Biological evaluation of novel 5-((1H-indol-3-yl) methyl)-2-(4-chlorobenzyl)-6-phenyl-imidazo[2,1-b][13,4]thiadiazole derivatives as novel BCL-2 specific inhibitors by Shivangi Sharma, Sadashivamurthy Shamanth, Humaira Siddiqua, Laijau Goyary, Kunigal S. Sagar, Susmita Kumari, Divya Sathees, Gudapureddy Radha, Bibha Choudhary, Sathees C. Raghavan, Kempegowda Mantelingu

“…Furthermore, their efficacy across different cancer cell lines highlights their broad potential as anticancer agents. Taken together, our results suggest that Disarib derivatives may have the potential to be developed as cancer therapeutic.…”
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Role of autophagy defects and significance of adherent-invasive <i>Escherichia coli</i> in Crohn's disease development by I. V. Mayev, D. N. Andreev, D. V. Rakitina, Yu. P. Baykova

“…According to modern concept, etiology of CD has complex nature and is determined by genetic predisposition, infectious agents and environmental factors. Alteration of autophagy process (defects of NOD2/ CARD15, ATG16L1, IRGM genes) is one of genetically determined disorders of innate immunity typical for CD. …”
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Association between the Hypertriglyceridemic Waist Phenotype and Prediabetes in Chinese Adults Aged 40 Years and Older by Kun Zhao, Shan-Shan Yang, Hai-Bin Wang, Kang Chen, Zhao-Hui Lu, Yi-Ming Mu

“…Methods. 12757 adults (4101 men and 8656 women) without diabetes or cardiovascular and cerebrovascular diseases, free of using lipid-modified agents, were enrolled in this cross-sectional study. …”
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The dual-function of bioactive peptides derived from oyster (Crassostrea gigas) proteins hydrolysates by Dongyang Zhu, Zhen Yuan, Di Wu, Chao Wu, Hesham R. El-Seedi, Ming Du

“…These results indicate that the digestive hydrolysates obtained from oyster proteins could be used as natural anti-diabetic and antioxidant agents.…”
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Fragipan Horizon Fragmentation in Slaking Experiments with Amendment Materials and Ryegrass Root Tissue Extracts by A. D. Karathanasis, L. W. Murdock, C. J. Matocha, J. Grove, Y. L. Thompson

“…Additional fragmentation occurs in a followup stage during which potential Si, Al, Fe, and Mn binding agents may be released into solution. Field experiments testing these findings are in progress.…”
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Emerging PPARγ-Independent Role of PPARγ Ligands in Lung Diseases by Ajit A. Kulkarni, Collynn F. Woeller, Thomas H. Thatcher, Sesquile Ramon, Richard P. Phipps, Patricia J. Sime

“…PPARγ ligands show great promise in moderating lung inflammation, as antiproliferative agents in combination to enhance standard chemotherapy in lung cancer and as treatments for pulmonary fibrosis, a progressive fatal disease with no effective therapy. …”
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Stress-Induced Premature Senescence or Stress-Induced Senescence-Like Phenotype: One In Vivo Reality, Two Possible Definitions? by Olivier Toussaint, Patrick Dumont, Jose Remacle, Jean-Francois Dierick, Thierry Pascal, Christophe Frippiat, Joao Pedro Magalhaes, Stephanie Zdanov, Florence Chainiaux

“…Other authors gave an enlarged functional definition encompassing any kind of irreversible arrest of proliferative cell types induced by damaging agents or cell cycle deregulations after overexpression of proto-oncogenes (definition 2). …”
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Digital Competence of Rural Teachers in Depopulated Regions of Spain: A Bibliometric Review by Pablo Fernández-Arias, María Sánchez-Jiménez, Álvaro Antón-Sancho, María Nieto-Sobrino, Diego Vergara

“…Rural teachers have the potential to be important agents of local development. To achieve this goal, they need to acquire high digital competence in order to effectively integrate technology into their pedagogical practices, thus enriching the learning experience of students and fostering their participation. …”
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Generation of Femtosecond Laser-Cut Decellularized Corneal Lenticule Using Hypotonic Trypsin-EDTA Solution for Corneal Tissue Engineering by Man-Il Huh, Kyoung-Pil Lee, Jeongho Kim, Soojin Yi, Byeong-Ung Park, Hong Kyun Kim

“…The decellularization efficacy of several agents (0.1%, 0.25%, and 0.5% of Triton X-100, SDS, and trypsin-EDTA (TE), resp.) with different tonicities was evaluated. …”
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Drug-Drug Interactions Between HIV Antivirals and Concomitant Drugs in HIV Patients: What We Know and What We Need to Know by Emanuela De Bellis, Danilo Donnarumma, Adele Zarrella, Salvatore Maria Mazzeo, Annarita Pagano, Valentina Manzo, Ines Mazza, Francesco Sabbatino, Graziamaria Corbi, Pasquale Pagliano, Amelia Filippelli, Valeria Conti

“…Protease inhibitors, followed by nonnucleoside reverse transcriptase inhibitors and integrase inhibitors have been recognized as the main players in DDIs with antivirals used to control co-infection, such as Hepatitis C virus, or with drugs commonly used to treat HIV comorbidities, such as lipid-lowering agents, proton pump inhibitors and anticancer drugs. …”
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Dimethyl fumarate effects on paraquat-induced hepatotoxicity in mice via anti-oxidative, anti-inflammatory, and anti-apoptotic activities by Maryam Kavianinia, Hadi Kalantar, Maryam Salehcheh, Layasadat Khorsandi, Saeedeh Shariati, Shokooh Mohtadi, Mohammad Javad Khodayar

“…Therefore, the use of agents that reduce these disorders can be effective in the treatment of PQ toxicity. …”
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Exclusive Use of Air as Gas Tamponade in Rhegmatogenous Retinal Detachment by Kang Yeun Pak, Seok Jae Lee, Han Jo Kwon, Sung Who Park, Ik Soo Byon, Ji Eun Lee

“…Patients whose eyes were treated exclusively with air tamponade since July 2014 were assigned to the air group, while those treated with heterogeneous gas agents before June 2014 were assigned to the control group. …”
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Metastatic brain tumors: from development to cutting‐edge treatment by Guilong Tanzhu, Liu Chen, Jiaoyang Ning, Wenxiang Xue, Ce Wang, Gang Xiao, Jie Yang, Rongrong Zhou

“…Moreover, preclinical agents often need to cross the blood–brain barrier to achieve high intracranial concentrations, including small‐molecule inhibitors, nanoparticles, and peptide drugs. …”
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Cardiovascular disease risk in Korean patients with systemic lupus erythematosus compared to diabetes mellitus and the general population by Jung-Yong Han, Soo-Kyung Cho, Yena Jeon, Gaeun Kang, Sun-Young Jung, Eun Jin Jang, Yoon-Kyoung Sung

“…Advanced age, male gender, and current use of glucocorticoids, immunosuppressive, and anti-platelet agents were associated with increased CVD risk in SLE patients. …”
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Black mulberry (Morus nigra L.) prevents deleterious effects of excess glucose in obese C. elegans decreasing lipofuscin accumulation and ROS production by Sonia Núñez, Adrián Millán-Laleona, Javier Cano-Lou, Andrea Corella, Cristina Moliner, Guillermo Cásedas, Filippo Maggi, Víctor López, Carlota Gómez-Rincón

“…Black mulberries have been traditionally used as antidiabetic agents and are a source of nutrients and phenolic compounds, particularly anthocyanins. …”
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Canadian Association of Gastroenterology Indicators of Safety Compromise following Colonoscopy in Clinical Practice by Mark R. Borgaonkar, David Pace, Muna Lougheed, Curtis Marcoux, Bradley Evans, Nikita Hickey, Meghan O’Leary, Jerry McGrath

“…Medication-related includes use of reversal agents 0.1%, hypoxia 9.9%, hypotension 15.4%, and hypertension 0.9%. …”
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Development of Antimicrobial Biopolymer Film Incorporated with a Mixture of Sodium Lactate and Diacetate and Studying its Efficacy Against Listeria monocytogenes and Microbiologica... by Katherine Sierra, Luis Guzman, Vianca Tashiguano, Micah T. Black, Payten Leeds, Jakob Doster, Laura J. Garner, Sungeun Cho, Yucheng Peng, Amit Morey

“…Additionally, incorporating antimicrobial agents can improve food safety and extend shelf life, thereby increasing the market acceptance of these environmentally friendly packaging solutions. …”
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Salmonella in Liquid Eggs and Other Foods in Fukuoka Prefecture, Japan by Koichi Murakami, Tamie Noda, Daisuke Onozuka, Nobuyuki Sera

“…Samples consisted of liquid eggs (n=30), meat (beef and pork) (n=781), offal (n=69), processed meats (n=2), seafood (n=232), processed seafood (dried fish) (n=76), vegetables (n=481), processed vegetables (n=87), fruits (n=167), and herbs (n=96) from 574 outlets and wholesale agents in 15 areas (five samples were undocumented regarding outlets). …”
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THORIUM, URANIUM AND RARE EARTH MINERALIZATION IN ROCKS OF THE UGAKHAN GOLD DEPOSIT, BODAIBO ORE REGION by E.V. Shepel, N.R. Ayupova, M.A. Rassomakhin, P.V. Khvorov

“…The rocks consist of quartz, feldspar (albite, orthoclase), Fe-Mg chlorite, mica (muscovite, sericite) and carbonates (calcite, dolomite, ankerite) and accessory titanite, rutile, tourmaline, zircon and apatite. …”
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Control of White Spot Lesion Adjacent to Orthodontic Bracket with Use of Fluoride Varnish or Chlorhexidine Gel by Manuel Restrepo, Diego G. Bussaneli, Fabiano Jeremias, Rita C. L. Cordeiro, Ana C. Magalhães, Denise M. Palomari Spolidorio, Lourdes Santos-Pinto

“…TMR was performed to quantify lesion depth and mineral content after caries induction to evaluate the effects of F, CHX, and CO 3 months after the last application of agents. The data were analyzed by repeated measures ANOVA and Tukey’s test. …”
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