Investigation of genes expression of the JAK/STAT signalling pathway and AMPs in the presence of Borrelia spirochetes in Ixodes ricinus by Magdalena Szczotko, Sandra Antunes, Ana Domingos, Małgorzata Dmitryjuk

“…Direct antimicrobial defence occurs through the rapid synthesis of numerous antimicrobial agents including antimicrobial peptides (AMPs). The tick Ixodes ricinus is one of the main vectors of the Lyme disease pathogen, the spirochete Borrelia burgdorferi sensu lato. …”
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Producing hydrogen from biomass and seawater using immobilized carbon nitride photocatalysts by Ana L. Machado, Ricardo A. Oliveira, Goran Dražić, Joana C. Lopes, Cláudia G. Silva, Joaquim L. Faria, Maria J. Sampaio

“…Methanol and saccharides such as cellobiose, fructose, glucose, saccharose and sorbitol were used as sacrificial agents to accelerate H2 production via photoreforming. …”
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Advances in Pure Drug Self-Assembled Nanosystems: A Novel Strategy for Combined Cancer Therapy by Runyan Niu, Xuexue Liu, Xian Yang, Xiao Du, Siliang Wang, Xiaolong Ma, Shaoping Yin, Lihua Shao, Jinping Zhang

“…These include combinations of chemotherapeutic agents, phototherapeutic approaches, the integration of chemotherapy with phototherapy, and the synergistic use of immunotherapy with other treatment methods. …”
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Immune-endocrine crossroads: the impact of nuclear receptors in Tuberculosis and Chagas disease by Ana R. Pérez, Ana R. Pérez, Oscar A. Bottasso, Oscar A. Bottasso, Oscar A. Bottasso, Natalia E. Santucci, Natalia E. Santucci

“…Tuberculosis and Chagas Disease are two critical chronic infections. The causative agents, Mycobacterium tuberculosis and Trypanosoma cruzi, have developed evasion strategies to establish chronic infections. …”
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Metronomic Cyclophosphamide and Methotrexate Chemotherapy Combined with 1E10 Anti-Idiotype Vaccine in Metastatic Breast Cancer by Jorge L. Soriano, Noyde Batista, Eduardo Santiesteban, Mayté Lima, Joaquín González, Robin García, Yohanka Zarza, María V. López, Myriam Rodríguez, Jorge L. Loys, Narciso Montejo, Frank Aguirre, Amparo Macías, Ana M. Vázquez

“…The use of low doses of cytotoxic agents continuously for prolonged periods is an alternative for the treatment of patients with metastatic breast cancer who have developed resistance to conventional chemotherapy. …”
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Isolation, Morphological and Molecular–Phenological Identification of Nematophagous Fungi Inhabiting the Soils of Agricultural Lands in Southern Kazakhstan by Gulzat Kanalbek, Akniyet Zhanuzak, Dmitry Faleev, Aidos Nusupov, Karlygash Mukhatayeva, Kenzhe-Karim Boguspaev

“…Nematophagous fungi, which include nematode-trapping, ovicidal, endoparasitic, toxin-producing, and special substance-producing fungi, are among the most effective biological agents in controlling phytoparasitic nematodes. To isolate and characterize nematophagous fungi, soil samples were collected at 12 sites in three regions of Southern Kazakhstan. …”
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Preparation and Application of Mesoporous Nanotitania Photocatalysts Using Different Templates and pH Media by S. M. Abdel-Azim, A. K. Aboul-Gheit, S. M. Ahmed, D. S. El-Desouki, M. S. A. Abdel-Mottaleb

“…Three types of surfactants, namely, cetyltrimethylammonium bromide, sodium dodecylbenzenesulfonate, and nonylphenol ethoxylate, were used as templating agents. The effects of surfactant type and pH on the morphology, particle size, surface area, pore-size distribution, UV-Vis absorbance, and TiO2 phase transformation were traced by SEM, TEM, BET, and XRD. …”
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Chemical Composition and Cytotoxic and Antioxidant Activities of Satureja montana L. Essential Oil and Its Antibacterial Potential against Salmonella Spp. Strains by Hanene Miladi, Rihab Ben Slama, Donia Mili, Sami Zouari, Amina Bakhrouf, Emna Ammar

“…EO may be considered as an interesting source of components used as potent agents in food preservation and for therapeutic or nutraceutical industries.…”
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Potential Piperolactam A Isolated From Piper betle as Natural Inhibitors of Brucella Species Aminoacyl‐tRNA Synthetase for Livestock Infections: In Silico Approach by Diding Latipudin, Sefren Geiner Tumilaar, Yoga Ramdani, Dudi Dudi, Dikdik Kurnia

“…Piperolactam A was isolated from P. betle by column chromatography and characterized by UV, IR, 1D and 2D NMRs and MS, then tested for their inhibition mechanism against the enzymes threonyl‐tRNA synthetase, leucyl‐tRNA synthetase (LeuRS) and methionyl‐tRNA synthetase in silico. The result in silico test is that piperolactam A has the potential to inhibit LeuRS enzyme with the greater binding affinity.…”
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Analgesia Evaluation of 2 NSAID Drugs as Adjuvant in Management of Chronic Temporomandibular Disorders by Fernando Kurita Varoli, Murillo Sucena Pita, Sandra Sato, João Paulo Mardegan Issa, Cássio do Nascimento, Vinícius Pedrazzi

“…The aim of this triple-blind full-randomized clinical trial was to quantify analgesia in masticatory muscles and temporomandibular joints after occlusal splint therapy associated with the adjuvant administration of nonsteroidal anti-inflammatory drugs (NSAID) isolated or associated with other therapeutic agents. Pain relief was also recorded. Eighteen volunteers who had been suffering from chronic pain in masticatory muscles due to temporomandibular disorders were selected after anamnesis and assessment using RDC/TMD translated to Portuguese. …”
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Sequential transcriptome profiling: comparative analysis of normal and canine lymphoma preceding detailed T-cell and B-cell subtype comparison by Yeji Kim, Yeji Kim, Jihyun Kim, Jihyun Kim, Yunji Song, Yunji Song, Keunhwan Jang, Se Eun Kim, Se Eun Kim, Se Eun Kim, Ha-Jung Kim, Ha-Jung Kim

“…Ongoing research spans multiple domains, aiming to uncover novel therapeutic targets, including small molecular weight inhibitors, antibody treatments, and subtype-specific selective agents.MethodsTranscriptional profiling was performed on canine lymphoma samples to identify genes and functional pathways associated with pathogenesis, treatment response, and prognosis. …”
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Controlling Listeria monocytogenes Scott A on Surfaces of Fully Cooked Turkey Deli Product Using Organic Acid-Containing Marinades as Postlethality Dips by Gerardo Casco, Jennifer L. Johnson, T. Matthew Taylor, Carlos N. Gaytán, Mindy M. Brashears, Christine Z. Alvarado

“…Combination organic acid dips prolonged the lag phase for 2 to 6 wk on turkey product surfaces and can be useful as antimicrobial agents for Lm control on postlethality exposed sliced deli products.…”
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Unveiling the antiglioblastoma potential of harmicens, harmine and ferrocene hybrids by Poje Goran, Šakić Davor, Marinović Marina, You Jiangyang, Tarpley Michael, Williams Kevin P., Golub Nikolina, Dernovšek Jaka, Tomašič Tihomir, Bešić Erim, Rajić Zrinka

“…The poor prognosis of glioblastoma multiforme, inadequate treatment options, and growing drug resistance urge the need to find new effective agents. Due to the significant anti-cancer potential of harmicens, hybrid compounds which comprise harmine/β-carboline and ferrocene moiety, we investigated their antiglioblastoma potential in vitro and mechanism of action (inhibition of DYRK1A, Hsp90, anti-oxidative activity). …”
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Antihyperlipidemic and Antiinflammatory Activity of Crude Oil Anguilla Marmorata [Q.] Gaimard in White Rats (Rattus Norvegicus) by Jamaluddin Jamaluddin, Khildah Khaerati, Ihwan Ihwan, Yusriadi Yusriadi, Andi Ratihsekarningrum Siradje, Apriyana Soputra, Novita Christiana Ponganan, Klerensia Defneir Titing, Novianti Batti, Andi Mustika, Andi Alfianto, Moh. Rifki, Janes Krisly, Finta Amalinda

“…Fish oil has omega-3 and omega-6 fatty acids, which provide health benefits such as prevention of an increase in total cholesterol, triglycerides, and a decrease in blood HDL, as well as being anti-inflammatory agents in humans. The present study was conducted to determine the antihyperlipidemic and anti-inflammatory activities of eel fish (Anguilla marmorata [Q.] …”
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Liver diseases: epidemiology, causes, trends and predictions by Can Gan, Yuan Yuan, Haiyuan Shen, Jinhang Gao, Xiangxin Kong, Zhaodi Che, Yangkun Guo, Hua Wang, Erdan Dong, Jia Xiao

“…Various factors including viruses, alcohol, metabolites, toxins, and other pathogenic agents can compromise liver function, leading to acute or chronic injury that may progress to end-stage liver diseases. …”
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CD4 T-Cell-Independent Antibody Response Reduces Enterovirus 71 Lethality in Mice by Decreasing Tissue Viral Loads by Li-Chiu Wang, Chia-Min Kao, Pin Ling, Ih-Jen Su, Tung-Miao Chang, Shun-Hua Chen

“…Lymphocyte and antibody responses have been suspected to aggravate EV71-induced neurological symptoms, so anti-inflammatory agents have been used to treat patients with neurological symptoms. …”
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Aquatic Invertebrate Antimicrobial Peptides in the Fight Against Aquaculture Pathogens by Tomás Rodrigues, Francisco Antonio Guardiola, Daniela Almeida, Agostinho Antunes

“…These AMPs could serve as feed additives, therapeutic agents, or in genetic engineering approaches like CRISPR/Cas9-mediated transgenesis to enhance resilience of farmed species. …”
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Co-infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and human coronavirus HKU1 (HCoV-HKU1) by Laszlo Madaras, Radean Anvari, Claudia Schuchardt-Peet, Abhinav Hoskote, Rahul Kashyap

“…Introduction: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and human coronavirus HKU1 (HCoV-HKU1) are two forms of human coronaviruses known to cause respiratory tract symptoms. …”
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O processo dialógico e a mediação da leitura na formação do sujeito leitor by Acrisonélia Medeiros de Sousa Rocha, Raquel do Rosário Santos, Ana Claudia Medeiros de Sousa

“…Considerações: o processo dialógico é essencial para a realização das atividades de mediação da leitura, devendo os agentes mediadores considerar as mais variadas formas de linguagens, que proporcionem maior conforto no compartilhamento de saberes por parte dos leitores.…”
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New Players for Advanced Prostate Cancer and the Rationalisation of Insulin-Sensitising Medication by Jennifer H. Gunter, Phoebe L. Sarkar, Amy A. Lubik, Colleen C. Nelson

“…We provide an update on current treatments for advanced prostate cancer and discuss whether metabolic dysfunction, developed during ADT, provides a unique therapeutic window for rapid translation of insulin-sensitising medication as combination therapy with antiandrogen targeting agents for the management of advanced prostate cancer.…”
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