Prostate cancer patients present a promising cohort for the exploration of insulin stabilising agents as adjunct treatments for hormone deprivation or enhancers of chemosensitivity for treatment of advanced prostate cancer.…”
Get full text

Imaging flow cytometry reveals the mechanism of equine arteritis virus entry and internalization by Agata Kublicka, Daria Lorek, Agata Mikołajczyk-Martinez, Grzegorz Chodaczek, Aleksandra Chwirot, Barbara Bażanów, Anna Karolina Matczuk

“…This study highlighted the potential of imaging flow cytometry to advance the study of viral entry and the evaluation of antiviral agents.…”
Get full text

Temperature-Sensitive Gels for Intratumoral Delivery of β-Lapachone: Effect of Cyclodextrins and Ethanol by Marcilio S. S. Cunha-Filho, Carmen Alvarez-Lorenzo, Ramón Martínez-Pacheco, Mariana Landin

“…This work evaluated the potential of Pluronics (varieties F127 and P123) in combination with solubilizing agents to be used as syringeable in situ gelling depots of intratumoral β-lapachone (βLAP). …”
Get full text

Ronnie James Dio: the man on the silver mountain by Joe Weber

“…He sold over 6,500,000 albums. This map shows every city he performed in during his career at a scale of 1:74,380,000, along with three insets at varying scales highlighting performances within different world regions, and a series of 28 separate inset maps at a scale of 1:575,000,000 showing the cities he performed in during each concert tour.…”
Get full text

High-Strength Hollow Glass Microsphere/Epoxy Resin Composite Insulation Materials for Deep In-Situ Condition Preserved Coring by Jianping Yang, Ling Chen, Zhiqiang He, Cong Li, Bo Yu, Zijie Wei, Zhiyu Zhao, Zongxin Hao

“…An epoxy resin matrix with high strength and high-temperature resistance was selected from among epoxy resins cured by different curing agents. Then, a series of composite insulation materials with different HGM volume fractions were prepared. …”
Get full text

Phosphatidylserine-Targeted Nanotheranostics for Brain Tumor Imaging and Therapeutic Potential by Lulu Wang MD, PhD, Amyn A. Habib MD, Akiva Mintz MD, PhD, King C. Li MD, Dawen Zhao MD, PhD

“…We have recently established PS-targeted nanoplatforms, aiming to enhance delivery of imaging contrast agents across the blood–brain barrier to facilitate imaging of brain tumors. …”
Get full text

E.V. Bretschneider as a doctor and his personal archives: Chinese period by S.A. Silakova

“…His works, except the handwritten albums on the daily life of Chinese people, have not been thoroughly studied earlier. …”
Get full text

Nesting Island Creation for Wading Birds by C. Leann White, Peter C. Frederick, Martin B. Main, James A. Rodgers, Jr.

“… Many long-legged wading birds such as little blue herons (Egretta caerulea), great blue herons (Ardea herodius), and great egrets (Ardea albus) nest together in large aggregations called breeding colonies. …”
Get full text

Laboratory Exploration of Several Potential Biocontrol Methods Against the Ambrosia Beetle, <i>Euwallacea interjectus</i> by Jialin Liu, Nan Jiang, Haiming Gao, Shengchang Lai, Yang Zhou, Dejun Hao, Lulu Dai

“…Both mites effectively parasitized beetle pupae and larvae, with no significant differences in efficacy between the two species. These agents demonstrate promise for the biological control of <i>E. interjectus</i>, offering insights for managing ambrosia beetle infestations.…”
Get full text

An Aggressive Form of Langerhan Cell Histiocytosis in an Adult: Therapeutic Challenges by Karan Seegobin, Satish Maharaj, Cherisse Baldeo, Amal Shukri, Fauzia N. Rana

“…A 35-year-old male with an incidental left iliac bone lesion was diagnosed with LCH. He later became symptomatic with hip pain and spread of the disease. …”
Get full text