Fractional Factorial Design and Desirability Function-Based Approach in Spice Paprika Processing Technology to Improve Extractable Colour Stability by Arnold Koncsek, Lajos Szokol, Vivien Krizsa, Hussein G. Daood, Lajos Helyes, Antal Véha, Balázs Szabó P.

“…Fractional factorial experimental design and desirability function-based approach was applied to moderate the adverse effect of the key-importance processing steps on colour agent content. Photochemical-accelerated shelf-life test was used for the empirically-based quality improvement. …”
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Embracing Generative Artificial Intelligence in Clinical Research and Beyond by Henry P. Foote, MD, Chuan Hong, PhD, Mohd Anwar, PhD, Maria Borentain, MD, Kevin Bugin, PhD, Nancy Dreyer, PhD, MPH, Josh Fessel, MD, PhD, Nitender Goyal, MD, Morgan Hanger, MPP, Adrian F. Hernandez, MD, Christoph P. Hornik, MD, PhD, MPH, Jennifer G. Jackman, PhD, MBA, Alistair C. Lindsay, MD, MPH, DPhil, Michael E. Matheny, MD, Kerem Ozer, MD, Jan Seidel, PhD, Norman Stockbridge, MD, PhD, Peter J. Embi, MD, Christopher J. Lindsell, PhD

“…Success is expected to require establishing rigorous data management and security protocols, fostering integrity and trust among stakeholders, and sharing information about the safety and effectiveness of AI applications. …”
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A cross-sectional study exploring the perception of exercise oncology in the Italian population by Anita Borsati, Diana Giannarelli, Giampaolo Pase, Christian Ciurnelli, Linda Toniolo, Ilaria Trestini, Daniela Tregnago, Lorenzo Belluomini, Marco Sposito, Jessica Insolda, Michele Milella, Federico Schena, Sara Pilotto, Alice Avancini

“…The questionnaire investigated sociodemographic factors, physical exercise levels, and perceptions about the importance, benefits, and safety of exercise, the support from oncologists and family/friends, as well as the capability and ease of patients of exercise.ResultsOverall, 838 persons participated in this survey. …”
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Successful Pregnancy Outcome in a Patient Treated with Pembrolizumab and Exposed to Fluoro-Deoxyglucose (¹⁸F-FDG) PET/CT: Case Report and Review of Literature by Anna Lucia Mastricci, Felice Sorrentino, Elisa Giansiracusa, Erika Zanzarelli, Graziana Silvana De Lucia, Vincenza Fernanda Fesce, Luigi Nappi, Lorenzo Vasciaveo

“…The PD-1/PD-L1 pathway, targeted by pembrolizumab, plays a critical role in maternal–fetal immune adaptation, raising concerns about its safety during pregnancy. <b>Case Report:</b> We report the case of a 36-year-old woman diagnosed with rHL who unknowingly became pregnant during treatment with pembrolizumab and ¹⁸F-FDG PET/CT scans. …”
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Establishment of the fingerprint of ganoderma lucidum spore powder and study on the anti-inflammatory activity of ganoderma lucidum spore oil by Yu Zhang, Lihui Hou, Le Wang, Yunshan Si, Hongjuan Wen, Ying Gao, Xiuhua Yu

“…[Results] The HPLC fingerprints were calibrated with a total of 12 peaks, of which peaks 1-5 were ganoderic acid C2, ganoderic acid G, ganoderic acid B, ganoderic acid A, ganoderic acid D, respectively; the current version of the Pharmacopoeia method of HPTLC showed that 10 batches of samples complied with the regulations, and the quality of raw materials of different origins was found to be similar to that of the HPLC fingerprints after 2 unfoldings by using trichloromethane-acetonitrile-methanol-formic acid (26∶4 ∶1∶1) as the unfolding agent. The differences of the spots were significant and similar to the HPLC fingerprints. …”
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Two-Step Transfer Learning Improves Deep Learning–Based Drug Response Prediction in Small Datasets: A Case Study of Glioblastoma by Jie Ju, Ioannis Ntafoulis, Michelle Klein, Marcel JT Reinders, Martine Lamfers, Andrew P Stubbs, Yunlei Li

“…The GBM is aggressive, and most patients do not benefit from the only approved chemotherapeutic agent TMZ. O6-methylguanine-DNA methyltransferase (MGMT) promoter methylation status is the only biomarker for TMZ responsiveness but has shown limited predictive power. …”
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Ratio-dependent competitions between a Wolbachia-uninfected bisexual strain and Wolbachia-infected thelytokous strain of the egg parasitoid, Trichogramma dendrolimi Matsumura (Hyme... by Qian-Jin Dong, Yue He, Yu-Zhe Dong, Wu-Nan Che, Jin-Cheng Zhou, Hui Dong

“…Abstract Background Wolbachia-infected thelytokous Trichogramma wasps have been considered as potential effective biocontrol agents against lepidopteran pests in agriculture and forests. …”
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From Continent to Ocean: Investigating the Multi-Element and Precious Metal Geochemistry of the Paraná-Etendeka Large Igneous Province Using Machine Learning Tools by J. J. Lindsay, H. S. R. Hughes, C. M. Yeomans, J. C. Ø. Andersen, I. McDonald

“…This asymmetry contrasts with the North Atlantic Igneous Province (NAIP), a similar geodynamic environment in which continent-edge lavas are also PGE-enriched, albeit on both sides of the plume-rift system. We conclude that, given the similarities in PGE studies of plume-rift environments, SCLM incorporation under progressively shallowing (i.e., rifting) asthenospheric conditions promotes the acquisition of metasomatic and residual PGE-bearing minerals, boosting the magma metal budget.…”
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Health risk assessment and microplastic pollution in streams through accumulation and interaction by heavy metals by A.M. Sabilillah, F.R. Palupi, B.K. Adji, A.P. Nugroho

“…However, little is known about the cumulative danger caused by the association of the microplastic and heavy metals. …”
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Patterns of pharmacological treatment in patients with atrial fibrillation: an analysis from the prospective GLORIA-AF Registry Phase III by Bernadette Corica, Giulio Francesco Romiti, Giuseppe Boriani, Brian Olshansky, Tze-Fan Chao, Menno V. Huisman, Marco Proietti, Gregory Y. H. Lip, on behalf of the GLORIA-AF Investigators

“…., treatment with ≥ 5 drugs) is common in patients with atrial fibrillation (AF) and has been associated with suboptimal management and worse outcomes. Little is known about how prescribed drug patterns affect management and prognosis in patients with AF. …”
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Exploring Web-Based Support for Suicidal Ideation in the Scottish Population: Usability Study by Heather McClelland, Rory C O'Connor, Laura Gibson, Donald J MacIntyre

“…The website included resources (eg, videos from lived experience and written guidance about how to respond to someone who may be experiencing suicidal thoughts) to help reduce distress, normalize experiences, and challenge distressing thoughts. …”
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β-crystals aied greater energy absorbing ethylene–propylene rubber in polypropylene blends for outstanding low-temperature toughness by Ruimiao Liang, Wenwen Yu, Jiahao Shen, Zhiyi Zhang, Zaifu Lin, Jiayi Wang, Lan Jia, Feng Chen, Yonggang Shangguan, Qiang Zheng

“…Modulating the β-crystalline phase and adding elastomers have traditionally been used to overcome the brittleness of polypropylene (PP); however, the synergistic mechanisms of these components in enhancing low temperatures toughness remain insufficiently explored. A β-nucleating agent (TMB-5) was incorporated into the polypropylene/ethylene–propylene rubber (PP/EPR) system to address the challenges of enhancing low-temperature toughness. …”
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Evidences of +896 A/G TLR4 Polymorphism as an Indicative of Prevalence of Complications in T2DM Patients by Carmela Rita Balistreri, Anna Rita Bonfigli, Massimo Boemi, Fabiola Olivieri, Antonio Ceriello, Stefano Genovese, Claudio Franceschi, Liana Spazzafumo, Paolo Fabietti, Giuseppina Candore, Calogero Caruso, Domenico Lio, Roberto Testa

“…However, no conclusive findings have been reported until now about the role of this polymorphism in development of T2DM and its complications, even if a recent meta-analysis showed its T2DM association in Caucasians. …”
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Molecular-genetic bases of plumage coloring in chicken by A. V. Makarova, O. V. Mitrofanova, A. B. Vakhrameev, N. V. Dementeva

“…This overview shows the nature of melanin coloration in birds using the example of chickens of various breeds and also attempts to systematize knowledge about the molecular-genetic mechanisms of the appearance of various types of coloration.…”
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Immediate results of the еndovascular aneurysm repair in abdominal aortic aneurysm patients with an unfavorable proximal neck by S.M. Furkalo, V.A. Kondratyuk, O.A. Vlasenko, I.V. Khasyanova, A.V. Khohlov, P.A. Gindich, I.A. Mazanovich, O.O. Pustyntsev

“…However, due to the anatomical characteristics of the aorta about 40 % of patients cannot be candidates for еndovascular aneurysm repair (EVAR). …”
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Severe infestation by tropical bedbugs (Cimex hemipterus) in Medellín, Colombia. Case series by Julián Felipe Porras-Villamil, Sandra Sáez-Durán, María Trelis-Villanueva, Rubén Bueno-Marí, Màrius Vicent Fuentes

“…The patients were prescribed symptomatic treatment and informed about measures to control infestations. A pest control company made several visits to eliminate the bed bugs, but they were ineffective. …”
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Digital twin-enhanced three-organ microphysiological system for studying drug pharmacokinetics in pregnant women by Katja Graf, José Martin Murrieta-Coxca, Tobias Vogt, Sophie Besser, Daria Geilen, Tim Kaden, Tim Kaden, Anne-Katrin Bothe, Diana Maria Morales-Prieto, Behnam Amiri, Behnam Amiri, Stephan Schaller, Ligaya Kaufmann, Martin Raasch, Ramy M. Ammar, Ramy M. Ammar, Christian Maass, Christian Maass

“…BackgroundPregnant women represent a vulnerable group in pharmaceutical research due to limited knowledge about drug metabolism and safety of commonly used corticosteroids like prednisone due to ethical and practical constraints. …”
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The Association of Thyroid Hormone Changes with Inflammatory Status and Prognosis in COVID-19 by Ceyda Dincer Yazan, Can Ilgin, Onur Elbasan, Tugce Apaydin, Saida Dashdamirova, Tayfun Yigit, Uluhan Sili, Aysegul Karahasan Yagci, Onder Sirikci, Goncagul Haklar, Hulya Gozu

“…In conclusion, evaluation of thyroid function tests during COVID-19 infection may give information about the prognosis of disease.…”
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Incidence of alexithymia in worsening symptoms and quality of life of Systemic Lupus Erythematosus patients (SLE) by Fabio Rapisarda, Concetta Mezzatesta, Antonina Butticè, Alessandro Raffa, Stefano Boca

“…Results: Comparisons between the two groups revealed significant differences in the Systemic Lupus Erythematosus (SLE) patients, compared to the control group, about the difficulty in identifying feelings and distinguishing them from the bodily sensations accompanying emotional activation, the use of conversion as a defence mechanism and the production of positive symptoms.Moreover, in the same group, the difficulty in identifying emotions was correlated with quality of life, since those who have difficulty identifying emotions have a poorer quality of life.Further analysis regarding the construct of alexithymia, within the patient group alone, revealed a tendency towards somatisation and the use of immature defence mechanisms, including conversion, acting out, projection, dissociation and displacement, highlighting a tendency to act out and project emotional suffering.Furthermore, there appeared to be difficulty in sharing emotional distress with others, indicating a deep sense of insecurity and a need for approval, as well as an incidence in the perception of the state of illness leading to a decline in the quality of life. …”
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Exogenous dsRNA triggers sequence-specific RNAi and fungal stress responses to control Magnaporthe oryzae in Brachypodium distachyon by Ying Zheng, Benjamin Moorlach, Desiree Jakobs-Schönwandt, Anant Patel, Chiara Pastacaldi, Stefan Jacob, Ana R. Sede, Manfred Heinlein, Minna M. Poranen, Karl-Heinz Kogel, Maria Ladera Carmona

“…We demonstrate that Magnaporthe oryzae (Mo), a globally significant crop pathogen, internalizes dsRNA across a broad size range of 21 to about 3000 bp. Incubation of fungal conidia with 10 ng/µL dsRNA, regardless of size or sequence, induced aberrant germ tube elongation, revealing a strong sequence-unspecific effect of dsRNA in this fungus. …”
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