Development and usability testing of a multifaceted intervention to reduce low-value injury care by Mélanie Bérubé, Alexandra Lapierre, Michael Sykes, Jeremy Grimshaw, Alexis F. Turgeon, François Lauzier, Monica Taljaard, Henry Thomas Stelfox, Holly Witteman, Simon Berthelot, Éric Mercier, Catherine Gonthier, Jérôme Paquet, Robert Fowler, Natalie Yanchar, Barbara Haas, Paule Lessard-Bonaventure, Patrick Archambault, Belinda Gabbe, Jason R. Guertin, Yougdong Ouyang, Lynne Moore, the Canadian Traumatic Brain Injury Research Consortium

“…The prototype’s usability was iteratively tested through four focus groups and four think-aloud sessions with trauma decision-makers (n = 18) from seven Level I to Level III trauma centers. …”
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An Overview of Solar Orbiter Observations of Interplanetary Shocks in Solar Cycle 25 by Domenico Trotta, Andrew Dimmock, Heli Hietala, Xochitl Blanco-Cano, Timothy S. Horbury, Rami Vainio, Nina Dresing, Immanuel Christopher Jebaraj, Francisco Espinosa Lara, Raúl Gómez-Herrero, Javier Rodriguez-Pacheco, Yulia Kartavykh, David Lario, Jan Gieseler, Miho Janvier, Milan Maksimovic, Nasrin Talebpour Sheshvan, Christopher J. Owen, Emilia K. J. Kilpua, Robert F. Wimmer-Schweingruber

“…The wave environment of the shocks has also been addressed, with about 50% of the events exhibiting clear shock-induced upstream fluctuations. …”
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Global digital elevation model (GDEM) product generation by correcting ASTER GDEM elevation with ICESat-2 altimeter data by B. Li, B. Li, B. Li, B. Li, H. Xie, H. Xie, S. Liu, Z. Ye, Z. Hong, Q. Weng, Q. Weng, Q. Weng, Y. Sun, Q. Xu, X. Tong

“…The results from the validation comparison show that the elevation accuracy of IC2-GDEM is evidently superior to that of the ASTER GDEM product: (1) the RMSE reduction ratio of the corrected GDEM elevation is between 16 % and 82 %, and the average reduction ratio is about 47 %; and (2) from the analysis of the different topographies and land covers, this error reduction is effective even in areas with high topographic relief (<span class="inline-formula">&gt;15<i>°</i></span>) and high vegetation cover (<span class="inline-formula">&gt;60 %</span>). …”
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L’aqueduc de l’Yzeron : nouvelles données sur le double siphon de Craponne (Métropole de Lyon) by David Baldassari

“…The main arches have disappeared.That being said, an existing nearby remnant of this aqueduct shows a preserved arch head where the stones have been tailored to measure up to 0.50 m in length.About a hundred putlock holes were identified on all faces of both piers. …”
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COVID-19 – if the cure is worse than the disease. The Italian chaos by Giuseppe FERRARI

“…Small and medium enterprises are the backbone of the Italian socio-economic environment and because of the lockdown are worried about their future. On the other side however, Italy has a labour market where duties and rights prevent flexibility and changes. …”

BRAF inhibitor monotherapy in BRAFV600E-mutated pediatric low-grade glioma: a single center’s experience by S. S. McThenia, S. S. McThenia, S. S. McThenia, K. M. Reddy, K. M. Reddy, E. Damaraju, E. Castellino, Z. He, R. Beer, F. Chien, F. Chien, F. Chien, R. C. Castellino, R. C. Castellino, R. C. Castellino, A. E. Goldman-Yassen, A. E. Goldman-Yassen, J. R. Fangusaro, J. R. Fangusaro, J. R. Fangusaro, T. MacDonald, T. MacDonald, T. MacDonald

“…The aim herein was to investigate the efficacy and tolerability of single agent BRAF inhibitor treatment in BRAFV600E altered pLGG.MethodsA single institution retrospective chart review analysis was performed on patients, 0 to 21 years of age, with newly diagnosed and/or progressive BRAFV600E mutated pLGGs (WHO Grade 1 or 2) at Children’s Healthcare of Atlanta treated off-study with BRAF inhibitor monotherapy between 2013-2023. 2-year progression free survival (PFS) and objective tumor response was evaluated. …”
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Activités artisanales sur la rive droite de la Vesle à Reims/Durocortorum by Émilie Jouhet, Michaël Brunet, Pierre Mathelart, Véronique Matterne

“…The latter were likely used to market alum, used in the dye fixation process. Over the course of the 4th c. …”
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The Objectivity of Nonexistent in the View of Mu'tazila and an Analysis of Received Criticisms on it by Aflatoon Sadeghi

“…On the other hand, when the Mu'tazila talk about non-existence and non-existence objects, they not only mean external non-existence as opposed to external existence and being but also both external non-existence and non-existence. …”
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Therapeutic benefit of the dual ALK/FAK inhibitor ESK440 in ALK-driven neuroblastoma by Seema Chugh, Jean C. Tien, Jennifer Hon, Carson Kenum, Rahul Mannan, Yunhui Cheng, Chi Chiang Li, Zainab I. Taher, Andrew D. Delekta, Pushpinder Singh Bawa, Ingrid J. Apel, Stephanie J. Miner, Xuhong Cao, Rohit Mehra, Saravana M. Dhanasekaran, Yuanyuan Qiao, Rajen Mody, Arul M. Chinnaiyan

“…These preclinical results indicate that ESK440 is a promising targeted agent for ALK-driven NB and support future clinical studies to evaluate its efficacy in NB patients.…”
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Impact of bedroom light exposure on glucose metabolic markers and the role of circadian-dependent meal timing: A population-based cross-sectional study by Qi Li, Yu-xiang Xu, Xiu-zhen Lu, Yu-ting Shen, Yu-hui Wan, Pu-yu Su, Fang-biao Tao, Xin Chen, Ying Sun

“…However, little is known about the effects of bedroom LAN exposure on glucose metabolism markers. …”
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Three in four children age 12–23 months missed opportunities for vaccination in Sub-Saharan African countries: a multilevel mixed effect analysis of demographic health and surveys... by Melak Jejaw, Tesfahun Zemene Tafere, Misganaw Guadie Tiruneh, Asebe Hagos, Getachew Teshale, Mikias Mered Tilahun, Wubshet D. Negash, Kaleb Assegid Demissie

“…Identifying contributing factors helps policymakers and planners to design potential interventions to avert missing opportunities for vaccination. Thus, this study aimed to assess the prevalence and factors associated with missed opportunities for vaccination. …”
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Genetic Mutations of Tim-3 Ligand and Exhausted Tim-3+ CD8+ T Cells and Survival in Diffuse Large B Cell Lymphoma by Tingting Zhang, Tianyuan Ren, Zheng Song, Jing Zhao, Lei Jiao, Zhenzhen Zhang, Jin He, Xianming Liu, Lihua Qiu, Lanfang Li, Shiyong Zhou, Bin Meng, Qiongli Zhai, Xiubao Ren, Zhengzi Qian, Xianhuo Wang, Huilai Zhang

“…A number of clinical trials are evaluating the efficacy of anti-Tim-3 therapies as a single agent or combinations in solid tumors and haematologic malignancies. …”
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Phosphorus-solubilizing fungi promote the growth of Fritillaria taipaiensis P. Y. Li by regulating physiological and biochemical reactions and protecting enzyme system–related gene... by Yueheng Wang, Lin Yuan, Lin Yuan, Yuhan Wang, Jiaqi Lang, Mingyan Ye, Qingqiu Liu, Qiang Ma, Nong Zhou

“…The MDA content was the lowest in S7, about 44.83% of that in the CK group. The activities of peroxidase (POD), superoxide dismutase (SOD), and catalase (CAT) were higher in all inoculation groups than those in the CK group; the changes in SOD and CAT activities were significant (P &lt; 0.05). …”
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Solar Energetic Particle Events Detected in the Housekeeping Data of the European Space Agency's Spacecraft Flotilla in the Solar System by Beatriz Sánchez‐Cano, Olivier Witasse, Elise W. Knutsen, Dikshita Meggi, Shayla Viet, Mark Lester, Robert F. Wimmer‐Schweingruber, Marco Pinto, Richard Moissl, Johannes Benkhoff, Hermann Opgenoorth, Uli Auster, Jos deBrujine, Peter Collins, Guido DeMarchi, David Fischer, Yoshifumi Futaana, James Godfrey, Daniel Heyner, Mats Holmstrom, Andrew Johnstone, Simon Joyce, Daniel Lakey, Santa Martinez, David Milligan, Elsa Montagnon, Daniel Müller, Stefano A. Livi, Timo Prusti, Jim Raines, Ingo Richter, Daniel Schmid, Peter Schmitz, Håkan Svedhem, Matt G. G. T. Taylor, Elena Tremolizzo, Dimitri Titov, Colin Wilson, Simon Wood, Joe Zender

“…The results of this study show how engineering sensors, for example, EDAC counters, can be used to infer information about the solar particle environment at each spacecraft location. …”
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Editorial by Ann-Kristin Kölln, Antony Mason, Jörg Tremmel, Markus Rutsche, Maria Lenk

“…Pistor’s review of the book is unequivocal: using methods from comparative politics, the authors provide a “very interesting argument” and “a clear empirical case for the youthquake during the 2017 General Election in the UK”. Pistor also welcomes especially two implications of the book: (1) many young British people are not as politically disenfranchised as general wisdom holds (and there is much more to be said about that); (2) many of them are not only cosmopolitans but also British cosmopolitans interested and engaged in national politics. …”
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PS1-11aop: Probing the Mass-loss History of a Luminous Interacting Supernova Prior to Its Final Eruption with Multiwavelength Observations by Adaeze L. Ibik, Maria R. Drout, Raffaella Margutti, David Matthews, V. Ashley Villar, Edo Berger, Ryan Chornock, Kate D. Alexander, Tarraneh Eftekhari, Tanmoy Laskar, Ragnhild Lunnan, Ryan J. Foley, David Jones, Dan Milisavljevic, Armin Rest, Daniel Scolnic, Peter K. G. Williams

“…While the mechanism by which this material is ejected is still debated, obtaining the full density profile of the circumstellar medium (CSM) could reveal more about this process. Here, we present an extensive multiwavelength study of PS1-11aop, a luminous and slowly declining Type IIn SNe discovered by the Pan-STARRS Medium Deep Survey. …”
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Spirituality-Based Intervention in Hypertension: EFfects on Blood PrEssure and EndotheliaL Function—FEEL Trial Results by Maria Emília Figueiredo Teixeira, Weimar Kunz Sebba Barroso, Andréa Araújo Brandão, Ana Luiza Lima Sousa, Roberto Esporcatte, Mário Henrique Elesbão de Borba, Ana Clara Neri Ávila Baleeiro, Beatriz Caldas Gonçalves, Enzo Inumaru, Enzo Mata de Sousa, Giovana Barros Leal, Henrique Soares de Araújo Pereira Farias, Juliana Alves de Souza, Lure Emilly Barreto da Silva, Matheus Canguçu de Paiva Queiroz, Frederico Rafael Moreira, Priscila Valverde de Oliveira Vitorino, John Eikelboom, Álvaro Avezum

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Climate change rivals fertilizer use in driving soil nitrous oxide emissions in the northern high latitudes: Insights from terrestrial biosphere models by Naiqing Pan, Hanqin Tian, Hao Shi, Shufen Pan, Josep G. Canadell, Jinfeng Chang, Philippe Ciais, Eric A. Davidson, Gustaf Hugelius, Akihiko Ito, Robert B. Jackson, Fortunat Joos, Sebastian Lienert, Dylan B. Millet, Stefan Olin, Prabir K. Patra, Rona L. Thompson, Nicolas Vuichard, Kelley C. Wells, Chris Wilson, Yongfa You, Sönke Zaehle

“…Nitrous oxide (N2O) is the most important stratospheric ozone-depleting agent based on current emissions and the third largest contributor to increased net radiative forcing. …”
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The efficacy and safety of Ginkgo biloba L. leaves extract combined with ACEI/ARB on diabetic kidney disease: a systematic review and meta-analysis of 41 randomized controlled tria... by Zehua Zhang, Shiyun Tang, Shiyu Liu, Yulin Leng, Xiaoxu Fu, Hongyan Xie, Hong Gao, Hong Gao, Chunguang Xie, Chunguang Xie

“…Randomized controlled trials about GBE and DKD were included. Review Manager 5.4 and Stata 16.0 were employed to conduct the analysis. …”
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BDC-DAL: A new algorithm using blueprint difference convolution and dual auxiliary supervision for lightweight face anti-spoofing(BDC-DAL：基于蓝图差分卷积和双重辅助监督的轻量化人脸活体检测算法)... by 叶继华(YE Jihua), 梁芳昕(LIANG Fangxin), 王超(WANG Chao), 肖顺杰(XIAO Shunjie), 宗义(ZONG Yi), 江爱文(JIANG Aiwen)

“…The experimental results show that the BDC-DAL method proposed in this paper dramatically reduces the model complexity, with the number of parameters reduced by nearly 90%; and the floating-point operations of the model reduced by about 10%. This shows that the BDC-DAL method successfully balances performance and resource consumption while achieving high efficiency and lightweight, providing a feasible solution for face recognition security in resource-constrained environments.…”
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