Hydrophobic deep eutectic solvents as novel, sustainable aids for intracellular protein release from Saccharomyces cerevisiae by Tjalling Gijsbert Tjalsma, Yannick Patrice Didion, Ziran Su, Magdalena Malankowska, Pablo Torres-Montero, José Luis Martínez, Manuel Pinelo

“…The DESs were synthesized from L-menthol, lidocaine, acetic acid, decanoic acid, oleic acid and lauric acid, and screened for viability. …”
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The multidrug-resistant Candida auris, Candida haemulonii complex and phylogenetic related species: Insights into antifungal resistance mechanisms by Lívia S. Ramos, Pedro F. Barbosa, Carolline M.A. Lorentino, Joice C. Lima, Antonio L. Braga, Raquel V. Lima, Lucas Giovanini, Ana Lúcia Casemiro, Nahyara L.M. Siqueira, Stefanie C. Costa, Célia F. Rodrigues, Maryam Roudbary, Marta H. Branquinha, André L.S. Santos

“…These emerging, widespread, and opportunistic pathogens have drawn significant attention due to their reduced susceptibility to commonly used antifungal agents, particularly azoles and polyenes, and, in some cases, therapy-induced resistance to echinocandins. …”
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De la Gran Recesión a la erupción volcánica de 2021: la turistificación como estrategia de desarrollo territorial de La Palma (Canarias) by David Ramos Pérez

“…Aunque el discurso no es novedoso, la amplia convergencia de actores políticos y empresariales que lo avalan lleva a pensar que se trata del intento más sólido de revertir la tradicional estructura productiva de la isla, dominada por el cultivo del plátano y un modelo de desarrollo turístico que se aleja de los patrones dominantes en Canarias. El artículo analiza la planificación territorial del turismo en La Palma desde 1990, demostrando el papel que ha tenido en su evolución el tránsito desde planteamientos reguladores de corte keynesiano a otros claramente deudores de los principios neoliberales. …”
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Transcription factor FOXD1 and miRNA-204-5p play a major role in B4GALNT2 downregulation in colon cancer by Martina Duca, Nadia Malagolini, Michela Pucci, Virginie Cogez, Anne Harduin-Lepers, Fabio Dall’Olio

“…Through an in silico analysis of The Cancer Genome Atlas and of the Cancer Cell Line Encyclopedia, we identified the transcription factors FOXD1, FOXF2 and PGR as well as mir-204-5p as potential inhibitory agents. Their transient transfection in the cell line GP2d, whose B4GALNT2 is closer to that of a normal mucosa, confirmed their inhibitory activity with a crucial role for FOXD1. …”
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Effect of 2,4-Thiazolidinedione on Limousin Cattle Growth and on Muscle and Adipose Tissue Metabolism by M. Arévalo-Turrubiarte, L. González-Dávalos, A. Yabuta, J. D. Garza, J. L. Dávalos, O. Mora, A. Shimada

“…The main adipogenic transcription factor PPARγ possesses high affinity to 2,4-TZD, a member of the Thiazolidinedione family of insulin-sensitizing compounds used as adipogenic agents. We evaluated 2,4-TZD’s effect on bovine growth and PPAR tissue expression. …”
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Tax-Deductible Provisions for Gluten-Free Diet in Canada Compared with Systems for Gluten-Free Diet Coverage Available in Various Countries by Maria Ines Pinto-Sanchez, Elena F Verdu, Maria C Gordillo, Julio C Bai, Stephen Birch, Paul Moayyedi, Premysl Bercik

“…More efforts are required by the Canadian medical community and the Canadian Celiac Association to act as agents in identifying ways of improving resource allocation in celiac disease.…”
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Effect of clay materials on phase separation in plastic bag waste-modified bitumen during high-temperature storage by Mohammed Nouali, Zohra Derriche, Elhem Ghorbel

“…Clay minerals are widely studied as compatibilizing agents, that prevent binder phase separation in bitumen/polymer/clay blends as often evaluated through softening point testing. …”
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INDIVIDUAÇÃO E LAÇOS SOCIAIS EM PERIFERIAS URBANAS: REFLEXÕES DESDE A PRODUÇÃO DE NARRATIVAS by Leandro R. Pinheiro

“…Neste sentido, tomando informações produzidas em incursões a contextos socialmente vulnerabilizados na cidade de Porto Alegre/RS, entre 2010 e 2017, o texto procura discutir os processos de individuação produzidos por seus moradores. …”
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Prospective clinical evidence from over 1,000 pan-cancer patients: a complement to fosaprepitant in the prevention of chemotherapy-induced nausea and vomiting by Lijuan He, Jize Wang, Weigao Pu, Haiyuan Li, Ben Liu, Zhuanfang Wang, Qinying Han, Yunpeng Wang, Bo Xu, Jike Hu, Guodong Sun, Hao Chen

“…No SAEs were recorded. 23.48% or 3.1% of patients needed rescue therapy for vomiting or nausea control respectively, most of which occurred in the acute phase. CR rate decreased with increasing emetogenicity of chemotherapeutic agents. …”
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Elucidating the synergistic effects of aeration and non-thermal plasma on the degradation pathways of specific pollutants in wastewater by Mahdiyeh Bakhtiyari-Ramezani, Narges Ziveh, Navid Ghaemi

“…Wastewater samples from Kaveh Industrial City underwent treatment in a DBD reactor to induce the formation of reactive agents. Water quality parameters, including turbidity, total dissolved solids (TDS), total suspended solids (TSS), chemical oxygen demand (COD), biochemical oxygen demand (BOD5), dissolved oxygen (DO), electrical conductivity (EC), and pH, were measured before and after synergetic plasma treatment. …”
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Comparative Effectiveness of Anti-Inflammatory Drug Treatments in Coronary Heart Disease Patients: A Systematic Review and Network Meta-Analysis by Ivan Wudexi, Elica Shokri, Mohamed Abo-Aly, Kazuhiro Shindo, Ahmed Abdel-Latif

“…Although many anti-inflammatory medications have failed to reduce adverse cardiovascular outcomes in the CAD population, selected medications show promise among subgroups of patients without ACS or after the first week following an acute ischemic event. Future studies examining the proper timing and targetable anti-inflammatory pathways are warranted.…”
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In vitro high-throughput screening of the antimicrobial activity of different compounds against Xylella fastidiosa subsp. pauca by Carmine Del Grosso, Luca Grandi, Tommaso Lombardi, Giusy D’Attoma, Nicolas Schmitt, Vito Rocco De Michele, Maria Saponari

“…Among the different European isolates, those of the subspecies pauca have been ranked as highly pathogenic, being the causal agents of the olive quick decline decimating olive trees in southern Italy. …”
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Regenerative viticulture and climate change resilience by Flora O'Brien, Alistair Nesbitt, Rebecca Sykes, Belinda Kemp

“…There is less consensus regarding the impact of RV approaches on grape yield, wine quality and greenhouse gas (GHG) emissions, as well as a lack of vineyard-based evidence demonstrating the efficacy of biostimulants and Biological Control Agents (BCAs). Research covering a range of regional or context specific environments regarding regenerative approaches or practices are limited, particularly when seeking to address opportunities for, and impacts of whole vineyard systems change–this is a complex area that has not yet been fully addressed. …”
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Saponins Effect on Human Insulin Amyloid Aggregation by Eleonora Mari, Silvia Vilasi, Paolo Moretti, Maria Rosalia Mangione, Giorgia Giorgini, Roberta Galeazzi, Maria Grazia Ortore

“…This basic research work can pave the way to further investigations concerning insulin amyloidosis, suggesting the use of saponins as amyloid inhibitors and/or stabilizing agents in solution.…”
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Unraveling the Complex Relationship Triad between Lipids, Obesity, and Inflammation by Shahida A. Khan, Ashraf Ali, Sarah A. Khan, Solafa A. Zahran, Ghazi Damanhouri, Esam Azhar, Ishtiaq Qadri

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Un nuevo método para la evaluación de la sustentabilidad agropecuaria en la provincia de Salta, Argentina by M.L. VEGA, M.A. IRIBARNEGARAY, M.E. HERNÁNDEZ, J.L ARZENO, R. OSINAGA, A.L. ZELARAYÁN, D.R. FERNÁNDEZ, F.H MÓNICO SERRANO, J.N. VOLANTE, L. SEGHEZZO

“…Los establecimientos evaluados presentaron un nivel aceptable de sustentabilidad, superando el umbral de aceptabilidad establecido para este estudio. …”
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Evaluation of various RNA-seq approaches for identification of gene outrons in the flatworm Opisthorchis felineus by N. I. Ershov, D. E. Maslov, N. P. Bondar

“…The parasitic flatworm Opisthorchis felineus is one of the causative agents of opisthorchiasis in humans. Recently, we assembled the O. felineus genome, but the correct genome annotation by means of standard methods was hampered by the presence of spliced leader trans-splicing (SLTS). …”
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A current review on animal models of anti-asthmatic drugs screening by Shivam Singh, Sunita Kularia, Shivakshi Shukla, Mithilesh Singh, Manish Kumar, Ashish Kumar Sharma

“…Both genetic and traditional models of anti-asthmatic agents, their characteristics, and their significance are summarized as: In-Vitro Animal Models: Histamine receptor assay, Cell Culture Method, WST Assay, Spasmolytic Activity of the Lungs of Guinea Pigs, Airway and Vascular Responses to an Isolated Lung, The Isolated Perfused Guinea Pig Trachea’s Reactivity. …”
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SETTLEMENTS AND TOPONOMY IN THE PĂTÂRLAGELE DEPRESSION: THE PĂNĂTĂU AND SIBICIU LOCALITIES by NICOLAE MUICĂ, DAVID TURNOCK

“…Un intérêt particulier est accordé à la toponymie présente dans les cartes à grande échelle et les textes clés (notamment le dictionnaire de Iorgulescu de 1892) à laquelle on ajoute le témoignage oral très riche. Les auteurs prêtent attention aussi bien aux terrasses qu’aux surfaces affectées par des glissements adjacents, puisque ces dernières ont été bien attrayantes aux pionniers de l’agriculture, à cause de leur fertilité et humidité, dans un temps que les terrasses étaient utilisées presque exclusivement pour une économie de marché.Quelques surfaces utilisées aujourd’hui pour le foin, pour les pâturages et les vergers de prunes étaient bien cultivées, alors que les terrains à fonction céréalière acquis dans la plaine du Bărăgan, par la réforme agraire de 1923 se sont diversifiés du point de vue économique d’une manière accélérée après 1945. …”
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Lipid Metabolism-Related Gene Signature Predicts Prognosis and Indicates Immune Microenvironment Infiltration in Advanced Gastric Cancer by Lijian He, Qiange Ye, Yanmei Zhu, Wenqi Zhong, Guifang Xu, Lei Wang, Zhangding Wang, Xiaoping Zou

“…Furthermore, our results indicated that most chemotherapeutic agents are more effective for AGC patients in the low-risk group than in the high-risk group, and risk scores for AGC are strongly correlated with drug sensitivity. …”
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