Poly-ADP ribose polymerase (PARP) inhibitor regimens for platinum-sensitive ovarian cancer in randomized, double-blind, phase III controlled trials: protocol for a systematic revie... by Xiaolian Peng, Jie Liu

“…However, there is insufficient comprehensive evidence regarding the comparison of different agents. To evaluate and compare the efficacy and side effects of various PARP inhibitors.MethodsWe plan to conduct a network meta-analysis that includes randomized, double-blind, controlled phase III trials of Niraparib, Rucaparib, Olaparib, or Veliparib in patients with Platinum-sensitive ovarian cancer. …”
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Treatment of a mutant KRAS lung cancer cell line with polyisoprenylated cysteinyl amide inhibitors activates the MAPK pathway, inhibits cell migration and induces apoptosis. by Matthew D Gregory, Kweku Ofosu-Asante, Jassy Mary S Lazarte, Pablo E Puente, Nada Tawfeeq, Nadine Belony, Yong Huang, Ite A Offringa, Nazarius S Lamango

“…Polyisoprenylated Cysteinyl amide Inhibitors (PCAIs) constitute a group of potential cancer therapy agents that we designed to specifically disrupt and suppress hyperactive G-protein signaling, such as that caused by mutated RAS proteins. …”
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The Role of SGLT2 Inhibitors in Heart Failure: A Systematic Review and Meta-Analysis by Vasiliki Tsampasian, Ranu Baral, Rahul Chattopadhyay, Maciej Debski, Shruti S Joshi, Johannes Reinhold, Marc R Dweck, Pankaj Garg, Vassilios S Vassiliou

“…This systematic review and meta-analysis aim to provide a concise evaluation of all the available evidence for the use of these agents in patients with heart failure (HF) regardless of their baseline diabetes status. …”
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EVALUACIÓN DEL EMPLEO DE POLVO DE HOJAS SECAS DE MORINGA EN UN SAZONADOR by Belkis Julia Fonseca Medina, Caridad Curbelo Hernández

“…Conclusiones: Es posible realizar la sustitución total del COADTEC por PHSM en el sazonador marca ԵoQue sin que se afecte la calidad sensorial establecida en las especificaciones de la norma cubana para condimentos, con beneficio económico y sustitución de importación.…”
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Assessing the Efficacy of Broad-Spectrum Antibiotics in Controlling Bacterial Contamination in the In Vitro Micropropagation of Ginger (Zingiber officinale Rosc) by Selam Tewelde, Subban Patharajan, Zenebe Teka, Desta Berhe Sbhatu

“…Hence, this article reports the finding of a study that aimed at testing the (a) effectiveness of three sterilization agents, namely, 0.25% w/v RBK (composed of ridomile, bayleton, and kocide at 1 : 1 : 1 ratio), 0.50% v/v NaOCl, and 70% v/v ethanol at three different treatment times in combination with 0.25% HgCl2; (b) efficacy of four broad-spectrum antibiotics and their combinations in controlling bacterial contaminants of ginger shoot tip explants and in vitro micropropagation media; and (c) effects of the antibiotics on the shooting performances of the explants of the cultivar. …”
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lncRNA-KCNQ1OT1: A Potential Target in Exosomes Derived from Adipose-Derived Stem Cells for the Treatment of Osteoporosis by Shan-zheng Wang, Jun Jia, Chang-hong Chen

“…KCNQ1OT1-Exos have a more significant inhibitory effect compared to ADSCs-Exos by the function of sponging miR-141-5p, suggesting that KCNQ1OT1-Exos can be promising agents in osteoporosis treatment.…”
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Factors affecting arteriovenous access patency after percutaneous transluminal angioplasty in chronic haemodialysis patients under vascular access monitoring and surveillance: a si... by Chung-Kuan Wu, Der-Cherng Tarng, Chia-Hsun Lin, Jyh-Gang Leu, Chih-Yu Yang

“…Among patients with PTA, those with acute myocardial infarction, high ferritin level or arteriovenous graft (AVG) had a significantly higher risk of reintervention post-PTA (p<0.05). …”
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Tormenta de Polvo: reflexiones de un día de campo en la Patagonia by Javier Grosso

“…El agua que ocupaba la zona, ahora desierta, impidió el crecimiento de vegetales que actúan como sostén del suelo, actuando ella misma como agente retensivo al otorgar peso a las partículas. …”
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Elevated POSTN expression predicts poor prognosis and is associated with radioresistance in cervical cancer patients treated with radical radiotherapy by Cui-qin Huang, Wen-tao Xiao, Xiang-rong Yao, Zhi-min Li, Jun-yan He

“…Drug sensitivity analysis suggested that high POSTN expression may be linked to resistance to multiple chemotherapeutic agents. Furthermore, weighted correlation network analysis (WGCNA) and gene set enrichment analysis (GSEA) identified EMT as a top enriched pathway in patients with high POSTN expression, suggesting it may play a critical role in radiotherapy resistance. …”
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Virological and Immunological Aspects of AIDS Pathogenesis by Brian Conway, Francisco J Diaz-Mitoma

“…As more antiretroviral agents become available. we will be in a position to intervene to “improve” laboratory markers and monitor them prospectively. potentially to maintain clinical latency for an indefinite period of time. …”
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Efficacy and Safety of Murivenna Anal Infiltration Compared to Diltiazem Topical Application in Chronic Anal Fissure: Protocol for a Prospective, Randomized, Open-Label Clinical Tr... by Pratap Shankar KM, Indu Puthan Purayil, Palengara Binitha, Amit Kumar Rai, Sophia Jameela, Azeem Ahmad, Chandra Sekhara Rao Bhogavalli, Narayanam Srikanth, Rabinarayan Acharya

“…There are various treatment options for anal fissure, ranging from pharmacological agents that reduce anal sphincter tone to surgical interventions for cases resistant to medical management. …”
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Mutations in the <i>A34R</i> gene increase the immunogenicity of vaccinia virus by S. N. Shchelkunov, T. V. Bauer, S. N. Yakubitskiy, A. A. Sergeev, A. S. Kabanov, S. A. Pyankov

“…Vaccination is the most simple and reliable approach of protection to virus infections. The most effective agents are live vaccines, usually low-virulence organisms for humans and closely related to pathogenic viruses or attenuated as a result of mutations/deletions in the genome of pathogenic virus. …”
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La costumbre al envenenamiento: El caso de los contaminantes atmosféricos de la ciudad de Guadalajara, México by Salvador Peniche-Camps, Mauro Cortez-Huerta

“…[Conclusiones]: Ignorar la posibilidad real de las afectaciones en la salud pública de la población urbana, derivadas de la concentración de agentes contaminantes en el aire, constituye una limitante de la política ambiental y de salud pública. …”
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Antibiotic Resistance of Enterobacteriaceae in Microbiomes Associated with Poultry Farming by Anna S. Krivonogova, Irina M. Donnik, Albina G. Isaeva, Egor A. Loginov, Maxim V. Petropavlovskiy, Elisey N. Bespamyatnykh

“…In broiler farming, maintenance and circulation of resistance agents depends on litter microbiota. In this research, the chicken that received the phytobiotic showed the lowest level of resistance to ciprofloxacin while the groups that received avilamycin A had the highest resistance results. …”
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Neglected Questions on the “Forgotten War”: South Korea and the United States on the Eve of the Korean War by Mark Caprio

“…They strengthened calls for close vigilance lest the communist state launch a second surprise, unprovoked attack against its southern neighbor. …”
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Zonas frías en el valle del Río Neuquén: su detección mediante imágenes NOAA-AVHRR by Marisa Gloria Cogliati

“…El estudio de las características del clima de la región así como de cada una de las variables climáticas tiene implicancias que poco a poco han sido consideradas por los diferentes agentes del sector productivo. Esto se ve reflejado en la cantidad de estaciones meteorológicas automáticas que han sido adquiridas en la región, tanto por el sector privado como por los organismos públicos relacionados al sector productivo fruti-hortícola (INTA, FUNBAPA; UNC, etc.). …”
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Advanced artificial intelligence with federated learning framework for privacy-preserving cyberthreat detection in IoT-assisted sustainable smart cities by Mahmoud Ragab, Ehab Bahaudien Ashary, Bandar M. Alghamdi, Rania Aboalela, Naif Alsaadi, Louai A. Maghrabi, Khalid H. Allehaibi

“…Abstract With the fast growth of artificial intelligence (AI) and a novel generation of network technology, the Internet of Things (IoT) has become global. Malicious agents regularly utilize novel technical vulnerabilities to use IoT networks in essential industries, the military, defence systems, and medical diagnosis. …”
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Do Maternal Vitamin D Levels Influence Vitamin D Levels in Preterm Neonates? by M. Panda, J. McIntosh, T. Chaudhari, A. L. Kent

“…Demographic data and data on VitD intake from parenteral nutrition, enteral feeds, and vitamin supplementation agents were collected. Results. 70 neonates were enrolled into the study. …”
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Evaluation of maSSS/maSES-PEG2-RM26 for their potential therapeutic use after labeling with Re-188. Could their [99mTc]Tc-labeled counterparts be used to estimate dosimetry? by Panagiotis Kanellopoulos, Quanyi Yu, Abouzayed Abouzayed, Ekaterina Bezverkhniaia, Vladimir Tolmachev, Anna Orlova

“…In GRPR expressing PC-3 cells, both [188Re]Re-labeled peptides displayed high cellular uptake (8.5 ± 0.1% and 5 ± 0.3% of added activity, respectively), heavily GRPR-driven, while retaining the radioantagonistic profile with slow internalization rates. Both agents demonstrated high receptor affinity when loaded with natRe (7.5 nM and 8 nM, respectively). …”
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Distribución espacial de lombrices de tierra y propiedades de un Inceptisol en la ceja de selva peruana by C. J. MESTANZA NOVOA, P. E. ZOROGASTÚA CRUZ

“…Las lombrices de tierra son los agentes más estudiados de la macrofauna del suelo. …”
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