The new thiazolidine-2,4-dione-based hybrids with promising antimycobacterial activity: design, synthesis, biological evaluation, and drug interaction analysis by Nazar Trotsko, Agnieszka Głogowska, Barbara Kaproń, Katarzyna Kozieł, Ewa Augustynowicz-Kopeć, Agata Paneth

“…The ever-increasing drug-resistant tuberculosis (TB) has invigorated the focus on the discovery and development of novel therapeutic agents and treatment options. Thiazolidinone-based compounds have shown good antitubercular properties in vitro. …”
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Realization of a cascade treatment algorithm for glaucoma in St. Petersburg by A.V. Antonova, V.P. Nikolaenko, V.V. Brzheskiy

“…Long-term (at least 3-year) therapy using (non)fixed-dose combinations of agents containing preservatives is the major modifiable risk factor for early filtration loss. …”
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Therapeutic potential of Curcuma longa against monkeypox: antioxidant, anti-inflammatory, and computational insights by Farouk Boudou, Amal Belakredar, Ahcen Keziz, Linda Aissani, Huda Alsaeedi, David Cronu, Mikhael Bechelany, Mikhael Bechelany, Ahmed Barhoum

“…The computational findings suggest that curcuminoids, particularly demethoxycurcumin, could serve as promising antiviral agents against monkeypox. These findings pave the way for further preclinical studies to validate the antiviral efficacy of C. longa bioactives and their potential applications in combating viral infections.…”
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Antistaphylococcal Triazole-Based Molecular Hybrids: Design, Synthesis and Activity by Kostiantyn Shabelnyk, Alina Fominichenko, Oleksii Antypenko, Olexandr Gaponov, Svitlana Koptieva, Svitlana Shyshkina, Oleksii Voskoboinik, Sergiy Okovytyy, Serhii Kovalenko, Valentyn Oksenych, Oleksandr Kamyshnyi

“…Conclusions: Obtained [2-(3-R-1<i>H</i>-[1,2,4]-triazol-5-yl)phenyl]amines reveal significant antistaphylococcal activity and deserve for further detailed study as effective antibacterial agents.…”
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De la police coloniale française à la police nationale marocaine : décolonisation et héritages policiers (1953-1960) by Benjamin Badier

“…The expulsion of the last French police agents coincides with an authoritarian shift against the Moroccan left, which denounces a police regime inherited from the colonial era.…”
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AICpred: Machine Learning-Based Prediction of Potential Anti-Inflammatory Compounds Targeting TLR4-MyD88 Binding Mechanism by Lucindah N. Fry-Nartey, Cyril Akafia, Ursula S. Nkonu, Spencer B. Baiden, Ignatus Nunana Dorvi, Kwasi Agyenkwa-Mawuli, Odame Agyapong, Claude Fiifi Hayford, Michael D. Wilson, Whelton A. Miller, Samuel K. Kwofie

“…Additionally, compounds known to inhibit TLR4, including TAK-242 (Resatorvid) and benzisothiazole derivative (M62812), were predicted as bioactive agents within the applicability domain with probabilities above 0.80. …”
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Sex and outcomes of patients with microsatellite instability-high and BRAF V600E mutated metastatic colorectal cancer receiving immune checkpoint inhibitors by Michael Hoffmeister, Hermann Brenner, Chiara Cremolini, Sara Lonardi, Filippo Pietrantonio, Julien Taieb, David Tougeron, Robyn L Ward, Marco Vitellaro, Thierry André, Pierre Laurent-Puig, Jitendra Jonnagaddala, Francesca Bergamo, Raghav Sundar, Claire Gallois, Michael J Overman, Jakob Nikolas Kather, Lisa Salvatore, Romain Cohen, Rossana Intini, Priya Jayachandran, Miriam Koopman, Javier Ros, Marwan Fakih, Vincenzo Nasca, Giacomo Mazzoli, Jeanine M L Roodhart, Filippo Ghelardi, Elena Elez, Durgesh Wankhede, Marta Ligero, Joseph Zhao, Koen Zwart, Jeroen Derksen, Nicholas Hawkins, Javier Carmona

“…Males receiving anti-PD-(L)1 monotherapy had the worst outcomes, with a 3-year PFS and 3-year OS of 23.9% and 41.8%, respectively, while the addition of anti-CTLA-4 agents rescued such a worse outcome. We also observed that females experienced a higher frequency of any-grade immune-related adverse events. …”
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Characteristics of adherent and non-adherent patients with hypertension in a Norwegian cross-sectional study by Eirik Olsen, Lene V. Halvorsen, Stine Rognstad, Arleen Aune, Karl Marius Brobak, Ola Undrum Bergland, Vibeke N. Kjær, Knut Liestøl, Marit D. Solbu, Rune Mo, Eva Gerdts, Morten Rostrup, Sverre E. Kjeldsen, Aud Høieggen, Mimi S. Opdal, Anne Cecilie K. Larstorp, Camilla L. Søraas

“…Methods: Patients with hypertension using ≥ 2 antihypertensive agents were invited to participate in this national study performed in a semi-blinded fashion. …”
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Microultrasound Molecular Imaging of Vascular Endothelial Growth Factor Receptor 2 in a Mouse Model of Tumor Angiogenesis by Joshua J. Rychak, James Graba, Alison M.Y. Cheung, Bina S. Mystry, Jonathan R. Lindner, Robert S. Kerbel, F. Stuart Foster

“…In the current study, we investigated the use of microbubble ultrasound contrast agents bearing targeting ligands specific for molecular markers of tumor angiogenesis using high-frequency microultrasound imaging. …”
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Rol de la protección radiológica en procedimientos de cardiología intervencionista by Teodoro Rivera Montalvo, Eduardo Santiago Uruchurtu Chavarín

“… El objetivo de la protección radiológica es permitir el aprovechamiento de la radiación en todas sus formas conocidas, con un riesgo aceptable tanto para el personal que trabaja con los rayos X como para la población en general y las generaciones futuras. …”
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Probiotics, Prebiotics, and Synbiotics: Gut and Beyond by Usha Vyas, Natarajan Ranganathan

“…Microbiomics has spurred a dramatic increase in scientific, industrial, and public interest in probiotics and prebiotics as possible agents for gut microbiota management and control. …”
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PATHOGENIC MICROORGANISMS ASSOCIATED WITH PERIODONTAL DISEASE IN INDIVIDUALS WITH TYPE 2 DIABETES by Mihaela Mariș, Sorana Maria Bucur, Mariș Marius, Mariana Păcurar, Kamel Earar

“…These findings reinforce the link between oral microbial agents and periodontal disease in patients with type 2 diabetes. …”
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Antifungal and enzymatic activities of endophytic fungi associated with Tamarix nilotica by Helal F. Al-Harthi

“…The most potent antifungal agents against Fusarium solani and Rhizoctonia solani are Aspergillus ochraceus (2 isolates) and Penicillium chrysogenum (16 isolates). …”
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Tourism and Cultural Landscapes in Southern China’s Highlands by Zhe Wang, Nelson Graburn

“…A stakeholder approach is applied in understanding the attitudes and practices of different agents towards terraced fields and traditional villages. …”
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SOST and DKK: Antagonists of LRP Family Signaling as Targets for Treating Bone Disease by James J. Mason, Bart O. Williams

“…Thus, devising methods to mimic the molecular consequences of this mutation to treat bone diseases associated with low bone mass is a promising avenue to pursue. Two groups of agents related to putative LRP5/6 functions are under development. …”
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Nanodoldurucu içeren beş farklı kompozitin yüzey sertliği ve pürüzlülüğü açısından değerlendirilmesi by Zeynep Göztaş, Gül Tosun, Esma Yıldız, Kamil Kahraman

“…Amaç: Bu çalışmanın amacı bir nanofil (Filtek Supreme XT) ve dört nanohibrit kompozitin (İvoclar Tetric EvoCeram, Dentsply Ceram X, Voco Grandio, Bisco Ælite) polisaj sonrası yüzey sertliklerini ve pürüzlülüklerini değerlendirmektir. …”
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ESTUDO DA VIABILIDADE E DESENVOLVIMENTO DE FILMES ATIVOS A PARTIR DE RESÍDUOS DA INDÚSTRIA VINÍCOLA by Helen Cristiny Dias, Arlete Barbosa Reis

“…Tendo em vista a produção de vinhos e sabendo que a casca da uva, principal componente do resíduo, possui em sua composição agentes com atividade antioxidante, este trabalho visa o desenvolvimento de filmes a base de quitosana com casca de uva para utilização em embalagens ativas. …”
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Offline solutions for agricultural extension: Integrating digital libraries into train-the-trainer programs by Laura Hosman, Rachel Nova

“…This article evaluates the effectiveness of a train-the-trainer (TTT) approach that integrates an offline digital library and competency-based training to address both the information and skills needs of extension agents in Rwanda. Using Harper et al.'s (2024) TTT framework, the study assesses a TTT workshop conducted with agriculture extension interns, focusing on their ability to train farmers in CA practices. …”
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The role of the Internet in the modern life of children and teenagers: analysis of a sociological survey by S. E. Titor

“…For residents of developed countries, mass media have largely replaced interpersonal communication as the main source of adaptive and meaningful information and, serving as agents of socialisation, now play the key role in forming people’s worldview. …”
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Biodegradable Polymers for Microencapsulation Systems by Joana Filipa Parente, Vânia Isabel Sousa, Juliana Filipa Marques, Marta Adriana Forte, Carlos José Tavares

“…The controlled release of encapsulated active agents is a research field that, over the years, has been constantly innovating due to the promising applications in the areas of pharmaceutical, cosmetic, textile industry, among others. …”
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