Real-world clinical experience with secukinumab in psoriatic arthritis: an observational study and a literature review by Eleonora Celletti, Giulio Gualdi, Emanuela Sabatini, Francesco Cipollone, Fabio Lobefaro, Paolo Amerio

“…An observational study was conducted on adult subjects with PsA and comorbidities, treated with secukinumab after prior therapy with conventional disease-modifying anti-rheumatic drugs or biological agents that were discontinued due to lack of efficacy or adverse drug reactions. …”
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Antifungal efficacy of chitosan-mediated fenugreek nanocomposite incorporated in tissue conditioner by Mohika Damle, Ponsekar Abraham Anandapandian, B. Eswaran, Swapnaneel Pradhan, Silvin Joe C J, Shreyas Dhumke

“…To address this, researchers have explored incorporating antifungal agents directly into tissue conditioners. Nanoparticles, particularly green-synthesized ones derived from fenugreek, have shown significant antifungal efficacy. …”
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Computational studies and structural insights for discovery of potential natural aromatase modulators for hormone-dependent breast cancer by Snehal Aditya Arvindekar, Sanket Rathod, Prafulla Balkrishna Choudhari, Pradnya Kiran Mane, Aditya Umesh Arvindekar, Suraj Narayan Mali, Bapu Thorat

“…Conclusion: The results presented 23 hit compounds that can be developed as anti-breast cancer modulating agents in the near future. Additionally, anthraquinone compounds with minor structural modification can also serve to be potential aromatase inhibitors. …”
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Anti-Inflammatory Potentials of β-Ketoester Derivatives of N-Ary Succinimides: In Vitro, In Vivo, and Molecular Docking Studies by Yahya S. Alqahtani, Muhammad Saeed Jan, Mater H. Mahnashi, Bandar A. Alyami, Ali O. Alqarni, Umer Rashid, Fawad Mahmood, Muhammad Tariq, Abdul Sadiq

“…On the basis of in vivo and in vitro results, compound D was subjected to various inflammation-causing agents such as histamine, prostaglandins E2, bradykinin, and leukotriene via the mouse paw edema test. …”
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Detection and Phylogenetic Characterization of Influenza D in Swedish Cattle by Ignacio Alvarez, Fereshteh Banihashem, Annie Persson, Emma Hurri, Hyeyoung Kim, Mariette Ducatez, Erika Geijer, Jean-Francois Valarcher, Sara Hägglund, Siamak Zohari

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Efficacy of Simple Eye Ointment, Polyethylene Cover, and Eyelid Taping in Prevention of Ocular Surface Disorders in Critically Ill Patients: A Randomized Clinical Trial by Mehdi Ahmadinejad, Esmat Karbasi, Yunes Jahani, Maryam Ahmadipour, Maryam Soltaninejad, Zahra Karzari

“…However, patients admitted to the intensive care unit (ICU) for several reasons including loss of consciousness, receiving sedative and neuromuscular blocking agents, and mechanical ventilation may lose eye-protective mechanisms causing exposure keratopathy. …”
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A contribuição do Programa ALI Produtividade para as micro e pequenas empresas da Região Central do estado do Rio Grande do Sul by Camila de Freitas Santos, Rafael Mozart da Silva

“… O presente estudo teve como objetivo geral analisar o impacto do Programa ALI Produtividade nas micro e pequenas empresas, em sua primeira edição realizada na região central do Estado do RS. O Programa ALI (Agentes Locais de Inovação) é uma iniciativa que visa impulsionar a produtividade e o desenvolvimento dessas empresas por meio da aplicação de estratégias de gestão eficientes e inovadoras. …”
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Analgesia and sedation strategies in neonates undergoing whole-body therapeutic hypothermia: A scoping review. by Mahima Joshi, Javed Muneer, Lawrence Mbuagbaw, Ipsita Goswami

“…The most frequently used pharmacological agents are opioids (Morphine, Fentanyl), benzodiazepine (Midazolam) and Alpha2 agonists (Dexmedetomidine). …”
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Prevalence of neonatal sepsis and associated factors among neonates admitted in the neonatal intensive care unit at Lira Regional Referral Hospital, Northern Uganda. by Brendah Katugume, JohnBaptist Muzungu, Nelson Okello, Eustes Kigongo, Deborah Andrinar Namutebi

“…Further research will be conducted on the major causative agents and outcomes of NS in the NICU of LRRH.…”
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Produção, Pré-Purificação e Encapsulamento de Enzima Proteolítica Secretada por Fungo Filamentoso by Jad Lorena Feitosa Simplicio, Bianca Muniz de Sousa, Humberto Oliveira da Silva Pereira, Yasmim Menezes do Nascimento, Adriana Crispim de Freitas

“…Com a enzima liofilizada realizou-se a determinação enzimática, coagulação do leite, análise termogravimétrica e análise térmica diferencial. …”
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Salomé, reine d’Angleterre : destins esthétiques de la Salomé d’Oscar Wilde (Aubrey Beardsley, Charles Bryant, Ken Russell) by Tristan Grünberg

“…Personnage hautement ambivalent, elle incarne ces valeurs chères à l’Esthétisme britannique, cultivant le goût du paradoxe, de la métamorphose, de l’ambiguïté morale et sexuelle. …”
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Prevalence, Treatment, and Unmet Needs of Migraine in the Middle East: A Systematic Review by Taoufik Alsaadi, AbuBakar Al Madani, Mohammed Alhatou, Mona Nada, Abdulrazaq Albilali, Ahmed Al-Qassabi, Hegab Mohamed, Haytham Mohamed, Rowan El Masry, Ghaidaa Ahmed Saifuddin, Suhail Abdullah AlRukn

“…The current treatment landscape for acute migraines encompasses anti-inflammatory agents, analgesics, triptans, ditans, calcitonin-gene-related peptides, and antiemetics. …”
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Effects of Propofol versus Sevoflurane on Postoperative Pain and Neuroendocrine Stress Response in Oocyte Pickup Patients by Yavuz Orak, Fatma İnanç Tolun, Murat Bakacak, Aslı Yaylalı, Hakan Kıran, Hafize Öksüz, Adem Doğaner, Işıl Yağmur, Ahmet Altun

“…The effects of anesthetic agents were different. In group P, in the preoperative and postoperative evaluation, ACTH, glucagon, and PGE2 increased postoperatively, while cortisol decreased. …”
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Insights into the effects of biomass feedstock and pyrolysis conditions on the energy storage capacity and durability of standard biochar-based phase-change composites by Dimberu G. Atinafu, Ji Yong Choi, Jihee Nam, Yujin Kang, Sumin Kim

“…However, the large-scale utilization of composite and pristine materials has severe drawbacks, primarily stemming from the complex fabrication routes of the encapsulating agents, leakage, and inadequate thermal stability. …”
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Le tourisme dans les paysages culturels des hauts plateaux du sud de la Chine by Zhe Wang, Nelson Graburn

“…En Asie, ces lieux désertés par leurs habitants sont aujourd’hui menacés par l’urbanisation et l’exode rural. …”
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Characterization of Patients with Central Nervous System Infections by Benigno Figueiras Ramos, Ángel Julio Romero Cabrera, Raúl López Fernández, Sandra Borroto Lecuona, Raúl Nieto Cabrera

“…<strong>Fundamento:</strong> las infecciones del sistema nervioso central se manifiestan con características propias según la forma clínica que adopten y los agentes causales que las producen. <strong><br />Objetivo:</strong> caracterizar a pacientes con infecciones del sistema nervioso central. …”
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Hubungan Lama Penggunaan Obat Anti Nyamuk Bakar dengan Kadar Kolinesterase Darah pada Masyarakat Kelurahan Jati Rumah Gadang Padang by Amelia ., Yustini Alioes, Sofina Rusdan

“…Pemeriksaan kadar kolinesterase menggunakan alat spektrofotometri. Data dianalisis dengan uji chi-square. …”
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Bioactivity and metabolic profiling of crude extracts from endophytic bacteria linked to Solanum mauritianum scope: Discovery of antibacterial and anticancer properties by Abraham Goodness Ogofure, Ezekiel Green

“…While this proliferative effect limits their direct application as anticancer agents, it raises intriguing possibilities for their role in tissue regeneration or repair. …”
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Effects of perioperative treatment of resectable adenocarcinoma of esophagogastric junction by immunotherapy (Adebrelimab) combined with chemotherapy (XELOX): protocol for a single... by Yingyi Li, Yuqin Cao, Xipeng Wang, Chengqiang Li, Liqin Zhao, Hecheng Li

“…Abstract Background For resectable adenocarcinoma of the esophagogastric junction (AEG), current treatment exploration primarily focuses on perioperative chemotherapy regimens combined with PD-1/PD-L1 inhibitors, but the long-term survival benefits of still require further investigation, and the use of upfront immunotherapy is typically restricted to patients with metastatic MSI-H (M1 MSI-H) disease due to their potential responsiveness to immunological agents. Adebrelimab, as a novel PD-L1 antibody, has not yet been proven for its efficacy and safety in adenocarcinoma of the esophagogastric junction. …”
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African animal trypanocide resistance: A systematic review and meta-analysis by Keneth Iceland, Kasozi, Ewan, Thomas MacLeod, Susan, Christina Welburn

“…In this study, we investigated the threat associated with AATr by using the major globally available chemotherapeutical agents. Methods: A total of seven electronic databases were screened for an article on trypanocide resistance in AATr by using keywords on preclinical and clinical trials with the number of animals with treatment relapse, days taken to relapse, and resistant gene markers using the PRISMA checklist. …”
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