Effect of decitabine on PD-L2 methylation in whole blood of iodine-induced autoimmune thyroiditis rats by Baiming Jin, Yanbo Qi, Hong Chao, Xiaolei Yang, Hongjie Li, Siyuan Wan

“…Following Dec intervention, the methylation level of the PD-L2 in rats increased and interferon and interleukin-23 levels decreased, albeit not significantly. However, the mRNA expression of PD-L2 decreased significantly after Dec intervention, and the thyroid function of EAT rats also showed a gradual improvement trend. …”
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The technical-reasoning network is recruited when people observe others make or teach how to make tools: An fMRI study by Alexandre Bluet, Emanuelle Reynaud, Giovanni Federico, Chloé Bryche, Mathieu Lesourd, Arnaud Fournel, Franck Lamberton, Danielle Ibarrola, Yves Rossetti, François Osiurak

“…Here, we contribute to this double process approach by reporting an fMRI study about the neurocognitive origins of social learning. …”
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Optimized D-α-tocopherol polyethylene glycol succinate/phospholipid self-assembled mixed micelles: A promising lipid-based nanoplatform for augmenting the antifungal activity of fl... by Badr-Eldin Shaimaa M., Aldawsari Hibah M., Fahmy Usama A., Ahmed Osama A. A., Alhakamy Nabil A., Elfaky Mahmoud A., Sirwi Alaa, Hawsawi Salman A., Alzahrani Ali H., Yaseen Abdulrahman Y., Qassim Mohannad, Kotta Sabna

“…Fluconazole (FLZ) is the most widely used antifungal agent for treating cutaneous candidiasis. Although oral FLZ has been proved to be effective, the incidence of side effects necessitates the development of an effective formulation that could surpass the pitfalls associated with systemic availability. …”
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Morphological and Molecular Characterization of a New Isospora (Apicomplexa: Eimeriidae) Species From a Singing Honeyeater (Gavicalis virescens Vieillot, 1817) (Passeriformes: Meli... by Yinhua Chen, Belinda Brice, Bruno P. Berto, Rongchang Yang

“…The oocyst wall is bilayered and ~1.0 μm thick, with a smooth outer layer making up about two‐thirds of the thickness. A micropyle cap, measuring ~2.0 × 4.5 μm, is present as a curved protrusion on the outer layer. …”
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Correlation of Serum Albumin Level to Lung Ultrasound Score and Its Role as Predictors of Outcome in Acute Respiratory Distress Syndrome Patients: A Prospective Observational Study by Souvik Chaudhuri, Sagar S. Maddani, Shwethapriya Rao, Sirish Gauni, N. R. Arjun, Pratibha Todur, Nitin Gupta

“…There is ambiguity in the literature regarding hypoalbuminemia as a cause of extravascular lung water and acute respiratory distress syndrome (ARDS) outcomes. …”
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Adsorption of Cellulase Isolated from on Chitosan/Alginate Particles Functionalized with Epichlorohydrin by Elaine C. Rodrigues, Bruna T. C. Bezerra, Barbara V. Farias, Wellington S. Adriano, Rodrigo S. Vieira, Diana C. S. Azevedo, Ivanildo J. Silva

“…The adsorption isotherm fitted well with Langmuir equation with maximum adsorption capacity of about 11 mg of cellulase/g of adsorbent. Successive cycles (adsorption/washing/elution) were performed and the results demonstrate the reversibility of the process and its potential for enzyme purification and separation. …”
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Synthesis, In vitro antimicrobial activity, and In silico bioinformatical approach of xanthone-fatty acid esters against Staphylococcus aureus, Escherichia coli, and Candida albica... by Yehezkiel Steven Kurniawan, Ervan Yudha, Jumina, Harno Dwi Pranowo, Eti Nurwening Sholikhah

“…Because of that, research in finding new antimicrobial agents is urgently needed. In this work, we combined the chemical structure of 3-hydroxyxanthone and some fatty acids through ester linkage to form xanthyl laurate, xanthyl myristate, xanthyl palmitate, xanthyl stearate, and xanthyl oleate in 78.68–89.77 % yield. …”
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Challenges of Assessing Maltreated Children Coming into Foster Care by Rachel Pritchett, Harriet Hockaday, Beatrice Anderson, Claire Davidson, Christopher Gillberg, Helen Minnis

“…While correlations were found between a carer’s level of concern about a child and the severity of a child’s problem, there were still a number of children displaying worrying problem scores whom foster carers did not report concern. …”
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Radiopharmacokinetic modelling and radiation dose assessment of 223Ra used for treatment of metastatic castration-resistant prostate cancer by Vera Höllriegl, Nina Petoussi-Henss, Kerstin Hürkamp, Juan Camilo Ocampo Ramos, Wei Bo Li

“…Bone retention was found to be about 30% at 4 h post-injection. Similar tendencies were observed in clinical trials of other authors. …”
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Cost-effectiveness Analysis of Lorlatinib in Patients Previously Treated with Anaplastic Lymphoma Kinase Inhibitors for Non-small Cell Lung Cancer in Greece by George Gourzoulidis, Oresteia Zisimopoulou, Nadia Boubouchairopoulou, Christina Michailidi, Chrissy Lowry, Charalampos Tzanetakos, Georgia Kourlaba

“…**Background:** Non-small cell lung cancer (NSCLC), which accounts for about 80%-85% of lungcancer cases, is a leading cause of cancer-related death worldwide. …”
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The Effects of Cigarette Smoking on the Cardiovascular System: Mechanisms of Damage, Risk Factors, and Prevention Strategies by Kinga Janowska, Joanna Szydziak, Aleksandra Hrapkowicz, Daria Dąbkowska, Olga Szeidl, Dominika Rehan, Agnieszka Mioskowska

“…Although extensive knowledge exists about tobacco smoke's impact on the cardiovascular system, further research is still needed. …”
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Long-range organization of intestinal 2D-crypts using exogenous Wnt3a micropatterning by Enara Larrañaga, Miquel Marin-Riera, Aina Abad-Lázaro, David Bartolomé-Català, Aitor Otero, Vanesa Fernández-Majada, Eduard Batlle, James Sharpe, Samuel Ojosnegros, Jordi Comelles, Elena Martinez

“…By adjusting the spacing between Wnt3a ligand patterns at the microscale over large surfaces, we override endogenous Wnt3a to precisely control the distribution and long-range order of crypt-like regions in primary epithelial monolayers. Additionally, an agent-based model integrating Wnt3a/BMP feedback and Eph/Ephrin repulsion effectively replicates experimental tissue compartmentalization, crypt size, shape, and organization. …”
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Time to Relapse and Relapse Predictors in Patients with Schizophrenia at Ayder Comprehensive Specialized Hospital, Northern Ethiopia by Habtamu Endashaw Hareru, Kebede Embaye Gezae, Daniel Sisay W/tsadik, Gebremedhin Berhe Gebregergs

“…As a result, it is advised that all parties involved focus on early detection and taking preventive measures against schizophrenia relapse, as well as providing regular psychoeducation about the significance of treatment adherence and connecting patients with substance misuse to substance rehabilitation centers.…”
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Self-care practices on hypertension: Prevalence and predictors in Puducherry, South India by Chandru Sivamani, Ganesh Kumar Saya, Revathi Ulaganeethi, Palanivel Chinnakali

“…Results: Out of 267 participants with hypertension, 158 (59.2 %) were >60 years of age and 182 (68.2 %) were females. About 79 (29.6 %) had poor self-care practices. Among 267, 63 (23.6 %) had uncontrolled hypertension and it was more among those with poor self-care practices (46.1 % Vs 24.5 %). …”
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Interactions of Self-Assembled <i>Bletilla Striata</i> Polysaccharide Nanoparticles with Bovine Serum Albumin and Biodistribution of Its Docetaxel-Loaded Nanoparticles by Guangyuan Zhang, Jin Qiao, Xin Liu, Yuran Liu, Ji Wu, Long Huang, Danyang Ji, Qingxiang Guan

“…Additionally, the area under the concentration–time curve (AUC_0–∞) of DTX-loaded BSPs-SA nanoparticles was about 1.42-fold higher compared with Duopafei^® in tumor-bearing mice. …”
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The divergent histories of Bose-Einstein statistics and the forgotten achievements of Władysław Natanson (1864–1937) by Michał Kokowski

“…This is followed by a rebuttal of many erroneous or simplified statements about him and his achievements. The already well-known terminological conventions have been recalled: “Bose statistics” and “Bose-Einstein statistics”, as well as recently introduced: “Planck-Bose statistics” (1984), “Natanson’s statistics” (1997)”, “Natanson-Bose-Einstein statistics” (2005), “Planck-Natanson-Bose-Einstein statistics” (2011), and “Natanson statistics” (2013). …”
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Case for hospital nurse-to-patient ratio legislation in Queensland, Australia, hospitals: an observational study by Carol Windsor, Patsy Yates, Linda H Aiken, Clint Douglas, Matthew D McHugh

“…Each additional patient per nurse was associated with poorer outcomes for nurses including 15% higher odds of emotional exhaustion (OR=1.15; 95% CI 1.07 to 1.23) and 14% higher odds of job dissatisfaction (OR=1.14; 95% CI 1.02 to 1.28), as well as higher odds of concerns about quality of care (OR=1.12; 95% CI 1.01 to 1.25) and patient safety (OR=1.32; 95% CI 1.11 to 1.57).Conclusions Before ratios were implemented, nurse staffing varied considerably across Queensland hospital medical-surgical wards and higher nurse workloads were associated with patient mortality, low quality of care, nurse emotional exhaustion and job dissatisfaction. …”
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Male involvement in antenatal care follow-up and its determinants in Ethiopia: a systematic review and meta-analysis by Gossa Fetene Abebe, Desalegn Girma, Melsew Setegn Alie, Lidiya Gutema Lemu, Yilkal Negesse, Zewditu Alelign

“…Male partners with secondary education or higher (Adjusted Odds Ratio (AOR) 2.72, 95% CI 1.81 to 4.10), government employment (AOR 2.09, 95% CI 1.49 to 2.94), attendance at health education (AOR 3.02, 95% CI 1.39 to 6.54) and knowledge about ANC or pregnancy danger signs (AOR 2.36, 95% CI 1.33 to 4.19) demonstrated a significant association with increased male involvement.Conclusion Male involvement in ANC in Ethiopia is low. …”
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Experience of induction of labour: a cross-sectional postnatal survey of women at UK maternity units by Helen Cheyne, Christine McCourt, Dharmintra Pasupathy, Julia Sanders, Sarah Jane Stock, Mairead Black, Cassandra Yuill, Mairi Harkness, Neelam Heera, Chlorice Wallace

“…Findings are reported as descriptive statistics with content analysis of women’s comments providing context.Results Information to support choice and understand what to expect about IOL is often inadequate or unavailable. Having IOL can create anxiety and remove options for birth that women had hoped would enhance their experience. …”
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The Probe for Renal Organic Cation Secretion (4-Dimethylaminostyryl)-N-Methylpyridinium (ASP+)) Shows Amplified Fluorescence by Binding to Albumin and Is Accumulated In Vivo by Jacob Schade Engbjerg, Vincenzo Costanzo, Donato Sardella, Luca Bordoni, Steen Jakobsen, Luciano D'Apolito, Jørgen Frøkiær, Francesco Trepiccione, Giovambattista Capasso, Sebastian Frische

“…Two-photon in vivo microscopy of male Münich Wistar Frömter rats showed that a bolus injection of ASP+ conferred a fluorescence signal to the blood plasma lasting for about 30 minutes. In the renal proximal tubule, the bolus resulted in a complex pattern of fluorescence including a rapid and strong transient signal at the brush border, a very low signal in the luminal fluid, and a slow transient intracellular signal. …”
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