Update on Remdesivir in the Treatment of Novel Coronavirus Pneumonia by Huang Feng, K. Vijaya Lakshmi, Chin Tat Ng, Murthy Sasikumar, Masita Arip, Masriana Hassan, Voon Kin Chin, Mogana Rajagopal, Omotayo Fatokun, N. Parvathi, Malarvili Selvaraja

“…Remdesivir, a COVID-19 therapeutic medication developed by Gilead Sciences, exerts antiviral effects by suppressing the RNA-dependent RNA polymerase of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). …”
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Withaferin A Inhibits Nuclear Factor-κB-Dependent Pro-Inflammatory and Stress Response Pathways in the Astrocytes by Francesca Martorana, Giulia Guidotti, Liliana Brambilla, Daniela Rossi

“…Astroglia are endowed with a wide range of toll-like receptors (TLR) by which they can sense infectious agents as well as endogenous danger signals released by damaged cells. …”
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Topical steroids as alternative to systemic hormonal treatment for inflammatory bowel diseases in pediatric practice by E. N. Fedulova, O. V. Shumilova, O. V. Fedorova, O. A. Tutina, G. V. Medyantseva

“…Anti-inflammatory treatment aimed to destruction of «vicious circle» of inflammatory responses occupies the main place in the treatment of IBD. CS are agents of choice of the second line. Prescription of CS is indicated at high severity of disease, active extraintestinal manifestations, absence of response to 5-aminosalicylic acid or dangerous side effects. …”
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“Quem não se comunica se trumbica”: comportamento decisório e estratégias de autopromoção do Supremo Tribunal Federal by Rebecca Magalhães, Ernani Carvalho

“…Resumo O pós-1988 trouxe maior protagonismo do Judiciário no jogo político, fato que pode derivar tanto de arranjos institucionais quanto de estratégias de seus agentes. Focando na segunda abordagem, discute-se se há uma estratégia de comunicação do Supremo Tribunal Federal (STF) com o público. …”
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Impact of interferon-free regimens in patients with chronic HCV and successfully ablated HCC by Amr Maged Mahmoud Rasheed, Maissa E. L. Raziky, Mohammad El Sayed, Mai Mehrez, Gamal Esmat

“…Patients and methods This trial was carried out on 90 Egyptian persons with chronic HCV infection who were eligible for treatment with oral antiviral agents (DAAs) with hepatic focal lesion(s). Patients were referred to from both the outpatient clinic and hepatocellular carcinoma clinic at the National Hepatology and Tropical Medicine Research Institute (NHTMRI), and the trial was conducted in the period between October 2017 and May 2021. …”
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Notas sobre la Calidad de la Atención a la Infancia by Robert G. Myers

“…Hay que ampliar la visión de calidad de programas de atención inicial para que incorporen beneficios potenciales para todos los participantes, incluso los mismos agentes educativos. Existe el reto de llevar de forma sistemática, al nivel nacional, las observaciones cualitativas de la calidad del proceso educativo que se hacen al nivel de centros individuales, para incorporarlas dentro de un sistema de indicadores…”
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Reevaluating the Concept of Treating Experimental Tumors with a Mixed Bacterial Vaccine: Coley’s Toxin by C. Maletzki, U. Klier, W. Obst, B. Kreikemeyer, M. Linnebacher

“…Data presented herein prove that the historical approach of using killed bacteria as active immunotherapeutic agents still holds promise, and further careful preclinical analyses may pave the way back into clinical applications.…”
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La persistencia de los ámbitos privilegiados de acumulación en la economía argentina by Ana Castellani, Esteban Serrani

“… La noción de ámbitos privilegiados de acumulación de capital resulta particularmente útil a la hora de pensar la naturaleza de la articulación entre intervención económica estatal, acción empresaria y desempeño de los grandes agentes económicos. En efecto, el análisis del caso argentino muestra con claridad cómo durante décadas la perversa articulación entre ciertas políticas públicas destinadas a financiar directamente o indirectamente al capital local y diversas acciones desplegadas por los grandes empresarios permitieron que un reducido grupo de firmas lograra internalizar amplios márgenes de beneficios extraordinarios, dando cuenta de la existencia de múltiples y cruzados ámbitos. …”
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The Active Compound Thymoquinone Alters Chondrogenic Differentiation of Human Mesenchymal Stem Cells via Modulation of Intracellular Signaling by Banu ISKENDER

“…Therefore, the current descriptive study aimed at highlighting the role of thymoquinone on the differentiation of human MSCs (hMSCs) since it is predicted that agents with known anti-inflammatory properties such as TQ have the potential to alter the chondrogenic differentiation of MSCs. …”
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Analysis of poisoning with OTC drugs for suicidal purposes among children and adolescents in Poland in the period 2012 - 2023 by Maria Kubicka, Paulina Polańska, Marta Gruszka, Martyna Zakrocka

“…Paracetamol poisoning remains the leading cause of intentional overdoses, with severe cases potentially resulting in acute liver failure or death if untreated. Girls account for a disproportionate number of cases, and many adolescents who attempt suicide lack prior psychiatric diagnoses. …”
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Development and Evaluation of in situ eye gel for delivery of gatifloxacin and betamethasone sodium phosphate by Fatima Mustafa Ali, Athmar Dhahir Habeeb Al-Shohani, Asma Buanz

“…Formulations containing different gelling agents at different concentrations were prepared to choose the optimum combination regarding physical properties and release. …”
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Bio-synthesised nanoparticles employment for eliminating metals from wastewater via implementation of a three level Box-Behnken technique by P. Jyolsna, V. Gowthami, A. Hajeera Aseen

“…The nanoadsorbents were prepared using a combination of Citrus X sinensis peel and Musa Cavendish peel extract, which served as the reducing agents, to produce a combined peel extract-silver nanoparticle product. …”
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African Swine Fever Outbreak at a Farm in Central Namibia by Alaster Samkange, Borden Mushonga, Douglas Mudimba, Bernard A. Chiwome, Mark Jago, Erick Kandiwa, Alec S. Bishi, Umberto Molini

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The role of KNDy neurons in human reproductive health by Aki Oride, Haruhiko Kanasaki

“…Modification of KNDy neurons by NKB agonists/antagonists is also being attempted to develop therapeutic agents for various menstrual abnormalities, including polycystic ovary syndrome and menopausal hot flashes. …”
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Antibacterial Activity and Mechanisms of Action of Inorganic Nanoparticles against Foodborne Bacterial Pathogens: A Systematic Review by Abayeneh Girma, Birhanu Abera, Bawoke Mekuye, Gedefaw Mebratie

“…Finding novel antibacterial agents with unique mechanisms of action against the current spoilage and foodborne bacterial pathogens is a central strategy to overcome antibiotic resistance. …”
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Prevalence of Plasmid-Mediated Quinolone Resistance Determinants and OqxAB Efflux Pumps among Extended-Spectrum β-Lactamase Producing Klebsiella pneumoniae Isolated from Patients w... by Mehdi Goudarzi, Mehdi Azad, Sima Sadat Seyedjavadi

“…The rates of resistance to antimicrobial agents in present study varied from 14.2% to 98.8%. …”
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Influence of Medication on Flare Up and Infection After Elective Orthopedic Surgery in Rheumatoid Arthritis Patient – A Narrative Review by Yaldi Rosadi, Yustin Marinta, Muthiah Nur Afifah

“…Conversely, discontinuance of antirheumatic agents increases the possibility of a disease flare. …”
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Systemic Thrombolysis for Treatment of Postpartum Saddle Embolism Complicated by Postpartum Hemorrhage: A Case Report and Brief Literature Review by Kathy Mostajeran, Hillary Boswell, Ziad Haidar

“…In nonpregnant populations, thrombolytic agents are well known to decrease the mortality in the setting of a massive pulmonary embolism. …”
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Fibrothorax and Severe Lung Restriction Secondary to Lupus Pleuritis and Its Successful Treatment by Pleurectomy by Sat Sharma, Robert Smith, Fahad Al-Hameed

“…Pleural disease is a common pulmonary manifestation of systemic lupus erythematosus (SLE) that usually responds to corticosteroids and other immunosuppressive agents. In the present report, a new approach, pleural decortication, was used in a patient with medically refractory chronic pleuritis secondary to severe SLE. …”
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Qualitative Phytochemical Profiling and In Vitro Antioxidant Potential Evaluation of South African Momordica Balsamina Linn Fruit Pulp by Buang Matseke, Sipho Mapfumari, Mmamosheledi Mothibe

“…These findings confirmed that <i>M. balsamina</i> is very rich in phytochemical compounds and has strong antioxidant potential; therefore, it could be a potential source of drugs which in the future may serve the production of synthetically improved therapeutic agents.…”
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