PPARs: Protectors or Opponents of Myocardial Function? by Christine J. Pol, Melissa Lieu, Konstantinos Drosatos

“…They can be activated by endogenous ligands, such as fatty acids, as well as by pharmacologic agents. Activators of PPARs are used for treating several metabolic complications, such as diabetes and hyperlipidemia that are directly or indirectly associated with HF. …”
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Targeted intervention of tumor microenvironment with HDAC inhibitors and their combination therapy strategies by Wanli Zhang, Luqi Ge, Yiwen Zhang, Zhentao Zhang, Wen Zhang, Feifeng Song, Ping Huang, Tong Xu

“…Overexpression of histone deacetylases (HDACs) is prevalent across various cancer types, positioning HDAC inhibitors as broadly applicable therapeutic agents. These inhibitors are known to enhance tumor immune antigenicity, potentially slowing tumor progression. …”
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Molecular glue degrader for tumor treatment by Yuhan Hu, Yan Yan, Jiehao Wang, Jiangxue Hou, Quande Lin

“…Recently, molecular glue, functioning via degradation of the target protein is emerging as a promising modality for the development of therapeutic agents, while exhibits greater advantages over PROTAC, including improved efficiency, resistance-free properties, and the capacity to selectively target “undruggable” proteins. …”
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Characterization of Thermo- and Detergent Stable Antigenic Glycosylated Cysteine Protease of Euphorbia nivulia Buch.-Ham. and Evaluation of Its Ecofriendly Applications by Shamkant B. Badgujar, Raghunath T. Mahajan

“…It exhibits remarkable protease activity in the presence of metal ions, oxidizing agents, organic solvents, and detergents. This enzyme showed potential role in leather processing industry due to its dehairing activity for animal hide without hydrolyzing fibrous proteins, producing, by this way, a better quality product. …”
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Effective Administration of Rituximab in Anti-MDA5 Antibody–Positive Dermatomyositis with Rapidly Progressive Interstitial Lung Disease and Refractory Cutaneous Involvement: A Case... by Yuka Ogawa, Dai Kishida, Yasuhiro Shimojima, Koichi Hayashi, Yoshiki Sekijima

“…However, the administration of rituximab (RTX) resulted in clinical remission as well as a visible reduction in anti-MDA5-Ab levels, suggesting that RTX could be a useful remedy in cases refractory to conventional immunosuppressive agents, especially those of RP-ILD related to anti-MDA5-Ab–positive DM.…”
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Designing intercultural space. A multi-scalar approach in the Albergheria neighbourhood in Palermo by Federico Wulff Barreiro, Renzo Lecardane, Paola La Scala

“…This paper illustrates a research-action resulting from a collective work developed on key urban spaces of the Albergheria neighbourhood of Palermo, where a design-led research based on a multi-scalar regeneration approach (urban, architectural and public space) can reframe the role of architecture and spatial practices as agents of social, intercultural inclusion and spatial reactivation at different scales.…”
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RAS/RAF/MEK/ERK and PI3K/PTEN/AKT Signaling in Malignant Melanoma Progression and Therapy by Ichiro Yajima, Mayuko Y. Kumasaka, Nguyen Dinh Thang, Yuji Goto, Kozue Takeda, Osamu Yamanoshita, Machiko Iida, Nobutaka Ohgami, Haruka Tamura, Yoshiyuki Kawamoto, Masashi Kato

“…Melanomagenesis is initially triggered by environmental agents including ultraviolet (UV), which induces genetic/epigenetic alterations in the chromosomes of melanocytes. …”
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Sedation in the intensive care unit (ICU) and procedural sedation: clinical guidelines and personal practice by O Budniuk, I Yovenko, D Havrychenko

“…The characteristics of pharmacological agents widely used for sedation — dexmedetomidine, midazolam, and propofol — are reviewed. …”
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Predicting, Treating and Preventing Postoperative Recurrence of Crohn’s Disease: The State of the Field by Anna M Borowiec, Richard N Fedorak

“…Furthermore, the postoperative prophylaxis profiles of available Crohn’s disease therapeutic agents such as 5-aminosalicylates, immunomodulators, steroids and probiotics have been disappointing. …”
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The Role of miRNAs as Biomarkers for Pregnancy Outcomes: A Comprehensive Review by Martina Barchitta, Andrea Maugeri, Annalisa Quattrocchi, Ottavia Agrifoglio, Antonella Agodi

“…To achieve this goal, exposure to xenochemicals, endogenous agents, and diet should be assessed. This study has the aim to provide a comprehensive review on the role of miRNAs as potential biomarkers for adverse pregnancy outcomes and prenatal environmental exposure.…”
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Efficient production system for hydrogel-based transparent soil for plant root observation by Naoyuki Sotta, Wenhao Li, Toru Fujiwara

“…One of the approaches to overcome this technical limitation is the use of “transparent soil” (TS), hydrogel-based beads produced by spherification of gelling agents. However, the production of TS by natural dripping of gelling solution can be labor intensive, time consuming and difficult to maintain consistent product quality. …”
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Living Shoreline Monitoring—How do I evaluate the environmental benefits of my living shoreline? by Laura Reynolds, Natalie C. Stephens, Savanna C. Barry, Ashley R. Smyth

“…In this new 11-page publication of the UF/IFAS Department of Soil and Water Sciences, we provide homeowners, land managers, and Extension agents materials lists, protocols, and data sheets for measuring change in ecosystem function. …”
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Review and Clinical Perspectives for the Use of Infliximab in Ulcerative Colitis by Remo Panaccione, Richard N Fedorak, Guy Aumais, Edmond-Jean Bernard, Charles N Bernstein, Alain Bitton, Ken Croitoru, Levinus A Dieleman, Robert Enns, Brian G Feagan, Denis Franchimont, Gordon R Greenberg, Anne-Marie Griffiths, John K Marshall, Pierre Pare, Sunil Patel, Robert Penner, Craig Render, Ernest Seidman, A Hillary Steinhart

“…Although the etiology of ulcerative colitis (UC) differs from that of Crohn’s disease, randomized controlled trials have demonstrated that infliximab is also beneficial for the treatment of moderate to severe UC in patients who are either intolerant of or refractory to immunosuppressant agents or steroids, or those who are steroid-dependent. …”
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Distributed nash equilibrium seeking for heterogeneous second-order nonlinear noncooperative games with communication delays by Rui Yu, Li Li, Qianyao Wang, Xianchao Zhang, Sixu Lu

“…Compared with existing noncooperative games, a class of noncooperative games that are more aligned with practical systems is discussed, where all agents have uncertain heterogeneous second-order nonlinear dynamics. …”
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Las redes sociales en la enseñanza universitaria: Aprovechamiento didáctico del capital social e intelectual by Pilar COLÁS-BRAVO, Jesús CONDE-JIMÉNEZ, Ángela MARTÍN-GUTIÉRREZ

“…Los resultados obtenidos muestran el potencial de lasredes sociales en la amplificación de las funciones docentesy discentes, así como en el aprovechamiento del capital social/intelectual de los agentes educativos.…”
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Virtuous integrative social robotics for ethical governance by Anshu Saxena Arora, Arlene Marshall, Amit Arora, John R. McIntyre

“…Virtue ethics is explored as a means for programming social robots as artificial moral agents, placing human values as the basis of robot design. …”
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Complete Whole Genome Sequence of Vibrio parahaemolyticus RP0132 Strain Isolated from Shrimp in Malaysia by Ke-Yan Loo, Loh Teng-Hern Tan, Jodi Woan-Fei Law, Kah-Ooi Chua, Priyia Pusparajah, Learn-Han Lee, Vengadesh Letchumanan

“…The findings will facilitate the development of effective anti-Vibrio agents to manage V. parahaemolyticus infections.  …”
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La contribución de las refugiadas colombianas a la Agenda Global de Desarrollo a través de su empoderamiento en la acción colectiva para la defensa de los derechos by Elena MUT-MONTALVA

“…They have emerged as social agents with the capacity for interlocution to claim rights in the different territories in which they experience their transnational existence within the framework of the Global Development Agenda. …”
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Anaerobic external combustion thermal engines by V. I. Karagusov

“…In open and underwater facilities, anaerobic nuclear-powered engines are used, as well as diesel engines with internal combustion with fuel reserves and oxidizing agents, often in cryogenic form. Internal combustion engines with all their advantages have several disadvantages. …”
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Synthesis and X-Ray Crystal Structure of (1E)-1-(4-Chlorophenyl)-N-hydroxy-3-(1H-imidazol-1-yl)propan-1-imine by Mohamed I. Attia, Hazem A. Ghabbour, Maha S. Almutairi, Soraya W. Ghoneim, Hatem A. Abdel-Aziz, Hoong-Kun Fun

“…Compound 4 is a useful intermediate for the synthesis of new imidazole-containing antifungal agents.…”
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