Peptide Design for Enhanced Anti-Melanogenesis: Optimizing Molecular Weight, Polarity, and Cyclization by Putri SA, Maharani R, Maksum IP, Siahaan TJ

“…Peptide optimizations through size modification, polarity change, and cyclization strategies have been shown to be promising as reliable and safe agents for melanin inhibition. Future studies exploring specific amino acid in peptide chains are required to improve efficacy and potential clinical applications of these anti-melanogenic peptides as a hyperpigmentation treatment. …”
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A Personalised Optimising Level Adaptation (OLA) Difficulty Algorithm for Scenario Simulations in Professional VR Simulators by Marcin Wolański Robert, Karol Jędrasiak

“…Project and methods: The OLA algorithm divides scenario activities into blocks and adjusts their difficulty based on user performance in comparison to a reference group of AI-controlled agents. The algorithm’s efficacy was tested across three proprietary VR simulators covering diverse professional scenarios: public speaking, hydrogen electrolysis and mechanical technician operations. …”
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A Comparative Study to Determine the Efficacy of Atosiban versus Nifedipine in Management of Preterm Labour by Vidya Gaikwad, Jay Patel, Suhas Gaikwad

“…The management of PTL involves the use of tocolytic agents to delay delivery, thereby allowing for further foetal development. …”
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Cross-sectional seroprevalence study of bovine herpesvirus 1, bovine respiratory syncytial virus, and parainfluenza virus 3 in cattle from Villavicencio, Colombia by Catalina Ballesteros González, Karen Briñez, Julio César Tobón, Danny Wilson Sanjuanelo Corredor, Fernando Vicosa Bauermann, Blanca Lisseth Guzmán Barragán

“…Many viruses are considered causative agents of BRDC, including bovine herpesvirus 1 (BoHV-1), bovine respiratory syncytial virus (BRSV), and parainfluenza virus 3 (PI-3). …”
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Advancing CNS Therapeutics: Enhancing Neurological Disorders with Nanoparticle-Based Gene and Enzyme Replacement Therapies by Liu S, Li H, Xi S, Zhang Y, Sun T

“…A major obstacle in treating these conditions is the blood-brain barrier (BBB), which restricts the passage of therapeutic agents to the brain. Nanotechnology, particularly the use of nanoparticles (NPs), offers a promising solution to this challenge. …”
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Green synthesis of iron nanoparticles to promote seed germination of Zea mays under salinity condition by Hiba Fouad Abdulfatah, May Fahmi Abdulrahman, Enas Fahd Naji

“…PPE contains biomaterials that have the ability to synthesize Fe NPs through the reduction the iron precursor salt (FeSO4•7H2O) and also act as capping and stabilizing agents. UV–Visible, FTIR, XRD, SEM, EDX, and nano zeta-potential analysis were used to investigate Fe NPs. …”
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Effectiveness of acid-tolerant antagonist-based biofungicide in the control of basal stem rot disease caused by ganoderma in oil palm seedlings on peat soil by Supriyanto, Sulistyowati Henny, Arifin Nur, Ruliyansyah Agus, Haris Ramadahan Tris

“…These results indicate that bio fungicides in powder formula containing acid-tolerant antagonists have the potential to be used as biological control agents for oil palm basal stem rot disease caused by Ganoderma in peatlands.…”
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NT5E (CD73) as a prognostic biomarker and therapeutic target associated with immune infiltration in lung adenocarcinoma by Leyan Chen, Tuoya Qi, Bishu Zhang, Xuelong Wang, Mingfeng Zheng

“…Additionally, drug sensitivity analysis highlights the potential of selumetinib and PD318088, both MEK1/2 inhibitors, to target NT5E in LUAD treatment, suggesting their use as single agents or in combination with other therapies. Collectively, these findings establish NT5E as a promising prognostic biomarker and therapeutic target in LUAD, particularly in the context of immune cell infiltration.…”
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Chemical Composition and Biological Activities of the Essential Oils of Chrysophyllum albidum G. Don (African Star Apple) by Daniel Nartey, Joseph Nana Gyesi, Lawrence Sheringham Borquaye

“…Don could find potential use in the food, cosmetic, and pharmaceutical industries as preservative and pharmaceutical agents.…”
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Isoproterenol mechanisms in inducing myocardial fibrosis and its application as an experimental model for the evaluation of therapeutic potential of phytochemicals and pharmaceutic... by Lujain Bader Eddin, Mohamed Fizur Nagoor Meeran, Niraj Kumar Jha, Samer N. Goyal, Shreesh Ojha

“…ISP has been used for decades to induce acute myocardial infarction. However, the use of low doses and chronic administration of ISP have been shown to induce cardiac fibrosis; this practice has increased in recent years. …”
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Los cursos de didácticas en Educación Especial: sus cambios a lo largo de los 50 años de la carrera en la Universidad de Costa Rica by María de los Angeles Carpio Brenes, Adriana Hernández Olivares, Argelia Scarlette Marmolejo Camacho

“…En este cambio epistemológico y del accionar docente, la carrera de Educación Especial de la UCR ha jugado un papel relevante como agente transformador, tal y como se evidencia en las modificaciones de los planes de estudio y de los programas de los cursos en sus 50 años de existencia. …”
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Design and assembly of plant-based COVID-19 candidate vaccines: reсent development and future prospects by E. A. Uvarova, P. A. Belavin, E. V. Deineko

“…The authors emphasize that plant expression systems have promise for the development of not only protective means under conditions of rapid response (subunit vaccines), but also therapeutic agents in the form of monoclonal antibodies against COVID-19 synthesized in plant cells.…”
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Antimicrobial peptide LL37 is potent against non-growing Escherichia coli cells despite a slower action rate by Salimeh Mohammadi, Derek Saucedo, Sattar Taheri-Araghi

“…ABSTRACT Antimicrobial peptides (AMPs) have long been considered as potential agents against non-growing, dormant cells due to their membrane-targeted action, which is largely independent of the cell’s growth state. …”
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Antithrombotic Therapy Duration after Patent Foramen Ovale Closure for Stroke Prevention: Impact on Long-Term Outcome by Joelle Kefer, Karlien Carbonez, Sophie Pierard, François-Pierre Mouthuy, Andre Peeters, Cedric Hermans, Catherine Lambert, Christophe DeMeester, Thierry Sluysmans, Agnes Pasquet

“…This study sought to compare the clinical outcome of patients receiving antithrombotic agents for a short (6 months) versus extended (>6 months) period after the procedure. …”
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Pain in pancreatitis: issue and ways out by A. V. Okhlobystin

“…Drug therapy of pancreatic pain is based on digestive enzymes, antisecretory and analgetic agents.…”
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The McGill University Health Centre Cancer Pain Clinic: A Retrospective Analysis of an Interdisciplinary Approach to Cancer Pain Management by Jordi Perez, Sara Olivier, Emmanouil Rampakakis, Manuel Borod, Yoram Shir

“…The total consumption of opioids remained stable; however, the consumption of short acting preparations decreased by 52% whereas the prescription of nonopioid agents increased. Beyond drug management, 60% of patients received other analgesic therapies, being the most common interventional pain procedures and psychosocial approaches. …”
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Spatio-temporal changes of water quality variables in a highly disturbed river by Z. Abdollahi, A. Kavian, S.H.R. Sadeghi

“…Many rivers in developing countries are unhealthy because they contain harmful physical, chemical and biological agents. Zanjanrud River, located in Zanjan Province, Iran, where recently faced human intervention needs a regular monitoring from upstream to downstream for sustainable management. …”
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Adverse drug reactions, multimorbidity and polypharmacy: a prospective analysis of 1 month of medical admissions by Girvan Burnside, Munir Pirmohamed, Rostam Osanlou, Dyfrig A Hughes, Lauren Walker

“…Drugs most commonly implicated were diuretics, steroid inhalers, anticoagulants and antiplatelets, proton pump inhibitors, chemotherapeutic agents and antihypertensives. 40.4% of ADRs were classified avoidable or possibly avoidable. …”
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Cancer stem cell populations are resistant to 5-aminolevulinic acid-photodynamic therapy (5-ALA-PDT) by Chantel P. J. Rice, Vipin Shankar Chelakkot, Noah T. Conohan, Kensuke Hirasawa

“…As cancer stem cells (CSCs) are known to drive resistance to other cancer treatments and have high efflux of chemotherapeutic agents via ABC-family transporters, we hypothesize that CSCs underlie 5-ALA-PDT resistance. …”
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Deformation and failure characteristics of soft rock tunnel surrounding rock under mining and water immersion conditions by XIE Panshi, FANG Jiarui, HU Bosheng, ZHANG Bo, ZHANG Xi, DUAN Siyu

“…Water immersion leads to the failure of anchoring agents, which reduces the anchorage strength of bolts and cables, thereby diminishing their load-bearing capacity and severely compromising the safety of the tunnel face. …”
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